Voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability,and their abnormal activity is related to several pathological processes,including cardiac arrhythmias,epilepsy,neurod...Voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability,and their abnormal activity is related to several pathological processes,including cardiac arrhythmias,epilepsy,neurodegenerative diseases,spasticity and chronic pain.In particular,chronic visceral pain,the central symptom of functional gastrointestinal disorders such as irritable bowel syndrome,is a serious clinical problem that affects a high percentage of the world population.In spite of intense research efforts and after the dedicated decade of pain control and research,there are not many options to treat chronic pain conditions.However,there is a wealth of evidence emerging to give hope that a more refined approach may be achievable.By using electronic databases,available data on structural and functional properties of VGSCs in chronic pain,particularly functional gastrointestinal hypersensitivity,were reviewed.We summarize the involvement and molecular bases of action of VGSCs in the pathophysiology of several organic and functionalgastrointestinal disorders.We also describe the efficacy of VGSC blockers in the treatment of these neurological diseases,and outline future developments that may extend the therapeutic use of compounds that target VGSCs.Overall,clinical and experimental data indicate that isoform-specific blockers of these channels or targeting of their modulators may provide effective and novel approaches for visceral pain therapy.展开更多
2012年11月23—26日，天然产物化学及化学生物学国际学术研讨会（International Symposium on Natural Products Chemistry and Chemical Biology 2012）在浙江大学召开。该系列会议是由浙江大学药物研究所副所长戚建华研究员和浙江大...2012年11月23—26日，天然产物化学及化学生物学国际学术研讨会（International Symposium on Natural Products Chemistry and Chemical Biology 2012）在浙江大学召开。该系列会议是由浙江大学药物研究所副所长戚建华研究员和浙江大学永谦讲座教授坂神洋次博士（日本名古屋大学教授）共同发起的，展开更多
师彦平，1965年2月生，1987年毕业于西北师范大学，1998年在兰州大学细胞生物学博士后流动站完成博士后研究工作，1998至2001年在美国波多黎各大学（University of Puerto Rico）从事海洋天然产物化学博士后研究，2001年获得中国科学院2...师彦平，1965年2月生，1987年毕业于西北师范大学，1998年在兰州大学细胞生物学博士后流动站完成博士后研究工作，1998至2001年在美国波多黎各大学（University of Puerto Rico）从事海洋天然产物化学博士后研究，2001年获得中国科学院2000年度“百人计划一引进国外杰出人才”基金资助回国，现为中国科学院兰州化学物理研究所研究员，博士研究生导师，中国科学院研究生院教授，中国科学院引进国外杰出人才（“百人计划”获得者），兰州大学特聘教授，甘肃省特聘科技专家，甘肃省555创新人才工程第二层次第一批入选者，中国化学会会员，甘肃省化学会理事和色谱专业委员会主任委员。展开更多
文摘Voltage-gated sodium channels (VGSCs) play a fundamental role in controlling cellular excitability,and their abnormal activity is related to several pathological processes,including cardiac arrhythmias,epilepsy,neurodegenerative diseases,spasticity and chronic pain.In particular,chronic visceral pain,the central symptom of functional gastrointestinal disorders such as irritable bowel syndrome,is a serious clinical problem that affects a high percentage of the world population.In spite of intense research efforts and after the dedicated decade of pain control and research,there are not many options to treat chronic pain conditions.However,there is a wealth of evidence emerging to give hope that a more refined approach may be achievable.By using electronic databases,available data on structural and functional properties of VGSCs in chronic pain,particularly functional gastrointestinal hypersensitivity,were reviewed.We summarize the involvement and molecular bases of action of VGSCs in the pathophysiology of several organic and functionalgastrointestinal disorders.We also describe the efficacy of VGSC blockers in the treatment of these neurological diseases,and outline future developments that may extend the therapeutic use of compounds that target VGSCs.Overall,clinical and experimental data indicate that isoform-specific blockers of these channels or targeting of their modulators may provide effective and novel approaches for visceral pain therapy.
文摘2012年11月23—26日，天然产物化学及化学生物学国际学术研讨会（International Symposium on Natural Products Chemistry and Chemical Biology 2012）在浙江大学召开。该系列会议是由浙江大学药物研究所副所长戚建华研究员和浙江大学永谦讲座教授坂神洋次博士（日本名古屋大学教授）共同发起的，
文摘师彦平，1965年2月生，1987年毕业于西北师范大学，1998年在兰州大学细胞生物学博士后流动站完成博士后研究工作，1998至2001年在美国波多黎各大学（University of Puerto Rico）从事海洋天然产物化学博士后研究，2001年获得中国科学院2000年度“百人计划一引进国外杰出人才”基金资助回国，现为中国科学院兰州化学物理研究所研究员，博士研究生导师，中国科学院研究生院教授，中国科学院引进国外杰出人才（“百人计划”获得者），兰州大学特聘教授，甘肃省特聘科技专家，甘肃省555创新人才工程第二层次第一批入选者，中国化学会会员，甘肃省化学会理事和色谱专业委员会主任委员。
