Peer-to-peer(P2P)spectrum sharing and energy trading are promising solutions to locally satisfy spectrum and energy demands in power Internet of Things(IoT).However,implementation of largescale P2P spectrum sharing an...Peer-to-peer(P2P)spectrum sharing and energy trading are promising solutions to locally satisfy spectrum and energy demands in power Internet of Things(IoT).However,implementation of largescale P2P spectrum sharing and energy trading confronts security and privacy challenges.In this paper,we exploit consortium blockchain and Directed Acyclic Graph(DAG)to propose a new secure and distributed spectrum sharing and energy trading framework in power IoT,named spectrum-energy chain,where a set of local aggregators(LAGs)cooperatively confirm the identity of the power devices by utilizing consortium blockchain,so as to form a main chain.Then,the local power devices verify spectrum and energy micro-transactions simultaneously but asynchronously to form local spectrum tangle and local energy tangle,respectively.Moreover,an iterative double auction based micro transactions scheme is designed to solve the spectrum and energy pricing and the amount of shared spectrum and energy among power devices.Security analysis and numerical results illustrate that the developed spectrum-energy chain and the designed iterative double auction based microtransactions scheme are secure and efficient for spectrum sharing and energy trading in power IoT.展开更多
Extensive effort has been devoted to the discovery,development,and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions.Genomic an...Extensive effort has been devoted to the discovery,development,and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions.Genomic and transcriptomic profiling are well-established means to identify disease-associated biomarkers.However,analysis of disease-associated peptidomes can also identify novel peptide biomarkers or signatures that provide sensitive and specific diagnostic and prognostic information for specific malignant,chronic,and infectious diseases.Growing evidence also suggests that peptidomic changes in liquid biopsies may more effectively detect changes in disease pathophysiology than other molecular methods.Knowledge gained from peptide-based diagnostic,therapeutic,and imaging approaches has led to promising new theranostic applications that can increase their bioavailability in target tissues at reduced doses to decrease side effects and improve treatment responses.However,despite major advances,multiple factors can still affect the utility of peptidomic data.This review summarizes several remaining challenges that affect peptide biomarker discovery and their use as diagnostics,with a focus on technological advances that can improve the detection,identification,and monitoring of peptide biomarkers for personalized medicine.展开更多
BACKGROUND Obesity is associated with an increased risk of multiple extradigestive complic-ations.Thus,understanding the global epidemiology of obesity and its relation-ship with extradigestive complications,such as c...BACKGROUND Obesity is associated with an increased risk of multiple extradigestive complic-ations.Thus,understanding the global epidemiology of obesity and its relation-ship with extradigestive complications,such as cardiovascular disease,type 2 diabetes mellitus,and non-alcoholic fatty liver disease is important.However,nutritional intervention can positively manage issues associated with obesity.Hence,the identification of the current high prevalence of extradigestive complica-tions among patients with obesity and the potential role of nutritional inter-ventions is also essential.AIM To determine the relationship between obesity and extradigestive complications and emphasize the importance of nutritional interventions in the management of patients with obesity.METHODS Overall,110 patients with obesity admitted to our hospital from February 2020 to November 2022 and 100 healthy individuals were included in the present study.Information of the study population,including demographic characteristics,such as age,sex,body mass index,indicators of extradigestive complications,dietary intake,and biomarkers was collected.The study design,participant selection,interventions,and development of the nutritional intervention program were described.The collected data were analyzed to assess the effect of nutritional inter-ventions on extradigestive complications.RESULTS As a part of nutritional intervention,the dietary structure was modified to decrease the saturated fatty acid and cholesterol intake and increase the dietary fiber and polyunsaturated fatty acid intake to improve the blood lipid levels and cardiovascular health.Mechanistic studies showed that these nutritional inter-ventions positively affected mechanisms that regulate lipid metabolism,improved inflammatory markers in the blood,and improved vascular functions.CONCLUSION The study discusses the consistency of the present results with previous findings to assess the clinical significance of the present findings.The study provides direction for future research on improving nutritional intervention strategies.展开更多
<strong>Purpose:</strong> The aim of the present study was to determine the degree of using floss and the demographic characteristics of medical faculties of Inner Mongolia Medical University. <strong&g...<strong>Purpose:</strong> The aim of the present study was to determine the degree of using floss and the demographic characteristics of medical faculties of Inner Mongolia Medical University. <strong>Materials and Methods:</strong> Participants completed the questionnaire in the classroom. These participants came from the medical faculties of Chinese Medicine and Western Medicine. These participants were interviewed to determine the demographic characteristics. Non-flossors responded according to their reasons for not flossing. <strong>Results:</strong> A total of 3481 effective data were available for analysis. The floss prevalence was 17.21%, which was lower by 5.72% for students living in rural areas, when compared to students living in urban areas. The largest proportion of non-flossing participants in rural areas answered, “I do not know what a floss is”, while participants in urban answered, “I do not want to use it”. The largest proportion of answered flossing frequency was less than once a month. <strong>Conclusion:</strong> The present study indicates that the prevalence of using floss in medical faculties in Inner Mongolia Medical University was higher, when compared to that in Sichuan province, China, but lower than that in other countries. Although the students use floss, more than one-third of students use floss less than once a month, which is close to “never”. The prevalence in rural areas is lower than those in urban areas. Male not only comprises the total number of prevalence, but also has a frequency greater than that in females. The emphasis on using floss should be improved in medical students.展开更多
以黄河上游多年调节水库龙羊峡及下游刘家峡水库为研究对象,考虑来水不确定性影响,建立梯级水库群多目标随机优化模型,并基于理想点法(technique for order preference by similarity to an ideal solution,TOPSIS)决策方法,求解当年发...以黄河上游多年调节水库龙羊峡及下游刘家峡水库为研究对象,考虑来水不确定性影响,建立梯级水库群多目标随机优化模型,并基于理想点法(technique for order preference by similarity to an ideal solution,TOPSIS)决策方法,求解当年发电量与年末水位Pareto方案集中最佳方案,探讨来水频率及起调水位对年末水位和发电量的影响,验证年末期望水位保证多年调节水库发电效益的可靠性。结果表明:在不确定来水条件下,龙羊峡水库年末期望水位与龙羊峡水库、刘家峡水库年期望发电量之间存在竞争关系;龙羊峡水库来水频率越低、起调水位越高时,龙羊峡水库年末水位越高,龙羊峡水库、刘家峡水库发电量越大;基于提出的年末水位优化方法可大幅缩减龙羊峡水库现行调度方式下年末水位范围,且保障发电效益的可靠性在98%以上。展开更多
基金supported by the National Key R&D Program of China(2020YFB1807801,2020YFB1807800)in part by Project Supported by Engineering Research Center of Mobile Communications,Ministry of Education(cqupt-mct-202003)+2 种基金in part by Key Lab of Information Network Security,Ministry of Public Security under Grant C19603in part by National Natural Science Foundation of China(Grant No.61901067 and 61901013)in part by Chongqing Municipal Natural Science Foundation(Grant No.cstc2020jcyj-msxmX0339).
文摘Peer-to-peer(P2P)spectrum sharing and energy trading are promising solutions to locally satisfy spectrum and energy demands in power Internet of Things(IoT).However,implementation of largescale P2P spectrum sharing and energy trading confronts security and privacy challenges.In this paper,we exploit consortium blockchain and Directed Acyclic Graph(DAG)to propose a new secure and distributed spectrum sharing and energy trading framework in power IoT,named spectrum-energy chain,where a set of local aggregators(LAGs)cooperatively confirm the identity of the power devices by utilizing consortium blockchain,so as to form a main chain.Then,the local power devices verify spectrum and energy micro-transactions simultaneously but asynchronously to form local spectrum tangle and local energy tangle,respectively.Moreover,an iterative double auction based micro transactions scheme is designed to solve the spectrum and energy pricing and the amount of shared spectrum and energy among power devices.Security analysis and numerical results illustrate that the developed spectrum-energy chain and the designed iterative double auction based microtransactions scheme are secure and efficient for spectrum sharing and energy trading in power IoT.
基金The work was primarily supported by research funding provided by the National Cancer Institute(U01CA252965)Eunice Kennedy Shriver National Institute of Child Health and Human Development(R01HD090927 and R01HD103511)+2 种基金National Institute of Allergy and Infectious Diseases(R01AI144168)U.S.Department of Defense(W8IXWH1910926)National Institute of Neurological Disorders and Stroke(R21NS130542).
文摘Extensive effort has been devoted to the discovery,development,and validation of biomarkers for early disease diagnosis and prognosis as well as rapid evaluation of the response to therapeutic interventions.Genomic and transcriptomic profiling are well-established means to identify disease-associated biomarkers.However,analysis of disease-associated peptidomes can also identify novel peptide biomarkers or signatures that provide sensitive and specific diagnostic and prognostic information for specific malignant,chronic,and infectious diseases.Growing evidence also suggests that peptidomic changes in liquid biopsies may more effectively detect changes in disease pathophysiology than other molecular methods.Knowledge gained from peptide-based diagnostic,therapeutic,and imaging approaches has led to promising new theranostic applications that can increase their bioavailability in target tissues at reduced doses to decrease side effects and improve treatment responses.However,despite major advances,multiple factors can still affect the utility of peptidomic data.This review summarizes several remaining challenges that affect peptide biomarker discovery and their use as diagnostics,with a focus on technological advances that can improve the detection,identification,and monitoring of peptide biomarkers for personalized medicine.
基金Wuxi Municipal Health Commission Maternal and Child Health Research Project,No.FYKY202206.
文摘BACKGROUND Obesity is associated with an increased risk of multiple extradigestive complic-ations.Thus,understanding the global epidemiology of obesity and its relation-ship with extradigestive complications,such as cardiovascular disease,type 2 diabetes mellitus,and non-alcoholic fatty liver disease is important.However,nutritional intervention can positively manage issues associated with obesity.Hence,the identification of the current high prevalence of extradigestive complica-tions among patients with obesity and the potential role of nutritional inter-ventions is also essential.AIM To determine the relationship between obesity and extradigestive complications and emphasize the importance of nutritional interventions in the management of patients with obesity.METHODS Overall,110 patients with obesity admitted to our hospital from February 2020 to November 2022 and 100 healthy individuals were included in the present study.Information of the study population,including demographic characteristics,such as age,sex,body mass index,indicators of extradigestive complications,dietary intake,and biomarkers was collected.The study design,participant selection,interventions,and development of the nutritional intervention program were described.The collected data were analyzed to assess the effect of nutritional inter-ventions on extradigestive complications.RESULTS As a part of nutritional intervention,the dietary structure was modified to decrease the saturated fatty acid and cholesterol intake and increase the dietary fiber and polyunsaturated fatty acid intake to improve the blood lipid levels and cardiovascular health.Mechanistic studies showed that these nutritional inter-ventions positively affected mechanisms that regulate lipid metabolism,improved inflammatory markers in the blood,and improved vascular functions.CONCLUSION The study discusses the consistency of the present results with previous findings to assess the clinical significance of the present findings.The study provides direction for future research on improving nutritional intervention strategies.
文摘<strong>Purpose:</strong> The aim of the present study was to determine the degree of using floss and the demographic characteristics of medical faculties of Inner Mongolia Medical University. <strong>Materials and Methods:</strong> Participants completed the questionnaire in the classroom. These participants came from the medical faculties of Chinese Medicine and Western Medicine. These participants were interviewed to determine the demographic characteristics. Non-flossors responded according to their reasons for not flossing. <strong>Results:</strong> A total of 3481 effective data were available for analysis. The floss prevalence was 17.21%, which was lower by 5.72% for students living in rural areas, when compared to students living in urban areas. The largest proportion of non-flossing participants in rural areas answered, “I do not know what a floss is”, while participants in urban answered, “I do not want to use it”. The largest proportion of answered flossing frequency was less than once a month. <strong>Conclusion:</strong> The present study indicates that the prevalence of using floss in medical faculties in Inner Mongolia Medical University was higher, when compared to that in Sichuan province, China, but lower than that in other countries. Although the students use floss, more than one-third of students use floss less than once a month, which is close to “never”. The prevalence in rural areas is lower than those in urban areas. Male not only comprises the total number of prevalence, but also has a frequency greater than that in females. The emphasis on using floss should be improved in medical students.
文摘以黄河上游多年调节水库龙羊峡及下游刘家峡水库为研究对象,考虑来水不确定性影响,建立梯级水库群多目标随机优化模型,并基于理想点法(technique for order preference by similarity to an ideal solution,TOPSIS)决策方法,求解当年发电量与年末水位Pareto方案集中最佳方案,探讨来水频率及起调水位对年末水位和发电量的影响,验证年末期望水位保证多年调节水库发电效益的可靠性。结果表明:在不确定来水条件下,龙羊峡水库年末期望水位与龙羊峡水库、刘家峡水库年期望发电量之间存在竞争关系;龙羊峡水库来水频率越低、起调水位越高时,龙羊峡水库年末水位越高,龙羊峡水库、刘家峡水库发电量越大;基于提出的年末水位优化方法可大幅缩减龙羊峡水库现行调度方式下年末水位范围,且保障发电效益的可靠性在98%以上。
