Ti、Zr和Hf元素协同优化Nb-Si基合金显微组织、相组成和室温断裂韧性

采用真空电弧熔炼制备Nb-16Si-xTi-yZr-zHf (x=18, 22;y=0, 4;z=0, 4;摩尔分数,%)合金并研究Ti、Zr与Hf元素对Nb-Si合金物相组成、显微组织、断裂韧性以及裂纹扩展行为的影响。结果表明:单独添加4%Zr元素能促进(Nb,X)3Si向Nb固溶体(Nbss)/γ-(Nb,X)5Si3共析反应的发生;同时添加Ti、Zr、Hf元素能进一步促进共析反应的发生。裂纹倾向于在(Nb,X)3Si中扩展,当裂纹途径Nb固溶体时会发生偏转。细密的Nbss/γ-(Nb,X)5Si3共晶组织以及层状Nbss/γ-(Nb,X)5Si3共晶组织可以使裂纹产生桥接与分支,阻碍裂纹的扩展。Nb-16Si-22Ti-4Zr-4Hf的合金化元素含量最高,因此,其室温断裂韧性最好(11.62 MPa·m1/2),相较于Nb-16Si-18Ti提高87.7%,性能的提升主要归因于存在层状共晶组织。

Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma

BACKGROUND Hepatocellular carcinoma(HCC)is a major health challenge with high incidence and poor survival rates in China.Systemic therapies,particularly tyrosine kinase inhibitors(TKIs),are the first-line treatment for advanced HCC,but resistance is common.The Rho GTPase family member Rho GTPase activating protein 12(ARHGAP12),which regulates cell adhesion and invasion,is a potential therapeutic target for overcoming TKI resistance in HCC.However,no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been reported.AIM To unveil the expression of ARHGAP12 in HCC,its role in TKI resistance and its potential associated pathways.METHODS This study used single-cell RNA sequencing(scRNA-seq)to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment analysis.CellChat was used to investigate focal adhesion(FA)pathway regulation.We integrated bulk RNA data(RNA-seq and microarray),immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels,correlating with clinical outcomes.We assessed ARHGAP12 expression in TKI-resistant HCC,integrated conventional HCC to explore its mechanism,identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and immunotherapy.RESULTS ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate FA.In malignant hepatocytes in high-score FA groups,MDK-[integrin alpha 6(ITGA6)+integrinβ-1(ITGB1)]showed specificity in ligand-receptor interactions.ARHGAP12 mRNA and protein were upregulated in bulk RNA,immunohistochemistry and proteomics,and higher expression was associated with a worse prognosis.ARHGAP12 was also found to be a TKI resistance gene that regulated the FA pathway.ITGB1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk RNA.High expression of ARHGAP12 was associated with adverse reactions to sorafenib,cabozantinib and regorafenib,but not to immunotherapy.CONCLUSION ARHGAP12 expression is elevated in HCC and TKI-resistant HCC,and its regulatory role in FA may underlie the TKI-resistant phenotype.

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly described.AIM To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in CRC.METHODS We enrolled 2271 Chinese CRC patients at the China-Japan Friendship Hospital.MMR proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain reaction.Microsatellite status was determined using an MSI detection kit.Statistical analyses were conducted using SPSS software and logistic regression.RESULTS The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,respectively.KRAS mutations were more likely to occur in patients with moderate-to-high differentiation.BRAF mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural invasion.Deficient MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous adenocarcinomas.KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,respectively.The dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II tumors.CONCLUSION This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

睑板腺功能障碍与睡眠质量的相关性研究

目的:研究睑板腺功能障碍(MGD)与睡眠质量之间的相关性。方法:回顾性病例对照研究。选取2021-01/2022-10我院收治的MGD患者150例,根据匹兹堡睡眠质量指数(PSQI)量表评分分为睡眠障碍组(75例,PSQI>10分)和对照组(75例,PSQI≤10分),均进行眼表疾病指数量表(OSDI)评分和睑板腺相关检查(睑缘形态、睑板腺分泌能力、睑板腺分泌物性质评分)、角膜荧光素染色(FL)评分、基础泪液分泌试验(SⅠt),检测泪膜破裂时间(BUT),评估睡眠指标(睡眠质量、睡眠潜伏期、主观睡眠质量、睡眠时间)。结果:两组患者OSDI评分、FL评分、SⅠt、BUT、睑缘形态评分、睑板腺分泌能力评分、睑板腺分泌物性质评分均有差异(P<0.05)。睡眠障碍组患者PSQI评分、睡眠潜伏期评分、主观睡眠质量评分、睡眠时间评分与OSDI评分、FL评分、睑板腺分泌能力评分和睑板腺分泌物性质评分均呈显著正相关性(P<0.05);PSQI评分、主观睡眠质量评分、睡眠时间评分与睑缘形态评分均呈显著正相关性(P<0.05);PSQI评分、睡眠潜伏期评分、主观睡眠质量评分与BUT、SⅠt均呈显著负相关性(P<0.05);睡眠时间评分与BUT呈显著负相关性(P<0.05);睡眠潜伏期评分与睑缘形态评分无明显相关性(P>0.05);睡眠时间评分与SⅠt无显著相关性(P>0.05)。结论:MGD患者眼表情况与多项睡眠质量指标均具有相关性,睡眠质量下降可能增加MGD的患病风险。

Efficacy and safety of gastroscopic hemostasis in the treatment of acute gastric hemorrhage: A meta-analysis

BACKGROUND Gastric cancer(GC)is a malignant tumor with a high incidence and mortality rate worldwide for which acute bleeding is a common clinical complication.Gastro-scopic hemostasis is an important method for treating acute bleeding in GC;however,its efficacy and safety remain controversial.AIM To systematically analyze the efficacy and safety of gastroscopic hemostasis for the treatment of acute gastric hemorrhage.METHODS The PUBMED,Web of Science,Wiley Library,EMBASE,Wanfang,CNKI,and VIP databases were searched for studies related to gastroscopic hemostatic treatment for acute GC published through February 20,2023.The literature was screened according to the inclusion and exclusion criteria,data were extracted,and lite-rature quality was evaluated.The meta-analysis was performed using RevMan software(version 5.3),while Begg’s test for publication bias was performed using Stata 13.0 software.RESULTS Six randomized controlled trials and two retrospective analyses were retrieved.Five studies had a low,two had an uncertain,and one had a high risk of bias.Compared with the control group,the hemostatic rate of gastroscopic hemostasis was increased[relative risk(RR)=1.24;95%confidence interval(CI):1.08 to 1.43;P=0.003];the rate of rebleeding(RR=0.27;95%CI:0.09 to 0.80;P=0.02),rate of surgery transfer(RR=0.16;95%CI:0.06 to 0.43;P=0.0003),serum C-reactive protein level[mean difference(MD)=-5.16;95%CI:-6.11 to 4.21;P<0.00001],interleukin-6 level(MD=-6.37;95%CI:-10.33 to-2.42;P=0.002),and tumor necrosis factor-αlevel(MD=-2.29;95%CI:-4.06 to-0.52;P=0.01)were decreased;and the quality of life improvement rate was increased(RR=1.95;95%C I=1.41-2.71;P<0.0001).Begg’s test revealed no significant publication bias.CONCLUSION The efficacy and safety of endoscopic hemostasis were higher than those of the control group,suggesting that it is an effective treatment for acute GC hemorrhage.

Three-dimensional assessment of movement patterns of Sichuan snub-nosed monkeys affected by habitat structure in temperate forests

DEAR EDITOR,Movement patterns can reflect species-specific characteristics of individuals and animal groups at a given scale. Accurate three-dimensional(3D) assessment can quantify the relationship between movement patterns of an animal and its unique habitat. Here, we evaluated the effects of habitat structure on movement patterns of the golden snub-nosed monkey(Rhinopithecus roxellana). We used airborne light detection and ranging(LiDAR) to map the 3D structure of the temperate forest in the Qinling Mountains(Shaanxi, China).

Dispersal behaviors stimulated by habitat alterations in golden snub-nosed monkeys(Rhinopithecus roxellana)in the Qinling Mountains, China

DEAR EDITOR,Combining location data, species distribution modeling(Max Ent), and major conservation events, we analyzed historical distribution changes in golden snub-nosed monkeys(Rhinopithecus roxellana) in the Qinling Mountains of China.

Effects of different intervention methods on psychological flexibility,negative emotions and sleep quality in chronic hepatitis B

BACKGROUND Patients with chronic hepatitis B(CHB)experience various problems,including low psychological flexibility,negative emotions,and poor sleep quality.Therefore,effective nursing interventions are required to reduce adverse events.Acceptance and commitment therapy(ACT)combined with enabling cognitivebehavioral education(ECBE)can improve patients'psychological and sleep.Therefore,we speculate that this may also be effective in patients with CHB.AIM To investigate the effects of different intervention methods on psychological flexibility,negative emotions,and sleep quality in patients with CHB.METHODS This retrospective study examined clinical and evaluation data of 129 patients with CHB.Intervention methods were divided into a conventional group(routine nursing,n=69)and a combination group(ACT combined with ECBE,n=60).We observed changes in psychological flexibility,negative emotions,sleep quality,and self-care ability in both groups.Observation items were evaluated using the Acceptance and Action Questionnaire-2nd Edition(AAQ-II),Self-Rating Anxiety Scale(SAS),Self-Rating Depression Scale(SDS),Pittsburgh Sleep Quality Index(PSQI),and Exercise of Self-Care Agency Scale(ESCA).RESULTS Compared with the conventional group,the AAQ-II score of the combined group was lower(F_(between-group effect)=8.548;F_(time effects)=25.020;F_(interaction effects)=52.930;all P<0.001),the SAS score(t=5.445)and SDS score(t=7.076)were lower(all P<0.001),as were the PSQI dimensions(tsleep quality=4.581,tfall sleep time=2.826,tsleep time=2.436,tsleep efficiency=5.787,tsleep disorder=5.008,thypnotic drugs=3.786,tdaytime dysfunction=4.812);all P<0.05).The ESCA scores for all dimensions were higher(thealth knowledge level=6.994,t self-concept=5.902,tself-responsibility=19.820,tself-care skills=8.470;all P<0.001).CONCLUSION ACT combined with ECBE in patients with CHB can improve psychological flexibility and sleep quality,alleviate negative emotions,and improve self-care.

Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells

AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie (XTSJ) decoction on gastric cancer stem-like cells (GCSCs).

Effect of a poloxamer 407-based thermosensitive gel on minimization of thermal injury to diaphragm during microwave ablation of the liver

AIM To assess the insulating effect of a poloxamer 407(P407)-based gel during microwave ablation of liver adjacent to the diaphragm.METHODS We prepared serial dilutions of P407, and 22.5%(w/w) concentration was identified as suitable for ablation procedures. Subsequently, microwave ablations were performed on the livers of 24 rabbits(gel, saline, control groups, n = 8 in each). The P407 solution and 0.9% normal saline were injected into the potential space between the diaphragm and liver in experimental groups. No barriers were applied to the controls. After microwave ablations, the frequency, size and degree of thermal injury were compared histologically among the three groups. Subsequently, another 8 rabbits were injected with the P407 solution and microwave ablation was performed. The levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST), blood urea nitrogen(BUN) and creatinine(Cr) in serum were tested at 1 d before microwave ablation and 3 and 7 d after operation. RESULTS In vivo ablation thermal injury to the adjacent diaphragm was evaluated in the control, saline and 22.5% P407 gel groups(P = 0.001-0.040). However, there was no significant difference in the volume of ablation zone among the three groups(P > 0.05). Moreover, there were no statistical differences among the preoperative and postoperative gel groups according to the levels of ALT, AST, BUN and Cr in serum(all P > 0.05).CONCLUSION Twenty-two point five percent P407 gel could be a more effective choice during microwave ablation of hepatic tumors adjacent to the diaphragm. Further studies for clinical translation are warranted.

Cronkhite-Canada syndrome polyps infiltrated with IgG4-positive plasma cells

Cronkhite-Canada syndrome(CCS) is a rare but serious protein-losing enteropathy, but little is known about the mechanism. Further more, misdiagnosis is common due to non-familiarity of its clinical manifestation. A 40-year-old male patient was admitted to our hospital because of diarrhea and hypogeusia associated with weight loss for 4 mo. On physical examination, skin pigmentation, dystrophic nail changes and alopecia were noted. He had no alike family history. Laboratory results revealed low levels of serum albumin(30.1 g/L, range: 35.0-55.0 g/L), serum potassium(2.61 mmol/L, range: 3.5-5.5 mmol/L) and blood glucose(2.6 mmol/L, range: 3.9-6.1 mmol/L). The erythrocyte sedimentation rate was elevated to 17 mm/h(range: 0-15 mm/h). X-ray of chest and mandible was normal. The endoscopic examination showed multiple sessile polyps in the stomach, small bowel and colorectum. Histopathologic examination of biopsies obtained from those polyps showed hyperplastic change, cystic dilatation and distortion of glands with inflammatory infiltration, eosinophilic predominance and stromal edema. Immune staining for IgG 4 plasma cells was positive in polyps of stomach and colon. The patient was diagnosed of CCS and treated with steroid, he had a good response to steroid. Both histologic findings and treatment response to steroid suggested an autoimmune mechanism underling CCS.

Interface repairing for AA5083/T2 copper explosive composite plate by friction stir processing

Multi-pass friction stir processing(M-FSP)was performed to repair the interface defects of AA5083/T2 copper explosive composite plates.The interface morphology and its bonding mechanism were explored.The results show that higher rotation speed and lower transverse speed produce more heat generated during FSP.The defect-free and good mechanical properties of the AA5083/T2 copper composite plate can be obtained under the condition of the rotation speed of 1200 r/min,the transverse speed of 30 mm/min and the overlap of 2/24.Moreover,M-FSP changes the interface bonding mechanism from metallurgical bonding to vortex connection,improving the bonding strength of composite plate,which can guarantee the repairing quality of composite plates.

Effects of age, sex and manual task on hand preference in wild Rhinopithecus roxellana

Golden snub-nosed monkeys(Rhinopithecus roxellana),as typical arboreal group-living Old World monkeys,provide an appropriate animal model to research manual laterality and explore the factors affecting hand preference in non-human primates(NHP).This study investigated hand preference based on63 subjects and four spontaneous manual tasks(including unimanual and bimanual feeding and grooming), and assessed the effects of age, gender and type of task on handedness in R. roxellana.A population-level left-handedness was found not only in the bimanual coordinated tasks(bimanual feeding and grooming), but also in one unimanual reaching task(unimanual feeding). There were no significant differences between the sexes in either direction or strength of hand preference among any task. However, a significant difference between adults and juveniles was found in the unimanual feeding task. This is the first report on handedness in unimanual and bimanual feeding tasks that require bipedal posture in wild R. roxellana. Furthermore,this study demonstrated spontaneous feeding tasks reported previously only in the quadrupedal posture in this species, supporting the importance of factors such as posture and task complexity in the evolution of primate manual lateralization.

基于循证的综合心理-社会干预对肠易激综合征患者的效果观察

背景随着社会的高速发展,我国人群中肠易激综合征(irritable bowel syndrome,IBS)的发病率也逐年上升.IBS作为一种慢性身心疾病,尚无治愈的特效药,但仍可通过心理认知及社会干预来强化药物疗效,但国内关于IBS患者的心理-社会干预研究则较少.目的观察基于循证的综合心理-社会干预对IBS患者的效果.方法纳入2019-03/2021-09首都医科大学附属北京康复医院就诊的140例IBS患者为研究对象,随机分为对照组和研究组,各70例.对照组患者给予常规IBS患者门诊随访及护理干预,研究组患者给予基于循证的综合心理-社会干预,均干预随访3 mo.利用胃肠道症状评定量表(gastrointestinal symptom rating scale,GSRS)、多道胃肠功能测定仪、用药依从性量表、肠易激综合征生活质量表(irritable bowel syndrome-quality of life questionnaire,IBS-QOL)、焦虑自评量表(selfrating anxiety scale,SAS)与抑郁自评量表(self-rating depression scale,SDS)比较分析干预前后两组胃肠道症状、直肠功能、用药依从性、生活质量及负面心理以评价干预效果.结果对照组脱落病例5例,研究组脱落病例3例,最终对照组65例完成研究,研究组67例完成研究.干预前,两组GSRS评分、直肠感觉阀值、直肠排便阀值、直肠疼痛阀值、直肠运动指数、用药依从性量表评分、IBS-QOL评分、SAS评分与SDS评分比较,差异无统计学意义(均P>0.05).干预后,两组GSRS评分、SAS评分与SDS评分均较本组干预前降低,且研究组GSRS评分、SAS评分与SDS评分低于对照组,差异有统计学意义(均P<0.05);两组直肠感觉阀值、直肠排便阀值、直肠疼痛阀值与直肠运动指数较干预前均有改善(均P<0.05),且研究组直肠感觉阀值、直肠排便阀值、直肠疼痛阀值与直肠运动指数的改善量均优于对照组(均P<0.05).此外,干预后对照组用药依从性评分与IBS-QOL评分较本组干预前差异无统计学意义;干预后,研究组用药依从性评分、IBS-QOL评分及疗效高于本组干预前和对照组,差异有统计学意义(P<0.05).结论基于循证的综合心理-社会干预方案可有效提高IBS患者用药依从性,降低患者负面心理,改善患者胃肠道相关症状及功能,提高患者生活质量,疗效显著,值得借鉴.

Polarity Reversal of Terahertz Electric Field from Heavily p-Doped Silicon Surfaces

Above-band-gap optical excitation of electron-hole pairs screens the doping-induced surface electric field and generates terahertz(THz)pulses via free-carrier transport.THz emission from a heavily doped silicon surface is much weaker than that of lightly doped samples.A polarity reversal of the THz electric field is observed in heavily doped p-type silicon,indicating that the doping related and carrier induced surface electric fields oppose each other.By comparing the penetration depth of the excitation laser with the thickness of the depletion layer for the doped silicon,it is shown that competition between diffusion and drift current causes the polarity reversal.

Loss prediction of three-level amplified spontaneous emission sources in radiation environment

A model of three-level amplified spontaneous emission(ASE)sources,considering radiation effect,is proposed to predict radiation induced loss of output power in radiation environment.Radiation absorption parameters of ASE sources model are obtained by the fitting of color centers generation and recovery process of gain loss data at lower dose rate.Gain loss data at higher dose is applied for self-validating.This model takes both the influence of erbium ions absorption and photon bleaching effect into consideration,which makes the prediction of different dose and dose rate more accurate and flexible.The fitness value between ASE model and gain loss data is 99.98%,which also satisfies the extrapolation at the low dose rate.The method and model may serve as a valuable tool to predict ASE performance in harsh environment.

Observation of mother-perpetrated infanticide in golden takins(Budorcas taxicolor bedfordi)

DEAR EDITOR,Infanticide by unrelated individuals is widely reported in the animal kingdom;however,little is known about cases perpetrated by a parent,particularly the mother.This article reports on three cases of mother-initiated infanticide in Qinling golden takins(Budorcas taxicolor bedfordi)from video and camera images.Based on previous reports in other animals,we propose that the infanticide events observed in golden takins were related to the parental manipulation mechanism-i.e.

PIK3CA突变影响因素对鳞状细胞肺癌预后的影响

目的探讨PIK3CA基因突变与鳞状细胞肺癌患者临床病理特征及预后的关系。方法选取2013年2月-2016年2月于上海长海医院收治的鳞状细胞肺癌患者81例,同时选取癌旁组织(≥5 cm)作为对照组,检测样本PIK3CA突变情况,以及随访患者生存情况。结果肺癌组织PIK3CA基因突变率高于癌旁组织(P <0.05);不同性别、年龄、分化程度、TNM期及有无淋巴结转移患者PIK3CA基因突变率比较差异无统计学意义(P>0.05);PIK3CA基因突变组患者中位生存期与PIK3CA基因未突变组比较差异有统计学意义(P <0.05);分化程度、TNM分期及PIK3CA基因突变是患者预后的影响因素(P <0.05)。结论鳞状细胞肺癌组织PIK3CA基因突变高于癌旁组织,但与病理特征无明显关系,PIK3CA基因突变患者预后较未突变者差。

Clinical significance of serum sB7-H3 and IL-1 in patients with hepatitis B related hepatocellular carcinoma

Objective: To explore the clinical significance of serum sB7-H3 and IL-1 in patients with hepatitis B associated hepatocellular carcinoma. Methods: 122 cases of patients with hepatitis B related liver diseases admitted to our hospital from January 2015 to June 2018 were selected, including 47 cases of patients with hepatitis B related hepatocellular carcinoma, 41 cases of patients with hepatitis B related cirrhosis and 34 cases of patients with hepatitis B virus, and 45 cases of healthy persons in the same period as normal control group. The serum sB7-H3, IL-1α, IL-1β levels were compared among the four groups. The relationship between serum sB7-H3, IL-1α, IL-1β and clinicopathological characteristics was analyzed, and the correlation of sB7-H3, IL-1α and IL-1β was analyzed by Pearson method. The efficacy of serum sB7-H3, IL-1α, IL-1β in early diagnosis and prognostic evaluation for hepatitis B associated hepatocellular carcinoma were analyzed by ROC and Logistic regression analysis. Results: The serum sB7-H3, IL-1α, IL-1β levels in the four groups were in order from high to low: hepatitis B related hepatocellular carcinoma>hepatitis B related cirrhosis>hepatitis B virus>normal control group, all above had statistical difference (P<0.05). The high levels of serum sB7-H3, IL-1α, IL-1β were significantly correlated with TNM stage, alpha fetoprotein level and lymph node metastasis (P<0.05). Spearman correlation analysis results showed that the serum level of sB7-H3 was positively correlated with IL-1α and IL-1β(r=0.837, 0.756;P<0.05), the serum level of IL-1α was positively correlated with IL-1β(r=0.734, P<0.05). The ROC curve and Logistic regression analysis showed that the AUC of sB7-H3, IL-1α, IL-1β and combined detection for the diagnosis of hepatitis B associated hepatocellular carcinoma was 0.893, 0.887, 0.881, 0.961 (P<0.05), respectively;the AUC of sB7-H3, IL-1α, IL-1β and combined detection for the prognostic evaluation for hepatitis B associated hepatocellular carcinoma was 0.843, 0.837, 0.834, 0.917, respectively. Conclusion:Serum sB7-H3, IL-1α, IL-1β levels could all be used for the early diagnosis and prognostic evaluation of hepatitis B associated hepatocellular carcinoma, and the combined detection is more effective, which has important clinical significance.

Analysis of the expression and prognostic value of ENO1 in ovarian cancer based on Oncomine database

Objective:Ovarian cancer is one of the leading causes of death in women,because of late diagnosis,recurrence and resistance to chemotherapy.Therefore,it's necessary to design a novel sensitive and specific maker to diagnose and treat patients of ovarian cancer.However,this study intends to explore the expression and prognostic value of ENO1 in ovarian cancer.Method:ENO1 data were collected from Oncomine database,and then were performed subgroup analysis and systematic analysis.Meanwhile,the prognostic significance of ENO1 was analyzed by an online survival analysis tool"Kaplan-Meier Plotter"(KM plotter)database.Results:In Oncomine database,a total of 14 studies were involved ENO1 in ovarian cancer tissues and normal tissues,including a total of 1001 samples.Comparing with normal tissues,ENO1 expression is higher(P<0.05).Moreover,the overall survival of ENO1 high expression in ovarian cancer is closely related with high survival(P<0.05).Further study indicated that ENO1 expression showed negative relation to the prognosis of serous ovarian cancer patients while ENO1 expression showed no effects on the prognosis of endometrioid ovarian cancer patients.Conclusion:Through exploration of tumor gene information in Oncomine database,ENO1 was found highly expressed in ovarian cancer and related to the prognosis of ovarian cancer,which might be a new marker for ovarian cancer prognosis and alternative drug therapy.