Elitism-based immune genetic algorithm and its application to optimization of complex multi-modal functions

A novel immune genetic algorithm with the elitist selection and elitist crossover was proposed, which is called the immune genetic algorithm with the elitism (IGAE). In IGAE, the new methods for computing antibody similarity, expected reproduction probability, and clonal selection probability were given. IGAE has three features. The first is that the similarities of two antibodies in structure and quality are all defined in the form of percentage, which helps to describe the similarity of two antibodies more accurately and to reduce the computational burden effectively. The second is that with the elitist selection and elitist crossover strategy IGAE is able to find the globally optimal solution of a given problem. The third is that the formula of expected reproduction probability of antibody can be adjusted through a parameter β, which helps to balance the population diversity and the convergence speed of IGAE so that IGAE can find the globally optimal solution of a given problem more rapidly. Two different complex multi-modal functions were selected to test the validity of IGAE. The experimental results show that IGAE can find the globally maximum/minimum values of the two functions rapidly. The experimental results also confirm that IGAE is of better performance in convergence speed, solution variation behavior, and computational efficiency compared with the canonical genetic algorithm with the elitism and the immune genetic algorithm with the information entropy and elitism.

2023年合成生物学在健康与医药领域的应用

自21世纪初以来,高通量DNA测序、大规模DNA合成与组装、高效率基因组编辑等技术不断取得突破,推动合成生物学“读-编-写”进入高通量、自动化的时代,已经开始影响或应用于生物医药、材料化工、农业、食品、能源、环境保护等多个领域。在健康与医药领域,合成生物学研究成果和技术创新可以在认识生命规律的基础上,解析疾病发生发展机制、寻找药物设计靶点、干预自然的生理代谢过程与机体的免疫应答机制、实现对人体生理状态的监测以及对疾病的诊断与治疗,从而深刻影响医疗模式、诊疗体系和生命健康产业。该文对2023年合成生物学在健康与医药领域的规划布局、研发进展和产业发展进行了系统性的梳理,并展望了该领域未来更广泛的应用前景。

表观遗传学研究进展

表观遗传学是在基因组DNA序列不发生变化的条件下,基因表达发生的改变也是可以遗传的,导致可遗传的表现型变化。表观遗传学主要包括DNA甲基化作用、组蛋白修饰作用、染色质重塑、遗传印记、随机染色体(X)失活及RNA世界等。与表观遗传学相关的疾病主要有肿瘤、心血管病、精神病和自身免疫系统性病等。现就表观遗传学与疾病进行综述。

遗传学的发展

介绍了遗传学形成和发展过程中 ,各阶段的代表人物、标志性成就和主要内容等。同时论述了遗传学的几个分支学科以及未来的前景等。

关于颁发、申报第十三届“李汝祺动物遗传学奖”

中国遗传学会将于2011年8月在新疆乌鲁木齐市召开的＂2011中国遗传学会大会＂上颁发第十三届＂李汝祺动物遗传学奖＂。此奖项从1986年开始到现在已颁发了十二届。从2011年开始,每年评选一次,由中国遗传学会＂李汝祺动物遗传学奖＂评审委员会评审后颁发,奖励名额每年不超过2名。中国遗传学会向获奖人颁发＂李汝祺动物遗传学奖＂证书和奖金。申请者应是中国遗传学会会员、年龄不超过45周岁（1966年以后出生）的动物遗传学工作者。在动物遗传学领域取得的研究结果有创新,观点明确、数据完整、结论可靠并已在公开刊物上发表。在应用领域有独创和革新,有授权的专利并已经确认对国民经济有一定意义并收到实效者都可申报此奖项。