Objective:To systematically review the effect of narrative nursing for cancer patients.Methods:Systematic searches in PubMed,EMBASE,The Cochrane Library,Web of Science,Chinese biomedical literature database,China Nati...Objective:To systematically review the effect of narrative nursing for cancer patients.Methods:Systematic searches in PubMed,EMBASE,The Cochrane Library,Web of Science,Chinese biomedical literature database,China National Knowledge Infrastructure,Wanfang medical and VIP database were performed for randomized controlled trials(RCTs)or quasi-RCTs which explored the effects of narrative nursing mode for cancer patients.Then,meta-analysis was performed by RevMan 5.3 after two independent investigators screened the literature,extracted the data and evaluated the risk of bias of all included studies.Results:A total of 15 studies were included,including 1778 cancer patients.The meta-analysis showed that narrative nursing could effectively relieve patients'anxiety and depression compared with the conventional nursing model(WMD=-9.04,95%CI=-11.82,-6.27;P<0.001),reduce the the inner shame(WMD=-2.28,95%CI=-3.76,-0.88;P=0.001),improved the mental resilience(WMD=18.20,95%CI=3.30,33.11;P<0.001)and the quality of life.Conclusion:This study has been systematically evaluated to show that narrative care can effectively improve the negative mood of patients with cancer and improve their quality of life.However,subject to the quality limitations of the included studies,the appeal conclusions are yet to be tested in more high-quality studies.展开更多
Objective:This study aimed to explore the efficacy and safety of Qingxin Fupi Jieyu formula(the herbal formula has the function of clear away the heart fire,tonify spleen,and relieve depression,QXFPJYF)in treating dig...Objective:This study aimed to explore the efficacy and safety of Qingxin Fupi Jieyu formula(the herbal formula has the function of clear away the heart fire,tonify spleen,and relieve depression,QXFPJYF)in treating digestive tract cancer-related cognitive impairment(CRCI).Methods:28 subjects with digestive tract CRCI were treated with QXFPJYF for 6 weeks.The scores of Montreal Cognitive Assessment and Mini-Mental State Examination were observed at four-time points(baseline,week 2,week 4,week 6).Besides,anxiety and depression scores and tumor markers were measured.Results:The scores of Montreal Cognitive Assessment and various fields were elevated steadily after treatment,such as visuospatial/executive,attention,language,delayed recall,and orientation.The differences were statistically significant(P<0.05)besides language score.The scores of Mini-Mental State Examination and various factors were elevated gradually at week 2,week 4 and week 6,including language and praxis,attention and calculation,recall and orientation,and the differences were statistically significant(P<0.05)except for recall score.The results also showed the change of tumor markers were not obvious,but anxious and depressed emotions were improved.More importantly,no subjects developed with obvious adverse reactions during the study.Conclusion:The finding indicated that QXFPJYF treated digestive tract CRCI with great efficacy and safety,which improved cognitive function from several fields.Nevertheless,the current study was limited by sample and medical ethics,and which was a self-control trial,some limitations needed to be acknowledged,further high-quality research is required to explore and verify it.展开更多
Astragalus polysaccharide has the beneficial effect of Qi-deficiency,and it also has several anti-tumor mechanisms,including pharmacological actions and clinical functions.Through literature review,this work concluded...Astragalus polysaccharide has the beneficial effect of Qi-deficiency,and it also has several anti-tumor mechanisms,including pharmacological actions and clinical functions.Through literature review,this work concluded anti-tumor mechanism and clinical application of astragalus polysaccharide,which was of considerable significance to expand and optimize its anti-tumor function and clinical application.展开更多
Background:Previously,Xiaoyan decoction(XYD)has been found to have a potential anti-tumor effect in vitro.The aim of this study was to explore the effect of XYD in A549 lung carcinoma xenograft mouse model.Method:The ...Background:Previously,Xiaoyan decoction(XYD)has been found to have a potential anti-tumor effect in vitro.The aim of this study was to explore the effect of XYD in A549 lung carcinoma xenograft mouse model.Method:The A549 lung carcinoma xenograft mouse model were established and divided into control and experiment group.The dynamic growth of the xenograft tumors was observed and the immune cells such as T cell,regulatory T cell(Treg)were explored by Fluorescence-activated cell sorter(FACS)analysis.In this study,network pharmacology was used to screen the anti-cancer monomers in XYD,and their effect targets were also predicted.Result:The result showed that the tumor growth was inhibited and the percent of Treg was down-regulated(P<0.05).Ten drug monomers were screened to inhibit lung cancer cell proliferation and promote cell apoptosis through PI3K/Akt pathway.Conclusion:Our results suggested that XYD inhibited tumor growth and improved the immunity of A549 lung carcinoma xenograft mouse model.展开更多
Objective:The efficacy of Cordyceps Sinensis(CS)on malignant tumors remains controversial.We undertook a systematic meta-analysis of randomized controlled clinical studies on this issue.Method:A comprehensive literatu...Objective:The efficacy of Cordyceps Sinensis(CS)on malignant tumors remains controversial.We undertook a systematic meta-analysis of randomized controlled clinical studies on this issue.Method:A comprehensive literature search(by the end of Sep.31,2017)was conducted in following electronic databases:China National Knowledge Infrastructure(CNKI),VIP database,Wan fang database(VIP),PubMed,Medline,and EMBASE.Relevant studies were included according to inclusion criteria.Pooled relative risk was estimated by using the fixed effects model or random effects model according to heterogeneity.Data were extracted independently and the standardized mean deviation(SMD)of the calculated results was obtained.Result:After selection,8 of 729 studies were included.The result showed that CS combined with chemotherapeutic drugs was favorable for the treatment of malignant tumor.The amount of CD3^+T cells in the experimental group was signi行cantly higher than that in the control group(SMD=0.86;95%CI=0.02,1.70;P<0.01;I2=91%).The amount of CD4^+T cells in the experimental group was significantly higher than that in the control group(SMD=0.95;95%CI=0.22,1.68;P<0.01;I2=88%).The amount of CD8^+T cells in the experimental group was significantly higher than that in the control group(SMD=-0.07;95%CI=-0.30,0.17;P=0.32;I^2=14%).The rate of CD4^+/CD8^+T cells in the experimental group was higher than that in the control group(SMD=27.76;95%CI=25.25,30.28;P=0.39;I^2=0%).And CS may retard the declining trend of KPS functional status evaluation(RR=0.46,95%CI=0.2780,0.7350;P<0.01),thus improving the patients'life quality.Conclusion:The current evidence suggested that CS is favorable to improve the efficacy of chemotherapeutic drugs in patients with malignant tumors,probably by improving immune system function.展开更多
Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis. A 78-year-old woman presented with left maxillary sinus carcinoma. The patient ...Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis. A 78-year-old woman presented with left maxillary sinus carcinoma. The patient received four courses of chemotherapy after surgery in our center. Eight months after treatment, the patient experienced local progress, severe gastrointestinal reactions and asthenia. Then apatinib was used as third-line treatment. Good curative effect was achieved with 250 mg apatinib per day, while adverse reaction such as hand and foot skin reaction affected the quality of her life. Traditional Chinese medicine exhibits good results and no obvious side effects in relieving hand and foot skin reaction. Traditional Chinese medicine is Chinese treasure, it remains challenging, and further investigations are needed.展开更多
Objective: To observe the efficacy of Liyan Baidu Decoction combined with Oxygen Spray in the treatment of radiation oropharyngeal cancer in patients with nasopharyngeal carcinoma. Methods: Forty patients with radiono...Objective: To observe the efficacy of Liyan Baidu Decoction combined with Oxygen Spray in the treatment of radiation oropharyngeal cancer in patients with nasopharyngeal carcinoma. Methods: Forty patients with radionomephicitis of nasopharyngeal carcinoma from 2015.03-2017.05 were randomly divided into treatment group (27 cases) and control group (23 cases). The treatment group was treated with Liyan Baidu Decoction combined with oxygen spray;the control group was treated with rehabilitation fluid. Results: Compared with the control group, the time of oral mucosal reaction was delayed (P < 0.05), the cumulative radiation of oral mucosal reaction increased (P < 0.05), and the oral mucosal reaction index decreased (P < 0.05). The degree of salivary gland damage was decreased (P < 0.05), and most of the KPS scores were improved compared with before treatment. However, the quality of life of Liyan Baidu Decoction group was higher than that of the control group (P < 0.05). Conclusion: Liyan Baidu decoction combined with oxygen spray may effectively delay the time of acute radioactive oral mucosal reaction in patients with nasopharyngeal carcinoma, and effectively reduce the radiation oral mucosal damage and salivary gland damage in patients with nasopharyngeal carcinoma. This study provides a clinical basis for the application of Liyan Baidu Decoction.展开更多
Background:Safflower is a traditional medicine that is widely used to treat various diseases.Safflower polysaccharide is one of the effective constituents of safflower.This study explored the anti-tumor effect of saff...Background:Safflower is a traditional medicine that is widely used to treat various diseases.Safflower polysaccharide is one of the effective constituents of safflower.This study explored the anti-tumor effect of safflower polysaccharide and its possible mechanism.Methods:The MTT assay was used to detect the proliferation of hepatocellular carcinoma cells(SMMC-7721 cells).We observed cell apoptosis with a fluorescence microscope.And we used qRT-PCR and western blot to detect the expression of cell cycle related factors.Results:Safflower polysaccharide could inhibit the growth of SMMC-7721 cells in a dose-dependent manner and induce its apoptosis.Compared with the blank group,the cell proliferation-related protein of CDC25B and Survivin were down-regulated in SMMC-7721 cells treated with safflower polysaccharide,while the cell apoptosis-related protein levels of P53 and P38MAPK were up-regulated(P<0.05).In addition,safflower polysaccharide inhibited the protein levels of CDC2(P<0.05).Conclusion:Safflower polysaccharide can inhibit the growth of hepatocellular carcinoma cells by inhibiting proliferation and promoting apoptosis,and the P38MAPK pathway may play an important role in this process.展开更多
Background:Combination therapy with traditional Chinese medicine and chemotherapy was proposed as a therapeutic strategy for non-small cell lung cancer patients.Therefore,we performed a systematic review and metaanaly...Background:Combination therapy with traditional Chinese medicine and chemotherapy was proposed as a therapeutic strategy for non-small cell lung cancer patients.Therefore,we performed a systematic review and metaanalysis of randomized controlled trials to assess effects of this combination therapy on non-small cell lung cancer.To evaluate the efficacy and safety of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the treatment of non-small cell lung cancer.Methods:A randomized controlled study of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the databases of China National Knowledge Infrastructure Database,WanFang Database,VIP Database,Sino-Med Database,PUBMED,EMBASE and Cochrane library was searched by computer.The literatures published from the database establishment to July 1,2020 were included in the search scope.After 2 evaluators independently evaluated and cross checked the quality of the study,Revman 5.3 was used to meta analyze the clinical effect of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy on patients with non-small cell lung cancer.Results:A total of 1,370 lung cancer patients were included in 20 RCTs.The results of meta-analysis showed that there were significant differences between the 2 groups in clinical efficacy(RR=1.32,95%CI(1.20,1.44)),quality of life(RR=1.44,95%CI(1.32,1.57)),immune function(MD=0.53,95%CI(0.23–0.83)),adverse reactions(RR=0.49,95%CI(0.41,0.58)).Conclusion:The Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy is effective and safe in the treatment of non-small cell lung cancer,and has great prospects for further development.However,the quality of evidence was very low-to-moderate.Considering the poor quality of evidence,we are not very confident in the results.We look forward to more research and update results in the future and improve the evidence quality.展开更多
Background:Uveal melanoma is the most prevalent intraocular malignancy.In preceding decades,many studies have been published on uveal melanoma.However,so far,uveal melanoma-related bibliometric studies have not been r...Background:Uveal melanoma is the most prevalent intraocular malignancy.In preceding decades,many studies have been published on uveal melanoma.However,so far,uveal melanoma-related bibliometric studies have not been reported.Methods:Uveal melanoma-related articles and reviews published between 2005 and 2019 were retrieved in the Web of Science Core Collection on March 15,2020.Three bibliometric tools(HistCite,VOSviewer,and CiteSpace)were employed to conduct the current study.Results:A total of 3,404 publications related to uveal melanoma were identified,involving 3015 articles(88.57%)and 389 reviews(11.43%)with 65,429 co-cited references in 9 languages,which were published by 2,875 institutions in 66 countries/regions.The United States contributed to most publications(n=1427,41.92%),and the Thomas Jefferson University was involved in most of the studies(n=160,5.56%).Investigative Ophthalmology&Visual Science published the majority of the papers(n=175,5.14%),whereas Ophthalmology received the most co-citations(n=7050).Shields CL owned the most publications and co-citations(n=122 and 2151,respectively).Gene and molecular biology aspects,prevalence,the main prognosis factor,and treatment were the intellectual foundations of uveal melanoma research.In the field of uveal melanoma,emerging hotspots of uveal melanoma include epidemiologic characteristics,prognosis factors,mechanisms of uveal melanoma development,the use of novel predictive tools,and clinical applications of novel targeted drugs.Conclusion:This first bibliometric study focused on the integral tendency of the past 15 years,identified landmark items,and revealed current research hotspots in the field of uveal melanoma,which will provide references for clinicians and researchers,as well as an example of visualization analysis to explore research hotspots in other fields.展开更多
Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese me...Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese medicine effective ingredients include paclitaxel,arsenical trioxide,camptothecin and so on.However,poor water solubility and low bioavailability of these traditional Chinese medicine ingredients severely hindered their clinical application.The rapid development of nanotechnology provided a new platform,new opportunities and new challenges for their effective delivery in vitro and in vivo.This minireview provides a concentrated summary of the most recent progresses made in this emerging field,highlighting the“combination ancient traditional Chinese medicine ingredients and advanced nanotechnology”strategy for favoring the construction of next generation cancer nanomedicines.展开更多
Esophageal cancer is one of the most common malignant tumors in the world. In recent years, the incidence and mortality of esophageal cancer have increased year by year, which has seriously threatened human health. Su...Esophageal cancer is one of the most common malignant tumors in the world. In recent years, the incidence and mortality of esophageal cancer have increased year by year, which has seriously threatened human health. Surgery, chemotherapy and radiotherapy, as the primary treatments of Western medicine, have achieved specific results in the clinic, but each has its limitations, this is mainly related to their side effects. The diversified treatment methods of traditional Chinese medicine have visible clinical effects, especially in terms of reducing toxicity and increasing efficiency. This present review reviews the research progress of esophageal cancer in terms of traditional Chinese medicine treatment, including the application of Chinese medicine extract, Chinese herbal compound, Chinese patent medicine and TCM external treatment in clinical practice, may provide valuable information for the adjuvant treatment of esophageal cancer with traditional Chinese medicine.展开更多
Background:Cancer incidence rate has been increasing in recent years,and it has improved people’s living and financial burden.The incidence and mortality of malignant tumors in the Heilongjiang cancer registry area i...Background:Cancer incidence rate has been increasing in recent years,and it has improved people’s living and financial burden.The incidence and mortality of malignant tumors in the Heilongjiang cancer registry area in 2016 were analyzed,which provided a scientific basis for the prevention and treatment of malignant tumors in Heilongjiang.Methods:The incidence and death data of tumors were collected from 10 tumor registration areas in Heilongjiang Province in 2016.According to the stratification of urban and rural areas and gender,the crude rate,standard rate,accumulative rates(0–74 years old)were calculated.The China 2000 population census data and Segi’s standard population were used for calculating age-standardized rates.Results:The incidence rate of malignant tumors in the Heilongjiang cancer registry area was 286.05/100,000 in 2016,age-standardized incidence rates by standard Chinese population and by standard world population were 168.11/100,000 and 164.69/100,000 with the cumulative incidence rate(0–74 years old)of 18.55%.The incidence of malignant tumors in urban areas was 313.60/100,000,and that in rural areas was 212.26/100,000.The frequency of malignant tumors in males was 295.94/100,000,higher than that in females(276.40/100,000).Lung cancer had the highest incidence followed by breast cancer,colorectal cancer,liver cancer and thyroid cancer.The mortality rate of malignant tumors in Heilongjiang cancer registration areas was 183.56/100,000,age-standardized mortality rates by standard Chinese population and by standard world population were 99.89/100,000 and 99.78/100,000 with the cumulative mortality rate(0–74 years old)of 10.95%.The mortality rate of malignant tumors in urban areas was 194.69/100,000,and that in rural areas was 153.73/100,000.The mortality rate of the male malignant tumor was 222.55/100,000,higher than that of a female malignant tumor(145.51/100,000).Lung cancer had the highest mortality followed by liver cancer,colorectal cancer,gastric cancer and breast cancer.Conclusion:Lung cancer,liver cancer,breast cancer and colorectal cancer were the most common cancers in Heilongjiang Province,which should be taken as the key cancer species for prevention and treatment.The incidence of thyroid cancer is higher in Heilongjiang Province,but the mortality rate is lower,which also needs attention.展开更多
Background:To investigate the therapeutic effect of cervical radiofrequency ablation on high risk-HPV persistent infection.Methods:One hundred patients with persistent high risk-HPV infection diagnosed in our hospital...Background:To investigate the therapeutic effect of cervical radiofrequency ablation on high risk-HPV persistent infection.Methods:One hundred patients with persistent high risk-HPV infection diagnosed in our hospital from April 2019 to February 2020 were selected.Those in the same period were randomly selected by SPSS19.0 software machine according to the ratio of 1:1,and divided into the treatment group(BBT-RF-A radiofrequency group)and the observation group(recombinant human interferon suppository group)with 50 cases in each group.The negative conversion rate of high risk-HPV between the 2 groups was compared at the 6th and 12th months after treatment,and the types of persistent HR-HPV infection in Changle were studied.Results:The negative conversion rates of HR-HPV in the treatment group were 60%(35/50)and 82%(41/50)at 6 and 12 months after treatment,respectively,while the negative conversion rates of high risk-HPV in the observation group were 30%(15/50)and 44%(22/50)at 6 and 12 months after treatment,respectively.The negative conversion rates in the treatment group were significantly higher than those in the observation group(P<0.05).Studying the main types of high risk-HPV persistent infection has guiding value for HPV vaccine injection in Changle.Conclusion:Self-clotting cutter radiofrequency ablation has a good effect on the negative conversion rate of high risk-HPV persistent infection.These results suggest that the main types of single persistent cervical HR-HPV infection are 16,52 and 58,not including the 18 types.展开更多
Objective: To evaluate the efficacy and safety of radiotherapy combined with zoledronic acid fOr the treatment of bone metastases. Methods: Use Pubmed, Cochrane Library, Embase, CBM, CNKI, Wanfang, Weipu tools to sear...Objective: To evaluate the efficacy and safety of radiotherapy combined with zoledronic acid fOr the treatment of bone metastases. Methods: Use Pubmed, Cochrane Library, Embase, CBM, CNKI, Wanfang, Weipu tools to search-related databases at home and abroad. From 2013.1 to March 2019, radiotherapy combined with zoledronic acid and radiotherapy alone for bone metastasis of lung cancer were collected. Experimental studies;quality evaluation and data extraction for each of the included studies, and Cochrane risk bias assessment tools for quality evaluation of the literature. Data processing was performed using RevMan 5.3 and Stata 15.0 software, including risk ratio (OR), 95% CI, I2, and P values. Line sensitivity test, publication bias evaluation is using Egger's, Bgge's method quantitative calculation using Revman 5.3 and Stata 15.0 software for statistical analysis. Results: The total of 8 articles was included, and the number of cases was 703. The results of the meta-analysis showed that the radiotherapy, combined with the zoledronic acid group was effective in the treatment of lung cancer with bone metastasis. The meta-analysis was Z = 6.31 (P < 0.00001), OR (95% CI = 3.57, (2.41, 5.30)), the difference was statistically significant. The combined effect of bone metastases was better than that of the single-stage group. The meta-analysis results were Z = 3.18 (P = 0.001) and OR (95% CI = 3.21, (1.57, 6.59)), indicating the therapeutic effect of the two groups in the treatment of bone metastases. The difference is statistically significant. Adverse reactions include: (1) bone marrow suppression, blood toxicity;(2) fever and rash;(3) nausea, vomiting, and fatigue;(4) liver damage and loss of appetite, meta-analysis results are: bone marrow suppression, blood toxicity: Z =0.73 ( P = 0.47), OR (95% CI = 0.58 (0.13, 2.54));fever, rash: Z = 0.36 (P = 0.36), OR (95% CI = 1.3 (0.31, 5.38));nausea, vomiting, Weakness: Z = 0.29 (P = 0.77), OR (95% CI = 0.85 (0.27, 2.62));liver function damage and loss of appetite: Z = 0.00 (P = 1.00), OR (95% CI = 1.00 (0.17, 6.00)). The P values of the four meta-analyses were all greater than 0.05, and the difference was not statistically significant, indicating that the addition of zoledronic acid to the bone metastasis of lung cancer did not aggravate the changes of the above four adverse reactions. Conclusion: Radiotherapy combined with the zoledronic acid group is better than the single radiotherapy group in treating pain caused by bone metastasis. It can effectively treat bone metastasis and will not aggravate the occurrence of adverse reactions.展开更多
Cancer related fatigue(CRF)is one of the most common and painful reactions in cancer patients.Due to the negative effects of cancer itself and long-term treatment,patients often feel continuous burnout,fatigue and pow...Cancer related fatigue(CRF)is one of the most common and painful reactions in cancer patients.Due to the negative effects of cancer itself and long-term treatment,patients often feel continuous burnout,fatigue and powerlessness in both mental and physical aspects.Fatigue related to cancer and cancer treatment will affect the physical and mental health of cancer patients for a long time and continuously,and it is hard to be relieved through rest.Nowadays,most of the researches focus on the clinical manifestations of patients with cancer,such as pain,nausea and vomiting,weight loss and so on.The fatigue feeling of cancer patients is often one of the most easily overlooked pain symptoms in the treatment process.The influence of CRF on cancer patients may be one of the reasons for reducing the survival time of cancer patients.This paper aims to summarize and explore the pathogenesis of cancer-related fatigue,in order to analyze the related factors of cancer-related fatigue from multi-dimensional and multi-angle,and provide reference for its comprehensive treatment in clinic.展开更多
文摘Objective:To systematically review the effect of narrative nursing for cancer patients.Methods:Systematic searches in PubMed,EMBASE,The Cochrane Library,Web of Science,Chinese biomedical literature database,China National Knowledge Infrastructure,Wanfang medical and VIP database were performed for randomized controlled trials(RCTs)or quasi-RCTs which explored the effects of narrative nursing mode for cancer patients.Then,meta-analysis was performed by RevMan 5.3 after two independent investigators screened the literature,extracted the data and evaluated the risk of bias of all included studies.Results:A total of 15 studies were included,including 1778 cancer patients.The meta-analysis showed that narrative nursing could effectively relieve patients'anxiety and depression compared with the conventional nursing model(WMD=-9.04,95%CI=-11.82,-6.27;P<0.001),reduce the the inner shame(WMD=-2.28,95%CI=-3.76,-0.88;P=0.001),improved the mental resilience(WMD=18.20,95%CI=3.30,33.11;P<0.001)and the quality of life.Conclusion:This study has been systematically evaluated to show that narrative care can effectively improve the negative mood of patients with cancer and improve their quality of life.However,subject to the quality limitations of the included studies,the appeal conclusions are yet to be tested in more high-quality studies.
文摘Objective:This study aimed to explore the efficacy and safety of Qingxin Fupi Jieyu formula(the herbal formula has the function of clear away the heart fire,tonify spleen,and relieve depression,QXFPJYF)in treating digestive tract cancer-related cognitive impairment(CRCI).Methods:28 subjects with digestive tract CRCI were treated with QXFPJYF for 6 weeks.The scores of Montreal Cognitive Assessment and Mini-Mental State Examination were observed at four-time points(baseline,week 2,week 4,week 6).Besides,anxiety and depression scores and tumor markers were measured.Results:The scores of Montreal Cognitive Assessment and various fields were elevated steadily after treatment,such as visuospatial/executive,attention,language,delayed recall,and orientation.The differences were statistically significant(P<0.05)besides language score.The scores of Mini-Mental State Examination and various factors were elevated gradually at week 2,week 4 and week 6,including language and praxis,attention and calculation,recall and orientation,and the differences were statistically significant(P<0.05)except for recall score.The results also showed the change of tumor markers were not obvious,but anxious and depressed emotions were improved.More importantly,no subjects developed with obvious adverse reactions during the study.Conclusion:The finding indicated that QXFPJYF treated digestive tract CRCI with great efficacy and safety,which improved cognitive function from several fields.Nevertheless,the current study was limited by sample and medical ethics,and which was a self-control trial,some limitations needed to be acknowledged,further high-quality research is required to explore and verify it.
基金This work was supported by grants from the National Natural Science Foundation of China(No.81603438).
文摘Astragalus polysaccharide has the beneficial effect of Qi-deficiency,and it also has several anti-tumor mechanisms,including pharmacological actions and clinical functions.Through literature review,this work concluded anti-tumor mechanism and clinical application of astragalus polysaccharide,which was of considerable significance to expand and optimize its anti-tumor function and clinical application.
基金This work is supported by Tianjin Science&Technology Plan Projects(No.17ZXMFSY00190)Tianjin Traditional Chinese Medicine Research Project,Tianjin health and family planning commission(No.2017003)the National Natural Science Foundation of China(No.81403220).
文摘Background:Previously,Xiaoyan decoction(XYD)has been found to have a potential anti-tumor effect in vitro.The aim of this study was to explore the effect of XYD in A549 lung carcinoma xenograft mouse model.Method:The A549 lung carcinoma xenograft mouse model were established and divided into control and experiment group.The dynamic growth of the xenograft tumors was observed and the immune cells such as T cell,regulatory T cell(Treg)were explored by Fluorescence-activated cell sorter(FACS)analysis.In this study,network pharmacology was used to screen the anti-cancer monomers in XYD,and their effect targets were also predicted.Result:The result showed that the tumor growth was inhibited and the percent of Treg was down-regulated(P<0.05).Ten drug monomers were screened to inhibit lung cancer cell proliferation and promote cell apoptosis through PI3K/Akt pathway.Conclusion:Our results suggested that XYD inhibited tumor growth and improved the immunity of A549 lung carcinoma xenograft mouse model.
文摘Objective:The efficacy of Cordyceps Sinensis(CS)on malignant tumors remains controversial.We undertook a systematic meta-analysis of randomized controlled clinical studies on this issue.Method:A comprehensive literature search(by the end of Sep.31,2017)was conducted in following electronic databases:China National Knowledge Infrastructure(CNKI),VIP database,Wan fang database(VIP),PubMed,Medline,and EMBASE.Relevant studies were included according to inclusion criteria.Pooled relative risk was estimated by using the fixed effects model or random effects model according to heterogeneity.Data were extracted independently and the standardized mean deviation(SMD)of the calculated results was obtained.Result:After selection,8 of 729 studies were included.The result showed that CS combined with chemotherapeutic drugs was favorable for the treatment of malignant tumor.The amount of CD3^+T cells in the experimental group was signi行cantly higher than that in the control group(SMD=0.86;95%CI=0.02,1.70;P<0.01;I2=91%).The amount of CD4^+T cells in the experimental group was significantly higher than that in the control group(SMD=0.95;95%CI=0.22,1.68;P<0.01;I2=88%).The amount of CD8^+T cells in the experimental group was significantly higher than that in the control group(SMD=-0.07;95%CI=-0.30,0.17;P=0.32;I^2=14%).The rate of CD4^+/CD8^+T cells in the experimental group was higher than that in the control group(SMD=27.76;95%CI=25.25,30.28;P=0.39;I^2=0%).And CS may retard the declining trend of KPS functional status evaluation(RR=0.46,95%CI=0.2780,0.7350;P<0.01),thus improving the patients'life quality.Conclusion:The current evidence suggested that CS is favorable to improve the efficacy of chemotherapeutic drugs in patients with malignant tumors,probably by improving immune system function.
基金National Natural Science Foundation of China (Grant No. 81603438).
文摘Squamous cell carcinoma arising at maxillary sinus is a rare neoplasm, characterized by aggressive growth pattern and glooming prognosis. A 78-year-old woman presented with left maxillary sinus carcinoma. The patient received four courses of chemotherapy after surgery in our center. Eight months after treatment, the patient experienced local progress, severe gastrointestinal reactions and asthenia. Then apatinib was used as third-line treatment. Good curative effect was achieved with 250 mg apatinib per day, while adverse reaction such as hand and foot skin reaction affected the quality of her life. Traditional Chinese medicine exhibits good results and no obvious side effects in relieving hand and foot skin reaction. Traditional Chinese medicine is Chinese treasure, it remains challenging, and further investigations are needed.
文摘Objective: To observe the efficacy of Liyan Baidu Decoction combined with Oxygen Spray in the treatment of radiation oropharyngeal cancer in patients with nasopharyngeal carcinoma. Methods: Forty patients with radionomephicitis of nasopharyngeal carcinoma from 2015.03-2017.05 were randomly divided into treatment group (27 cases) and control group (23 cases). The treatment group was treated with Liyan Baidu Decoction combined with oxygen spray;the control group was treated with rehabilitation fluid. Results: Compared with the control group, the time of oral mucosal reaction was delayed (P < 0.05), the cumulative radiation of oral mucosal reaction increased (P < 0.05), and the oral mucosal reaction index decreased (P < 0.05). The degree of salivary gland damage was decreased (P < 0.05), and most of the KPS scores were improved compared with before treatment. However, the quality of life of Liyan Baidu Decoction group was higher than that of the control group (P < 0.05). Conclusion: Liyan Baidu decoction combined with oxygen spray may effectively delay the time of acute radioactive oral mucosal reaction in patients with nasopharyngeal carcinoma, and effectively reduce the radiation oral mucosal damage and salivary gland damage in patients with nasopharyngeal carcinoma. This study provides a clinical basis for the application of Liyan Baidu Decoction.
基金This research was funded by the National Natural Science Foundation of China(81704054)China postdoctoral science foundation(2014M551288)+1 种基金Postdoctoral Scientific Research Developmental Fund(LBH-Q19184)Foundation for Innovative Talents of Heilongjiang University of Chinese Medicine(054321).
文摘Background:Safflower is a traditional medicine that is widely used to treat various diseases.Safflower polysaccharide is one of the effective constituents of safflower.This study explored the anti-tumor effect of safflower polysaccharide and its possible mechanism.Methods:The MTT assay was used to detect the proliferation of hepatocellular carcinoma cells(SMMC-7721 cells).We observed cell apoptosis with a fluorescence microscope.And we used qRT-PCR and western blot to detect the expression of cell cycle related factors.Results:Safflower polysaccharide could inhibit the growth of SMMC-7721 cells in a dose-dependent manner and induce its apoptosis.Compared with the blank group,the cell proliferation-related protein of CDC25B and Survivin were down-regulated in SMMC-7721 cells treated with safflower polysaccharide,while the cell apoptosis-related protein levels of P53 and P38MAPK were up-regulated(P<0.05).In addition,safflower polysaccharide inhibited the protein levels of CDC2(P<0.05).Conclusion:Safflower polysaccharide can inhibit the growth of hepatocellular carcinoma cells by inhibiting proliferation and promoting apoptosis,and the P38MAPK pathway may play an important role in this process.
文摘Background:Combination therapy with traditional Chinese medicine and chemotherapy was proposed as a therapeutic strategy for non-small cell lung cancer patients.Therefore,we performed a systematic review and metaanalysis of randomized controlled trials to assess effects of this combination therapy on non-small cell lung cancer.To evaluate the efficacy and safety of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the treatment of non-small cell lung cancer.Methods:A randomized controlled study of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy in the databases of China National Knowledge Infrastructure Database,WanFang Database,VIP Database,Sino-Med Database,PUBMED,EMBASE and Cochrane library was searched by computer.The literatures published from the database establishment to July 1,2020 were included in the search scope.After 2 evaluators independently evaluated and cross checked the quality of the study,Revman 5.3 was used to meta analyze the clinical effect of the Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy on patients with non-small cell lung cancer.Results:A total of 1,370 lung cancer patients were included in 20 RCTs.The results of meta-analysis showed that there were significant differences between the 2 groups in clinical efficacy(RR=1.32,95%CI(1.20,1.44)),quality of life(RR=1.44,95%CI(1.32,1.57)),immune function(MD=0.53,95%CI(0.23–0.83)),adverse reactions(RR=0.49,95%CI(0.41,0.58)).Conclusion:The Chinese patent medicine Kang’ai injection adjunct with TP chemotherapy is effective and safe in the treatment of non-small cell lung cancer,and has great prospects for further development.However,the quality of evidence was very low-to-moderate.Considering the poor quality of evidence,we are not very confident in the results.We look forward to more research and update results in the future and improve the evidence quality.
基金National Natural Science Foundation of China Regional Science Fund Project(81460697)Guizhou Provincial Postgraduate Workstation Program(Educational Department)(JYSZ[2014]018)+3 种基金National Natural Science Foundation Regional Science Fund Project(81460691)Guizhou Provincial Science and Technology Department((2016)4032)National Natural Science Foundation of China Regional Science Fund Project(81660833)Guizhou Provincial Department of Education(GZS[2016]08).
文摘Background:Uveal melanoma is the most prevalent intraocular malignancy.In preceding decades,many studies have been published on uveal melanoma.However,so far,uveal melanoma-related bibliometric studies have not been reported.Methods:Uveal melanoma-related articles and reviews published between 2005 and 2019 were retrieved in the Web of Science Core Collection on March 15,2020.Three bibliometric tools(HistCite,VOSviewer,and CiteSpace)were employed to conduct the current study.Results:A total of 3,404 publications related to uveal melanoma were identified,involving 3015 articles(88.57%)and 389 reviews(11.43%)with 65,429 co-cited references in 9 languages,which were published by 2,875 institutions in 66 countries/regions.The United States contributed to most publications(n=1427,41.92%),and the Thomas Jefferson University was involved in most of the studies(n=160,5.56%).Investigative Ophthalmology&Visual Science published the majority of the papers(n=175,5.14%),whereas Ophthalmology received the most co-citations(n=7050).Shields CL owned the most publications and co-citations(n=122 and 2151,respectively).Gene and molecular biology aspects,prevalence,the main prognosis factor,and treatment were the intellectual foundations of uveal melanoma research.In the field of uveal melanoma,emerging hotspots of uveal melanoma include epidemiologic characteristics,prognosis factors,mechanisms of uveal melanoma development,the use of novel predictive tools,and clinical applications of novel targeted drugs.Conclusion:This first bibliometric study focused on the integral tendency of the past 15 years,identified landmark items,and revealed current research hotspots in the field of uveal melanoma,which will provide references for clinicians and researchers,as well as an example of visualization analysis to explore research hotspots in other fields.
基金This research was funded by the Postdoctoral Research Grant in Henan Province(201901025)National Natural Science Foundation of China(82003298).
文摘Various effective ingredients extracted from traditional Chinese medicine have achieved more and more attention in the field of cancer therapy due to their high bioactivity and good safety.These traditional Chinese medicine effective ingredients include paclitaxel,arsenical trioxide,camptothecin and so on.However,poor water solubility and low bioavailability of these traditional Chinese medicine ingredients severely hindered their clinical application.The rapid development of nanotechnology provided a new platform,new opportunities and new challenges for their effective delivery in vitro and in vivo.This minireview provides a concentrated summary of the most recent progresses made in this emerging field,highlighting the“combination ancient traditional Chinese medicine ingredients and advanced nanotechnology”strategy for favoring the construction of next generation cancer nanomedicines.
文摘Esophageal cancer is one of the most common malignant tumors in the world. In recent years, the incidence and mortality of esophageal cancer have increased year by year, which has seriously threatened human health. Surgery, chemotherapy and radiotherapy, as the primary treatments of Western medicine, have achieved specific results in the clinic, but each has its limitations, this is mainly related to their side effects. The diversified treatment methods of traditional Chinese medicine have visible clinical effects, especially in terms of reducing toxicity and increasing efficiency. This present review reviews the research progress of esophageal cancer in terms of traditional Chinese medicine treatment, including the application of Chinese medicine extract, Chinese herbal compound, Chinese patent medicine and TCM external treatment in clinical practice, may provide valuable information for the adjuvant treatment of esophageal cancer with traditional Chinese medicine.
文摘Background:Cancer incidence rate has been increasing in recent years,and it has improved people’s living and financial burden.The incidence and mortality of malignant tumors in the Heilongjiang cancer registry area in 2016 were analyzed,which provided a scientific basis for the prevention and treatment of malignant tumors in Heilongjiang.Methods:The incidence and death data of tumors were collected from 10 tumor registration areas in Heilongjiang Province in 2016.According to the stratification of urban and rural areas and gender,the crude rate,standard rate,accumulative rates(0–74 years old)were calculated.The China 2000 population census data and Segi’s standard population were used for calculating age-standardized rates.Results:The incidence rate of malignant tumors in the Heilongjiang cancer registry area was 286.05/100,000 in 2016,age-standardized incidence rates by standard Chinese population and by standard world population were 168.11/100,000 and 164.69/100,000 with the cumulative incidence rate(0–74 years old)of 18.55%.The incidence of malignant tumors in urban areas was 313.60/100,000,and that in rural areas was 212.26/100,000.The frequency of malignant tumors in males was 295.94/100,000,higher than that in females(276.40/100,000).Lung cancer had the highest incidence followed by breast cancer,colorectal cancer,liver cancer and thyroid cancer.The mortality rate of malignant tumors in Heilongjiang cancer registration areas was 183.56/100,000,age-standardized mortality rates by standard Chinese population and by standard world population were 99.89/100,000 and 99.78/100,000 with the cumulative mortality rate(0–74 years old)of 10.95%.The mortality rate of malignant tumors in urban areas was 194.69/100,000,and that in rural areas was 153.73/100,000.The mortality rate of the male malignant tumor was 222.55/100,000,higher than that of a female malignant tumor(145.51/100,000).Lung cancer had the highest mortality followed by liver cancer,colorectal cancer,gastric cancer and breast cancer.Conclusion:Lung cancer,liver cancer,breast cancer and colorectal cancer were the most common cancers in Heilongjiang Province,which should be taken as the key cancer species for prevention and treatment.The incidence of thyroid cancer is higher in Heilongjiang Province,but the mortality rate is lower,which also needs attention.
文摘Background:To investigate the therapeutic effect of cervical radiofrequency ablation on high risk-HPV persistent infection.Methods:One hundred patients with persistent high risk-HPV infection diagnosed in our hospital from April 2019 to February 2020 were selected.Those in the same period were randomly selected by SPSS19.0 software machine according to the ratio of 1:1,and divided into the treatment group(BBT-RF-A radiofrequency group)and the observation group(recombinant human interferon suppository group)with 50 cases in each group.The negative conversion rate of high risk-HPV between the 2 groups was compared at the 6th and 12th months after treatment,and the types of persistent HR-HPV infection in Changle were studied.Results:The negative conversion rates of HR-HPV in the treatment group were 60%(35/50)and 82%(41/50)at 6 and 12 months after treatment,respectively,while the negative conversion rates of high risk-HPV in the observation group were 30%(15/50)and 44%(22/50)at 6 and 12 months after treatment,respectively.The negative conversion rates in the treatment group were significantly higher than those in the observation group(P<0.05).Studying the main types of high risk-HPV persistent infection has guiding value for HPV vaccine injection in Changle.Conclusion:Self-clotting cutter radiofrequency ablation has a good effect on the negative conversion rate of high risk-HPV persistent infection.These results suggest that the main types of single persistent cervical HR-HPV infection are 16,52 and 58,not including the 18 types.
文摘Objective: To evaluate the efficacy and safety of radiotherapy combined with zoledronic acid fOr the treatment of bone metastases. Methods: Use Pubmed, Cochrane Library, Embase, CBM, CNKI, Wanfang, Weipu tools to search-related databases at home and abroad. From 2013.1 to March 2019, radiotherapy combined with zoledronic acid and radiotherapy alone for bone metastasis of lung cancer were collected. Experimental studies;quality evaluation and data extraction for each of the included studies, and Cochrane risk bias assessment tools for quality evaluation of the literature. Data processing was performed using RevMan 5.3 and Stata 15.0 software, including risk ratio (OR), 95% CI, I2, and P values. Line sensitivity test, publication bias evaluation is using Egger's, Bgge's method quantitative calculation using Revman 5.3 and Stata 15.0 software for statistical analysis. Results: The total of 8 articles was included, and the number of cases was 703. The results of the meta-analysis showed that the radiotherapy, combined with the zoledronic acid group was effective in the treatment of lung cancer with bone metastasis. The meta-analysis was Z = 6.31 (P < 0.00001), OR (95% CI = 3.57, (2.41, 5.30)), the difference was statistically significant. The combined effect of bone metastases was better than that of the single-stage group. The meta-analysis results were Z = 3.18 (P = 0.001) and OR (95% CI = 3.21, (1.57, 6.59)), indicating the therapeutic effect of the two groups in the treatment of bone metastases. The difference is statistically significant. Adverse reactions include: (1) bone marrow suppression, blood toxicity;(2) fever and rash;(3) nausea, vomiting, and fatigue;(4) liver damage and loss of appetite, meta-analysis results are: bone marrow suppression, blood toxicity: Z =0.73 ( P = 0.47), OR (95% CI = 0.58 (0.13, 2.54));fever, rash: Z = 0.36 (P = 0.36), OR (95% CI = 1.3 (0.31, 5.38));nausea, vomiting, Weakness: Z = 0.29 (P = 0.77), OR (95% CI = 0.85 (0.27, 2.62));liver function damage and loss of appetite: Z = 0.00 (P = 1.00), OR (95% CI = 1.00 (0.17, 6.00)). The P values of the four meta-analyses were all greater than 0.05, and the difference was not statistically significant, indicating that the addition of zoledronic acid to the bone metastasis of lung cancer did not aggravate the changes of the above four adverse reactions. Conclusion: Radiotherapy combined with the zoledronic acid group is better than the single radiotherapy group in treating pain caused by bone metastasis. It can effectively treat bone metastasis and will not aggravate the occurrence of adverse reactions.
文摘Cancer related fatigue(CRF)is one of the most common and painful reactions in cancer patients.Due to the negative effects of cancer itself and long-term treatment,patients often feel continuous burnout,fatigue and powerlessness in both mental and physical aspects.Fatigue related to cancer and cancer treatment will affect the physical and mental health of cancer patients for a long time and continuously,and it is hard to be relieved through rest.Nowadays,most of the researches focus on the clinical manifestations of patients with cancer,such as pain,nausea and vomiting,weight loss and so on.The fatigue feeling of cancer patients is often one of the most easily overlooked pain symptoms in the treatment process.The influence of CRF on cancer patients may be one of the reasons for reducing the survival time of cancer patients.This paper aims to summarize and explore the pathogenesis of cancer-related fatigue,in order to analyze the related factors of cancer-related fatigue from multi-dimensional and multi-angle,and provide reference for its comprehensive treatment in clinic.