Nanomedicine integrating the lipidic derivative of 5-fluorouracil,miriplatin and PD-L1 si RNA for enhancing tumor therapy

Immunosuppressive microenvironments present critical problems in clinical chemotherapy.To regulate the tumor immune microenvironment for enhancing antitumor effect,a combination of immune checkpoint inhibitors(ICIs)with chemotherapeutics has been applied clinically.In this study,miriplatin(MiPt),the lipidic derivative of 5-fluorouracil(Fu-OA),as well as the programmed death ligand 1(PD-L1)target si RNA(siPD-L1)were integrated into Lip-Pt/Fu@siPD-L1 nanoparticles(NPs)for chemo-immunotherapy.In vitro results showed that Lip-Pt/Fu@siPD-L1 NPs could exhibit effective siRNA gene silencing and promote the phagocytosis of tumor cells by macrophages.Furthermore,in vivo results revealed that LipPt/Fu@siPD-L1 NPs showed significantly higher anti-tumor efficiency than that of the physical mixing of Mi Pt,5-fluorouracil,and Lip@siPD-L1 NPs(delivery of siPD-L1 by liposomes).The best anti-tumor efficiency of Lip-Pt/Fu@siPD-L1 NPs resulted from the synergistic immunotherapeutic effects of Mi Pt and siPD-L1 based on the inhibition of CD47 expression and the downregulation of PD-L1 in tumor cells,which elicited a robust anti-tumor immune response through the activation of macrophage phagocytosis and immune checkpoint inhibition.The Lip-Pt/Fu@siPD-L1 NPs provide a potential strategy for tumor chemo-immunotherapy.

The Study on the Anti-corrosion Performance of NiTi Alloy in Human Body Solution with the Fabricating Processes of Laser Irradiation and PDMS Modification

This paper presents a new and safe method of fabricating super-hydrophobic surface on NiTi Shape Memory Alloy(SMA),which aims to further improve the corrosion resistance performance and biocompatibility of NiTi SMA.The super-hydrophobic surfaces with Water Contact Angle(WCA)of 155.4°±0.9°and Water Sliding Angle(WSA)of 4.4°±1.1°were obtained by the hybrid of laser irradiation and polydimethylsiloxane(PDMS)modification.The forming mechanism was systematically revealed via Scanming Electron Microscopy(SEM)and X-ray Photoelectron Spectroscopy(XPS).The ant-corrosion of samples was investigated in Simulated Body Fluid(SBF)via the potentiodynamie polarization(PDP)and Electrochemical Impedance Spectroscopy(EIS)tests.PDMS super-hydrophobic coatings showed superior anti-corrosion performance.The Ni ions release experiment was also conducted and the corresponding result demonstrated that the super-hydrophobic samplcs effectively inhibited the rclease of Ni ions both in clctrolyte and SBF Besides,biocompaibility was further analyzed,indicating that the prepared super-hydrophobic surfaces present a huge potential advantage in biocompatibility.

On the accurate characterization of quantum-dot light-emitting diodes for display applications

Quantum dot light-emitting diodes(QLEDs)are a class of high-performance solution-processed electroluminescent(EL)devices highly attractive for next-generation display applications.Despite the encouraging advances in the mechanism investigation,material chemistry,and device engineering of QLEDs,the lack of standard protocols for the characterization of QLEDs may cause inaccurate measurements of device parameters and invalid comparison of different devices.Here,we report a comprehensive study on the characterizations of QLEDs using various methods.We show that the emission non-uniformity across the active area,nonLambertian angular distributions of EL intensity,and discrepancies in the adopted spectral luminous efficiency functions could introduce significant errors in the device efficiency.Larger errors in the operational-lifetime measurements may arise from the inaccurate determination of the initial luminance and inconsistent methods for analyzing the luminance-decay curves.Finally,we suggest a set of recommended practices and a checklist for device characterizations,aiming to help the researchers in the QLED field to achieve accurate and reliable measurements.

The effects of coil-stretch transition behavior of polyfluorene inks on single droplet formation during inkjet printing

For drop-on-demand(DOD)inkjet printing,stable and single ink droplet fo rmation without satellite dots is the key to improve the print quality.The formation of stable and single droplet is influenced by filament break up and the polymer chain’s coil-stretch transition behavior.In this paper,the droplet formation behaviors of polyfluorene(PFO)ink at various driving voltages(V),polymer chain’s coil-stretch transition mechanism and its effects on single ink droplet formation are investigated.It indicates that when 5863 V,Wi>0.5,the PFO molecular chain is stretched because of the high hydrodynamic forces,resulting unwanted satellite droplets.When 55<V<58V,the droplet shrinks into the nozzle,which indicates that the kinetic energy supplied by the deformation of the piezoelectric transducer isn't enough to force thedroplet to be jetted from the nozzle.