A multi-source information fusion layer counting method for penetration fuze based on TCN-LSTM

When employing penetration ammunition to strike multi-story buildings,the detection methods using acceleration sensors suffer from signal aliasing,while magnetic detection methods are susceptible to interference from ferromagnetic materials,thereby posing challenges in accurately determining the number of layers.To address this issue,this research proposes a layer counting method for penetration fuze that incorporates multi-source information fusion,utilizing both the temporal convolutional network(TCN)and the long short-term memory(LSTM)recurrent network.By leveraging the strengths of these two network structures,the method extracts temporal and high-dimensional features from the multi-source physical field during the penetration process,establishing a relationship between the multi-source physical field and the distance between the fuze and the target plate.A simulation model is developed to simulate the overload and magnetic field of a projectile penetrating multiple layers of target plates,capturing the multi-source physical field signals and their patterns during the penetration process.The analysis reveals that the proposed multi-source fusion layer counting method reduces errors by 60% and 50% compared to single overload layer counting and single magnetic anomaly signal layer counting,respectively.The model's predictive performance is evaluated under various operating conditions,including different ratios of added noise to random sample positions,penetration speeds,and spacing between target plates.The maximum errors in fuze penetration time predicted by the three modes are 0.08 ms,0.12 ms,and 0.16 ms,respectively,confirming the robustness of the proposed model.Moreover,the model's predictions indicate that the fitting degree for large interlayer spacings is superior to that for small interlayer spacings due to the influence of stress waves.

具有定向电荷传递能力的晶态线型聚酰亚胺材料驱动光催化CO_(2)还原

利用太阳能和半导体催化材料将CO_(2)还原为具有高附加值的含碳化学品为解决能源危机等问题提供了一个有前景的解决方案.目前半导体光催化CO_(2)还原的效率仍然很低,这主要是光激发的载流子复合严重等问题导致的.探索有效策略来增强半导体光催化材料光生电荷分离和传输性能被认为是提高CO_(2)还原效率的关键之一.设计制备具有定向电荷传输性能的光催化材料将有助于抑制光生电荷复合,从而实现高效光催化性能.线型共轭有机聚合物具有直链状结构、明晰和多样的元素组成、良好的水热稳定性等优点在光催化领域受到持续的关注和研究.本文通过均苯四甲酸二酐和二胺单体的缩合反应制备了三例晶态线型共轭聚酰亚胺材料用于光催化CO_(2)还原.利用粉末X射线衍射、傅里叶红外光谱、扫描电子显微镜、透射电子显微镜、紫外可见吸收光谱和气体吸附测试等对合成的聚酰亚胺的晶态结构、光吸收性质、形貌结构和孔结构等进行了表征.利用光电化学、电子顺磁共振波普分析、电位分析和密度泛函理论计算等研究了构筑单元的电子推拉效应对聚合物电荷分离及催化性能的影响.结果表明,三种结晶型聚酰亚胺均对CO_(2)具有良好的吸附能力且满足光催化CO_(2)还原电势的能带结构要求.光生载流子的复合程度随着重复结构单元偶极距的增强而降低,其中基于苯并噻吩砜的晶态线型聚酰亚胺(CLP-CS)具有最优的载流子分离能力.在光催化CO_(2)还原反应中,CLP-CS表现出高达1700μmol h-1gcat-1的CO析出效率和90%的选择性.CLP-CS在高低温和紫外灯照射等极端条件下,仍保持良好的结构稳定性和催化活性.实验发现,聚合物的CO_(2)还原活性与重复结构单元的偶极距及方向密切有关.局部结构的不对称性,扩大了分子偶极,增强了材料的内建电场驱动力.此外,长程有序的线型结构为光生电荷传输提供了快速迁移通道,促进了载流子迁移.综上,本文报道了基于晶态线型聚合物的光催化体系,为实现光生电荷定向传输和开发高效光催化材料提供了途径.

Prognostic-related genes for pancreatic cancer typing and immunotherapy response prediction based on single-cell sequencing data and bulk sequencing data

Pancreatic cancer is associated with high mortality and is one of the most aggressive of malignancies,but studies have not fully evaluated its molecular subtypes,prognosis and response to immunotherapy of different subtypes.The purpose of this study was to explore the molecular subtypes and the key genes associated with the prognosis of pancreas cancer patients and study the clinical phenotype,prognosis and response to immunotherapy using single-cell seq data and bulk RNA seq data,and data retrieved from GEO and TCGA databases.Methods:Single-cell seq data and bioinformatics methods were used in this study.Pancreatic cancer data were retrieved from GEO and TCGA databases,the molecular subtypes of pancreatic cancer were determined using the six cGAS-STING related pathways,and the clinical phenotype,mutation,immunological characteristics and pathways related to pancreatic cancer were evaluated.Results:Pancreatic cancer was classified into 3 molecular subtypes,and survival analysis revealed that patients in Cluster3(C3)had the worst prognosis,whereas Cluster1(C1)had the best prognosis.The clinical phenotype and gene mutation were statistically different among the three molecular subtypes.Analysis of immunotherapy response revealed that most immune checkpoint genes were differentially expressed in the three subtypes.A lower risk of immune escape was observed in Cluster1(C1),indicating higher sensitivity to immunotherapeutic drugs and subjects in this Cluster are more likely to benefit from immunotherapy.The pathways related to pancreatic cancer were differentially enriched among the three subtypes.Five genes,namely SFRP1,GIPR,EMP1,COL17A and CXCL11 were selected to construct a prognostic signature.Conclusions:Single-cell seq data were to classify pancreatic cancer into three molecular subtypes based on differences in clinical phenotype,mutation,immune characteristics and differentially enriched pathways.Five prognosis-related genes were identified for prediction of survival of pancreatic cancer patients and to evaluate the efficacy of immunotherapy in various subtypes.

早期非小细胞肺癌患者立体定向放射治疗的预后分析

背景与目的随着人口老龄化和肺癌筛查受重视程度的提高,近年来早期肺癌就诊量呈上升趋势。其病理类型以非小细胞肺癌(non-small cell lung cancer,NSCLC)为主,可被划分为可手术早期肺癌和不可手术早期肺癌。立体定向放射治疗(stereotactic body radiation therapy,SBRT)是不可手术早期NSCLC的首选治疗方法。本研究旨在探讨我院早期NSCLC患者行SBRT后的预后及其影响因素,以期提高早期NSCLC患者接受SBRT后的生存期。方法收集2010年8月-2020年8月在我院接受SBRT的早期NSCLC患者的临床资料及随访情况,采用Kaplan-Meier法评估预后,采用Cox比例风险模型进行多因素分析寻找影响预后的因素。结果共纳入165例患者,中位随访时间为43.2(范围:4.8-132.1)个月。1年、2年、5年局部控制(local control,LC)率分别为98.1%、94.8%和86.5%,卡氏功能状态评分(Karnofsky performance status,KPS)>80分是LC的独立预后因素(P=0.02);1年、2年、5年总生存(overall survival,OS)率分别为97.6%、93.0%和68.9%,生物等效剂量(biological equivalent dose whenα/β=10,BED_(10))>132 Gy是OS的独立预后因素(P=0.04);1年、2年、5年无进展生存(progression-free survival,PFS)率分别为93.3%、79.5%和55.3%;1年、2年、5年无远处转移生存(distance metastasis free survival,DMFS)率分别为94.5%、83.2%和58.4%,BED_(10)>150 Gy是DMFS的独立预后因素(P=0.02);1年、2年、5年区域控制(region control,RC)率分别为98.8%、95.4%和87.9%。结论SBRT治疗早期NSCLC疗效好,KPS>80分是影响LC的独立预后因素;BED_(10)>132Gy是OS的独立预后因素;BED_(10)>150 Gy是DMFS的独立预后因素。

Roles of gypsum/salt-bearing sequence in hydrocarbon accumulation and storage

Gypsum/salt beds are widely developed in petroliferous basins across the world.Most basins with gypsum/salt beds have been proven to host abundant hydrocarbon resources.Previous studies on the effects of gypsum/salt beds on hydrocarbon reservoirs primarily focused on their excellent sealing property as cap rocks.However,an increasing number of exploration discoveries have shown that gypsum/salt beds have the potential to promote the formation of high-quality source rocks and hydrocarbon reservoirs.Gypsum/salt beds influence the generation,preservation and accumulation of hydrocarbons.Based on the systematic analysis of the generation of hydrocarbons in global gypsum/saltbearing sequences,the study discussed the control of gypsum/salt beds on play elements,and explore the relationship between the development of gypsum/salt beds and global large-and medium-scale hydrocarbon reservoirs.Furthermore,we analyzed the correlation between typical gypsum/saltbearing sequences and their hydrocarbon generation potentials in China.In-depth analysis shows three patterns in terms of the spatial superimposition of gypsum/salt beds and source rocks,that is,postsalt pattern,inter-salt pattern and pre-salt pattern.Among others,the source rocks of the inter-salt pattern are widely developed in salt basins and of great potential for hydrocarbon exploration.

Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction

From pregnancy to parturition, Sprague-Dawley rats were daily administered a low protein diet to establish a model of intrauterine growth restriction. From the 12th day of pregnancy, 300 mg/kg taurine was daily added to food until spontaneous delivery occurred. Brain tissues from normal neonatal rats at 6 hours after delivery, neonatal rats with intrauterine growth restriction, and neo- natal rats with intrauterine growth restriction undergoing taurine supplement were obtained for fur- ther experiments. The terminal deoxyribonucleotidyl transferase （TdT）-mediated biotin-16-dUTP nick-end labeling assay revealed that the number of apoptotic cells in the brain tissue of neonatal rats with intrauterine growth restriction significantly increased. Taurine supplement in pregnant rats reduced cell apoptosis in brain tissue from neonatal rats with intrauterine growth restriction. Immu- nohistochemical staining revealed that taurine supplement increased glial cell line-derived neuro- trophic factor expression and decreased caspase-3 expression in the cerebral cortex of intrauterine growth-restricted fetal rats. These results indicate that taurine supplement reduces cell apoptosis through the glial cell line-derived neurotrophic factor-caspase-3 signaling pathway, resulting in a protective effect on the intrauterine growth-restricted fetal rat brain.

Effect of terrain on landscape patterns and ecological effects by a gradient-based RS and GIS analysis

Terrain is an important environment factor that plays a vital role in human development by influencing the spatial layout of land use patterns. The terrain niche index, combined with slope and elevation, can comprehensively present detailed information about spatial differences in terrain and is superior to single terrain factors. We applied remote sensing and geographical information system to terrain gradient, used the non-dimensional distribution index to examine spatial distribution characteristics of various landscape types, and analyzed the ecological effects of landscape were quantitatively on terrain gradients. Eco-environment quality (EEQ) was evaluated using the forestry operation area as the evaluation unit. The spatial distributions in various landscapes were significantly influenced by terrain factors, especially by bodies of water, cropland and residential land. The spatial distribution varied greatly in different terrain gradients for similar landscape types. The areas associated with good, intermediate and poor EEQ were occupied primarily by natural landscape, semi-natural and largely artificial landscapes, respectively.

Analysis of the Relationship between the Cloud Water Path and Precipitation Intensity of Mature Typhoons in the Northwest Pacific Ocean

The relationship between precipitation intensity and cloud water in typhoon systems remains unclear.This study combined time-and space-synchronized precipitation and spectral data obtained by the Precipitation Radar(PR)as well as the Visible and Infrared Scanner(VIRS)onboard the TRMM satellite,to overcome the limitations of precipitation properties and cloud parameters not being synchronized in previous studies.A merged dataset of near-surface rain rate(RR)and corresponding cloud water path(CWP)was established and used to analyze the potential correlation between cloud microphysical properties and precipitation,to deepen our understanding of the evolution of cloud to rain.In addition,25 collocated satellite overpasses of mature typhoon cases in the Northwest Pacific Ocean from 1998 to 2012 were obtained,and the relationships between the CWP and RR of 144515 pixels were analyzed in detail.The results show that the CWP and RR of mature typhoon systems with different precipitation types,precipitation cloud phases,and vertical depths of precipitation can be fitted by a notable sigmoid function,which may be useful for estimating CWP and parameterizing precipitation in models.Furthermore,the relationship was applied and tested with an independent sample to show that RR is a significant indicator of CWP.

High-Performance Photo-Modulated Thin-Film Transistor Based on Quantum dots/Reduced Graphene Oxide Fragment-Decorated ZnO Nanowires

In this paper, a photo-modulated transistor based on the thin-film transistor structure was fabricated on the flexible substrate by spin-coating and magnetron sputtering. A novel hybrid material that composed of Cd Se quantum dots and reduced graphene oxide(RGO) fragment-decorated ZnO nanowires was synthesized to overcome the narrow optical sensitive waveband and enhance the photo-responsivity. Due to the enrichment of the interface and heterostructure by RGO fragments being utilized, the photo-responsivity of the transistor was improved to 2000 AW^(-1) and the photo-sensitive wavelength was extended from ultraviolet to visible. In addition, a positive back-gate voltage was employed to reduce the Schottky barrier width of RGO fragments and ZnO nanowires. As a result, the amount of carriers was increased by 10 folds via the modulation of back-gate voltage. With these inherent properties, such as integrated circuit capability and wide optical sensitive waveband, the transistor will manifest great potential in the future applications in photodetectors.

Pseudo-capacitance of ruthenium oxide/carbon black composites for electrochemical capacitors

Hydrous ruthenium oxide was formed by a new process. The precursor was obtained by mixing the aqueous solutions of RuCl3xH2O and NaHCO3. The addition of NaHCO3 led to the formation of an oxide with extremely fine RuO2 particles forming a porous network structure in the oxide electrode. Polyethylene glycol was added as a controller to partly inhibit the sol-gel reaction. The rate capacitance of 530 F·g^-1 was measured for the powder formed at an optimal annealing temperature of 210℃. Several details concerning this new material, including crystal structure, particle size as a function of temperature, and electrochemical properties, were also reported. In addition, the rate capacitance of the composite electrode reached 800 F·g^-1 after carbon black was added. By using the modified electrode of a RuO2/carbon black composite electrode, the electrochemical capacitor exhibits high energy density and stable power characteristics. The values of specific energy and maximum specific power of 24 Wh·kg^-1 and 4 kW·kg^-1, respectively, are demonstrated for a cell voltage between 0 and 1 V.

Efficacy and safety of degarelix in patients with prostate cancer:Results from a phase III study in China

Objective:To establish non-inferiority of gonadotropin-releasing hormone degarelix compared with goserelin in suppressing and maintaining castrate testosterone levels from Day 28 to Day 364 in Chinese patients with prostate cancer.Methods:This is an open-label,multi-centre study in which men aged18 years were randomised in a 1:1 ratio to once-a-month subcutaneous injection of either degarelix(240/80 mg)or goserelin(3.6 mg)for 12 months.The primary endpoint was difference in 1-year cumulative probability of suppressing testosterone to ≤0.5 ng/mL.Non-inferiority was to be established if the lower 95% confidence interval(CI)limit for difference in cumulative probability between the treatment arms was greater than -10%.Secondary endpoints included cumulative probability of prostate-specific-antigen-progression-free-survival(PSA-PFS).Safety was also assessed.Results:Baseline demographics and disease characteristics were similar between degarelix(n=142)and goserelin(n=141)treatment arms.The difference in cumulative probability of maintaining castrate levels from Day 28-364 was 3.6%(95%CI:-1.5%,8.7%),demonstrating non-inferiority of degarelix.The cumulative probability of PSA-PFS at Day 364 was higher for degarelix(82.3%,95%CI:74.7%,87.7%)versus goserelin(71.7%,95%CI:63.2%,78.5%,p=0.038).Adverse events(AEs)were similar between treatment arms,except for more injection site reactions with degarelix versus goserelin.Four(2.8%)and nine(6.4%)patients discontinued due to AEs in degarelix and goserelin groups,respectively.

TOEPLITZ OPERATORS WITH POSITIVE OPERATOR-VALUED SYMBOLS ON VECTOR-VALUED GENERALIZED FOCK SPACES

In this article,we study some characterizations of Toeplitz operators with positive operator-valued function as symbols on the vector-valued generalized Bargmann-Fock spaces Fψ^2.Main results including Fock-Carleson condition,bounded Toeplitz operators,compact Toeplitz operators,and Toeplitz operators in the Schatten-p class are all considered.

来源于人膀胱癌细胞株EJ的HSP70负载的DC所激发的特异性CTL细胞的体外应答效应(英文)

Objective: To investigate whether human dendritic cells (DC) derived from peripheral blood mononuclear cells (PBMC), which were pulsed by heat shock protein 70 (HSP70) isolated from human bladder tumor cell lines of EJ, were able to induce peptide specific cytotoxic T-lymphocytes (CTL) response in vitro and give the experimental foundation for the future clinical trials of immunotherapy in bladder tumor. Methods: The EJ-derived HSP70 co-cultured with DC from the healthy volunteers' PBMC, along with the crude lysate (the supernatant before HSP70 purification) from EJ cells were used as the experimental groups and DC not pulsed by any tumor cells antigen were the blank control. The autologous T-lymphocytes were added into the above various DC groups, and after incubation, the stimulation indexes (SI) and interferon-γ (IFN-γ) were detected to evaluate the immune activities of various DC groups. The killing effects of CTL to target cells, EJ and Hela cells, were determined with 51Cr releasing test. Results: Both DC/HSP70 and DC/the crude lysate could effectively activate CTL in vitro and kill target cells EJ. The killing effect of DC/HSP70 to EJ was much stronger than DC/the crude lysate (the supernatant before HSP70 purification) (P < 0.05). DC without any tumor cell antigens had a lower killing power to EJ. Meanwhile, DC/ HSP70 had little killing power to Hela non-relevant to bladder tumor histopathologically as compared with EJ cells (P < 0.05). Conclusion: The DC pulsed by HSP70 derived from the autologous tumor cells could induce a peptide complexes specific CTL response to tumor cells, and the CTL response induced by the DC/HSP70 was stronger, which display the basis of the possible clinical application of DC/HSP70 for bladder tumor.

Spatiotemporal variation and driving factors of water yield services on the Qingzang Plateau

Water resources are a basic need for social sustainable development and human existence.As an important national strategy for water resources security,spatial and temporal patterns and driving mechanisms of water yield ecosystem services on the Qingzang Plateau(QP)are critical for water resources management,optimal water allocation and the improvement of ecological water protection efficiency.However,only a few relevant studies are currently available.In this study,we simulated the water yield(WY)of the QP over 34 years,from 1982 to 2015,using the InVEST model and analyzed the spatiotemporal dynamic relationships between WY and climate change as well as between WY and vegetation change,using geographically weighted regression(GWR)models.The results showed that:1)from 1982 to 2015,the WY of the QP increased at an average rate of 3.8 mm/yr;2)WY presented a reduced spatial pattern from southeast to northwest;and 3)the WY driving factors have individual and spatial differences.In terms of the area percentage in promoting WY when analyzing each driving factor,precipitation(99.8%)and air pressure(53.3%)played the major roles in promoting WY,while temperature(71.9%),wind speed(57.2%),net primary productivity(87.2%),radiation(68.3%)and lake(87.7%)played negative roles.The areas where WY are dominated by temperature are the largest(41.1%),and followed by areas dominated by pressure(19.7%)and precipitation(18.5%).The results of this study provide scientific support for formulating regional water resources policy,social and economic development planning and other macro decisions for the QP.

Concentration-induced structural diversity and catalytic activity of BF3/n-BuOH complexes for n-decene polymerization

The BF3/n-BuOH complexes were investigated as active species in catalyzing n-decene polymerization reaction.The structures of BF3/n-BuOH complexes were characterized not only by modern spectrum but also by calculation at theoretical level. The results confirmed that BF3/n-BuOH complexes changed from BF3·(n-BuOH)2 complexes to BF3·n-BuOH complexes with the mass fraction of BF3 increasing. These two complexes have different catalytic activity, but BF3·n-BuOH was superior. The highest n-decene conversion could reach 99% and the most excellent selectivity of n-decene trimer and tetramer could reach up to 80% yield by a series of controlled conditions. This work can help to understand the catalytic active species of n-decene polymerization and provide support for industrialization of poly-alpha-olefins(PAOs).

Multi-Owner Keyword Search over Shared Data without Secure Channels in the Cloud

Searchable encryption allows cloud users to outsource the massive encrypted data to the remote cloud and to search over the data without revealing the sensitive information. Many schemes have been proposed to support the keyword search in a public cloud. However,they have some potential limitations. First,most of the existing schemes only consider the scenario with the single data owner. Second,they need secure channels to guarantee the secure transmission of secret keys from the data owner to data users. Third,in some schemes,the data owner should be online to help data users when data users intend to perform the search,which is inconvenient.In this paper,we propose a novel searchable scheme which supports the multi-owner keyword search without secure channels. More than that,our scheme is a non-interactive solution,in which all the users only need to communicate with the cloud server. Furthermore,the analysis proves that our scheme can guarantee the security even without secure channels. Unlike most existing public key encryption based searchable schemes,we evaluate the performance of our scheme,which shows that our scheme is practical.

Photosynthetic biomaterials: applications of photosynthesis in algae as oxygenerator in biomedical therapies

For most organisms,molecular oxygen is indispensable for normal physiological metabolism;in humans,prolonged hypoxia in tissues can induce many diseases,exemplified by cardiovascular disease,chronic wounds,and tissue necrosis.Therefore,the oxygen in our environment is vital for life.As a main source of oxygen in the natural world that transforms light energy into chemical energy and oxygen,photosynthesis has been widely studied in scientific research and used in production of food,fuel,and medicine.In recent years,photosynthesis has become more closely involved in biomedicine and has been widely used in photodynamic therapy,tissue regeneration,transplantation,and in treatment of specific diseases.This review summarizes innovative applications of photosynthesis in biomedical research and highlights the theory and implications of clinical treatment for specific diseases.

北京市种猪集中测定情况分析与展望

为掌握北京市种猪生产性能水平,文章对2015—2020年北京市种猪集中收测结果,包括达100 kg体重日龄、达100 kg体重活体背膘厚、30~100 kg平均日增重和饲料转化率相关数据进行了分析比较,并结合种猪生产企业现状,对集中测定的重要性进行探讨与展望,以期为指导种猪选育,开展联合育种工作提供更多思路。

Proteomic identification of potential target proteins regulated by an ASK1-mediated proteolysis pathway

ASK1 (ARABIDOPSIS 象 SKP1 一样) 蛋白质是招募的 ubiquitin ligase 建筑群指向的 SCF (Skp1-Cullin-F 盒子蛋白质) 的一个批评部件为由 26S proteosome 的降级的蛋白质。为了调查蛋白质，那被调停 ASK1 的解朊作用小径在 Arabidopsis 花影响，我们用二维的电气泳动(2-DE ) 比较了 Arabidopsis 野类型和 ask1 异种花芽的 proteomes。有在与野类型花相比的 ask1 异种花的更高或更低的丰富的十个蛋白质点被切除并且使分析遭到了到进一步集体的 spectrometry (MS ) 。结果证明他们是涉及相片形态发生，生理节奏的摆动，翻译以后的过程，压力反应和房间扩大或延伸的蛋白质，建议那些过程在 ask1 异种被影响。基因也是的这些的抄本层次基于 Affymetrix 基因芯片比较了微数组数据。没有重要差别为大多数基因被观察，建议有在 ask1 异种的累积的提高的层次的蛋白质能是一条调停 ASK1 的解朊作用小径调整的候选人目标。阐明的这些结果帮助在 Arabidopsis 发展过程并且也的 ASK1 的多种的功能表明关于基因功能学习蛋白质层次的重要性和必要性。