Developing Customized Evaluation Software for Clinical Trials: An Example with Obstructive Lung Diseases

Corresponding customized software tool is usually unavailable, which increases the time and workload for evaluating the results of a clinical trial. In the present paper, we demonstrate the development process of a customized software for one clinical trial on patients with obstructive lung disease. Over hundred patients and volunteers as controlled were included in the clinical trial. They were examined by spirometry and EIT in a seated position during spontaneous tidal breathing. Subsequently, standard vital capacity maneuver and forced full expiration maneuver were performed. In order to evaluate the offline data, a customized software was developed. The requirements of the software were defined by investigators. The software was then tested on patients’ data and refined based on feedbacks of the investigators. We finalized the customized software with analysis of various disease-specific parameters and indices. Compared to the data process with device specific programs and other commercial software, the customized software is more flexible, user-friendly and extendable. As conclusion, customized software simplifies the evaluation process distinctly and helps physicians to focus on study design and result interpretation.

Cell:新分子或可有效清除肝脏和血液中的脂肪

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

地球超级万年历——锆石

如果将地球自诞生至今的历史化为一天,则直到年夜前一分多钟,我们人类才出现。那么;我们是如何得知以前的历史、了解地球的诞生呢?地球不会说话,无法亲口告诉我们它的年龄,所以我们必须借助一种能够"铭刻时间"的奇特矿物——锆石。测量地球的年龄,为什么要靠这连名字都那么拗口的石头呢?难道不能在地球上那些没有人类或其他生物干扰的地方随机提取一些岩石矿物的样本来测量吗?这当然是不行的!因为通过火山活动、板块运动等方式回收老旧的岩石,并将新生的岩石带到地表,地球不断地更新着自己的外貌,同时也掩盖了自己的真实年龄。