2D black arsenic phosphorous

Since the successful exfoliation of graphene in 2014,twodimensional(2D)materials have explosively increased in the past few years[1].2D pnictogen materials with intriguing properties beyond graphene are gradually coming into eyesight,such as black phosphorous(BP)[2],arsenene[3],antimonene[4],bismuthine[5],etc.BP is a star material in 2D materials.

Efficacy of Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural or Peritoneal Effusions

Background and objective Once the malignant pleural or peritoneal effusion is developed it is difficult to control.This report presents a new method for controlling the malignant effusions.Methods Forty-eight patients,29 males and 19 females with an average age of 61.2 years old,who were satisfied with the study inclusion criteria,were recruited in this study.Twenty-seven and 21 patients had a malignant pleural and peritoneal effusion,respectively.After draining most of fluids,these patients received intra-cavity infusion of rAd-p53 once per week for 4 weeks,at dose of 2×1012 viral particles(VP) diluted into 200 mL of saline solution for pleural effusions,and 4×1012 VP diluted into 500 mL of saline solution for peritoneal effusions.Results Participants were followed up for a median time of 13.6 month.A total of 11 cases,7 with pleural effusions and 4 with peritoneal effusions achieved a complete response(CR),and 20 cases(12 pleural effusions and 8 peritoneal effusions) had a partial response(PR).The overall response rate is 64.6%.Patients' quality of life,assessed by using Karnofsky performance scale(KPS) scores,was improved by an average of 26.4.The one-year of overall survival rate was 54.2% with a median survival time of 12.5 months.There were no serious side effects observed except for self-limited fever found in 79.8% of the cases.Conclusions Intra-cavity infusion of rAd-p53 is an effective and safe treatment for the patients with malignant pleural or peritoneal effusions,especially for those patients who can't tolerate the standard treatments.

基于SEER数据库构建原发性纵隔生殖细胞瘤患者生存预测的列线图

背景与目的原发性纵隔生殖细胞瘤(primary mediastinal germ cell tumor,PMGCT)是一种相对罕见且偶尔会具有高度侵袭性的纵隔肿瘤。目前对PMGCT的疾病特异性生存期(disease special survival,DSS)的相关研究报道较少,大数据分析亦相对较少,DSS预后模型也较为少见。本研究旨在探讨影响PMGCT DSS的预后相关因素,并构建简便、有效、可对PMGCT患者DSS预后情况进行预测的列线图。方法回顾性分析从监测、流行病学和最终结果(Surveillance,Epidemiology,and End Results,SEER)数据库提取的1975年-2019年共347例PMGCT患者的临床病理资料。采用Kaplan-Meier法及Log-rank检验估计DSS。执行Cox比例风险回归模型筛选影响预后的独立危险因素,构建个体化列线图预测PMGCT患者的3年、5年、8年DSS。通过受试者工作特征(receiver operating characteristic,ROC)曲线、校正曲线及决策曲线分析(decision curve analysis,DCA)评估模型的预测精度。结果PMGCT患者的3年、5年、8年生存率分别为84.6%、83.6%、83.3%。单因素Cox回归分析显示组织学分型、手术与否、年龄、肿瘤大小、肿瘤转移情况及肿瘤分期6项因素可影响PMGCT的预后(P<0.05),多因素Cox回归分析显示组织学分型、手术与否、年龄、肿瘤大小是PMGCT患者预后的独立危险因素(P<0.05),利用这些独立危险因素构建了列线图模型。ROC的曲线下面积(area under the curve,AUC)为0.824,3年、5年、8年生存时间的校正曲线以及DCA曲线,三者结果提示本研究的列线图评估预测结果与真实结果之间有良好的一致性。结论PMGCT中组织学分型为精原细胞瘤的患者比非精原细胞瘤患者预后更佳,年龄>40岁、肿瘤大小≥15 cm且未进行过手术治疗的患者预后不佳。列线图模型可以对PMGCT患者的DSS进行准确直观的预测。

Research trends on artificial intelligence and endoscopy in digestive diseases: A bibliometric analysis from 1990 to 2022

BACKGROUND Recently,artificial intelligence(AI)has been widely used in gastrointestinal endoscopy examinations.AIM To comprehensively evaluate the application of AI-assisted endoscopy in detecting different digestive diseases using bibliometric analysis.METHODS Relevant publications from the Web of Science published from 1990 to 2022 were extracted using a combination of the search terms“AI”and“endoscopy”.The following information was recorded from the included publications:Title,author,institution,country,endoscopy type,disease type,performance of AI,publication,citation,journal and H-index.RESULTS A total of 446 studies were included.The number of articles reached its peak in 2021,and the annual citation numbers increased after 2006.China,the United States and Japan were dominant countries in this field,accounting for 28.7%,16.8%,and 15.7%of publications,respectively.The Tada Tomohiro Institute of Gastroenterology and Proctology was the most influential institution.“Cancer”and“polyps”were the hotspots in this field.Colorectal polyps were the most concerning and researched disease,followed by gastric cancer and gastrointestinal bleeding.Conventional endoscopy was the most common type of examination.The accuracy of AI in detecting Barrett’s esophagus,colorectal polyps and gastric cancer from 2018 to 2022 is 87.6%,93.7%and 88.3%,respectively.The detection rates of adenoma and gastrointestinal bleeding from 2018 to 2022 are 31.3%and 96.2%,respectively.CONCLUSION AI could improve the detection rate of digestive tract diseases and a convolutional neural network-based diagnosis program for endoscopic images shows promising results.

广藿香不同部位UPLC指纹图谱及化学模式识别研究

目的建立广藿香药材不同部位的UPLC指纹图谱,研究广藿香不同部位的质量差异。方法采用UPLC法建立广藿香不同部位化学指纹图谱,结合相似度评价、热图聚类分析(CA)、主成分分析(PCA)及正交偏最小二乘法-判别分析(OPLS-DA)对18批广藿香药材、茎、叶的UPLC指纹图谱进行分析,并测定广藿香酮含量。结果18批广藿香药材及不同部位的UPLC指纹图谱均确定了9个相同的共有峰,并通过对照品指认4、6、9号峰分别为毛蕊花糖苷、异毛蕊花糖苷和广藿香酮。CA和PCA结果表明广藿香叶和茎的质量差异大,叶和药材的质量较接近。OPLS-DA发现5种成分是造成不同批次样品质量差异的主要标志物。含量测定结果表明同一批广藿香中的广藿香酮含量均为茎>药材>叶。结论广藿香不同部位的化学成分相似,但含量存在显著性差异,本研究可为广藿香药材的质量控制及资源开发利用提供参考。

Melatonin inhibits ESCC tumor growth by mitigating the HDAC7/β-catenin/c-Myc positive feedback loop and suppressing the USP10-maintained HDAC7 protein stability

Background:Melatonin,a natural hormone secreted by the pineal gland,has been reported to exhibit antitumor properties through diverse mechanisms of action.However,the oncostatic function of melatonin on esophageal squamous cell carcinoma(ESCC) remains elusive.This study was conducted to investigate the potential effect and underlying molecular mechanism of melatonin as single anticancer agent against ESCC cells.Methods:ESCC cell lines treated with or without melatonin were used in this study.In vitro colony formation and 5-Ethynyl-2’-deoxyuridine(EdU) incorporation assays,and nude mice tumor xenograft model were used to confirm the proliferative capacities of ESCC cells.RNA-seq,qPCR,Western blotting,recombinant lentivirus-mediated target gene overexpression or knockdown,plasmids transfection and co-IP were applied to investigate the underlying molecular mechanism by which melatonin inhibited ESCC cell growth.IHC staining on ESCC tissue microarray and further survival analyses were performed to explore the relationship between target genes’ expression and prognosis of ESCC.Results:Melatonin treatment dose-dependently inhibited the proliferative ability and the expression of histone deacetylase 7(HDAC7),c-Myc and ubiquitin-specific peptidase 10(USP10) in ESCC cells(P<0.05).The expressions of HDAC7,c-Myc and USP10 in tumors were significantly higher than the paired normal tissues from 148 ESCC patients(P<0.001).Then,the Kaplan-Meier survival analysis suggested that ESCC patients with high HDAC7,c-Myc or USP10levels predicted worse overall survival(log-rank P<0.001).Co-IP and Western blotting further revealed that HDAC7physically deacetylated and activated β-catenin thus promoting downstream target c-Myc gene transcription.Notably,our mechanistic study validated that HDAC7/β-catenin/c-Myc could form the positive feedback loop to enhance ESCC cell growth,and USP10 could deubiquitinate and stabilize HDAC7 protein in the ESCC cells.Additionally,we verified that inhibition of the HDAC7/β-catenin/c-Myc axis and USP10/HDAC7 pathway mediated the anti-proliferative action of melatonin on ESCC cells.Conclusions:Our findings elucidate that melatonin mitigates the HDAC7/β-catenin/c-Myc positive feedback loop and inhibits the USP10-maintained HDAC7 protein stability thus suppressing ESCC cell growth,and provides the reference for identifying biomarkers and therapeutic targets for ESCC.

A novel seed cone of Pinus from the Miocene of coastal Southeast China indicates kinship with Southeast Asian pines

Pinus is an economically and ecologically important genus whose members are dominant components globally in low-latitude mountainous and mid-latitude temperate forests.Pinus species richness is currently concentrated in subtropical mid-low latitudes of the Northern Hemisphere,differing from the latitudinal diversity gradient mostly recognized in woody angiosperms.How the present pattern was developing in Earth's past is still poorly studied,particularly in eastern Asia.Here,a new fossil species,Pinus shengxianica sp.nov.is described based on a fossil seed cone from the Late Miocene Shengxian Formation in Zhejiang,southeast China.A co-occurring cone is recognized as a known fossil species,Pinus speciosa Li.Extensive comparison of extant and fossil members of Pinus suggests P.shengxianica shares a striking cone similarity to Pinus merkusii and Pinus latteri(subsection Pinus)from tropical Southeast Asia in having annular bulges around the umbo on the apophysis.The morphological resemblance indicates these two extant low-latitude pines probably possess a close affinity with the present newly-discovered P.shengxianica and originated from East Asian mid-low latitude ancestors during this generic re-diversification in the Miocene.This scenario is consistent with the evolutionary trajectory reflected by the pine fossil history and molecular data,marking the Miocene as a key period for the origin and evolution of most extant pines globally.The co-occurrences of diverse conifers and broadleaved angiosperms preferring diverse niches demonstrate Late Miocene eastern Zhejiang was one of the hot spots for coniferophyte diversity and hosted a needled-broadleaved mixed forest with complex vegetation structure and an altitudinal zonation.

Wind-speed forecasting model based on DBN-Elman combined with improved PSO-HHT

Random and fluctuating wind speeds make it difficult to stabilize the wind-power output,which complicates the execution of wind-farm control systems and increases the response frequency.In this study,a novel prediction model for ultrashort-term wind-speed prediction in wind farms is developed by combining a deep belief network,the Elman neural network,and the Hilbert-Huang transform modified using an improved particle swarm optimization algorithm.The experimental results show that the prediction results of the proposed deep neural network is better than that of shallow neural networks.Although the complexity of the model is high,the accuracy of wind-speed prediction and stability are also high.The proposed model effectively improves the accuracy of ultrashort-term wind-speed forecasting in wind farms.

Modelling individual head-related transfer function(HRTF)based on anthropometric parameters and generic HRTF amplitudes

The head-related transfer function(HRTF)plays a vital role in immersive virtual reality and augmented reality technologies,especially in spatial audio synthesis for binaural reproduction.This article proposes a deep learning method with generic HRTF amplitudes and anthropometric parameters as input features for individual HRTF generation.By designing fully convolutional neural networks,the key anthropometric parameters and the generic HRTF amplitudes were used to predict each individual HRTF amplitude spectrum in the full-space directions,and the interaural time delay(ITD)was predicted by the transformer module.In the amplitude prediction model,the attention mechanism was adopted to better capture the relationship of HRTF amplitude spectra at two distinctive directions with large angle differences in space.Finally,with the minimum phase model,the predicted amplitude spectrum and ITDs were used to obtain a set of individual head-related impulse responses.Besides the separate training of the HRTF amplitude and ITD generation models,their joint training was also considered and evaluated.The root-mean-square error and the log-spectral distortion were selected as objective measurement metrics to evaluate the performance.Subjective experiments further showed that the auditory source localisation performance of the proposed method was better than other methods in most cases.

中国非小细胞肺癌免疫检查点抑制剂治疗专家共识(2020年版)

非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌最常见的病理类型。晚期NSCLC的系统性抗肿瘤治疗经历了化疗、靶向治疗及免疫治疗的变革,患者总体生存时间不断延长。免疫检查点抑制剂(immune checkpoint inhibitors,ICIs),尤其是程序性死亡分子-1(programmed cell death protein 1,PD-1)/程序性死亡分子配体-1(programmed death-ligand 1,PD-L1)抗体已成为表皮生长因子受体(epidermal growth factor receptor,EGFR)/间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)阴性晚期NSCLC一线及二线的标准治疗和局部晚期NSCLC同步放化疗后标准治疗,并在辅助/新辅助治疗中显示出可喜的结果,改变了NSCLC整体治疗格局。随着越来越多的ICIs在国内获批肺癌适应证,中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)NSCLC专家委员会牵头,组织该领域的专家,结合2019年版专家共识,参考最新国内外文献、临床研究数据及系统评价,在专家共同讨论的基础上,达成统一意见并制定、更新本共识,为国内同行更好地应用ICIs治疗NSCLC提供参考意见。

眼附属器淋巴瘤的临床病理分析

目的:探讨眼附属器淋巴瘤(OAL)的发病情况、临床表现及病理分型,以提高临床诊治水平。方法:选取2005-08/2013-07在华西医院眼科确诊的OAL患者147例,收集患者的一般情况、临床表现、临床检查(影像学、病理学)结果、治疗及预后情况等临床资料进行回顾性研究。结果:本研究纳入OAL患者147例,其中男91例(61.9%),女56例(38.1%);年龄3.5~87岁;病程20d^10a;发病部位以眼眶最多见(106/147);最常见的临床表现为眼部包块、眼睑肿胀、眼球突出;病理分型以黏膜相关淋巴组织边缘区B细胞淋巴瘤最多见(112/147),且其预后最好,而弥漫大B细胞淋巴瘤、结外NK/T细胞淋巴瘤,鼻型预后最差。结论:OAL病理类型复杂,发病部位和临床表现多样,免疫组织化学染色是OAL鉴别诊断的重要依据,其预后与病理类型密切相关。

技术依赖与社会构建视角下的社交媒体竞争力研究综述

如今,移动社交媒体成为了满足人们信息交流与分享等需求的综合平台,企业和政府都希望提升社交媒体竞争力来获得竞争优势。而现有移动社交媒体竞争力研究仍然不多,传统社交媒体相关研究大多关注技术依赖(如:人机交互)或社会构建理论视角,结合二者的相关研究将成为未来的重要方向。为进一步推动移动社交媒体竞争力研究的发展,本文从竞争力形成因素、转变规律和社会经济影响3个研究方向对国内外相关文献进行了总体的回顾与分析。同时,分别从人机交互与社会构建理论视角对社交媒体竞争力的相关研究作进一步的分析和归纳,总结了人机交互理论视角下的7个研究范畴和社会构建视角下的3个研究类别。最后,根据所建立的社交媒体竞争力总体研究框架,为移动社交媒体竞争力研究的进一步发展提出若干研究方向与建议。

基于道钉中心点定位的几何特征扣件定位算法

针对因轨道图像中图像歪斜、尺寸不一等导致定位失效、精度降低的问题,提出基于道钉中心点定位的几何结构特征扣件定位算法。采用先定位道钉中心点再定位扣件的思想。首先在图像预处理得到边缘图像的基础上,对图像边缘进行腐蚀与膨胀处理,使道钉边缘具备似圆性,再通过改进Hough变换进行圆形检测定位道钉所处大致区域并进行扩充,然后从原图像中粗提取出道钉区域图像;随后进行边缘检测并采用OpenCV轮廓提取及多边形检测算法精确拟合道钉六边形,计算出道钉中心点;最后根据提出的几何结构特征扣件定位算法计算各顶点的位置,从而实现轨道扣件的精确定位。仿真实验结果表明,该算法定位准确度达99.33%,定位精度达0.997,定位速率为29.8张/秒,优于相关对比算法。同时,在不同的天气条件、道钉腐蚀、道钉遮挡等情况下,新算法具备较好的鲁棒性及一定的抗干扰能力。

免疫检查点抑制剂治疗EGFR-TKI耐药晚期非小细胞肺癌的疗效及不良反应

目的:探讨免疫检查点抑制剂(immune checkpoint inhibitor,ICI)治疗表皮生长因子受体酪氨酸激酶抑制剂(epidermal growth factor receptor-tyrosine kinase inhibitor,EGFR-TKI)耐药晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效及不良反应。方法:收集2015年1月至2019年3月在解放军总医院接受ICI治疗的EGFR-TKI耐药晚期NSCLC患者临床资料,采用统计学方法分析EGFR-TKI耐药晚期NSCLC患者免疫治疗疗效及不良反应,阐明临床特征与免疫治疗疗效和患者预后的关系。结果:联合治疗较单药治疗者肿瘤客观缓解率(objective response rate,ORR)显著提高(28.6%vs.7.1%,P<0.01)。肿瘤分化差、联合治疗及年龄>60岁者分别较肿瘤分化好(5.1个月vs.2.8个月,P=0.030)、单药治疗(6.8个月vs.2.3个月,P<0.001)及年龄≤60岁者(7.1个月vs.4.7个月,P=0.020)无进展生存期(progression free survival,PFS)延长。联合治疗、肿瘤治疗缓解者分别较单药治疗(26.9个月vs.7.1个月)、肿瘤稳定者和进展者(30.8个月vs.18.7个月vs.12.8个月)总生存期(overall survival,OS)延长(P<0.001)。多因素分析显示年龄>60岁和联合治疗是PFS独立保护性因素(P<0.001)。联合治疗组的总体不良反应发生率较单药治疗组升高,但≥3级不良反应发生率两组间无显著性差异(P=0.28)。结论:ICI单药治疗EGFR-TKI耐药晚期NSCLC患者的疗效较差,而联合治疗能显著提高疗效,改善患者的预后。尽管联合治疗的总体不良反应发生率较高,但大体上不良反应可控。

小多道地震震源效果在海域活动断裂探测中的对比研究

海域地震区划与活动断裂的探测和识别密切相关。文中在台湾海峡闽东南隆起带开展了活动断裂的地球物理探测研究,选取GI枪震源与电火花震源剖面进行对比分析,发现了晚更新世以来活动的3条基底断裂构造和2条垂向延伸较小的细小断裂。基底断裂可在GI枪震源剖面和电火花震源剖面上识别,细小断裂则只能在电火花剖面上识别;3条基底断裂在2种剖面上的错断地层位置、几何形态接近,但断裂周围的地层形态及次级断裂展布样式受分辨率的影响存在成像差异。相似的断裂探测结果体现了这2种方法的有效性,而剖面成像差异则说明在实际工作中开展组合探测的必要性。基于2种数据的融合结果,对断裂F_(1)的构造属性进行更为详细的分析说明:断裂F_(1)是基底先存断裂晚更新世活化的结果,为一坳陷边界断层,呈伸展正断活动,分析认为其应归属为华南沿海滨海断裂带。因此,在海域地震区划和海域地震危险性评价工作中,应重视多种探测方法的组合使用,以便获取更加详实的断裂信息。

机械臂的区间二型模糊超螺旋滑模控制

针对不确定性条件下机械臂的轨迹跟踪问题,提出一种基于区间二型模糊逼近扰动的超螺旋滑模控制方法.首先将机械臂的建模误差、摩擦项、外部扰动等均视为广义扰动,然后利用自适应区间二型模糊逼近广义扰动.接着通过一个嵌套自适应律来设计基于超螺旋算法的趋近律,进而提出超螺旋滑模控制器.通过Lyapunov稳定性理论验证了趋近律的稳定性,基于此证明了系统的稳定性,并导出了区间二型模糊自适应律.仿真实验表明,区间二型模糊具有更好的逼近效果,超螺旋滑模控制能够抑制系统的扰动,本文所提算法具有响应快速和鲁棒性强的优点.

蛋白糖基化修饰在肿瘤多药耐药中的作用

恶性肿瘤为目前人类延长预期寿命的最大障碍。化疗是临床上抗肿瘤治疗的重要手段,但恶性肿瘤极易在化疗中产生多药耐药性(multidrug resistance,MDR)从而导致患者的不良预后。恶性肿瘤的MDR已被证实通过多种机制产生,如药物转运与吸收、细胞凋亡和DNA损伤修复等。蛋白糖基化修饰在肿瘤MDR中扮演重要角色。本文通过对蛋白糖基化修饰在肿瘤MDR中的分子机制进行综述,以期为临床上恶性肿瘤MDR的逆转提供理论基础。

胃腺癌中SIX1和CD147的表达及意义

目的检测胃腺癌中SIX1和CD147两个因子的表达,关注二者的相关性及其临床意义.方法本实验选择79例胃腺癌作为观察组,留取临床资料及术后留取的石蜡标本,选择45例正常胃黏膜的石蜡标本作为对照组,应用免疫组化二步法检测二组中SIX1和CD147的表达.结果二组中SIX1和CD147的表达差别有统计学意义,观察组中SIX1和CD147的表达与肿瘤的最大径和浸润深度密切相关, SIX1的表达与淋巴结转移密切相关,CD147的表达与分化程度密切相关,线性相关分析显示观察组中SIX1和CD147的表达具有正相关性,观察组中SIX1和CD147的表达与生存时间相关.结论 SIX1和CD147在胃腺癌组织中表达明显升高,对肿瘤的形成和发展有一定的调节作用. SIX1和CD147可能具有正向协同作用, SIX1和CD147的表达与预后相关.

感染性肾结石患者尿代谢及细菌培养结果分析

目的分析感染性肾结石患者的尿代谢及细菌培养结果。方法选择2015年1月至2018年1月天津中医药大学第一附属医院收治的感染性肾结石患者87例,根据结石成分将其分为单纯感染性肾结石组[磷酸铵镁和(或)碳酸磷灰石,32例]和混合感染性肾结石组[磷酸铵镁和(或)碳酸磷灰石+草酸钙,55例]。比较两组一般临床资料、尿代谢检测结果、尿细菌培养结果及复发情况。结果两组性别、年龄、合并糖尿病、尿石症家族史情况比较差异无统计学意义(P>0.05)。单纯感染性肾结石组有尿路感染病史及慢性尿路感染因素的人数比例大于混合感染性肾结石组,差异有统计学意义(P<0.05)。混合感染性肾结石组大肠杆菌阳性比例高于单纯感染性肾结石组,变形杆菌阳性比例低于单纯感染性肾结石组,差异有统计学意义(P<0.05)。混合感染性肾结石组高钙尿症、高草酸尿症、高尿酸尿症发生率均高于单纯感染性肾结石组,差异有统计学意义(P<0.05)。术后复查,单纯感染性肾结石组复发感染和新发结石的人数比例均高于混合感染性肾结石组,差异有统计学意义(71.88%vs 32.73%,50.00%vs 20.00%;P<0.05)。结论与单纯感染性肾结石患者比较,混合感染性肾结石患者尿代谢异常的发生率更高,这可能与其结石成因有关,故对此类患者除了控制感染外,还应针对尿代谢异常情况进行治疗。

Comparison of transthoracic and transabdominal surgical approaches for the treatment of adenocarcinoma of the cardia

Background and Objective: Transthoracic and transabdominal approaches are commonly used for the surgical treatment of adenocarcinoma of the cardia. Which approach is better has been controversial for quite a long time. Our study aimed to compare the surgical trauma, range of lymph node dissection, and the prognosis of the transthoracic and transabdominal approaches for the treatment of adenocarcinoma of the cardia. Methods: The medical records of 331 patients with adenocarcinoma of the cardia treated in our hospital between 1994 and 2003 were analyzed. Of the 331 patients, 284 underwent operation via transthoracic approach and 47 via transabdominal approach. Surgery-related status, postoperative complications, range of removed lymph nodes and prognosis of the two groups were compared. Results: There was no significant difference in surgery-related status and postoperative complications between the two groups (P >0.05). The mean number of removed lymph nodes from the thoracic cavity was much higher in transthoracic group than in transabdominal group (P < 0.001), while that from the abdominal cavity was similar in both groups (P = 0.404). The thoracic lymph node metastasis rate was 18.8% in transthoracic group and 13.3% in transabdominal group. The median survival time was 29 months in transthoracic group and 28 months in transabdominal group, and the 5-year survival rates were 34.9% and 40.1% (P= 0.599). Conclusions: For the surgical treatment of adenocarcinoma of the cardia, the surgical trauma of the transthoracic approach is similar with that of transabdominal approach. The transthoracic approach has the advantage in thoracic lymph node dissection. The two approaches have no obvious effect on the prognosis.