Ultrasound assisted multicomponent reactions:A green method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines usingβ-cyclodextrin as a supramolecular reusable catalyst in water

We demonstrate a superficial method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular,biodegradable,and reusable catalyst in aqueous medium.The reaction product is in excellent yield with moderate to excellent selectivity.The mechanistic transformation presumably proceeds via a one-pot,multicomponent cyclization of dimedone in the presence of aromatic aldehydes and aromatic amines/INH,undergoing a tandem Michael addition reaction.The proposed approach in this study provides a highly efficient and environmentally benign route to N-substituted 1,8-dioxo-decahydroacridines.