The human brain is highly plastic.Cognitive training is usually used to modify functional connectivity of brain networks.Moreover,the structures of brain networks may determine its dynamic behavior which is related to...The human brain is highly plastic.Cognitive training is usually used to modify functional connectivity of brain networks.Moreover,the structures of brain networks may determine its dynamic behavior which is related to human cognitive abilities.To study the effect of functional connectivity on the brain dynamics,the dynamic model based on functional connections of the brain and the Hindmarsh–Rose model is utilized in this work.The resting-state fMRI data from the experimental group undergoing abacus-based mental calculation(AMC)training and from the control group are used to construct the functional brain networks.The dynamic behavior of brain at the resting and task states for the AMC group and the control group are simulated with the above-mentioned dynamic model.In the resting state,there are the differences of brain activation between the AMC group and the control group,and more brain regions are inspired in the AMC group.A stimulus with sinusoidal signals to brain networks is introduced to simulate the brain dynamics in the task states.The dynamic characteristics are extracted by the excitation rates,the response intensities and the state distributions.The change in the functional connectivity of brain networks with the AMC training would in turn improve the brain response to external stimulus,and make the brain more efficient in processing tasks.展开更多
Models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally impracticable.in silico methods are also gaining acceptance with regulatory authoriti...Models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally impracticable.in silico methods are also gaining acceptance with regulatory authorities as an alternative to animal testing.For example,the Environmental Protection Agency aims to eliminate animal testi ng by 2035.展开更多
At the beginning of the 16th century,Paracelsus coined the maxim:“the dose makes the poison”.This principle can be applied to all living organisms,including organs and cells.The brain and its glial and neuronal cell...At the beginning of the 16th century,Paracelsus coined the maxim:“the dose makes the poison”.This principle can be applied to all living organisms,including organs and cells.The brain and its glial and neuronal cells are no exception.Even small compounds that are essential for the life of brain cells can become truly toxic when overdosed.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.62276229 and 32071096).
文摘The human brain is highly plastic.Cognitive training is usually used to modify functional connectivity of brain networks.Moreover,the structures of brain networks may determine its dynamic behavior which is related to human cognitive abilities.To study the effect of functional connectivity on the brain dynamics,the dynamic model based on functional connections of the brain and the Hindmarsh–Rose model is utilized in this work.The resting-state fMRI data from the experimental group undergoing abacus-based mental calculation(AMC)training and from the control group are used to construct the functional brain networks.The dynamic behavior of brain at the resting and task states for the AMC group and the control group are simulated with the above-mentioned dynamic model.In the resting state,there are the differences of brain activation between the AMC group and the control group,and more brain regions are inspired in the AMC group.A stimulus with sinusoidal signals to brain networks is introduced to simulate the brain dynamics in the task states.The dynamic characteristics are extracted by the excitation rates,the response intensities and the state distributions.The change in the functional connectivity of brain networks with the AMC training would in turn improve the brain response to external stimulus,and make the brain more efficient in processing tasks.
文摘Models and simulations are particularly useful for exploring ideas and concepts in the biological sciences that are expe rimentally impracticable.in silico methods are also gaining acceptance with regulatory authorities as an alternative to animal testing.For example,the Environmental Protection Agency aims to eliminate animal testi ng by 2035.
文摘At the beginning of the 16th century,Paracelsus coined the maxim:“the dose makes the poison”.This principle can be applied to all living organisms,including organs and cells.The brain and its glial and neuronal cells are no exception.Even small compounds that are essential for the life of brain cells can become truly toxic when overdosed.
