Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and transportation of red blood cells (RBCs) in blood vessels, leading to various clinical complications. Sickle cell disease is a widesprea...Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and transportation of red blood cells (RBCs) in blood vessels, leading to various clinical complications. Sickle cell disease is a widespread genetic disease in Black Africa. The objective of this study was to evaluate the sickling inhibition activity of Griffonia simplicifolia. Quantitative and qualitative tests were used to determine the major groups of secondary metabolites present in the Griffonia simplicifolia leaves extracts and the modified Emmel test was used to perform the study of sickling inhibition activity. The OECD 423 toxicity study showed that at a single dose of 2000 mg/kg bw, Griffonia simplicifolia leaves extracts are not toxic. All tested substances inhibit erythrocyte falciformation in a dose-dependent manner. The percentages of inhibition were 50.35%, 73% and 94.23% for aqueous extract, hydromethanolic extract and phenylalanine respectively at the concentration of 15 mg/mL. The methanolic extract (70%) had higher activity compared to the aqueous extract. These results suggest that the Griffonia simplicifolia extracts have some potential to be used as alternative antisickling therapy in SCD management.展开更多
为了对柴油机的经济性和排放参数进行高效、准确的预测,根据4190型船用柴油机实验数据与边界参数,建立AVL-BOOST甲醇/柴油混合燃料柴油机仿真模型;利用模型进行仿真实验,并建立甲醇掺混比、废气再循环(exhaust gas recirculation,EGR)...为了对柴油机的经济性和排放参数进行高效、准确的预测,根据4190型船用柴油机实验数据与边界参数,建立AVL-BOOST甲醇/柴油混合燃料柴油机仿真模型;利用模型进行仿真实验,并建立甲醇掺混比、废气再循环(exhaust gas recirculation,EGR)率、喷油提前角和进气压力4个控制参数对有效油耗率和NO x排放预测数据集;利用该数据集对5种不同核函数的高斯过程回归(Gaussian process regression,GPR)模型进行训练;最后将最优的平方指数高斯过程回归(squared exponential-Gaussian process regression,SE-GPR)模型、AVL-BOOST仿真数据和柴油机实验数据进行对比。结果表明:在数据量为180组时,SE-GPR模型对有效油耗率和NO x排放均取得拟合关联度99%以上,均方根误差(root mean square error,RMSE)分别为1.859,0.3445,平均绝对误差(mean absolute error,MAE)分别为0.954,0.2489;并且,相较于AVL-BOOST仿真实验,SE-GPR模型对实验数据具有更好的拟合性。展开更多
文摘Sickle cell disease (SCD) is a genetic blood disorder that affects the shape and transportation of red blood cells (RBCs) in blood vessels, leading to various clinical complications. Sickle cell disease is a widespread genetic disease in Black Africa. The objective of this study was to evaluate the sickling inhibition activity of Griffonia simplicifolia. Quantitative and qualitative tests were used to determine the major groups of secondary metabolites present in the Griffonia simplicifolia leaves extracts and the modified Emmel test was used to perform the study of sickling inhibition activity. The OECD 423 toxicity study showed that at a single dose of 2000 mg/kg bw, Griffonia simplicifolia leaves extracts are not toxic. All tested substances inhibit erythrocyte falciformation in a dose-dependent manner. The percentages of inhibition were 50.35%, 73% and 94.23% for aqueous extract, hydromethanolic extract and phenylalanine respectively at the concentration of 15 mg/mL. The methanolic extract (70%) had higher activity compared to the aqueous extract. These results suggest that the Griffonia simplicifolia extracts have some potential to be used as alternative antisickling therapy in SCD management.
文摘为了对柴油机的经济性和排放参数进行高效、准确的预测,根据4190型船用柴油机实验数据与边界参数,建立AVL-BOOST甲醇/柴油混合燃料柴油机仿真模型;利用模型进行仿真实验,并建立甲醇掺混比、废气再循环(exhaust gas recirculation,EGR)率、喷油提前角和进气压力4个控制参数对有效油耗率和NO x排放预测数据集;利用该数据集对5种不同核函数的高斯过程回归(Gaussian process regression,GPR)模型进行训练;最后将最优的平方指数高斯过程回归(squared exponential-Gaussian process regression,SE-GPR)模型、AVL-BOOST仿真数据和柴油机实验数据进行对比。结果表明:在数据量为180组时,SE-GPR模型对有效油耗率和NO x排放均取得拟合关联度99%以上,均方根误差(root mean square error,RMSE)分别为1.859,0.3445,平均绝对误差(mean absolute error,MAE)分别为0.954,0.2489;并且,相较于AVL-BOOST仿真实验,SE-GPR模型对实验数据具有更好的拟合性。