Solving the problems of low electrical conductivity and poor cycling durability in transition metal oxidesbased anode materials for lithium-ion batteries(LIBs)and sodium-ion batteries(SIBs)has already turned into an u...Solving the problems of low electrical conductivity and poor cycling durability in transition metal oxidesbased anode materials for lithium-ion batteries(LIBs)and sodium-ion batteries(SIBs)has already turned into an urgent requirement.In this paper,we successfully synthesized Co_(2)VO_(4)/Co compounds with Co-VMOF(metal-organic framework)as a sacrificial template and investigated their electrochemical mechanism in order to improve the electrochemical properties of LIBs and SIBs.The optimized heaping configuration and the existence of metallic Co catalyzed the formation of radical ions,thereby facilitating higher conductivity,shortening Li+and Na+transport paths,and providing more active sites.Co_(2)VO_(4)/Co constructed with 2-methylimidazole as a ligand showed a discharge capacity of 1605.1 mA h g^(-1)after 300 cycles at 0.1 A g^(-1)in LIB and 677.2 mA h g^(-1)in SIB.Density functional theory(DFT)calculation emphasizes the crucial role of Co_(2)VO_(4)/Co in enhancing electrode conductivity,decreasing the migratory energy barrier,and thereby strengthening electrochemical properties.This heterostructure building technique may pave the way for the development of high-performance LIBs and SIBs.Furthermore,the problem of the low first-loop coulombic efficiency faced by transition metal oxides is improved.展开更多
A new kind of step-flow growth mode is proposed,which adopts sidewall as step source on patterned GaN substrate.The terrace width of steps originated from the sidewall was found to change with the growth temperature a...A new kind of step-flow growth mode is proposed,which adopts sidewall as step source on patterned GaN substrate.The terrace width of steps originated from the sidewall was found to change with the growth temperature and ammonia flux.The growth mechanism is explained and simulated based on step motion model.This work helps better understand the behaviors of step advancement and puts forward a method of precisely modulating atomic steps.展开更多
In recent years, additive manufacturing (AM), known as “3D printing”, has experienced exceptional growth thanks to the development of mechatronics and materials science. Fused filament deposition (FDM) manufacturing...In recent years, additive manufacturing (AM), known as “3D printing”, has experienced exceptional growth thanks to the development of mechatronics and materials science. Fused filament deposition (FDM) manufacturing is the most widely used technique in the field of AM, due to low operating and material costs. However, the materials commonly used for this technology are virgin thermoplastics. It is worth noting a considerable amount of waste exists due to failed print and disposable prototypes. In this regard, using green and sustainable materials is essential to limit the impact on the environment. The recycled, bio-based, and blended recycled materials are therefore a potential approach for 3D printing. In contrast, the lack of understanding of the mechanism of interlayer adhesion and the degradation of materials for FDM printing has posed a major challenge for these green materials. This paper provides an overview of the FDM technique and material requirements for 3D printing filaments. The main objective is to highlight the advantages and disadvantages of using recycled, bio-based, and blended materials based on thermoplastics for 3D printing filaments. In this work, solutions to improve the mechanical properties of 3D printing parts before, during, and after the printing process are pointed out. This paper provides an overview on choosing which materials and solutions depend on the specific application purposes. Moreover, research gaps and opportunities are mentioned in the discussion and conclusions sections of this study.展开更多
Foamed zinc was prepared by infiltration casting process.The mechanical properties and corrosion resistance of the samples were studied,and the feasibility of the foamed zinc as a bone implant material was discussed.A...Foamed zinc was prepared by infiltration casting process.The mechanical properties and corrosion resistance of the samples were studied,and the feasibility of the foamed zinc as a bone implant material was discussed.All the compression stress-strain curves of open-cell zinc foams with various cell size(1-4 mm)and porosity(55%-67%)show three stages:elastic stage,plastic stage,and densification stage.The compression strength increases with decreasing density.The smooth stress-strain response indicates a progressively deformation of open-cell zinc foam.In addition,the cell wall or edge bending and fracture are the dominated mechanisms for failure of open cell zinc foam.The immersion test for determining the corrosion rate of open cell zinc foam was conducted in simulated body fluid.It was found that zinc foam with a small cell size and high porosity showed a higher corrosion rate.In addition,open-cell zinc foams can effectively induce Ca-P deposition in immersion tests,showing good bioactivity.Therefore,the open cell zinc foam prepared in this experiment has a good potential application as a human bone substitute material.展开更多
Levulinic acid(LA)is one of the top-12 most promising biomass-based platform chemicals,which has a wide range of applications in a variety of fields.However,separation and purification of LA from aqueous solution or a...Levulinic acid(LA)is one of the top-12 most promising biomass-based platform chemicals,which has a wide range of applications in a variety of fields.However,separation and purification of LA from aqueous solution or actual hydrolysate continues to be a challenge.Among various downstream separation technologies,liquid-liquid extraction is a low-cost,effective,and simple process to separate LA.The key breakthrough lies in the development of extractants with high extraction efficiency,good hydrophobicity,and low cost.In this work,three hydrophobic deep eutectic solvents(DESs)based on tri-n-octylamine(TOA)as hydrogen bond acceptor(HBA)and alcohols(butanol,2-octanol,and menthol)as hydrogen bond donors(HBDs)were developed to extract LA from aqueous solution.The molar ratios of HBD and HBA,extraction temperature,contact time,solution pH,and initial LA concentration,DES/water volume ratios were systematically investigated.Compared with 2-octanol-TOA and menthol-TOA DES,the butanol-TOA DES exhibited the superior extraction performance for LA,with a maximum extraction efficiency of 95.79±1.4%.Moreover,the solution pH had a great impact on the LA extraction efficiency of butanol-TOA(molar ratio=3:1).It is worth noting that the extraction equilibrium time was less than 0.5 h.More importantly,the butanol-TOA(3:1)DES possesses good extraction abilities for low,medium,and high concentrations of LA.展开更多
The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neu...The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering technique.This imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum transfers.To satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 atm.It uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 m2.The detector works in air,which is separated from the vacuum environment to facilitate installation and maintenance.The characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental measurements.The results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam experiment.The detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event rate.Observations of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.展开更多
The Wnt/β-catenin signaling pathway is the main target of tooth regeneration regulation.Treatment of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway,yet the function of this pathway in tooth regene...The Wnt/β-catenin signaling pathway is the main target of tooth regeneration regulation.Treatment of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway,yet the function of this pathway in tooth regeneration remains unclear.Here,we found that AZD2858 promotes the accumulation ofβ-catenin in the nuclei of stem cells from the apical papilla(SCAPs)and enhances cell proliferation.Single-cell sequencing was performed on SCAPs treated with AZD2858.Eight clusters were identified,namely SCAPs-CNTNAP2,SCAPs-DTL,SCAPs-MYH11,SCAPs-MKI67,SCAPs-CXCL8,SCAPs-TPM2,SCAPs-IFIT2 and SCAPs-NEK10.The pseudo-time trajectory analysis showed that AZD2858 enhanced the evolution of SCAPs from SCAPs-TMP2 clusters to SCAPs-MYH11,SCAPs-CNTNAPs and SCAPs-NEK10 clusters via up-regulation of PRKCA,SMURF2,MAGI2,RBMS3,EXT1,CAMK2D,PLCB4,and PLCB1.These results demonstrate that AZD2858 enhances the proliferation of SCAPs-TPM2 cluster by activating the non-canonical Wnt/β-catenin signaling pathway.展开更多
Atherosclerotic cardiovascular disease(ASCVD)includes a group of disorders of the heart and blood vessels and accounts for major morbidity and premature death worldwide.Periodontitis is a chronic inflammatory disease ...Atherosclerotic cardiovascular disease(ASCVD)includes a group of disorders of the heart and blood vessels and accounts for major morbidity and premature death worldwide.Periodontitis is a chronic inflammatory disease with the gradual destruction of supporting tissues around the teeth,including gingiva,periodontal ligament,alveolar bone,and cementum.Periodontitis has been found to potentially increase the risk of ASCVD.Generally,oral microorganisms and inflammation are the major factors for periodontitis to the incidence of ASCVD.Recently,evidence has shown that the loss of masticatory function is another important factor of periodontitis to the incidence of ASCVD.In this review,we illustrate the recent finding of the relationship between periodontitis and ASCVD,from a microscale perspective-oral microorganisms,inflammation,and tooth loss.With the high prevalence of periodontitis,it is important to add oral therapy as a regular ASCVD prevention strategy.Regular dental visits could be a helpful strategy for ASCVD patients or general medical practitioners.展开更多
The YOLOx-s network does not sufficiently meet the accuracy demand of equipment detection in the autonomous inspection of distribution lines by Unmanned Aerial Vehicle(UAV)due to the complex background of distribution...The YOLOx-s network does not sufficiently meet the accuracy demand of equipment detection in the autonomous inspection of distribution lines by Unmanned Aerial Vehicle(UAV)due to the complex background of distribution lines,variable morphology of equipment,and large differences in equipment sizes.Therefore,aiming at the difficult detection of power equipment in UAV inspection images,we propose a multi-equipment detection method for inspection of distribution lines based on the YOLOx-s.Based on the YOLOx-s network,we make the following improvements:1)The Receptive Field Block(RFB)module is added after the shallow feature layer of the backbone network to expand the receptive field of the network.2)The Coordinate Attention(CA)module is added to obtain the spatial direction information of the targets and improve the accuracy of target localization.3)After the first fusion of features in the Path Aggregation Network(PANet),the Adaptively Spatial Feature Fusion(ASFF)module is added to achieve efficient re-fusion of multi-scale deep and shallow feature maps by assigning adaptive weight parameters to features at different scales.4)The loss function Binary Cross Entropy(BCE)Loss in YOLOx-s is replaced by Focal Loss to alleviate the difficulty of network convergence caused by the imbalance between positive and negative samples of small-sized targets.The experiments take a private dataset consisting of four types of power equipment:Transformers,Isolators,Drop Fuses,and Lightning Arrestors.On average,the mean Average Precision(mAP)of the proposed method can reach 93.64%,an increase of 3.27%.The experimental results show that the proposed method can better identify multiple types of power equipment of different scales at the same time,which helps to improve the intelligence of UAV autonomous inspection in distribution lines.展开更多
To the Editor: Hypoxic hepatitis(HH), also known as ischemic hepatitis or shock liver, is a liver injury characterized by necrosis of centrilobular hepatocytes with a rapid increase in serum aminotransferase levels. T...To the Editor: Hypoxic hepatitis(HH), also known as ischemic hepatitis or shock liver, is a liver injury characterized by necrosis of centrilobular hepatocytes with a rapid increase in serum aminotransferase levels. The incidence rate of HH among patients in the intensive care unit(ICU) was found to be 0.9%-11.9% [1]. Occurrence of HH appears to have a significant impact on the clinical outcome.展开更多
Analyzing and comparing the effects of labor-saving cultivation modes on photosynthesis,as well as studying their vertical canopy architecture,can improve the tree structure of high-quality and high-yield citrus and s...Analyzing and comparing the effects of labor-saving cultivation modes on photosynthesis,as well as studying their vertical canopy architecture,can improve the tree structure of high-quality and high-yield citrus and selection of labor-saving cultivation modes.The photosynthesis of 1080 leaves of two labor-saving cultivation modes(wide-row and narrow-plant mode and fenced mode)comparing with the traditional mode were measured,and nitrogen content of all leaves and photosynthetic nitrogen use efficiency(PNUE)were determined.Unmanned aerial vehicle(UAV)-based light detection and ranging(LiDAR)data were used to assess the vertical architecture of three citrus cultivation modes.Results showed that for the wide-row and narrow-plant and traditional modes leaf photosynthetic CO_(2) assimilation rate,stomatal conductance,and transpiration rate of the upper layer were significantly higher than those of the middle layer,and values of the middle layer were markedly higher than those of the lower layer.In the fenced mode,a significant difference in photosynthetic factors between the upper and middle layers was not observed.A vertical canopy distribution had a more significant effect on PNUE in the traditional mode.Leaves in the fenced mode had distinct photosynthetic advantages and higher PNUE.UAV-based LiDAR data effectively revealed the differences in the vertical canopy architecture of citrus trees by enabling calculating the density and height percentile of the LiDAR point cloud.The point cloud densities of three cultivation modes were significantly different for all LiDAR density slices,especially at higher canopy heights.The labor-saving modes,particularly the fenced mode,had significantly higher height percentile data.展开更多
To eliminate unnecessary background information,such as soft tissues in original CT images and the adverse impact of the similarity of adjacent spines on lumbar image segmentation and surgical path planning,a two‐sta...To eliminate unnecessary background information,such as soft tissues in original CT images and the adverse impact of the similarity of adjacent spines on lumbar image segmentation and surgical path planning,a two‐stage approach for localising lumbar segments is proposed.First,based on the multi‐scale feature fusion technology,a non‐linear regression method is used to achieve accurate localisation of the overall spatial region of the lumbar spine,effectively eliminating useless background information,such as soft tissues.In the second stage,we directly realised the precise positioning of each segment in the lumbar spine space region based on the non‐linear regression method,thus effectively eliminating the interference caused by the adjacent spine.The 3D Intersection over Union(3D_IOU)is used as the main evaluation indicator for the positioning accuracy.On an open dataset,3D_IOU values of 0.8339�0.0990 and 0.8559�0.0332 in the first and second stages,respectively is achieved.In addition,the average time required for the proposed method in the two stages is 0.3274 and 0.2105 s respectively.Therefore,the proposed method performs very well in terms of both pre-cision and speed and can effectively improve the accuracy of lumbar image segmentation and the effect of surgical path planning.展开更多
The purpose of this work is to evaluate the use of a two-dimensional (2D) planar ion chamber array to characterize leakage radiation from the head of the linear accelerator. Ion chamber arrays provide a benefit over a...The purpose of this work is to evaluate the use of a two-dimensional (2D) planar ion chamber array to characterize leakage radiation from the head of the linear accelerator. Ion chamber arrays provide a benefit over a singular ion chamber measurement as they allow for the measurement of a larger area in order to isolate the point of maximum leakage dose and the small size of each individual ion chamber minimizes volume-averaging effects. A Varian Truebeam<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><sup><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">®</span></span></sup></span> undergoing acceptance testing was used for all measurements. The gantry was wrapped in Portal Pack for Localization (PPL) radiographic film in order to isolate the location of maximum leakage. A calibration curve was developed and used to determine dose-to-film. An Ion Chamber Profiler (IC Profiler<sup><span style="font-size:6.5pt;font-family:;" "=""><span style="white-space:nowrap;">™</span></span></sup>) manufactured by Sun Nuclear Corporation was used to confirm measurements by the PPL film. All measurements were normalized to leakage at 100 cm from the target relative to the central axis. Three points were investigated with the IC Profiler, including the top of the gantry, the Varian logo, and the side of the gantry. For the three locations, respectively, the PPL film and the IC profiler were measured 0.142% and 0.131%, 0.036% and 0.030%, and 0.014% and 0.019%. The good agreement between the PPL film and the IC Profiler provides confidence in the use of a more efficient and accurate ion chamber array for head leakage measurements.展开更多
基金financially supported by the Open Fund of Energy and Materials Chemistry Joint Laboratory of SCNU and TINCI,China (SCNU-TINCI-202207)。
文摘Solving the problems of low electrical conductivity and poor cycling durability in transition metal oxidesbased anode materials for lithium-ion batteries(LIBs)and sodium-ion batteries(SIBs)has already turned into an urgent requirement.In this paper,we successfully synthesized Co_(2)VO_(4)/Co compounds with Co-VMOF(metal-organic framework)as a sacrificial template and investigated their electrochemical mechanism in order to improve the electrochemical properties of LIBs and SIBs.The optimized heaping configuration and the existence of metallic Co catalyzed the formation of radical ions,thereby facilitating higher conductivity,shortening Li+and Na+transport paths,and providing more active sites.Co_(2)VO_(4)/Co constructed with 2-methylimidazole as a ligand showed a discharge capacity of 1605.1 mA h g^(-1)after 300 cycles at 0.1 A g^(-1)in LIB and 677.2 mA h g^(-1)in SIB.Density functional theory(DFT)calculation emphasizes the crucial role of Co_(2)VO_(4)/Co in enhancing electrode conductivity,decreasing the migratory energy barrier,and thereby strengthening electrochemical properties.This heterostructure building technique may pave the way for the development of high-performance LIBs and SIBs.Furthermore,the problem of the low first-loop coulombic efficiency faced by transition metal oxides is improved.
基金This work was supported by the National Key Research and Development Program of China(2022YFB2802801)the National Natural Science Foundation of China(61834008,U21A20493)+1 种基金the Key Research and Development Program of Jiangsu Province(BE2020004,BE2021008-1)the Suzhou Key Laboratory of New-type Laser Display Technology(SZS2022007).
文摘A new kind of step-flow growth mode is proposed,which adopts sidewall as step source on patterned GaN substrate.The terrace width of steps originated from the sidewall was found to change with the growth temperature and ammonia flux.The growth mechanism is explained and simulated based on step motion model.This work helps better understand the behaviors of step advancement and puts forward a method of precisely modulating atomic steps.
文摘In recent years, additive manufacturing (AM), known as “3D printing”, has experienced exceptional growth thanks to the development of mechatronics and materials science. Fused filament deposition (FDM) manufacturing is the most widely used technique in the field of AM, due to low operating and material costs. However, the materials commonly used for this technology are virgin thermoplastics. It is worth noting a considerable amount of waste exists due to failed print and disposable prototypes. In this regard, using green and sustainable materials is essential to limit the impact on the environment. The recycled, bio-based, and blended recycled materials are therefore a potential approach for 3D printing. In contrast, the lack of understanding of the mechanism of interlayer adhesion and the degradation of materials for FDM printing has posed a major challenge for these green materials. This paper provides an overview of the FDM technique and material requirements for 3D printing filaments. The main objective is to highlight the advantages and disadvantages of using recycled, bio-based, and blended materials based on thermoplastics for 3D printing filaments. In this work, solutions to improve the mechanical properties of 3D printing parts before, during, and after the printing process are pointed out. This paper provides an overview on choosing which materials and solutions depend on the specific application purposes. Moreover, research gaps and opportunities are mentioned in the discussion and conclusions sections of this study.
基金Key Research and Development Program of Liaoning Province(2019JH2/10100008)the Plan for Innovative Talents in Liaoning Higher Education Institutions(LR2018011)the Plan for Young and Middle-aged Science and Technology Innovation Talent of Shenyang(RC170204).
文摘Foamed zinc was prepared by infiltration casting process.The mechanical properties and corrosion resistance of the samples were studied,and the feasibility of the foamed zinc as a bone implant material was discussed.All the compression stress-strain curves of open-cell zinc foams with various cell size(1-4 mm)and porosity(55%-67%)show three stages:elastic stage,plastic stage,and densification stage.The compression strength increases with decreasing density.The smooth stress-strain response indicates a progressively deformation of open-cell zinc foam.In addition,the cell wall or edge bending and fracture are the dominated mechanisms for failure of open cell zinc foam.The immersion test for determining the corrosion rate of open cell zinc foam was conducted in simulated body fluid.It was found that zinc foam with a small cell size and high porosity showed a higher corrosion rate.In addition,open-cell zinc foams can effectively induce Ca-P deposition in immersion tests,showing good bioactivity.Therefore,the open cell zinc foam prepared in this experiment has a good potential application as a human bone substitute material.
基金supported by the Key Area Research&Development Program of Guangdong Province(2020B0101070001)the National Natural Science Foundation of China(21978053,51508547)。
文摘Levulinic acid(LA)is one of the top-12 most promising biomass-based platform chemicals,which has a wide range of applications in a variety of fields.However,separation and purification of LA from aqueous solution or actual hydrolysate continues to be a challenge.Among various downstream separation technologies,liquid-liquid extraction is a low-cost,effective,and simple process to separate LA.The key breakthrough lies in the development of extractants with high extraction efficiency,good hydrophobicity,and low cost.In this work,three hydrophobic deep eutectic solvents(DESs)based on tri-n-octylamine(TOA)as hydrogen bond acceptor(HBA)and alcohols(butanol,2-octanol,and menthol)as hydrogen bond donors(HBDs)were developed to extract LA from aqueous solution.The molar ratios of HBD and HBA,extraction temperature,contact time,solution pH,and initial LA concentration,DES/water volume ratios were systematically investigated.Compared with 2-octanol-TOA and menthol-TOA DES,the butanol-TOA DES exhibited the superior extraction performance for LA,with a maximum extraction efficiency of 95.79±1.4%.Moreover,the solution pH had a great impact on the LA extraction efficiency of butanol-TOA(molar ratio=3:1).It is worth noting that the extraction equilibrium time was less than 0.5 h.More importantly,the butanol-TOA(3:1)DES possesses good extraction abilities for low,medium,and high concentrations of LA.
基金supported by the National Key R&D Program of China (No. 2021YFA1600703)National Natural Science Foundation of China (No. 12175254)Youth Innovation Promotion Association CAS
文摘The multi-physics instrument(MPI)is the first user cooperative instrument at the China Spallation Neutron Source(CSNS).It was designed to explore the structures of complex materials at multiple scales based on the neutron total scattering technique.This imposes the requirements for the detector,including a high detection efficiency to reduce the measurement time and a large solid angle coverage to cover a wide range of momentum transfers.To satisfy these demands,a large-area array of 3He-filled linear position-sensitive detectors(LPSDs)was constructed,each with a diameter of 1 inch and pressure of 20 atm.It uses an orbicular layout of the detector and an eight-pack module design for the arrangement of 3He LPSDs,covering a range of scattering angles from 3°to 170°with a total detector area of approximately 7 m2.The detector works in air,which is separated from the vacuum environment to facilitate installation and maintenance.The characteristics of the MPI detector were investigated through Monte Carlo(MC)simulations using Geant4 and experimental measurements.The results suggest that the detectors are highly efficient in the wavelength range of the MPI,and an efficiency over 25%is achievable for above 0.1 A neutrons.A minimal position resolution of 6.4 mm full width at half maximum(FWHM)along the tube length was achieved at a working voltage of 2200 V,and a deviation below 2 mm between the real and measured positions was attained in the beam experiment.The detector module exhibited good consistency and an excellent counting rate capacity of up to 80 kHz,which satisfied the requirements of experiments with a high event rate.Observations of its operation over the past year have shown that the detector works steadily in sample experiments,which allows the MPI to serve the user program successfully.
基金the fund of National Natural Science Foundation of China(82170951)Beijing Natural Science Foundation(7222079).
文摘The Wnt/β-catenin signaling pathway is the main target of tooth regeneration regulation.Treatment of cells with AZD2858 stimulates the Wnt/β-catenin signaling pathway,yet the function of this pathway in tooth regeneration remains unclear.Here,we found that AZD2858 promotes the accumulation ofβ-catenin in the nuclei of stem cells from the apical papilla(SCAPs)and enhances cell proliferation.Single-cell sequencing was performed on SCAPs treated with AZD2858.Eight clusters were identified,namely SCAPs-CNTNAP2,SCAPs-DTL,SCAPs-MYH11,SCAPs-MKI67,SCAPs-CXCL8,SCAPs-TPM2,SCAPs-IFIT2 and SCAPs-NEK10.The pseudo-time trajectory analysis showed that AZD2858 enhanced the evolution of SCAPs from SCAPs-TMP2 clusters to SCAPs-MYH11,SCAPs-CNTNAPs and SCAPs-NEK10 clusters via up-regulation of PRKCA,SMURF2,MAGI2,RBMS3,EXT1,CAMK2D,PLCB4,and PLCB1.These results demonstrate that AZD2858 enhances the proliferation of SCAPs-TPM2 cluster by activating the non-canonical Wnt/β-catenin signaling pathway.
基金supported by the National Natural Science Foundation of China(82001067)the Innovation Research Team Project of Beijing Stomatological Hospital,Capital Medical University(CXTD202201)+2 种基金Beijing Municipal Administration of Hospitals’Youth Program(QML20191504)Scientific Research Common Program of Beijing Municipal Commission of Education(KM202110025009)Beijing Talents Fund(2018000021469G285).
文摘Atherosclerotic cardiovascular disease(ASCVD)includes a group of disorders of the heart and blood vessels and accounts for major morbidity and premature death worldwide.Periodontitis is a chronic inflammatory disease with the gradual destruction of supporting tissues around the teeth,including gingiva,periodontal ligament,alveolar bone,and cementum.Periodontitis has been found to potentially increase the risk of ASCVD.Generally,oral microorganisms and inflammation are the major factors for periodontitis to the incidence of ASCVD.Recently,evidence has shown that the loss of masticatory function is another important factor of periodontitis to the incidence of ASCVD.In this review,we illustrate the recent finding of the relationship between periodontitis and ASCVD,from a microscale perspective-oral microorganisms,inflammation,and tooth loss.With the high prevalence of periodontitis,it is important to add oral therapy as a regular ASCVD prevention strategy.Regular dental visits could be a helpful strategy for ASCVD patients or general medical practitioners.
基金supported by the National Natural Science Foundation of China under Grants 62362040,61662033supported by the Science and Technology Project of the State Grid Jiangxi Electric Power Co.,Ltd.of China under Grant 521820210006.
文摘The YOLOx-s network does not sufficiently meet the accuracy demand of equipment detection in the autonomous inspection of distribution lines by Unmanned Aerial Vehicle(UAV)due to the complex background of distribution lines,variable morphology of equipment,and large differences in equipment sizes.Therefore,aiming at the difficult detection of power equipment in UAV inspection images,we propose a multi-equipment detection method for inspection of distribution lines based on the YOLOx-s.Based on the YOLOx-s network,we make the following improvements:1)The Receptive Field Block(RFB)module is added after the shallow feature layer of the backbone network to expand the receptive field of the network.2)The Coordinate Attention(CA)module is added to obtain the spatial direction information of the targets and improve the accuracy of target localization.3)After the first fusion of features in the Path Aggregation Network(PANet),the Adaptively Spatial Feature Fusion(ASFF)module is added to achieve efficient re-fusion of multi-scale deep and shallow feature maps by assigning adaptive weight parameters to features at different scales.4)The loss function Binary Cross Entropy(BCE)Loss in YOLOx-s is replaced by Focal Loss to alleviate the difficulty of network convergence caused by the imbalance between positive and negative samples of small-sized targets.The experiments take a private dataset consisting of four types of power equipment:Transformers,Isolators,Drop Fuses,and Lightning Arrestors.On average,the mean Average Precision(mAP)of the proposed method can reach 93.64%,an increase of 3.27%.The experimental results show that the proposed method can better identify multiple types of power equipment of different scales at the same time,which helps to improve the intelligence of UAV autonomous inspection in distribution lines.
基金supported by grants from the National Natural Science Foundation of China (81571475, 81471480, 81671956 and 81630037)the Zhejiang Provincial Program for the Cultivation of High-level Innovative Health Talentsthe Key Program of the Independent Design Project of National Clinical Research Center for Child Health (G20B0009)。
文摘To the Editor: Hypoxic hepatitis(HH), also known as ischemic hepatitis or shock liver, is a liver injury characterized by necrosis of centrilobular hepatocytes with a rapid increase in serum aminotransferase levels. The incidence rate of HH among patients in the intensive care unit(ICU) was found to be 0.9%-11.9% [1]. Occurrence of HH appears to have a significant impact on the clinical outcome.
基金supported by the National Key Research and Development Plan(no.2019YFD1000104)a project supported by the Fundamental Research Funds for the Central University(no.2662020YLPY020)supported by two National Natural Fund Projects(no.31901963 and 31972356)and an earmarked fund for CARS 26.
文摘Analyzing and comparing the effects of labor-saving cultivation modes on photosynthesis,as well as studying their vertical canopy architecture,can improve the tree structure of high-quality and high-yield citrus and selection of labor-saving cultivation modes.The photosynthesis of 1080 leaves of two labor-saving cultivation modes(wide-row and narrow-plant mode and fenced mode)comparing with the traditional mode were measured,and nitrogen content of all leaves and photosynthetic nitrogen use efficiency(PNUE)were determined.Unmanned aerial vehicle(UAV)-based light detection and ranging(LiDAR)data were used to assess the vertical architecture of three citrus cultivation modes.Results showed that for the wide-row and narrow-plant and traditional modes leaf photosynthetic CO_(2) assimilation rate,stomatal conductance,and transpiration rate of the upper layer were significantly higher than those of the middle layer,and values of the middle layer were markedly higher than those of the lower layer.In the fenced mode,a significant difference in photosynthetic factors between the upper and middle layers was not observed.A vertical canopy distribution had a more significant effect on PNUE in the traditional mode.Leaves in the fenced mode had distinct photosynthetic advantages and higher PNUE.UAV-based LiDAR data effectively revealed the differences in the vertical canopy architecture of citrus trees by enabling calculating the density and height percentile of the LiDAR point cloud.The point cloud densities of three cultivation modes were significantly different for all LiDAR density slices,especially at higher canopy heights.The labor-saving modes,particularly the fenced mode,had significantly higher height percentile data.
基金Original Innovation Joint Fund:L202010 and the National Key Research and Development Program of China:2018YFB1307604National Key Research and Development Program of China,Grant/Award Numbers:2018YFB1307604。
文摘To eliminate unnecessary background information,such as soft tissues in original CT images and the adverse impact of the similarity of adjacent spines on lumbar image segmentation and surgical path planning,a two‐stage approach for localising lumbar segments is proposed.First,based on the multi‐scale feature fusion technology,a non‐linear regression method is used to achieve accurate localisation of the overall spatial region of the lumbar spine,effectively eliminating useless background information,such as soft tissues.In the second stage,we directly realised the precise positioning of each segment in the lumbar spine space region based on the non‐linear regression method,thus effectively eliminating the interference caused by the adjacent spine.The 3D Intersection over Union(3D_IOU)is used as the main evaluation indicator for the positioning accuracy.On an open dataset,3D_IOU values of 0.8339�0.0990 and 0.8559�0.0332 in the first and second stages,respectively is achieved.In addition,the average time required for the proposed method in the two stages is 0.3274 and 0.2105 s respectively.Therefore,the proposed method performs very well in terms of both pre-cision and speed and can effectively improve the accuracy of lumbar image segmentation and the effect of surgical path planning.
文摘The purpose of this work is to evaluate the use of a two-dimensional (2D) planar ion chamber array to characterize leakage radiation from the head of the linear accelerator. Ion chamber arrays provide a benefit over a singular ion chamber measurement as they allow for the measurement of a larger area in order to isolate the point of maximum leakage dose and the small size of each individual ion chamber minimizes volume-averaging effects. A Varian Truebeam<span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><sup><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;"><span style="font-family:Verdana, Helvetica, Arial;white-space:normal;background-color:#FFFFFF;">®</span></span></sup></span> undergoing acceptance testing was used for all measurements. The gantry was wrapped in Portal Pack for Localization (PPL) radiographic film in order to isolate the location of maximum leakage. A calibration curve was developed and used to determine dose-to-film. An Ion Chamber Profiler (IC Profiler<sup><span style="font-size:6.5pt;font-family:;" "=""><span style="white-space:nowrap;">™</span></span></sup>) manufactured by Sun Nuclear Corporation was used to confirm measurements by the PPL film. All measurements were normalized to leakage at 100 cm from the target relative to the central axis. Three points were investigated with the IC Profiler, including the top of the gantry, the Varian logo, and the side of the gantry. For the three locations, respectively, the PPL film and the IC profiler were measured 0.142% and 0.131%, 0.036% and 0.030%, and 0.014% and 0.019%. The good agreement between the PPL film and the IC Profiler provides confidence in the use of a more efficient and accurate ion chamber array for head leakage measurements.