According to regional characteristics and the actual situation in Lin ’an City, an evaluation index system of land comprehensive carrying capacity composed of three support subsystems (eco-environment, social and ec...According to regional characteristics and the actual situation in Lin ’an City, an evaluation index system of land comprehensive carrying capacity composed of three support subsystems (eco-environment, social and economic carrying capaci-ties) containing 22 evaluation indexes was established to evaluate the comprehen-sive carrying capacity of land resource in Lin’an City during 2005-2012. Meanwhile, based on the target data of overal land use plan, the level of land comprehensive carrying capacity was predicted at the end of the plan period (2020) .The results showed that land comprehensive carrying capacity had a significant growth in Lin ’an from 2005 to 2012, and the development trend was basical y sustainable. The sub-systems also had been greatly improved, in which the constant improvement of ec-ological environment carrying capacity made the largest contribution to the constant raising of land comprehensive carrying capacity. The degree of coordination between the systems was poor, in which eco-environment carrying capacity had the maxi-mum growth, far more than the social and economic carrying capacities. According to the land comprehensive carrying capacity in 2020, utilization of land resources in Lin'an city can achieve sustainable development in general. Final y, proposals of im-proving comprehensive carrying capacity were put forward in terms of the enhance-ment of eco-environment protection, accelerating economic development and policy guidance.展开更多
Objective: To study clinical features of the patients with multiple myeloma(MM) accompanied by renal insufficiency and investigate the related risk factors of renalimpairment. Methods: A control study of clinical char...Objective: To study clinical features of the patients with multiple myeloma(MM) accompanied by renal insufficiency and investigate the related risk factors of renalimpairment. Methods: A control study of clinical characteristics was performed between 91 patientswith renal insufficiency due to MM and 165 patients with normal renal function in MM during the sameperiod. The data were statistically analyzed by chi-square test and logistic regression analysis.Results: Renal insufficiency was the initial presentation in 48 (52.7%) of the 91 patients, and 30(62.5%) of the 48 patients were misdiagnosed. The prognosis of group with renal insufficiency wassignificantly poorer than that of group with normal renal function: mortality in 3 months, 3months-1 year was 26/91 vs 14/165 (P 【 0.0001), 14/91 vs 12/165 (P 【 0.05) respectively, andpatients survived 】 1 year was 18/91 vs 95/165 (P 【 0.0001). The incidence of hypercalcemia,hyperuricemic, severe anemia, high serum M-protein concentration and lytic bone lesions weresignificantly higher in renal insufficiency group than those in control group (P 【 0.05). Logisticregression analysis identified 5 risk factors of renal impairment, including, severe anemia(Exp(β)=13.819, P 【 0.0001), use of nephrotoxic drugs (Exp(β)=6.217, P = 0.001), high serumM-protein concentration (Exp(β) = 5.026, P = 0.001), male (Exp(β)=3.745, P=0.006), andhypercalcemia (Exp(β)=3A72, P=0.006), but age, serum density of uric acid, type of serum M-protein,and Bence Jones proteinuria were not significantly associated with renal insufficiency. Conclusion:Renal insufficiency was a common early complication of MM, which often resulted in misdiagnosis.The status of these patients tended to be very bad, with many other complications, when MM wasdiagnosed, so their prognosis was poor. The occurrence of renal insufficiency in patients with MMand hypercalcemia, severe anemia, high serum M-protein concentration, especially use of nephrotoxicdrugs should be alert.展开更多
We systematically reviewed the clinical trials which recruited antioxidants in the therapy of pancreatitis and evaluated whether antioxidants improve the outcome of patients with pancreatitis. Electronic bibliographic...We systematically reviewed the clinical trials which recruited antioxidants in the therapy of pancreatitis and evaluated whether antioxidants improve the outcome of patients with pancreatitis. Electronic bibliographic databases were searched for any studies which investigated the use of antioxidants in the management of acute pancreatitis (AP) or chronic pancreatitis (CP) and in the prevention of post-endoscopic retrograde cholangio-pancreatography (post-ERCP) pancreatitis (PEP) up to February 2009. Twenty-two randomized, placebo-controlled, clinical trials met our criteria and were included in the review. Except for a cocktail of antioxidants which showed improvement in outcomes in three different clinical trials, the results of the administration of other antioxidants in both AP and CP clinical trials were incongruent and heterogeneous.Furthermore, antioxidant therapy including allopurinol and N-acetylcysteine failed to prevent the onset of PEP in almost all trials. In conclusion, the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP, CP or PER Further double blind, randomized, placebo-controlled clinical trials with large sample size need to be conducted.展开更多
Objective: To investigate the predictability of MRI and the possiblebiological markers of cavernous sinus invasion of pituitary adenomas associated with fourphenomenas: angiogenesis, cell proliferation, apoptosis and ...Objective: To investigate the predictability of MRI and the possiblebiological markers of cavernous sinus invasion of pituitary adenomas associated with fourphenomenas: angiogenesis, cell proliferation, apoptosis and matrix metalloproteinase. Methods: Weevaluated 45 patients with pituitary adenoma according to the MRI, surgical findings and theimmunohistochemistry staining of tumor tissues. Results: The results have shown that the sensitivityof MRI for predicting cavernous sinus invasion in this prospective study was 60%, its specificity85%, its positive predictive value 83.33%, negative predictive value 62.96%. 45 specimens ofpituitary adenomas were analyzed for expression of F8, VEGF, Ki-67, c-myc, Bcl-2, nm23 and MMP-9immunoreactivity using immunoperoxidase staining. MVD was assessed using F8-related antigen. Theresults have shown that MVD of invasive pituitary adenomas was significantly higher than that ofnoninvasive (P 【 0.001). There was an association between the invasion of pituitary adenomas andKi-67 LI (P = 0.039) or the expression of VEGF (P 【 0.001) and MMP-9 (P 【 0.001). But c-myc LI andBcl-2 expression have no association with invasiveness of pituitary adenomas (P = 0.061 versus P =0.201). On the other hand, there is an inverse relationship between nm23 expression and tumorinvasion (P 【 0.001). Conclusion: Parasellar extension of pituitary adenomas through the medial wallof the cavernous sinus is diagnosed at surgery, and with sensitive gadolinium-enhanced MRI, itsextent can be partly determined by radiology. Although our study has shown that MVD and theexpression of VEGF, Ki-67, nm23 and MMP-9 have associations with invasiveness of pituitary adenomas,they are lack of specificity. These markers can only provide some useful information.展开更多
The Language Policy for Higher Education (2002) and University of Cape Town's Language Plan (2001) suggest that language is central to our social and academic engagement at every level: to our communication with...The Language Policy for Higher Education (2002) and University of Cape Town's Language Plan (2001) suggest that language is central to our social and academic engagement at every level: to our communication with those around us, to our learning, and to our identities. The purpose of this paper is to show how the medical school, after making progress towards implementing the University of Cape Town's Language Plan of 2001, is compelled to encourage isiXhosa language developers to develop the necessary and relevant vocabulary responding to the needs of the target users. In some cases, there is a need to adopt terms that are already available and being used by the speech community to align them in the curriculum. Research conducted by analyzing field notes, having plenary discussions with students, observations during clinical practice, reflecting on the curriculum and study materials material. Results indicated the significance of teaching isiXhosa drawing from the medical jargon understood amongst patients, doctors, and nurses. This paper discusses the status enjoyed by isiXhosa to date, language teaching and teaching matters pertaining to isiXhosa, and reflection on whether there is benefit in learning isiXhosa.展开更多
Here we report the first discovery of a relatively complete skull of Choerolophodon from the late early Miocene Dalanggou quarry of Linxia Basin, Gansu Province in China. The skull is low and elongated, with two ename...Here we report the first discovery of a relatively complete skull of Choerolophodon from the late early Miocene Dalanggou quarry of Linxia Basin, Gansu Province in China. The skull is low and elongated, with two enamel-less and out ward-and-upward curved incisors and the choerolophodont molars. These characters indicate that the new specimen can be as signed to the genus Choerolophodon, as it is quite distinct from other common gomphotheres in northern China such as Gom photherium, Platybelodon, and Sinomastodon. The skull is also primitive in possessing laterally-expanded zygomatic arches, anteriorly-positioned orbits, weakly-developed cheek teeth cement, and retention of a P4. Prior to this discovery, Cho erolophodon was found primarily from the middle-late Miocene of Africa, Eastern Europe, and western and southern Asia. The discovery of this new material expands the known temporal and spatial distributions of this taxon and helps us better un derstand the phylogeny, evolution, and adaptive radiation of gomphotheres in early Miocene of China.展开更多
Based on the supercritical "wingl" which was released in the DPW-III conference, multi-objective optimization has been done to increase the lift-drag ratio at cruise condition and improve transonic buffet boundary a...Based on the supercritical "wingl" which was released in the DPW-III conference, multi-objective optimization has been done to increase the lift-drag ratio at cruise condition and improve transonic buffet boundary and drag-rise performance. Hicks-Henne shape functions are used to represent the bump shape. In the design optimization to increase lift-drag ratio, the objectives involve the cruise point and three other off-design points nearby. In the other optimization process to improve buffet and drag-rise performance, three buffet onset points near the cruise point and one drag-rise point are selected as the design points. Non-dominating sort genetic algorithm II (NSGA-II) is used in both processes. Additionally, individual analysis for every selected point on the Pareto frontier is conducted in order to avoid local convergence and achieve global optimum. Re- sults of optimization for aerodynamic efficiency show a decrease of 11 counts in drag at the cruise point. Drag at nearby off-design points are also reduced to some extent. Similar approaches are made to improve buffet and drag-rise characteristics, resulting in significant improvements in both ways.展开更多
The origin of power-law distributions in self-organized criticality is investigated by treating the variation of the number of active sites in the system as a stochastic process. An avalanche is mapped to a first-retu...The origin of power-law distributions in self-organized criticality is investigated by treating the variation of the number of active sites in the system as a stochastic process. An avalanche is mapped to a first-return random-walk process in a one-dimensional lattice. In order to understand the reason of variant exponents for the power-law distributions in different self-organized critical systems, we introduce the correlations among evolution steps. Power-law distributions of the lifetime and spatial size are found when the random walk is unbiased with equal probability to move in opposite directions. It is found that the longer the correlation length, the smaller values of the exponents for the power-law distributions.展开更多
基金Supported by National Natural Science Foundation of China(41401416)Jiangsu Agricultural Self-innovation Foundation(CX-13-3055)Jiangsu Fundamental Research Plan(BK20140759)~~
文摘According to regional characteristics and the actual situation in Lin ’an City, an evaluation index system of land comprehensive carrying capacity composed of three support subsystems (eco-environment, social and economic carrying capaci-ties) containing 22 evaluation indexes was established to evaluate the comprehen-sive carrying capacity of land resource in Lin’an City during 2005-2012. Meanwhile, based on the target data of overal land use plan, the level of land comprehensive carrying capacity was predicted at the end of the plan period (2020) .The results showed that land comprehensive carrying capacity had a significant growth in Lin ’an from 2005 to 2012, and the development trend was basical y sustainable. The sub-systems also had been greatly improved, in which the constant improvement of ec-ological environment carrying capacity made the largest contribution to the constant raising of land comprehensive carrying capacity. The degree of coordination between the systems was poor, in which eco-environment carrying capacity had the maxi-mum growth, far more than the social and economic carrying capacities. According to the land comprehensive carrying capacity in 2020, utilization of land resources in Lin'an city can achieve sustainable development in general. Final y, proposals of im-proving comprehensive carrying capacity were put forward in terms of the enhance-ment of eco-environment protection, accelerating economic development and policy guidance.
文摘Objective: To study clinical features of the patients with multiple myeloma(MM) accompanied by renal insufficiency and investigate the related risk factors of renalimpairment. Methods: A control study of clinical characteristics was performed between 91 patientswith renal insufficiency due to MM and 165 patients with normal renal function in MM during the sameperiod. The data were statistically analyzed by chi-square test and logistic regression analysis.Results: Renal insufficiency was the initial presentation in 48 (52.7%) of the 91 patients, and 30(62.5%) of the 48 patients were misdiagnosed. The prognosis of group with renal insufficiency wassignificantly poorer than that of group with normal renal function: mortality in 3 months, 3months-1 year was 26/91 vs 14/165 (P 【 0.0001), 14/91 vs 12/165 (P 【 0.05) respectively, andpatients survived 】 1 year was 18/91 vs 95/165 (P 【 0.0001). The incidence of hypercalcemia,hyperuricemic, severe anemia, high serum M-protein concentration and lytic bone lesions weresignificantly higher in renal insufficiency group than those in control group (P 【 0.05). Logisticregression analysis identified 5 risk factors of renal impairment, including, severe anemia(Exp(β)=13.819, P 【 0.0001), use of nephrotoxic drugs (Exp(β)=6.217, P = 0.001), high serumM-protein concentration (Exp(β) = 5.026, P = 0.001), male (Exp(β)=3.745, P=0.006), andhypercalcemia (Exp(β)=3A72, P=0.006), but age, serum density of uric acid, type of serum M-protein,and Bence Jones proteinuria were not significantly associated with renal insufficiency. Conclusion:Renal insufficiency was a common early complication of MM, which often resulted in misdiagnosis.The status of these patients tended to be very bad, with many other complications, when MM wasdiagnosed, so their prognosis was poor. The occurrence of renal insufficiency in patients with MMand hypercalcemia, severe anemia, high serum M-protein concentration, especially use of nephrotoxicdrugs should be alert.
文摘We systematically reviewed the clinical trials which recruited antioxidants in the therapy of pancreatitis and evaluated whether antioxidants improve the outcome of patients with pancreatitis. Electronic bibliographic databases were searched for any studies which investigated the use of antioxidants in the management of acute pancreatitis (AP) or chronic pancreatitis (CP) and in the prevention of post-endoscopic retrograde cholangio-pancreatography (post-ERCP) pancreatitis (PEP) up to February 2009. Twenty-two randomized, placebo-controlled, clinical trials met our criteria and were included in the review. Except for a cocktail of antioxidants which showed improvement in outcomes in three different clinical trials, the results of the administration of other antioxidants in both AP and CP clinical trials were incongruent and heterogeneous.Furthermore, antioxidant therapy including allopurinol and N-acetylcysteine failed to prevent the onset of PEP in almost all trials. In conclusion, the present data do not support a benefit of antioxidant therapy alone or in combination with conventional therapy in the management of AP, CP or PER Further double blind, randomized, placebo-controlled clinical trials with large sample size need to be conducted.
文摘Objective: To investigate the predictability of MRI and the possiblebiological markers of cavernous sinus invasion of pituitary adenomas associated with fourphenomenas: angiogenesis, cell proliferation, apoptosis and matrix metalloproteinase. Methods: Weevaluated 45 patients with pituitary adenoma according to the MRI, surgical findings and theimmunohistochemistry staining of tumor tissues. Results: The results have shown that the sensitivityof MRI for predicting cavernous sinus invasion in this prospective study was 60%, its specificity85%, its positive predictive value 83.33%, negative predictive value 62.96%. 45 specimens ofpituitary adenomas were analyzed for expression of F8, VEGF, Ki-67, c-myc, Bcl-2, nm23 and MMP-9immunoreactivity using immunoperoxidase staining. MVD was assessed using F8-related antigen. Theresults have shown that MVD of invasive pituitary adenomas was significantly higher than that ofnoninvasive (P 【 0.001). There was an association between the invasion of pituitary adenomas andKi-67 LI (P = 0.039) or the expression of VEGF (P 【 0.001) and MMP-9 (P 【 0.001). But c-myc LI andBcl-2 expression have no association with invasiveness of pituitary adenomas (P = 0.061 versus P =0.201). On the other hand, there is an inverse relationship between nm23 expression and tumorinvasion (P 【 0.001). Conclusion: Parasellar extension of pituitary adenomas through the medial wallof the cavernous sinus is diagnosed at surgery, and with sensitive gadolinium-enhanced MRI, itsextent can be partly determined by radiology. Although our study has shown that MVD and theexpression of VEGF, Ki-67, nm23 and MMP-9 have associations with invasiveness of pituitary adenomas,they are lack of specificity. These markers can only provide some useful information.
文摘The Language Policy for Higher Education (2002) and University of Cape Town's Language Plan (2001) suggest that language is central to our social and academic engagement at every level: to our communication with those around us, to our learning, and to our identities. The purpose of this paper is to show how the medical school, after making progress towards implementing the University of Cape Town's Language Plan of 2001, is compelled to encourage isiXhosa language developers to develop the necessary and relevant vocabulary responding to the needs of the target users. In some cases, there is a need to adopt terms that are already available and being used by the speech community to align them in the curriculum. Research conducted by analyzing field notes, having plenary discussions with students, observations during clinical practice, reflecting on the curriculum and study materials material. Results indicated the significance of teaching isiXhosa drawing from the medical jargon understood amongst patients, doctors, and nurses. This paper discusses the status enjoyed by isiXhosa to date, language teaching and teaching matters pertaining to isiXhosa, and reflection on whether there is benefit in learning isiXhosa.
基金supported by the Knowledge Innsovation Program of Chinese Academy of Sciences (Grant Nos. KZCX2-YW-Q09-120, KZCX2-YW-120)National Natural Science Foundation of China (Grant Nos. 40730210, 41002010)+1 种基金Ministry of Science and Technology of China (Grant No. 2006CB806400)Key Laboratory of Evolutionary Systematics of Vertebrates, CAS (Grant No. 2010LESV004)
文摘Here we report the first discovery of a relatively complete skull of Choerolophodon from the late early Miocene Dalanggou quarry of Linxia Basin, Gansu Province in China. The skull is low and elongated, with two enamel-less and out ward-and-upward curved incisors and the choerolophodont molars. These characters indicate that the new specimen can be as signed to the genus Choerolophodon, as it is quite distinct from other common gomphotheres in northern China such as Gom photherium, Platybelodon, and Sinomastodon. The skull is also primitive in possessing laterally-expanded zygomatic arches, anteriorly-positioned orbits, weakly-developed cheek teeth cement, and retention of a P4. Prior to this discovery, Cho erolophodon was found primarily from the middle-late Miocene of Africa, Eastern Europe, and western and southern Asia. The discovery of this new material expands the known temporal and spatial distributions of this taxon and helps us better un derstand the phylogeny, evolution, and adaptive radiation of gomphotheres in early Miocene of China.
文摘Based on the supercritical "wingl" which was released in the DPW-III conference, multi-objective optimization has been done to increase the lift-drag ratio at cruise condition and improve transonic buffet boundary and drag-rise performance. Hicks-Henne shape functions are used to represent the bump shape. In the design optimization to increase lift-drag ratio, the objectives involve the cruise point and three other off-design points nearby. In the other optimization process to improve buffet and drag-rise performance, three buffet onset points near the cruise point and one drag-rise point are selected as the design points. Non-dominating sort genetic algorithm II (NSGA-II) is used in both processes. Additionally, individual analysis for every selected point on the Pareto frontier is conducted in order to avoid local convergence and achieve global optimum. Re- sults of optimization for aerodynamic efficiency show a decrease of 11 counts in drag at the cruise point. Drag at nearby off-design points are also reduced to some extent. Similar approaches are made to improve buffet and drag-rise characteristics, resulting in significant improvements in both ways.
基金Supported in part by the National Natural Science Foundation of China under Grant Nos.10635020 and 10775057by the Ministry of Education of China under Grant Nos.306022,IRT0624by the Programme of Introducing Talents of Discipline to Universities under Grant No.B08033
文摘The origin of power-law distributions in self-organized criticality is investigated by treating the variation of the number of active sites in the system as a stochastic process. An avalanche is mapped to a first-return random-walk process in a one-dimensional lattice. In order to understand the reason of variant exponents for the power-law distributions in different self-organized critical systems, we introduce the correlations among evolution steps. Power-law distributions of the lifetime and spatial size are found when the random walk is unbiased with equal probability to move in opposite directions. It is found that the longer the correlation length, the smaller values of the exponents for the power-law distributions.