Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan.The astrocytic regulation of neuronal activity has been increasingly recognized in recent years.Astroc...Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan.The astrocytic regulation of neuronal activity has been increasingly recognized in recent years.Astrocytes are now recognized as playing a more complex role than mere bystanders in the central nervous system.However,their role in regulating the sleep neurocircuitry is not well understood.From this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the hypothalamus.We briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.展开更多
目的采用Meta分析评价正念干预(MBI)对脑卒中患者睡眠障碍的改善效果。方法计算机检索Embase、PubMed、Cochrane Library、Web of Science、CINAHL、中国知网、万方、维普、中国生物医学文献数据库,检索时间为建库至2022年10月31日。依...目的采用Meta分析评价正念干预(MBI)对脑卒中患者睡眠障碍的改善效果。方法计算机检索Embase、PubMed、Cochrane Library、Web of Science、CINAHL、中国知网、万方、维普、中国生物医学文献数据库,检索时间为建库至2022年10月31日。依照纳入和排除标准筛选文献并对纳入文献进行资料提取和质量评价,使用RevMan5.3软件进行Meta分析。结果共纳入12篇文献,1006例患者,其中观察组502例,对照组504例。Meta分析结果显示,观察组的匹兹堡睡眠质量指数(PSQI)评分低于对照组(P<0.00001);合并结果显示,两组的总睡眠时间(TST)、醒觉次数(AT)、醒觉时间(AWT)、睡眠效率(SE)、3期持续睡眠时间(S_(3))、4期持续睡眠时间(S_(4))、非快速眼动睡眠期(NREM)、醒觉时间占总记录时间比例(AR)、总微醒觉次数(MAT)、快速动眼期微醒觉次数(MAT-REM)比较,差异具有统计学意义(P<0.05)。结论MBI可在短期内缓解脑卒中患者睡眠障碍及伴随的焦虑、抑郁等负性情绪,但是能否长期从中获益尚需开展高质量、大样本、多中心随访研究。展开更多
Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal b...Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.展开更多
基金supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(2017R1A5A2015391 and 2020M3E5D9079764)(to KS).
文摘Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s lifespan.The astrocytic regulation of neuronal activity has been increasingly recognized in recent years.Astrocytes are now recognized as playing a more complex role than mere bystanders in the central nervous system.However,their role in regulating the sleep neurocircuitry is not well understood.From this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the hypothalamus.We briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.
文摘目的采用Meta分析评价正念干预(MBI)对脑卒中患者睡眠障碍的改善效果。方法计算机检索Embase、PubMed、Cochrane Library、Web of Science、CINAHL、中国知网、万方、维普、中国生物医学文献数据库,检索时间为建库至2022年10月31日。依照纳入和排除标准筛选文献并对纳入文献进行资料提取和质量评价,使用RevMan5.3软件进行Meta分析。结果共纳入12篇文献,1006例患者,其中观察组502例,对照组504例。Meta分析结果显示,观察组的匹兹堡睡眠质量指数(PSQI)评分低于对照组(P<0.00001);合并结果显示,两组的总睡眠时间(TST)、醒觉次数(AT)、醒觉时间(AWT)、睡眠效率(SE)、3期持续睡眠时间(S_(3))、4期持续睡眠时间(S_(4))、非快速眼动睡眠期(NREM)、醒觉时间占总记录时间比例(AR)、总微醒觉次数(MAT)、快速动眼期微醒觉次数(MAT-REM)比较,差异具有统计学意义(P<0.05)。结论MBI可在短期内缓解脑卒中患者睡眠障碍及伴随的焦虑、抑郁等负性情绪,但是能否长期从中获益尚需开展高质量、大样本、多中心随访研究。
基金supported by grants from Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA22096018(to JY)Guangxi Key Research and Development Program,No.AB22080053(to DD)+6 种基金Major Project of Science and Technology of Guangxi Zhuang Autonomous Region,No.Guike-AA23023004(to MZ)the National Natural Science Foundation of China,Nos.82260021(to MZ),82060315(to DD)the Natural Science Foundation of Guangxi Zhuang Autonomous Region,No.2021GXNSFBA220007(to GD)Clinical Research Center For Medical Imaging in Hunan Province,No.2020SK4001(to JL)Key Emergency Project of Pneumonia Epidemic of Novel Coronavirus Infection in Hunan Province,No.2020SK3006(to JL)Science and Technology Innovation Program of Hunan Province,No.2021RC4016(to JL)Key Project of the Natural Science Foundation of Hunan Province,No.2024JJ3041(to JL).
文摘Sleep disturbances are among the most prevalent neuropsychiatric symptoms in individuals who have recovered from severe acute respiratory syndrome coronavirus 2 infections.Previous studies have demonstrated abnormal brain structures in patients with sleep disturbances who have recovered from coronavirus disease 2019(COVID-19).However,neuroimaging studies on sleep disturbances caused by COVID-19 are scarce,and existing studies have primarily focused on the long-term effects of the virus,with minimal acute phase data.As a result,little is known about the pathophysiology of sleep disturbances in the acute phase of COVID-19.To address this issue,we designed a longitudinal study to investigate whether alterations in brain structure occur during the acute phase of infection,and verified the results using 3-month follow-up data.A total of 26 COVID-19 patients with sleep disturbances(aged 51.5±13.57 years,8 women and 18 men),27 COVID-19 patients without sleep disturbances(aged 47.33±15.98 years,9 women and 18 men),and 31 age-and gender-matched healthy controls(aged 49.19±17.51 years,9 women and 22 men)were included in this study.Eleven COVID-19 patients with sleep disturbances were included in a longitudinal analysis.We found that COVID-19 patients with sleep disturbances exhibited brain structural changes in almost all brain lobes.The cortical thicknesses of the left pars opercularis and left precuneus were significantly negatively correlated with Pittsburgh Sleep Quality Index scores.Additionally,we observed changes in the volume of the hippocampus and its subfield regions in COVID-19 patients compared with the healthy controls.The 3-month follow-up data revealed indices of altered cerebral structure(cortical thickness,cortical grey matter volume,and cortical surface area)in the frontal-parietal cortex compared with the baseline in COVID-19 patients with sleep disturbances.Our findings indicate that the sleep disturbances patients had altered morphology in the cortical and hippocampal structures during the acute phase of infection and persistent changes in cortical regions at 3 months post-infection.These data improve our understanding of the pathophysiology of sleep disturbances caused by COVID-19.
