To look for predictive markers preceding Alzheimer’s dementia. Methods: This study involved multitudinal assessment of individuals in whom there was cognitive impairment that was insufficient to warrant a diagnosis o...To look for predictive markers preceding Alzheimer’s dementia. Methods: This study involved multitudinal assessment of individuals in whom there was cognitive impairment that was insufficient to warrant a diagnosis of dementia, which were followed up for mean 11 months. Results: A diagnosis of probable AD was made in 58% of cases, VD in 21 %, FLD in 5% and dementia of uncertain aetiology in the remainder. 42% subjects with memory loss are as result of ageassociated cognitive decline, 25% subjects are due to cerebralvascular accident, 1 .8% subjects due to menopausal symptoms. 30.4% are of memry loss of unknown aetiology. Cognitive markers preceding dementia found within this stUdy actually have discriminant function of the earliest changes of AD from age-associated cognitive decline. The group that developed dementia on follow-up does not differ significanily from the memory loss group on the WAIS-R total scores or on the digit forward , digit backward and picture completion. However, the subtest score for similarities on the WAIS-R is sighficanly lower in patients who became demented comparing with the rest of sample. Verbal memory such as story recall immediate and story recall delayed, verbal learning discriminant index, verbal fluency raw score showed significant lower in patients who became dementia . Moreover digit copy transformed score on the SSRS also is very significanily lower in patients who became demented than those who were stable memory loss. The kidney deficiency syndrom of Chinese medicine was most common in QD, and the phlegm syndrome and the blood stasis syndrome were more common. The scores of the picture completion subtest and the story recall immdiate subtest were significanily correlated to the score of the phlegm syndrome respectively. The scores of the picture completion subtest and the similarities subtest were significanily correlated with the score of the kidney deficiency syndrome respectively .Suggestion: Often a significandy long interval, well in excess of the mean follow up of 11 months in our study, is required before one can he certain that a person with no dementia but with significant memory impairment, is or is not going on to develop a dementia. Folstein MMSE scores are significanily predictive for the outcome of cognitive impairment. The digit copy transformed score and the similarities were more significantly predictive for the outcome than the above four measures of verbal memory. The scores of neuropsychological test were correlated to the scores of syndrome of Chinese medicine.展开更多
To study the effect and the mechanism of Zuogui Pill on the deficiency of kidney essence and liver blood.Methods:Established the model of deficiency of kidney essence and liver blood of rat(the model of MSG regenerati...To study the effect and the mechanism of Zuogui Pill on the deficiency of kidney essence and liver blood.Methods:Established the model of deficiency of kidney essence and liver blood of rat(the model of MSG regeneration rat).Observing the deficiency kidney essence and liver blood and ARN or regeneration liver of expression transforming growth factor type 1 beta(TGF β 1).Results:The liver regeneration of the model of MSG regeneration rat,postoperated on 11th day,the degree of liver regeneration was 0 58±0 03,the rate of liver weight/body weight was 3 27±0 12,MI was 0 11±0 02,RBC was 3 83±0 09×10 12 /L,Hb was 119 0±8 3g/L.The group of treatment by Zuogui Pill(dosage 5g/kg daily),postoperated on 11th day,the degree of liver regeneration was 0 84±0 04,the rate of liver weight/body weight was 3 85±0 14,MI was 0 11±0 02,RBC was 5 12±0 06×10 12 /L,Hb was 172 7±3 9g/L.The above datum were significantly different among the groups.The observation results showed MSG induced injury to ARN of the rat treated with monosodium glutamate.Comparing to the model of MSG regeneration rat group,it showed that Zuogui Pill could obviously inhibited the ARN injury in the rat treated with monosodium glutamate.The maladjustment in liver regeneration of the model of MSG regeneration rat,in the end,the liver regeneration was significantly inhibited.The effect of promoting liver regeneration in the model of MSG regeneration rat treated by gastrogavage Zuogui Pill.All data are reported as means±SE.When this analysis revealed a significant difference(p<0 05 or p<0 01).TGF β 1 has an obviously higher expression in liver and ARN during liver regeneration of the model of MSG regeneration rat.The effect of regulation of TGF β 1 expression in liver and ARN of the model of MSG regeneration rat treated by gastrogavage Zuogui Pill.The effect inhibited the deficiency of kidney essence and liver blood of the model MSG regeneration rat treated by gastrogavage Zuogui Pill.Conclusion:The deficiency of kidney essence and liver blood of the model of MSG regeneration rat can be improved gastrogavage Zuogui Pill.The effect of regulation TGF β 1 expression in liver and ARN of the model of MSG regeneration rat treated by gastrogavage.展开更多
文摘To look for predictive markers preceding Alzheimer’s dementia. Methods: This study involved multitudinal assessment of individuals in whom there was cognitive impairment that was insufficient to warrant a diagnosis of dementia, which were followed up for mean 11 months. Results: A diagnosis of probable AD was made in 58% of cases, VD in 21 %, FLD in 5% and dementia of uncertain aetiology in the remainder. 42% subjects with memory loss are as result of ageassociated cognitive decline, 25% subjects are due to cerebralvascular accident, 1 .8% subjects due to menopausal symptoms. 30.4% are of memry loss of unknown aetiology. Cognitive markers preceding dementia found within this stUdy actually have discriminant function of the earliest changes of AD from age-associated cognitive decline. The group that developed dementia on follow-up does not differ significanily from the memory loss group on the WAIS-R total scores or on the digit forward , digit backward and picture completion. However, the subtest score for similarities on the WAIS-R is sighficanly lower in patients who became demented comparing with the rest of sample. Verbal memory such as story recall immediate and story recall delayed, verbal learning discriminant index, verbal fluency raw score showed significant lower in patients who became dementia . Moreover digit copy transformed score on the SSRS also is very significanily lower in patients who became demented than those who were stable memory loss. The kidney deficiency syndrom of Chinese medicine was most common in QD, and the phlegm syndrome and the blood stasis syndrome were more common. The scores of the picture completion subtest and the story recall immdiate subtest were significanily correlated to the score of the phlegm syndrome respectively. The scores of the picture completion subtest and the similarities subtest were significanily correlated with the score of the kidney deficiency syndrome respectively .Suggestion: Often a significandy long interval, well in excess of the mean follow up of 11 months in our study, is required before one can he certain that a person with no dementia but with significant memory impairment, is or is not going on to develop a dementia. Folstein MMSE scores are significanily predictive for the outcome of cognitive impairment. The digit copy transformed score and the similarities were more significantly predictive for the outcome than the above four measures of verbal memory. The scores of neuropsychological test were correlated to the scores of syndrome of Chinese medicine.
文摘To study the effect and the mechanism of Zuogui Pill on the deficiency of kidney essence and liver blood.Methods:Established the model of deficiency of kidney essence and liver blood of rat(the model of MSG regeneration rat).Observing the deficiency kidney essence and liver blood and ARN or regeneration liver of expression transforming growth factor type 1 beta(TGF β 1).Results:The liver regeneration of the model of MSG regeneration rat,postoperated on 11th day,the degree of liver regeneration was 0 58±0 03,the rate of liver weight/body weight was 3 27±0 12,MI was 0 11±0 02,RBC was 3 83±0 09×10 12 /L,Hb was 119 0±8 3g/L.The group of treatment by Zuogui Pill(dosage 5g/kg daily),postoperated on 11th day,the degree of liver regeneration was 0 84±0 04,the rate of liver weight/body weight was 3 85±0 14,MI was 0 11±0 02,RBC was 5 12±0 06×10 12 /L,Hb was 172 7±3 9g/L.The above datum were significantly different among the groups.The observation results showed MSG induced injury to ARN of the rat treated with monosodium glutamate.Comparing to the model of MSG regeneration rat group,it showed that Zuogui Pill could obviously inhibited the ARN injury in the rat treated with monosodium glutamate.The maladjustment in liver regeneration of the model of MSG regeneration rat,in the end,the liver regeneration was significantly inhibited.The effect of promoting liver regeneration in the model of MSG regeneration rat treated by gastrogavage Zuogui Pill.All data are reported as means±SE.When this analysis revealed a significant difference(p<0 05 or p<0 01).TGF β 1 has an obviously higher expression in liver and ARN during liver regeneration of the model of MSG regeneration rat.The effect of regulation of TGF β 1 expression in liver and ARN of the model of MSG regeneration rat treated by gastrogavage Zuogui Pill.The effect inhibited the deficiency of kidney essence and liver blood of the model MSG regeneration rat treated by gastrogavage Zuogui Pill.Conclusion:The deficiency of kidney essence and liver blood of the model of MSG regeneration rat can be improved gastrogavage Zuogui Pill.The effect of regulation TGF β 1 expression in liver and ARN of the model of MSG regeneration rat treated by gastrogavage.
