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Improvement of cardiac function and reversal of gap junction remodeling by Neuregulin-1β in volume-overloaded rats with heart failure 被引量:11
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作者 Xue-Hui Wang Xiao-Zhen Zhuo +4 位作者 ya-juan ni Min Gong Ting-Zhong Wang Qun Lu Ai-Qun Ma 《Journal of Geriatric Cardiology》 CAS CSCD 2012年第2期172-179,共8页
Objective We performed experiments using Neuregulin-1β (NRG-1β) treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions (GJs) during heart failu... Objective We performed experiments using Neuregulin-1β (NRG-1β) treatment to determine a mechanism for the protective role derived from its beneficial effects by remodeling gap junctions (GJs) during heart failure (HF). Methods Rat models of I-IF were established by aortocaval fistula. Forty-eight rats were divided randomly into the HF (HF, n = 16), NRG-1β trealanent (NRG, n = 16), and sham operation (S, n = 16) group. The rats in the NRG group were administered NRG-1β (10 μg/kg per day) for 7 days via the tail vein, whereas the other groups were injected with the same doses of saline, Twelve weeks after operation, Connexin 43 (Cx43) expression in single myocytes obtained from the left ventricle was determined by immunocytochemistry. Total protein was extracted from frozen left ventricular tissues for immunoblotting assay, and the ultrastmcture of myocytes was observed by transmission electron microscopy. Results Compared with the HF group, the cardiac fimction of rats in the NRG group was markedly improved, irregular distribution and deceased Cx43 expression were relieved. The ultrastmcture of myocytes was seriously damaged in HF rats, and NRG-1β reduced these pathological damages. Conclusions Short-term NRG-1β treatment can rescue pump failure in experimental models of volume overload-induced HF, which is related to the recovery of GJs structure and the improvement of Cx43 expression. 展开更多
关键词 qeuregulin-1β Cardiac function Heart failure Connexin 43 Gap junction REMODELING
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Bioactive xanthones from whole plants of Gentianella acuta
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作者 sheng-cai yang jing-ya ruan +4 位作者 yan-xia liu zhi-juan ding ya-juan ni tao wang yi zhang 《Chinese Herbal Medicines》 CAS 2018年第1期99-102,共4页
Objective: To study the constituents from the whole plants of Gentianella acuta and their biological activities.Methods: The compounds were isolated by multiple chromatographic methods and the structures of mentione... Objective: To study the constituents from the whole plants of Gentianella acuta and their biological activities.Methods: The compounds were isolated by multiple chromatographic methods and the structures of mentioned isolates were determined by routine NMR experiments and chemical methods.Results: A phytochemical investigation to obtain intestine motility inhibitor resulted in the isolation of one new xanthone glycoside,gentixanthonoside A(1),along with nine tetrahydroxanthones,1,3,5R,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone(2),1,3,5S,8S-tetrahydroxy-5,6,7,8-tetrahydroxanthone(3),amarellin E(4),amarellin F(5),swertiachoside B(6),amarellin D(7),amarellin C(8),amarellin A(9),and amarellin B(10)from the whole plants of G.acuta.Conclusion: Compounds 2 –10 showed significant reduce effects on contraction tension at 40 μM. 展开更多
关键词 Gentianella acuta (Michx.) Hulten intestine motility Mongolia native medicine XANTHONES
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