Abstract Objective To investigate the clinical and bacteriologic features of patients with systemic lupus erythematosus (SLE) complicated by bacterial and/or fungal infections. Methods Statistical analys...Abstract Objective To investigate the clinical and bacteriologic features of patients with systemic lupus erythematosus (SLE) complicated by bacterial and/or fungal infections. Methods Statistical analysis was made on basis of the clinical and bacteriologic data of 86 patients with SLE complicated by bacterial and/or fungal infections. Results One hundred and thirty three episodes of infections occured in 86 patients with SLE, in which 51.13% were nosocomial infections and 76.69% occured in the blood system, respiratory tract, lungs and urinary tract. Gram negative bacilli, gram positive cocci, fungal and other bacterial infections accounted for 39.85%, 31.58%, 18.80% and 9.77%, respectively. In the bacterial infections, 18.52% were caused by L form bacteria and more than 60% of the patients had no apparent toxic manifestations. The odds ratio (OR) of infection increased significantly in patients with damaged functions of the heart, lungs and kidneys, and in those who received high dosage steroids. Conclusions Patients with SLE tend to develop nosocomial infections with gram negative bacilli which are the most common pathogens. The clinical manifestations of the infection are atypical. Careful inspection and monitoring, timely collecting the specimens for L form bacterial culture can reduce misdiagnosis and missed diagnosis of the infection.展开更多
文摘Abstract Objective To investigate the clinical and bacteriologic features of patients with systemic lupus erythematosus (SLE) complicated by bacterial and/or fungal infections. Methods Statistical analysis was made on basis of the clinical and bacteriologic data of 86 patients with SLE complicated by bacterial and/or fungal infections. Results One hundred and thirty three episodes of infections occured in 86 patients with SLE, in which 51.13% were nosocomial infections and 76.69% occured in the blood system, respiratory tract, lungs and urinary tract. Gram negative bacilli, gram positive cocci, fungal and other bacterial infections accounted for 39.85%, 31.58%, 18.80% and 9.77%, respectively. In the bacterial infections, 18.52% were caused by L form bacteria and more than 60% of the patients had no apparent toxic manifestations. The odds ratio (OR) of infection increased significantly in patients with damaged functions of the heart, lungs and kidneys, and in those who received high dosage steroids. Conclusions Patients with SLE tend to develop nosocomial infections with gram negative bacilli which are the most common pathogens. The clinical manifestations of the infection are atypical. Careful inspection and monitoring, timely collecting the specimens for L form bacterial culture can reduce misdiagnosis and missed diagnosis of the infection.
