Drug abuse directly endangers human health and social security,hence its sensitive and rapid detection is vitally important.In recent years,organic film-based fluorescent sensing technology has attracted more and more...Drug abuse directly endangers human health and social security,hence its sensitive and rapid detection is vitally important.In recent years,organic film-based fluorescent sensing technology has attracted more and more attention in the detection of drugs and explosives due to its advantages of simple operation and rapid detection.For film-based fluorescent sensors,in addition to sensitive materials,the surface morphology of the film is also an important factor affecting the performance.In previous studies,the regulation of surface morphology mainly depends on concentration changes or complex templates.Here,a novel fluorescent polymer probe was designed and synthesized,and a simple and efficient ultraviolet(UV)-ozone substrate treatment method is used to adjust their surface morphology.The results show that film has an excellent fluorescence enhancement effect upon exposure to methylphenethylamine(MPEA,a simulant of methamphetamine)vapor.The sensing effect of the film is significantly improved after UV-ozone substrate treatment,and the limit of detection was decreased by 10.4 times from 2.59 to 0.25 ppm.Further experiments show that the sensing performance of other fluorescent probe can also be improved by the UV-ozone substrate treatment.This convenient and general method may become a very effective approach to improve the performance of film-based fluorescent sensors.展开更多
There are great needs for real-time detection of volatile organic amines(VOA)through low-cost detection methods in public health,food safety,and environmental monitoring area.Organic thin-film fluorescent probe(OTFFP)...There are great needs for real-time detection of volatile organic amines(VOA)through low-cost detection methods in public health,food safety,and environmental monitoring area.Organic thin-film fluorescent probe(OTFFP)is expected to become a new and efficient means of detecting VOA because of its fast response,high sensitivity,no contamination to the analyte and ease to prepare a portable instrument.Compared with the mature detection methods in solution,research on solid fluorescence sensing has been less studied.In this article,we review recent progress in OTFFP research for VOA vapour.We mainly focus on the new fluorescent sensing mechanisms applied in solid state in recent years and the design principle of probes for different types of organic amines(such as primary amine,secondary amine,tertiary amine and aromatic amine).We also review the material structures of these probes and the strategies to enhance their sensitivity or selectivity.展开更多
In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluor...In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluorescence with typical aggregation-induced enhanced emission(AIE) effect for forming a cubic-like microcrystal structure in THF-H2 O mixed solvent.The microcrystals presented significantly higher fluorescence than that of amorphous aggregates. The DMA microcrystals suspension showed a good response to 2,4,6-trinitrophenol(TNP) with a LOD of 1.2×10^(-7) M, which is the best result of TNP detection in aqueous solution. Quantum chemical calculation revealed that DMA is a donor(D)-receptor(A) type molecule with methoxy unit as donor and carbonyl moiety as receptor. Its emission arises from an intramolecular charge transfer(ICT) from methoxy units to carbonyl units. NMR indicated that there is a strong hydrogen bond interaction between DMA and TNP.Hydrogen bond interaction can effectively decrease the intermolecular distance of DMA and TNP, which will increase the efficiency of photoinduced electron transfer(PET) and fluorescence resonance energy transfer(FRET), and hence will be advantageous for its selectivity. The microcrystal induced enhanced emission could be generally used for kinds of target molecules analysis.展开更多
Background:Presbyopia has become a global disease affecting the world's aging population.Among various treatments,cataract extraction and intraocular lens(IOL)implantation have become the most popular and common m...Background:Presbyopia has become a global disease affecting the world's aging population.Among various treatments,cataract extraction and intraocular lens(IOL)implantation have become the most popular and common methods of presbyopia correction.During the twentieth century,IOLs have underwent significant innovation and advancements to meet the patients'high demands for functional vision at all distances.Main Text:To meet the increasing needs for excellent near and intermediate vision for daily activities,some premium IOLs with more than one focus have been developed,for example,the refractive MfIOLs,diffractive MfIOLs,extended depth of field(EDOF)IOLs,and accommodating IOLs(AIOLs)were introduced to meet this need.In addition,the add-on MfIOLs have been explored as promising supplementary IOLs for pseudophakic presbyopia.When selecting the MfIOLs,the IOLs'features,patients’characteristics,preoperative eye conditions,and treatment expectations should be considered.Conclusions:In this review,we focus on the multifocal IOLs(MfIOLs)commonly used for presbyopia correction and systematically summarized their optical designs and clinical outcomes.More evidence-based studies are required to provide guidelines for MfIOL selection,provide maximum visual benefits,and develop personalized visual solutions in the future.展开更多
Nitrate explosive is hard to detect due to lack of aromatic ring and weak interaction with fluorescence probe.More challenging is even to differentiate the dinitrates with multiple nitrate explosives based on photo in...Nitrate explosive is hard to detect due to lack of aromatic ring and weak interaction with fluorescence probe.More challenging is even to differentiate the dinitrates with multiple nitrate explosives based on photo induced electron transfer or aggregation caused fluorescence change mechanism.A highly selective dinitrate explosive probe was designed based on a new strategy-stepwise aggregation of multiple anchored fluorene dimer 8Py-2 F.Compared with its monomer counterpart 2Py-F,8Py-2 F showed a selective and stepwise fluorescence quenching to dinitrate explosives-ethylene glycol(EGDN)and triethylene glycol dinitrate(TEGDN).The limits of detection(LODs)are 2.72μM for TEGDN and 0.46μM for EGDN,which is three orders of magnitude lower than those of 2Py-F.The stepwise quenching process is well matched with the stepwise aggregation process as evidence by scanning electron microscopy(SEM).Nuclear magnetic resonance(NMR)and quantum chemical calculation proved the interaction force between the dinitrate and 8Py-2 F is hydron bonding interaction,and interaction distance is far less than that of the multiple nitrates coming from the flexibility of the chain and steric hinderance,which resulted in a self-adaptive interaction and higher selectivity.The new strategy is beneficial for the differentiation of the chemicals with similar energy level which is difficult to realize via other method,and the new method provides fluorometric probe for dinitrate explosive detection and makes it an ideal candidate for chemical detection and analysis in public safety and environmental monitoring.展开更多
There is a growing need for protective instruments that can be used in extreme environments,including those encountered during exoplanet exploration,anti-terrorism activities,and in chemical plants.These instruments s...There is a growing need for protective instruments that can be used in extreme environments,including those encountered during exoplanet exploration,anti-terrorism activities,and in chemical plants.These instruments should have the ability to detect external threats visually and monitor internal physiological signals in real time for maximum safety.To address this need,multifunctional semiconducting fibers with visual detection ranging from yellow to red and near-field communication(NFC)capabilities have been developed for use in personal protective clothing.A composite conductive yarn with semiconducting fluorescent probe molecules is embroidered on the clothing,forming an NFC coil that allows for the visual monitoring of atmospheric safety through color changes.The fluorescence detection system was able to selectively detect diethyl chlorophosphate(DCP),a substitute for the toxic gas sarin,with a detection limit of 6.08 ppb,which is lower than the life-threatening concentration of sarin gas.Furthermore,an intelligent protective suit with the abovementioned dual functions was fabricated with good mechanical cycle stability and repeatability.Real-time physiological signals such as the temperature and humidity of the wearer could be read through the NFC conveniently.Such intelligent protective suits can quickly provide an early warning to the identified low-dose DCP and evaluate the health of wearer according to the changes in physiological signals.This study offers a smart,low-cost strategy for designing intelligent protective devices for extreme environments.展开更多
基金supported by the National Natural Science Foundation of China(Nos.62022085,61901456,61831021,61731016,and 61771460)the National Key R&D Program of China(No.2018AAA0103100)the Science and Technology Commission of Shanghai Municipality(Nos.19YF1455700 and 19142203500).
文摘Drug abuse directly endangers human health and social security,hence its sensitive and rapid detection is vitally important.In recent years,organic film-based fluorescent sensing technology has attracted more and more attention in the detection of drugs and explosives due to its advantages of simple operation and rapid detection.For film-based fluorescent sensors,in addition to sensitive materials,the surface morphology of the film is also an important factor affecting the performance.In previous studies,the regulation of surface morphology mainly depends on concentration changes or complex templates.Here,a novel fluorescent polymer probe was designed and synthesized,and a simple and efficient ultraviolet(UV)-ozone substrate treatment method is used to adjust their surface morphology.The results show that film has an excellent fluorescence enhancement effect upon exposure to methylphenethylamine(MPEA,a simulant of methamphetamine)vapor.The sensing effect of the film is significantly improved after UV-ozone substrate treatment,and the limit of detection was decreased by 10.4 times from 2.59 to 0.25 ppm.Further experiments show that the sensing performance of other fluorescent probe can also be improved by the UV-ozone substrate treatment.This convenient and general method may become a very effective approach to improve the performance of film-based fluorescent sensors.
基金the National Natural Science Foundation of China(61325001,21273267,61321492,51473182)grant from Youth Innovation Promotion Association CAS(2015190)Shanghai Municipal Commission of Economy and Informatization
文摘There are great needs for real-time detection of volatile organic amines(VOA)through low-cost detection methods in public health,food safety,and environmental monitoring area.Organic thin-film fluorescent probe(OTFFP)is expected to become a new and efficient means of detecting VOA because of its fast response,high sensitivity,no contamination to the analyte and ease to prepare a portable instrument.Compared with the mature detection methods in solution,research on solid fluorescence sensing has been less studied.In this article,we review recent progress in OTFFP research for VOA vapour.We mainly focus on the new fluorescent sensing mechanisms applied in solid state in recent years and the design principle of probes for different types of organic amines(such as primary amine,secondary amine,tertiary amine and aromatic amine).We also review the material structures of these probes and the strategies to enhance their sensitivity or selectivity.
基金supported by the Ministry of Science and Technology (2016YFA0200800)the National Natural Science Foundation of China (51473182, 61731016, 61771460)the Youth Innovation Promotion Association of Chinese Academy of Sciences (2015190)
文摘In this contribution, we reported a very simple and small molecule material, 2,5-dimethoxyterephthalaldehyde(DMA). It exhibited a relatively weak fluorescence in solution, while showed a steadily increased green fluorescence with typical aggregation-induced enhanced emission(AIE) effect for forming a cubic-like microcrystal structure in THF-H2 O mixed solvent.The microcrystals presented significantly higher fluorescence than that of amorphous aggregates. The DMA microcrystals suspension showed a good response to 2,4,6-trinitrophenol(TNP) with a LOD of 1.2×10^(-7) M, which is the best result of TNP detection in aqueous solution. Quantum chemical calculation revealed that DMA is a donor(D)-receptor(A) type molecule with methoxy unit as donor and carbonyl moiety as receptor. Its emission arises from an intramolecular charge transfer(ICT) from methoxy units to carbonyl units. NMR indicated that there is a strong hydrogen bond interaction between DMA and TNP.Hydrogen bond interaction can effectively decrease the intermolecular distance of DMA and TNP, which will increase the efficiency of photoinduced electron transfer(PET) and fluorescence resonance energy transfer(FRET), and hence will be advantageous for its selectivity. The microcrystal induced enhanced emission could be generally used for kinds of target molecules analysis.
基金the National Natural Science Foundation of China(Grant No.81970779 to Zhu Yanan).
文摘Background:Presbyopia has become a global disease affecting the world's aging population.Among various treatments,cataract extraction and intraocular lens(IOL)implantation have become the most popular and common methods of presbyopia correction.During the twentieth century,IOLs have underwent significant innovation and advancements to meet the patients'high demands for functional vision at all distances.Main Text:To meet the increasing needs for excellent near and intermediate vision for daily activities,some premium IOLs with more than one focus have been developed,for example,the refractive MfIOLs,diffractive MfIOLs,extended depth of field(EDOF)IOLs,and accommodating IOLs(AIOLs)were introduced to meet this need.In addition,the add-on MfIOLs have been explored as promising supplementary IOLs for pseudophakic presbyopia.When selecting the MfIOLs,the IOLs'features,patients’characteristics,preoperative eye conditions,and treatment expectations should be considered.Conclusions:In this review,we focus on the multifocal IOLs(MfIOLs)commonly used for presbyopia correction and systematically summarized their optical designs and clinical outcomes.More evidence-based studies are required to provide guidelines for MfIOL selection,provide maximum visual benefits,and develop personalized visual solutions in the future.
基金supported by the research program from the Ministry of Science and Technology(2017YFC0821100)the National Natural Science Foundation of China(61731016,61771460)a grant from the Youth Innovation Promotion Association CAS(2015190)
文摘Nitrate explosive is hard to detect due to lack of aromatic ring and weak interaction with fluorescence probe.More challenging is even to differentiate the dinitrates with multiple nitrate explosives based on photo induced electron transfer or aggregation caused fluorescence change mechanism.A highly selective dinitrate explosive probe was designed based on a new strategy-stepwise aggregation of multiple anchored fluorene dimer 8Py-2 F.Compared with its monomer counterpart 2Py-F,8Py-2 F showed a selective and stepwise fluorescence quenching to dinitrate explosives-ethylene glycol(EGDN)and triethylene glycol dinitrate(TEGDN).The limits of detection(LODs)are 2.72μM for TEGDN and 0.46μM for EGDN,which is three orders of magnitude lower than those of 2Py-F.The stepwise quenching process is well matched with the stepwise aggregation process as evidence by scanning electron microscopy(SEM).Nuclear magnetic resonance(NMR)and quantum chemical calculation proved the interaction force between the dinitrate and 8Py-2 F is hydron bonding interaction,and interaction distance is far less than that of the multiple nitrates coming from the flexibility of the chain and steric hinderance,which resulted in a self-adaptive interaction and higher selectivity.The new strategy is beneficial for the differentiation of the chemicals with similar energy level which is difficult to realize via other method,and the new method provides fluorometric probe for dinitrate explosive detection and makes it an ideal candidate for chemical detection and analysis in public safety and environmental monitoring.
基金support from the Fundamental Research Funds for the Central Universities(Nos.2232020A-03,and 2232021G-12)the National Natural Science Foundation of China(Grant No.52003049,and 62022085)+1 种基金the Science and Technology Commission of Shanghai Municipality(Nos.21520710700)We would also like to express our thanks to Jianxin Liu from Shanghai Feiju Microelectronics Co.,Ltd.for his technical assistance,and Prof.Wei Xu for his helpful discussions in theoretical calculation.
文摘There is a growing need for protective instruments that can be used in extreme environments,including those encountered during exoplanet exploration,anti-terrorism activities,and in chemical plants.These instruments should have the ability to detect external threats visually and monitor internal physiological signals in real time for maximum safety.To address this need,multifunctional semiconducting fibers with visual detection ranging from yellow to red and near-field communication(NFC)capabilities have been developed for use in personal protective clothing.A composite conductive yarn with semiconducting fluorescent probe molecules is embroidered on the clothing,forming an NFC coil that allows for the visual monitoring of atmospheric safety through color changes.The fluorescence detection system was able to selectively detect diethyl chlorophosphate(DCP),a substitute for the toxic gas sarin,with a detection limit of 6.08 ppb,which is lower than the life-threatening concentration of sarin gas.Furthermore,an intelligent protective suit with the abovementioned dual functions was fabricated with good mechanical cycle stability and repeatability.Real-time physiological signals such as the temperature and humidity of the wearer could be read through the NFC conveniently.Such intelligent protective suits can quickly provide an early warning to the identified low-dose DCP and evaluate the health of wearer according to the changes in physiological signals.This study offers a smart,low-cost strategy for designing intelligent protective devices for extreme environments.
