本文报道了特殊生理状态的妊娠初期、末期以及不同胎次断乳后田鼠的几种主要内分泌器官的重量((?)±S.E.M)。这些器官占体重的百分比(mg/100g,不包括胎儿重),并与对照组及相应的实验组进行了 t 检验。证明了妊娠及断乳后田鼠垂体前...本文报道了特殊生理状态的妊娠初期、末期以及不同胎次断乳后田鼠的几种主要内分泌器官的重量((?)±S.E.M)。这些器官占体重的百分比(mg/100g,不包括胎儿重),并与对照组及相应的实验组进行了 t 检验。证明了妊娠及断乳后田鼠垂体前叶、肾上腺、甲状腺、卵巢及胰腺重量增加,胸腺重量下降。展开更多
Podoplanin （PDPN） is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells （LECs） in the vascular system and fibroblastic reticular cells （FRCs） in lymph nodes. PDPN on...Podoplanin （PDPN） is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells （LECs） in the vascular system and fibroblastic reticular cells （FRCs） in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Proxl and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.展开更多
Dear Editor, In plants, the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cel...Dear Editor, In plants, the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cell types. The SWEET sugar transporter family is one such class and is represented by 17 members in Arabidopsis. AtSWEET1 was the first plant SWEET transporter to be characterized; it acts as a glucose uniporter in multiple systems （Chen et al., 2010）.展开更多
基金Acknowledgements This study was supported by a grant from the National Natural Science Foundation of China （No. 31400692）.
文摘Podoplanin （PDPN） is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells （LECs） in the vascular system and fibroblastic reticular cells （FRCs） in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Proxl and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.
文摘Dear Editor, In plants, the transport of sugars from the site of biosynthesis to the site of utilization or storage relies on sugar transporters located in different subcellular compartments and different vascular cell types. The SWEET sugar transporter family is one such class and is represented by 17 members in Arabidopsis. AtSWEET1 was the first plant SWEET transporter to be characterized; it acts as a glucose uniporter in multiple systems （Chen et al., 2010）.
