Lung cancer is one of the leading causes of death with one of the lowest survival rates. However, a subset of lung cancer patients who are of Asian origin and carry somatic mutations in epidermal growth factor recepto...Lung cancer is one of the leading causes of death with one of the lowest survival rates. However, a subset of lung cancer patients who are of Asian origin and carry somatic mutations in epidermal growth factor receptor or EGFR have responded remarkable well to two tyrosine kinase inhibitors, gefitinib and erlotinib. While EGFR mutation profiles have been reported from Japan, South Korea, and Taiwan, there is no such report from mainland of China where the largest pool of patients reside. In this report, we identified ten somatic mutations from a total of 41 lung cancer patients in China. Among them, seven mutations were found in 17 adenocarcinomas. In contrast to previous reports, eight of these mutations are deletions in exon 19 and two of these deletions are homozygous. These results suggest that a large portion of Chinese adenocarcinoma patients could benefit from gefitinib or erlotinib. This unique mutation profile provides a rationale to develop the next generation of EGFR inhibitors more suitable for the Chinese population.展开更多
Ordered ZnS semiconductor nanoparticles were in situ synthesized in metal halide perovskite organic/inorganic layered hybrids (CnH2n+1NH3)2ZnCl4 (n=10 and 12) by reaction of their spin-casting films with H2S gas. Tra...Ordered ZnS semiconductor nanoparticles were in situ synthesized in metal halide perovskite organic/inorganic layered hybrids (CnH2n+1NH3)2ZnCl4 (n=10 and 12) by reaction of their spin-casting films with H2S gas. Transmission electron microscopy, UV-vis spectroscopy and small-angle X-ray diffraction were used to characterize the morphology and the structure of formed nanoparticles. Obtained results indicate an effective way to incorporate functional inorganic nanoparticles into structured organic matrices.展开更多
Two new chiral pyridine prolinol derivatives have been synthesized from N-alkylation of (S)-a,a-diphenyl-2-pyrrolidinemethanol with 2-bromomethylpyridine and 2, 6-dibromo- methyl-pyridine. The catalytic asymmetric bo...Two new chiral pyridine prolinol derivatives have been synthesized from N-alkylation of (S)-a,a-diphenyl-2-pyrrolidinemethanol with 2-bromomethylpyridine and 2, 6-dibromo- methyl-pyridine. The catalytic asymmetric borane reduction of prochiral ketones and the asymmetric addition of diethylzinc to benzaldehyde were investigated.展开更多
The synthesis, the crystal structure and the reaction of the hetero-binuclear complex [MnRe(CO)6(-SH)(-SC(H)PPri3)(PPh3)] are reported. The results of single crystal X-ray structure analysis showed that the fragment...The synthesis, the crystal structure and the reaction of the hetero-binuclear complex [MnRe(CO)6(-SH)(-SC(H)PPri3)(PPh3)] are reported. The results of single crystal X-ray structure analysis showed that the fragments Mn(CO)3 and Re(CO)3 were bridged by SH and SC(H)PPri3. The title complexes can react with BunLi and RX forming complexes MnRe(CO)6(-SR)(-SC(H)PPri3)(PPh3) (R = Me, CH2CH=CH2, SnBu3n).展开更多
Working in China has brought a satisfaction like never before for Suwito. In this exciting market, he has put his leadership skills to the best use and lifted the revenue and profit of CB Richard Ellis (CBRE) in China...Working in China has brought a satisfaction like never before for Suwito. In this exciting market, he has put his leadership skills to the best use and lifted the revenue and profit of CB Richard Ellis (CBRE) in China to a new level in 2004. An Indonesian Chinese, he often makes travels across China and visits museums and galleries to learn about his Chinese roots. With so much uncertainty surrounding China's real estate market,he firmly makes his opinion: A more rapid rate of real estate appreciation must be expected.展开更多
On November 15, 2004, Wang Jirong, vice director of the State Environmental Protection Administration (SEPA), led a team of officials to the top floor of the CCTV tower in western Beijing. They were there to look at t...On November 15, 2004, Wang Jirong, vice director of the State Environmental Protection Administration (SEPA), led a team of officials to the top floor of the CCTV tower in western Beijing. They were there to look at the city's boiler chimneys and identify those belching black-smoke. Under the blue sky, the visibility was extremely good, at around 30 kilometers. But when Wang's eyes shifted to the west, he coul not help noticing a massive smoke cap,展开更多
基金supported by the GIBH funds provided by the Chinese Academy of Sciences,the City of Guangzhou and Guangdong Province
文摘Lung cancer is one of the leading causes of death with one of the lowest survival rates. However, a subset of lung cancer patients who are of Asian origin and carry somatic mutations in epidermal growth factor receptor or EGFR have responded remarkable well to two tyrosine kinase inhibitors, gefitinib and erlotinib. While EGFR mutation profiles have been reported from Japan, South Korea, and Taiwan, there is no such report from mainland of China where the largest pool of patients reside. In this report, we identified ten somatic mutations from a total of 41 lung cancer patients in China. Among them, seven mutations were found in 17 adenocarcinomas. In contrast to previous reports, eight of these mutations are deletions in exon 19 and two of these deletions are homozygous. These results suggest that a large portion of Chinese adenocarcinoma patients could benefit from gefitinib or erlotinib. This unique mutation profile provides a rationale to develop the next generation of EGFR inhibitors more suitable for the Chinese population.
文摘Ordered ZnS semiconductor nanoparticles were in situ synthesized in metal halide perovskite organic/inorganic layered hybrids (CnH2n+1NH3)2ZnCl4 (n=10 and 12) by reaction of their spin-casting films with H2S gas. Transmission electron microscopy, UV-vis spectroscopy and small-angle X-ray diffraction were used to characterize the morphology and the structure of formed nanoparticles. Obtained results indicate an effective way to incorporate functional inorganic nanoparticles into structured organic matrices.
文摘Two new chiral pyridine prolinol derivatives have been synthesized from N-alkylation of (S)-a,a-diphenyl-2-pyrrolidinemethanol with 2-bromomethylpyridine and 2, 6-dibromo- methyl-pyridine. The catalytic asymmetric borane reduction of prochiral ketones and the asymmetric addition of diethylzinc to benzaldehyde were investigated.
基金the National Natural Science Foundation of China (No. 29672018) for financial support.
文摘The synthesis, the crystal structure and the reaction of the hetero-binuclear complex [MnRe(CO)6(-SH)(-SC(H)PPri3)(PPh3)] are reported. The results of single crystal X-ray structure analysis showed that the fragments Mn(CO)3 and Re(CO)3 were bridged by SH and SC(H)PPri3. The title complexes can react with BunLi and RX forming complexes MnRe(CO)6(-SR)(-SC(H)PPri3)(PPh3) (R = Me, CH2CH=CH2, SnBu3n).
文摘Working in China has brought a satisfaction like never before for Suwito. In this exciting market, he has put his leadership skills to the best use and lifted the revenue and profit of CB Richard Ellis (CBRE) in China to a new level in 2004. An Indonesian Chinese, he often makes travels across China and visits museums and galleries to learn about his Chinese roots. With so much uncertainty surrounding China's real estate market,he firmly makes his opinion: A more rapid rate of real estate appreciation must be expected.
文摘On November 15, 2004, Wang Jirong, vice director of the State Environmental Protection Administration (SEPA), led a team of officials to the top floor of the CCTV tower in western Beijing. They were there to look at the city's boiler chimneys and identify those belching black-smoke. Under the blue sky, the visibility was extremely good, at around 30 kilometers. But when Wang's eyes shifted to the west, he coul not help noticing a massive smoke cap,
