通过减少饮食中脂肪量，几乎每个人都将获益。但低脂肪饮食可能对女性乳腺癌患者的益处尤大。在圣安东尼奥乳腺癌研讨会上公布的一项新研究提出，低脂肪的饮食可以延长一些乳腺癌女性患者的生命。初步调查结果是基于早期乳腺癌妇女患者...通过减少饮食中脂肪量，几乎每个人都将获益。但低脂肪饮食可能对女性乳腺癌患者的益处尤大。在圣安东尼奥乳腺癌研讨会上公布的一项新研究提出，低脂肪的饮食可以延长一些乳腺癌女性患者的生命。初步调查结果是基于早期乳腺癌妇女患者开展的，这些女性患者参与了Women′s Intervention Nutrition Study 研究，所有妇女都进行了手术治疗和激素疗法，或进行了化疗和放疗的各种组合（这取决于她们的肿瘤的特性）。在研究开始，这两个群体女性所获得的热量平均29．6％来自脂肪。六年后，低脂饮食组妇女这一数字减少为23％，而对照组攀升至31．4％（低脂肪饮食的女性体重也失去了6斤左右）。展开更多
Background: Ultralow- fat diets are known to reduce high- density lipoprotein cholesterol(HDL- C) levels. In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and...Background: Ultralow- fat diets are known to reduce high- density lipoprotein cholesterol(HDL- C) levels. In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and HDL- C levels were examined to determine whether exercise moderates this dietary effect on serum lipids and apolipoproteins. Methods: We performed a 3- month, prospective, nonrandomized lifestyle intervention study(≤ 10% dietary fat; aerobic exercise [180 min/wk], group support, and yoga [60 min/day]) in 120 subjects with or at risk for coronary artery disease. Results: After 3 months, dietary fat intake was reduced to 8.7% ± 2.6% of total intake and the median weekly exercise time was 194 minutes. High- density lipoprotein cholesterol levels decreased by 8.3± 11.3 mg/dL(P< .001), and triglyceride levels increased by 17.6± 102.7 mg/dL(P=.026). A small dense low- density lipoprotein cholesterol(LDL- C) phenotype emerged indicated by a 13.8% LDL- C reduction accompanied by only a 2.3% reduction in apolipoprotein B levels(P=.064). Among subjects with exercise amounts less than those of the group median,HDL- C reductions were greater in those with more than(- 13.5± 16.0 mg/dL) versus less than(- 2.5± 7.5 mg/dL) the median reductions in fat intake(P=.026). Even among subjects who exercised >194 min/wk, HDL- C was reduced compared with baseline(- 7.4± 7.9 mg/dL, P< .001). Conclusions: An ultralow- fat diet as a component of a comprehensive lifestyle intervention induces reductions in HDL- C and the emergence of a dyslipidemic lipid profile. Aerobic exercise only partially mitigates this effect.展开更多
文摘通过减少饮食中脂肪量，几乎每个人都将获益。但低脂肪饮食可能对女性乳腺癌患者的益处尤大。在圣安东尼奥乳腺癌研讨会上公布的一项新研究提出，低脂肪的饮食可以延长一些乳腺癌女性患者的生命。初步调查结果是基于早期乳腺癌妇女患者开展的，这些女性患者参与了Women′s Intervention Nutrition Study 研究，所有妇女都进行了手术治疗和激素疗法，或进行了化疗和放疗的各种组合（这取决于她们的肿瘤的特性）。在研究开始，这两个群体女性所获得的热量平均29．6％来自脂肪。六年后，低脂饮食组妇女这一数字减少为23％，而对照组攀升至31．4％（低脂肪饮食的女性体重也失去了6斤左右）。
文摘Background: Ultralow- fat diets are known to reduce high- density lipoprotein cholesterol(HDL- C) levels. In the setting of a multicomponent lifestyle intervention program, relationships between exercise variables and HDL- C levels were examined to determine whether exercise moderates this dietary effect on serum lipids and apolipoproteins. Methods: We performed a 3- month, prospective, nonrandomized lifestyle intervention study(≤ 10% dietary fat; aerobic exercise [180 min/wk], group support, and yoga [60 min/day]) in 120 subjects with or at risk for coronary artery disease. Results: After 3 months, dietary fat intake was reduced to 8.7% ± 2.6% of total intake and the median weekly exercise time was 194 minutes. High- density lipoprotein cholesterol levels decreased by 8.3± 11.3 mg/dL(P< .001), and triglyceride levels increased by 17.6± 102.7 mg/dL(P=.026). A small dense low- density lipoprotein cholesterol(LDL- C) phenotype emerged indicated by a 13.8% LDL- C reduction accompanied by only a 2.3% reduction in apolipoprotein B levels(P=.064). Among subjects with exercise amounts less than those of the group median,HDL- C reductions were greater in those with more than(- 13.5± 16.0 mg/dL) versus less than(- 2.5± 7.5 mg/dL) the median reductions in fat intake(P=.026). Even among subjects who exercised >194 min/wk, HDL- C was reduced compared with baseline(- 7.4± 7.9 mg/dL, P< .001). Conclusions: An ultralow- fat diet as a component of a comprehensive lifestyle intervention induces reductions in HDL- C and the emergence of a dyslipidemic lipid profile. Aerobic exercise only partially mitigates this effect.
