On September 5, 2022, a magnitude Ms 6.8 earthquake occurred along the Moxi fault in the southern part of the Xianshuihe fault zone located in the southeastern margin of the Tibetan Plateau,resulting in severe damage ...On September 5, 2022, a magnitude Ms 6.8 earthquake occurred along the Moxi fault in the southern part of the Xianshuihe fault zone located in the southeastern margin of the Tibetan Plateau,resulting in severe damage and substantial economic loss. In this study, we established a coseismic landslide database triggered by Luding Ms 6.8 earthquake, which includes 4794 landslides with a total area of 46.79 km^(2). The coseismic landslides primarily consisted of medium and small-sized landslides, characterized by shallow surface sliding. Some exhibited characteristics of high-position initiation resulted in the obstruction or partial obstruction of rivers, leading to the formation of dammed lakes. Our research found that the coseismic landslides were predominantly observed on slopes ranging from 30° to 50°, occurring at between 1000 m and 2500 m, with slope aspects varying from 90° to 180°. Landslides were also highly developed in granitic bodies that had experienced structural fracturing and strong-tomoderate weathering. Coseismic landslides concentrated within a 6 km range on both sides of the Xianshuihe and Daduhe fault zones. The area and number of coseismic landslides exhibited a negative correlation with the distance to fault lines, road networks, and river systems, as they were influenced by fault activity, road excavation, and river erosion. The coseismic landslides were mainly distributed in the southeastern region of the epicenter, exhibiting relatively concentrated patterns within the IX-degree zones such as Moxi Town, Wandong River basin, Detuo Town to Wanggangping Township. Our research findings provide important data on the coseismic landslides triggered by the Luding Ms 6.8 earthquake and reveal the spatial distribution patterns of these landslides. These findings can serve as important references for risk mitigation, reconstruction planning, and regional earthquake disaster research in the earthquake-affected area.展开更多
目的调查陕西省农村老年癌症患者住院期间的常见症状,分析患者症状群的种类及其与生活质量的相关性。方法采用整群抽样法,选取2022年7月至8月在陕西省9家不同医疗机构住院的597例农村老年癌症患者作为调查对象,采用一般资料调查表、中...目的调查陕西省农村老年癌症患者住院期间的常见症状,分析患者症状群的种类及其与生活质量的相关性。方法采用整群抽样法,选取2022年7月至8月在陕西省9家不同医疗机构住院的597例农村老年癌症患者作为调查对象,采用一般资料调查表、中文版安德森症状测评量表(M.D.Anderson symptom inventory,MDASI)、中文版癌症治疗功能评价系统量表(functional assessment of cancer therapy,FACT)进行症状群和生活质量的调查并采用Pearson相关性分析两者相关性。结果陕西省住院的农村老年癌症患者其症状发生率最高的前4个分别为:疲劳(乏力)(75.88%)、胃口变差(75.54%)、睡眠不安(66.83%)、苦恼(66.33%)。情绪是农村老年癌症患者发生率最高的症状困扰(393例,65.83%)。4个症状群分别为胃肠道症状群(恶心、呕吐)、神经相关症状群(瞌睡、口干、身体麻木、健忘、气短)、疲乏症状群(疼痛、疲乏、胃口变差)及情绪症状群(苦恼、悲伤、睡眠不安)。生活质量总分为(55.33±8.46)分,处于中等水平,并与4个症状群呈负相关(均P<0.001)。结论陕西省住院的农村老年癌症患者面临多种症状困扰,症状之间协同形成4个症状群,与生活质量呈负相关,应给予更多关注,实施精准化干预措施,减少症状群负担,以提高其生活质量。展开更多
目的:基于网络药理学方法探讨复方斑蝥胶囊治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)的作用机制。方法:从中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platfo...目的:基于网络药理学方法探讨复方斑蝥胶囊治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)的作用机制。方法:从中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)筛选复方斑蝥胶囊中11味中药的活性成分及作用靶点,利用药物靶标数据库TTD、人类基因数据库(the human gene database,GeneCards)、美国国家生物技术信息中心(NCBI)筛选NSCLC相关靶点基因,通过STRING数据库对疾病与药物共同靶点构建蛋白-蛋白相互作用(PPI)网络模型,运用Cytoscape 3.5.1软件构建化合物-关键靶点相互作用网络图,利用DAVID6.8数据库对共同靶点进行生物过程和信号通路富集分析。结果:共筛选出复方斑蝥胶囊的210种活性成分和310个作用靶点,与治疗NSCLC相关靶点155个,关键靶点68个,主要通过作用于丝氨酸/苏氨酸特异性蛋白激酶1、肿瘤蛋白质53、血管内皮生长因子A、白细胞介素6、促分裂原活化蛋白激酶3、胱天蛋白酶3、JUN激酶、髓细胞增生原癌基因、肿瘤坏死因子、促分裂原活化蛋白激酶1、促分裂原活化蛋白激酶8、信号转导因子和转录激活因子3(急性期应答因子)、表皮生长因子、前列腺素内过氧化物合成酶2(前列腺素G/H合成酶和环氧酶)、雌激素受体1关键靶蛋白调控癌症通路、PI3K-Akt信号通路、癌症中的蛋白多糖通路、NSCLC通路等发挥治疗NSCLC的作用。结论:复方斑蝥胶囊可能通过多靶点、多途径治疗NSCLC。展开更多
基金supported by the National Natural Science Foundation of China project (No. 42372339)the China Geological Survey Project (Nos. DD20221816, DD20190319)。
文摘On September 5, 2022, a magnitude Ms 6.8 earthquake occurred along the Moxi fault in the southern part of the Xianshuihe fault zone located in the southeastern margin of the Tibetan Plateau,resulting in severe damage and substantial economic loss. In this study, we established a coseismic landslide database triggered by Luding Ms 6.8 earthquake, which includes 4794 landslides with a total area of 46.79 km^(2). The coseismic landslides primarily consisted of medium and small-sized landslides, characterized by shallow surface sliding. Some exhibited characteristics of high-position initiation resulted in the obstruction or partial obstruction of rivers, leading to the formation of dammed lakes. Our research found that the coseismic landslides were predominantly observed on slopes ranging from 30° to 50°, occurring at between 1000 m and 2500 m, with slope aspects varying from 90° to 180°. Landslides were also highly developed in granitic bodies that had experienced structural fracturing and strong-tomoderate weathering. Coseismic landslides concentrated within a 6 km range on both sides of the Xianshuihe and Daduhe fault zones. The area and number of coseismic landslides exhibited a negative correlation with the distance to fault lines, road networks, and river systems, as they were influenced by fault activity, road excavation, and river erosion. The coseismic landslides were mainly distributed in the southeastern region of the epicenter, exhibiting relatively concentrated patterns within the IX-degree zones such as Moxi Town, Wandong River basin, Detuo Town to Wanggangping Township. Our research findings provide important data on the coseismic landslides triggered by the Luding Ms 6.8 earthquake and reveal the spatial distribution patterns of these landslides. These findings can serve as important references for risk mitigation, reconstruction planning, and regional earthquake disaster research in the earthquake-affected area.
文摘目的调查陕西省农村老年癌症患者住院期间的常见症状,分析患者症状群的种类及其与生活质量的相关性。方法采用整群抽样法,选取2022年7月至8月在陕西省9家不同医疗机构住院的597例农村老年癌症患者作为调查对象,采用一般资料调查表、中文版安德森症状测评量表(M.D.Anderson symptom inventory,MDASI)、中文版癌症治疗功能评价系统量表(functional assessment of cancer therapy,FACT)进行症状群和生活质量的调查并采用Pearson相关性分析两者相关性。结果陕西省住院的农村老年癌症患者其症状发生率最高的前4个分别为:疲劳(乏力)(75.88%)、胃口变差(75.54%)、睡眠不安(66.83%)、苦恼(66.33%)。情绪是农村老年癌症患者发生率最高的症状困扰(393例,65.83%)。4个症状群分别为胃肠道症状群(恶心、呕吐)、神经相关症状群(瞌睡、口干、身体麻木、健忘、气短)、疲乏症状群(疼痛、疲乏、胃口变差)及情绪症状群(苦恼、悲伤、睡眠不安)。生活质量总分为(55.33±8.46)分,处于中等水平,并与4个症状群呈负相关(均P<0.001)。结论陕西省住院的农村老年癌症患者面临多种症状困扰,症状之间协同形成4个症状群,与生活质量呈负相关,应给予更多关注,实施精准化干预措施,减少症状群负担,以提高其生活质量。
文摘目的:基于网络药理学方法探讨复方斑蝥胶囊治疗非小细胞肺癌(non-small cell lung cancer,NSCLC)的作用机制。方法:从中药系统药理学数据库与分析平台(traditional Chinese medicine systems pharmacology database and analysis platform,TCMSP)筛选复方斑蝥胶囊中11味中药的活性成分及作用靶点,利用药物靶标数据库TTD、人类基因数据库(the human gene database,GeneCards)、美国国家生物技术信息中心(NCBI)筛选NSCLC相关靶点基因,通过STRING数据库对疾病与药物共同靶点构建蛋白-蛋白相互作用(PPI)网络模型,运用Cytoscape 3.5.1软件构建化合物-关键靶点相互作用网络图,利用DAVID6.8数据库对共同靶点进行生物过程和信号通路富集分析。结果:共筛选出复方斑蝥胶囊的210种活性成分和310个作用靶点,与治疗NSCLC相关靶点155个,关键靶点68个,主要通过作用于丝氨酸/苏氨酸特异性蛋白激酶1、肿瘤蛋白质53、血管内皮生长因子A、白细胞介素6、促分裂原活化蛋白激酶3、胱天蛋白酶3、JUN激酶、髓细胞增生原癌基因、肿瘤坏死因子、促分裂原活化蛋白激酶1、促分裂原活化蛋白激酶8、信号转导因子和转录激活因子3(急性期应答因子)、表皮生长因子、前列腺素内过氧化物合成酶2(前列腺素G/H合成酶和环氧酶)、雌激素受体1关键靶蛋白调控癌症通路、PI3K-Akt信号通路、癌症中的蛋白多糖通路、NSCLC通路等发挥治疗NSCLC的作用。结论:复方斑蝥胶囊可能通过多靶点、多途径治疗NSCLC。
