Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla...Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla(L. Karst)methanol extract. T. aphylla leaves extract was administered intraperitoneally(100 mg,250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated haemoglobin.Results: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of extract.Conclusions: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature.展开更多
The proposed site of the Diamer Bhasha Dam in northern Pakistan is situated in an active tectonic zone with intensive seismicity,which makes it necessary for seismic hazard analysis(SHA).Deterministic and probabilisti...The proposed site of the Diamer Bhasha Dam in northern Pakistan is situated in an active tectonic zone with intensive seismicity,which makes it necessary for seismic hazard analysis(SHA).Deterministic and probabilistic approaches have been used for SHA of the dam site.The Main Mantle Thrust(MMT),Main Karakaram Thrust(MKT),Raikot-Sassi Fault(RKSF)and Kohistan Fault(KF)have been considered as major seismic sources,all of which can create maximum ground shaking with maximum potential earthquake(MPE).Deterministically estimated MPE for magnitudes of 7.8,7.7,7.6,and 7.1 can be produced from MMT,MKT,RKSF and KF,respectively.The corresponding peak ground accelerations(PGA)of 0.07,0.11,0.13 and 0.05 g can also be generated from these earthquakes,respectively.The deterministic analysis predicts a so-called floating earthquake as a MPE of magnitude=7.1 as close as 10 km away from the site.The corresponding PGA was computed as 0.38 g for a maximum design earthquake at the project site.However,the probabilistic analysis revealed that the PGA with 50%probability of exceedance in 100 years is 0.18 g.Thus,this PGA value related to the operational basis earthquake(OBE)is suggested for the design of this project with shear wave velocity(V_(s30))equal to 760 m/s under dense soil and soft rock conditions.展开更多
基金supported by Institute of Basic Medical Sciences, Khyber Medical University with grant no. of 06472414
文摘Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla(L. Karst)methanol extract. T. aphylla leaves extract was administered intraperitoneally(100 mg,250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated haemoglobin.Results: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of extract.Conclusions: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature.
文摘The proposed site of the Diamer Bhasha Dam in northern Pakistan is situated in an active tectonic zone with intensive seismicity,which makes it necessary for seismic hazard analysis(SHA).Deterministic and probabilistic approaches have been used for SHA of the dam site.The Main Mantle Thrust(MMT),Main Karakaram Thrust(MKT),Raikot-Sassi Fault(RKSF)and Kohistan Fault(KF)have been considered as major seismic sources,all of which can create maximum ground shaking with maximum potential earthquake(MPE).Deterministically estimated MPE for magnitudes of 7.8,7.7,7.6,and 7.1 can be produced from MMT,MKT,RKSF and KF,respectively.The corresponding peak ground accelerations(PGA)of 0.07,0.11,0.13 and 0.05 g can also be generated from these earthquakes,respectively.The deterministic analysis predicts a so-called floating earthquake as a MPE of magnitude=7.1 as close as 10 km away from the site.The corresponding PGA was computed as 0.38 g for a maximum design earthquake at the project site.However,the probabilistic analysis revealed that the PGA with 50%probability of exceedance in 100 years is 0.18 g.Thus,this PGA value related to the operational basis earthquake(OBE)is suggested for the design of this project with shear wave velocity(V_(s30))equal to 760 m/s under dense soil and soft rock conditions.
