Professor Lv Wenliang believes that cirrhosis is a disease of the essence of vacuity and evil,and the patient suffers from vacuity and poison stasis for a long time.Is Yin and Yang but turbulent,qi and blood disorder,...Professor Lv Wenliang believes that cirrhosis is a disease of the essence of vacuity and evil,and the patient suffers from vacuity and poison stasis for a long time.Is Yin and Yang but turbulent,qi and blood disorder,liver and spleen is not consistent.Therefore,when the temporary syndrome from the Yin system Yang,to its outline;Adjust the air and blood to tamp the base;The liver and spleen should be dredged and the spleen should be regulated in accordance with its nature.Based on this objective,this paper discusses the clinical method of treating cirrhosis of liver by professor LV,so as to know its inverse,its shield and its life.展开更多
Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially common. Liver fibrosis and c...Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially common. Liver fibrosis and cirrhosis involve excess production of extracellular matrix,which is closely related to liver sinusoidal endothelial cells(LSECs). Damaged LSECs can synthesize transforming growth factor-beta and platelet-derived growth factor,which activate hepatic stellate cells and facilitate the synthesis of extracellular matrix. Herein,we highlight the angiogenic cytokines of LSECs related to liver fibrosis and cirrhosis at different stages and focus on the formation and development of liver fibrosis and cirrhosis. Inhibition of LSEC angiogenesis and antiangiogenic therapy are described in detail. Targeting LSECs has high therapeutic potential for liver diseases. Further understanding of the mechanism of action will provide stronger evidence for the development of anti-LSEC drugs and new directions for diagnosis and treatment of liver diseases.展开更多
基金Major national science and technology special project(No.2018ZX10303-502-003)national key R&D plan key research project of Chinese medicine modernization(No.2018YFC1705702)Beijing Tianjin Hebei national key clinical specialty liver disease collaborative ward project(No.GZY-GCS-2017-60)
文摘Professor Lv Wenliang believes that cirrhosis is a disease of the essence of vacuity and evil,and the patient suffers from vacuity and poison stasis for a long time.Is Yin and Yang but turbulent,qi and blood disorder,liver and spleen is not consistent.Therefore,when the temporary syndrome from the Yin system Yang,to its outline;Adjust the air and blood to tamp the base;The liver and spleen should be dredged and the spleen should be regulated in accordance with its nature.Based on this objective,this paper discusses the clinical method of treating cirrhosis of liver by professor LV,so as to know its inverse,its shield and its life.
基金Supported by the Young Elite Scientists Sponsorship Program by CAST,No.2016QNRC001Beijing Natural Science Foundation,No.7172187
文摘Cirrhosis develops from liver fibrosis and is the severe pathological stage of all chronic liver injury. Cirrhosis caused by hepatitis B virus and hepatitis C virus infection is especially common. Liver fibrosis and cirrhosis involve excess production of extracellular matrix,which is closely related to liver sinusoidal endothelial cells(LSECs). Damaged LSECs can synthesize transforming growth factor-beta and platelet-derived growth factor,which activate hepatic stellate cells and facilitate the synthesis of extracellular matrix. Herein,we highlight the angiogenic cytokines of LSECs related to liver fibrosis and cirrhosis at different stages and focus on the formation and development of liver fibrosis and cirrhosis. Inhibition of LSEC angiogenesis and antiangiogenic therapy are described in detail. Targeting LSECs has high therapeutic potential for liver diseases. Further understanding of the mechanism of action will provide stronger evidence for the development of anti-LSEC drugs and new directions for diagnosis and treatment of liver diseases.
