Novel sandwich structure-like nanofiber multilayered meshes were fabricated via electrospinning. The purpose of the present work was to control zoledronic acid release via the novel structure of sandwich structure-lik...Novel sandwich structure-like nanofiber multilayered meshes were fabricated via electrospinning. The purpose of the present work was to control zoledronic acid release via the novel structure of sandwich structure-like meshes. The in vitro release experiments reveal that the drug release speed and initial burst release were controllable by adjusting the thicknesses of electrospun barrier mesh and drug-loaded mesh. Compared with those of other drug delivery systems, the main advantages of the sandwich structure-like fiber meshes are facile preparation conditions and the generality for hydrophobic and hydrophilic pharmaceuticals.展开更多
Tapered dielectric structures in metal have exhibited extraordinary performance in both surface plasmon polariton （SPP） waveguiding and SPP focusing. This is crucial to plasmonic research and industrial plasmonic de...Tapered dielectric structures in metal have exhibited extraordinary performance in both surface plasmon polariton （SPP） waveguiding and SPP focusing. This is crucial to plasmonic research and industrial plasmonic device integration. We present a method that facilitates easy fabrication of smooth-surfaced sub-micron tapered structures in large scale simply with electron beam lithography （EBL）. When a PMMA layer is spin-coated on previously-EBL-defined PMMA structures, steep edges can be transformed into a declining slope to form tapered PMMA structures, scaled from 10nm to 1000nm. Despite the simplicity of our method, patterns with PMMA surface smoothness can be well-positioned and replicated in large numbers, which therefore gives scientists easy access to research on the properties of tapered structures.展开更多
文摘Novel sandwich structure-like nanofiber multilayered meshes were fabricated via electrospinning. The purpose of the present work was to control zoledronic acid release via the novel structure of sandwich structure-like meshes. The in vitro release experiments reveal that the drug release speed and initial burst release were controllable by adjusting the thicknesses of electrospun barrier mesh and drug-loaded mesh. Compared with those of other drug delivery systems, the main advantages of the sandwich structure-like fiber meshes are facile preparation conditions and the generality for hydrophobic and hydrophilic pharmaceuticals.
基金Supported by the National Natural Science Foundation of China under Grant Nos 90606023, 10574003 and 20731160012, the National Basic Research Program of China under Grant Nos 2007CB936202 and 2009CB623703, and Hong Kong＇s NSFC/RGC Joint Research Scheme under Grant No N-HKUST615/06.
文摘Tapered dielectric structures in metal have exhibited extraordinary performance in both surface plasmon polariton （SPP） waveguiding and SPP focusing. This is crucial to plasmonic research and industrial plasmonic device integration. We present a method that facilitates easy fabrication of smooth-surfaced sub-micron tapered structures in large scale simply with electron beam lithography （EBL）. When a PMMA layer is spin-coated on previously-EBL-defined PMMA structures, steep edges can be transformed into a declining slope to form tapered PMMA structures, scaled from 10nm to 1000nm. Despite the simplicity of our method, patterns with PMMA surface smoothness can be well-positioned and replicated in large numbers, which therefore gives scientists easy access to research on the properties of tapered structures.
