利用吲哚-2-酰胺和苯基炔丙醇为原料,在三氟甲磺酸铜[Cu(OTf)_(2)]催化下,成功构建了吲哚并氮杂卓酮类化合物。该方法实现了吲哚C-3位和酰胺N—H的官能团化,表现出优异化学选择性。通过^(1)H NMR、^(13) C NMR和HRMS对所得化合物的结构...利用吲哚-2-酰胺和苯基炔丙醇为原料,在三氟甲磺酸铜[Cu(OTf)_(2)]催化下,成功构建了吲哚并氮杂卓酮类化合物。该方法实现了吲哚C-3位和酰胺N—H的官能团化,表现出优异化学选择性。通过^(1)H NMR、^(13) C NMR和HRMS对所得化合物的结构进行了表征。实验最优条件为:反应温度60℃,反应时间5 h,溶剂1,2-二氯乙烷(DCE),5 mol%Cu(OTf)_(2),吲哚-2-酰胺:苯基炔丙醇为1∶1.2,收率73%。展开更多
Four title compounds were synthesized, their spectral properties including IR,MS, 1H NMR and their steric structures were studied. The conformation of the seven-mem-bered ring is chair-like and the two phenyl substitu...Four title compounds were synthesized, their spectral properties including IR,MS, 1H NMR and their steric structures were studied. The conformation of the seven-mem-bered ring is chair-like and the two phenyl substituents on the β-lactam ring adopt cis configuration. It is proposed that the reaction of 1,5-benzothiazepines with acyl chloride is a stereospecific one.展开更多
The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by sly acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.The results indicate that the rea...The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by sly acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.The results indicate that the reaction proceeds with a general acid catalytic mechanism in the presence of acetic arid, and in lactic arid, in other stronger arids-methanol solution, the mechanism is of a special arid catalytic one. The result also shows that R2 has an effect on the reaction rate.展开更多
文摘Four title compounds were synthesized, their spectral properties including IR,MS, 1H NMR and their steric structures were studied. The conformation of the seven-mem-bered ring is chair-like and the two phenyl substituents on the β-lactam ring adopt cis configuration. It is proposed that the reaction of 1,5-benzothiazepines with acyl chloride is a stereospecific one.
文摘The kinetics and mechanism of intramolecular condensation of amino ketones catalyzed respectively by sly acids in methanol solution were studied by means of UV spectroscopy and 1H NMR.The results indicate that the reaction proceeds with a general acid catalytic mechanism in the presence of acetic arid, and in lactic arid, in other stronger arids-methanol solution, the mechanism is of a special arid catalytic one. The result also shows that R2 has an effect on the reaction rate.