BACKGROUND Li-Fraumeni syndrome(LFS)is a rare autosomal dominant cancer-predisposing syndrome,which can manifest as a polymorphic spectrum of malignancies.LFS is associated with an early onset in life,with the majorit...BACKGROUND Li-Fraumeni syndrome(LFS)is a rare autosomal dominant cancer-predisposing syndrome,which can manifest as a polymorphic spectrum of malignancies.LFS is associated with an early onset in life,with the majority of cases occurring prior to the age of 46.Notwithstanding the infrequency of primary cardiac tumors,it behooves clinicians to remain vigilant in considering the differential diagnosis of such tumors in LFS patients who present with a cardiac mass.This is due to the markedly elevated risk for malignancy in this particular population,far surpassing that of the general populace.CASE SUMMARY Herein,we present a case of a 30-year-old female with LFS who was found to have a tricuspid valve leaflet mass.CONCLUSION This case exemplifies valuable learning points in the diagnostic approach for this exceptionally rare patient population.展开更多
目的 对急性肾损伤的研究现状、趋势及热点进行可视化分析。方法 收集中国知网、Web of Science核心合集数据库中关于急性肾损伤的相关文献,搜索时间为2012年1月至2021年12月。使用Cite Space 6.2.R3软件对国家、作者、关键词等进行可...目的 对急性肾损伤的研究现状、趋势及热点进行可视化分析。方法 收集中国知网、Web of Science核心合集数据库中关于急性肾损伤的相关文献,搜索时间为2012年1月至2021年12月。使用Cite Space 6.2.R3软件对国家、作者、关键词等进行可视化分析。结果 中文文献发文量处于平稳状态,英文文献发文量急速上升。相关研究主要集中在美国、中国、德国。中文文献发文量前三位的作者为丁小强、梁馨苓、倪兆慧,英文文献发文量前三位的作者为Ronco C、Kellum JA、Bellomo R。中文文献中高频关键词前三位为脓毒症、危险因素、预后,共形成11个聚类,突现词有心力衰竭、线粒体等。英文文献高频关键词前三位为mortality、outcome、disease,共形成8个聚类,突现词有infection、care等。结论 国外急性肾损伤的发展较迅速;急性肾损伤的病因、发病机制、替代治疗、预后为研究热点;研究前沿为保护、预测模型、液体复苏等方面。展开更多
文摘BACKGROUND Li-Fraumeni syndrome(LFS)is a rare autosomal dominant cancer-predisposing syndrome,which can manifest as a polymorphic spectrum of malignancies.LFS is associated with an early onset in life,with the majority of cases occurring prior to the age of 46.Notwithstanding the infrequency of primary cardiac tumors,it behooves clinicians to remain vigilant in considering the differential diagnosis of such tumors in LFS patients who present with a cardiac mass.This is due to the markedly elevated risk for malignancy in this particular population,far surpassing that of the general populace.CASE SUMMARY Herein,we present a case of a 30-year-old female with LFS who was found to have a tricuspid valve leaflet mass.CONCLUSION This case exemplifies valuable learning points in the diagnostic approach for this exceptionally rare patient population.
