Due to minimum consideration of an actual network topology, the existing peer-to-peer (P2P) overlay networks, such as CAN, Chord, Pastry and Tapestry, will lead to high latency and low efficiency. In TaChord, a topolo...Due to minimum consideration of an actual network topology, the existing peer-to-peer (P2P) overlay networks, such as CAN, Chord, Pastry and Tapestry, will lead to high latency and low efficiency. In TaChord, a topology-aware routing approach in P2P overlays and an improved design in Chord are presented. TaChord and other algorithms are evaluated by physical hops, interdomain-adjusted latency, and aggregate bandwidth used per message. Experimental results demonstrate that TaChord has the drastic improvement in routing performance where average physical hop is half that of chord, and the impact of cache management strategies in the TaChord overlay cannot be neglected.展开更多
An adaptive topology learning approach is proposed to learn the topology of a practical camera network in an unsupervised way. The nodes are modeled by the Gaussian mixture model. The connectivity between nodes is jud...An adaptive topology learning approach is proposed to learn the topology of a practical camera network in an unsupervised way. The nodes are modeled by the Gaussian mixture model. The connectivity between nodes is judged by their cross-correlation function, which is also used to calculate their transition time distribution. The mutual information of the connected node pair is employed for transition probability calculation. A false link eliminating approach is proposed, along with a topology updating strategy to improve the learned topology. A real monitoring system with five disjoint cameras is built for experiments. Comparative results with traditional methods show that the proposed method is more accurate in topology learning and is more robust to environmental changes.展开更多
9-intersection model is the most popular framework used for formalizing the spatial relations between two spatial objectsA andB. It transforms the topological relationships between two simple spatial objectsA andB int...9-intersection model is the most popular framework used for formalizing the spatial relations between two spatial objectsA andB. It transforms the topological relationships between two simple spatial objectsA andB into point-set topology problem in terms of the intersections ofA’s boundary (?A), interior (A 0) and (A ?) withB’s boundary (?B), interior (B 0) and exterior (B ?). It is shown in this paper that there exist some limitations of the original 9-intersection model due to its definition of an object’s exterior as its complement, and it is difficult to distinguish different disjoint relations and relations between complex objects with holes, difficult or even impossible to compute the intersections with the two object’s complements (?A∩B ?,A 0∩?B ?,A ?∩?B,A ?∩B 0 andA ?∩B ?)since the complements are infinitive. The authors suggest to re-define the exterior of spatial object by replacing the complement with its Voronoi region. A new Voronoi-based 9-intersection (VNI) is proposed and used for formalizing topological relations between spatial bojects. By improving the 9-intersection model, it is now possible to distinguish disjoint relations and to deal with objects with holes. Also it is possible to compute the exterior-based intersections and manipulate spatial relations with the VNI.展开更多
AIM:rAAV mediated endostatin gene therapy has been examined as a new method for treating cancer.However, a sustained and high protein delivery is required to achieve the desired therapeutic effects.We evaluated the im...AIM:rAAV mediated endostatin gene therapy has been examined as a new method for treating cancer.However, a sustained and high protein delivery is required to achieve the desired therapeutic effects.We evaluated the impact of topoisomerase inhibitors in rAAV delivered endostatin gene therapy in a liver tumor model. METHODS:rAAV containing endostatin expression cassettes were transduced into hepatoma cell lines.To test whether the topoisomerase inhibitor pretreatment increased the expression of endostatin,Western blotting and ELISA were performed.The biologic activity of endostatin was confirmed by endothelial cell proliferation and tube formation assays. The anti-tumor effects of the rAAV-endostatin vector combined with a topoisomerase inhibitor,etoposide,were evaluated in a mouse liver tumor model. RESULTS:Topoisomerase inhibitors,including camptothecin and etoposide,were found to increase the endostatin exPression level in vitro.The over-expressed endostatin, as a result of pretreatment with a topoisomerase inhibitor, was also biologically active.In animal experiments,the combined therapy of topoisomerase inhibitor,etoposide with the rAAV-endostatin vector had the best tumor- suppressive effect and tumor foci were barely observed in livers of the treated mice.Pretreatment with an etoposide increased the level of endostatin in the liver and serum of rAAV-endostatin treated mice.Finally,the mice treated With rAAV-endostatin in combination with etoposide showed the longest survival among the experimental models. CONCLUSION:rAAV delivered endostatin gene therapy in combination with a topoisomerase inhibitor pretreatment is an effective modality for anticancer gene therapy.展开更多
This paper attempts toregard spatial relation transformationas an important process in map gener-alization. The spatial relation generali-zation can be divided into the compo-nents of abstraction: topology, dis-tance ...This paper attempts toregard spatial relation transformationas an important process in map gener-alization. The spatial relation generali-zation can be divided into the compo-nents of abstraction: topology, dis-tance and orientation. The concept‘ spatial relation resolution' is intro-duced to describe the constraints ofrelative spatial relation. On the basisof nine intersection models, the cardi-nal direction models and the iso-dis-tance-relation models, this paper givesthree sorts of relation resolution repre-sentations for topological, distance andorientation relation, respectively. Twomapping implementations in map gen-eralization is discussed.展开更多
In the quotient space theory of granular computing,the universe structure is assumed to be a topology,therefore,its application is still limited.In this study,based on the quotient space model,the universe structure i...In the quotient space theory of granular computing,the universe structure is assumed to be a topology,therefore,its application is still limited.In this study,based on the quotient space model,the universe structure is assumed as an algebra instead of a topology.As to obtain the algebraic quotient operator,the granulation must be uniquely determined by a congruence relation,and all the congruence relations form a complete semi-order lattice,which is the theoretical basis of granularities ' completeness.When the given equivalence relation is not a congruence relation,it defines the concepts of upper quotient and lower quotient,and discusses some of their properties which demonstrate that falsity preserving principle and truth preserving principle are still valid.Finally,it presents the algorithms and example of upper quotient and lower quotient.The work extends the quotient space theory from structure,and provides theoretical basis for the combination of the quotient space theory and the algebra theory.展开更多
A new method based on the traditional method of ray scanning has been introduced to resolve the problem of judging the color in the chromaticity diagram by employing the line segments approximate curve—— using polyg...A new method based on the traditional method of ray scanning has been introduced to resolve the problem of judging the color in the chromaticity diagram by employing the line segments approximate curve—— using polygonal approximate closed curve. Then a vector coordinate could be used to describe the curve instead of curve equations. So it is easy to judge the topology relation between an area and a point or a locus. And any data processing method has been used to save memory, which makes the improved ray scanning method is quite useful in the measurement of color.展开更多
An observer-based fault diagnosis method and a fault tolerant control for open-switch fault and current sensor fault are proposed for interleaved flyback converters of a micro-inverter system. First, based on the topo...An observer-based fault diagnosis method and a fault tolerant control for open-switch fault and current sensor fault are proposed for interleaved flyback converters of a micro-inverter system. First, based on the topology of a grid-connected micro-inverter, a mathematical model of the flyback converters is established. Second, a state observer is applied to estimate the currents online and generate corresponding residuals. The fault is diagnosed by comparing the residuals with the thresholds. Finally, a fault-tolerant control that consists of a fault-tolerant topology for the faulty switch and a simple software redundancy control for the faulty current sensor, is proposed to achieve a fault-tolerant operation. The feasibility and effectiveness of the proposed method has been verified by simulation and experimental results.展开更多
This paper describes the geometric and statistical properties of areal object under randomness. In order to describe formally such a uncertain topological relation, a new formal model (i.e. 4ID model) is proposed. On ...This paper describes the geometric and statistical properties of areal object under randomness. In order to describe formally such a uncertain topological relation, a new formal model (i.e. 4ID model) is proposed. On the basis of this, the effects of positional uncertainty on topological relations between areal objects are investigated in detail. Some possibility functions for the determination of relations are constructed based on the assumption that randomness of point location complies with a normal distribution, and the concept of uncertain sets of topological relations under randomness is introduced.展开更多
In this paper, the relations of the network topology and the moving consensus of multi-agent systems are studied. A consensus-prestissimo scale-free network model with the static preferential-consensus attachment is p...In this paper, the relations of the network topology and the moving consensus of multi-agent systems are studied. A consensus-prestissimo scale-free network model with the static preferential-consensus attachment is presented on the rewired link of the regular network. The effects of the static preferential-consensus BA network on the algebraic connectivity of the topology graph are compared with the regular network. The robustness gain to delay is analyzed for variable network topology with the same scale. The time to reach the consensus is studied for the dynamic network with and without communication delays. By applying the computer simulations, it is validated that the speed of the convergence of multi-agent systems can be greatly improved in the preferential-consensus BA network model with different configuration.展开更多
文摘Due to minimum consideration of an actual network topology, the existing peer-to-peer (P2P) overlay networks, such as CAN, Chord, Pastry and Tapestry, will lead to high latency and low efficiency. In TaChord, a topology-aware routing approach in P2P overlays and an improved design in Chord are presented. TaChord and other algorithms are evaluated by physical hops, interdomain-adjusted latency, and aggregate bandwidth used per message. Experimental results demonstrate that TaChord has the drastic improvement in routing performance where average physical hop is half that of chord, and the impact of cache management strategies in the TaChord overlay cannot be neglected.
基金The National Natural Science Foundation of China(No.60972001)the Science and Technology Plan of Suzhou City(No.SS201223)
文摘An adaptive topology learning approach is proposed to learn the topology of a practical camera network in an unsupervised way. The nodes are modeled by the Gaussian mixture model. The connectivity between nodes is judged by their cross-correlation function, which is also used to calculate their transition time distribution. The mutual information of the connected node pair is employed for transition probability calculation. A false link eliminating approach is proposed, along with a topology updating strategy to improve the learned topology. A real monitoring system with five disjoint cameras is built for experiments. Comparative results with traditional methods show that the proposed method is more accurate in topology learning and is more robust to environmental changes.
基金Project supported by the National Natural Science Foundation of China(No.49471059)
文摘9-intersection model is the most popular framework used for formalizing the spatial relations between two spatial objectsA andB. It transforms the topological relationships between two simple spatial objectsA andB into point-set topology problem in terms of the intersections ofA’s boundary (?A), interior (A 0) and (A ?) withB’s boundary (?B), interior (B 0) and exterior (B ?). It is shown in this paper that there exist some limitations of the original 9-intersection model due to its definition of an object’s exterior as its complement, and it is difficult to distinguish different disjoint relations and relations between complex objects with holes, difficult or even impossible to compute the intersections with the two object’s complements (?A∩B ?,A 0∩?B ?,A ?∩?B,A ?∩B 0 andA ?∩B ?)since the complements are infinitive. The authors suggest to re-define the exterior of spatial object by replacing the complement with its Voronoi region. A new Voronoi-based 9-intersection (VNI) is proposed and used for formalizing topological relations between spatial bojects. By improving the 9-intersection model, it is now possible to distinguish disjoint relations and to deal with objects with holes. Also it is possible to compute the exterior-based intersections and manipulate spatial relations with the VNI.
基金Supported by a faculty research grant of Yonsei University College of Medicine for 2002,No.2002-06
文摘AIM:rAAV mediated endostatin gene therapy has been examined as a new method for treating cancer.However, a sustained and high protein delivery is required to achieve the desired therapeutic effects.We evaluated the impact of topoisomerase inhibitors in rAAV delivered endostatin gene therapy in a liver tumor model. METHODS:rAAV containing endostatin expression cassettes were transduced into hepatoma cell lines.To test whether the topoisomerase inhibitor pretreatment increased the expression of endostatin,Western blotting and ELISA were performed.The biologic activity of endostatin was confirmed by endothelial cell proliferation and tube formation assays. The anti-tumor effects of the rAAV-endostatin vector combined with a topoisomerase inhibitor,etoposide,were evaluated in a mouse liver tumor model. RESULTS:Topoisomerase inhibitors,including camptothecin and etoposide,were found to increase the endostatin exPression level in vitro.The over-expressed endostatin, as a result of pretreatment with a topoisomerase inhibitor, was also biologically active.In animal experiments,the combined therapy of topoisomerase inhibitor,etoposide with the rAAV-endostatin vector had the best tumor- suppressive effect and tumor foci were barely observed in livers of the treated mice.Pretreatment with an etoposide increased the level of endostatin in the liver and serum of rAAV-endostatin treated mice.Finally,the mice treated With rAAV-endostatin in combination with etoposide showed the longest survival among the experimental models. CONCLUSION:rAAV delivered endostatin gene therapy in combination with a topoisomerase inhibitor pretreatment is an effective modality for anticancer gene therapy.
基金the LIESMARS Foundation (No. (02)0301) the National Natural Science Foundation of China (No. 40101023).
文摘This paper attempts toregard spatial relation transformationas an important process in map gener-alization. The spatial relation generali-zation can be divided into the compo-nents of abstraction: topology, dis-tance and orientation. The concept‘ spatial relation resolution' is intro-duced to describe the constraints ofrelative spatial relation. On the basisof nine intersection models, the cardi-nal direction models and the iso-dis-tance-relation models, this paper givesthree sorts of relation resolution repre-sentations for topological, distance andorientation relation, respectively. Twomapping implementations in map gen-eralization is discussed.
基金Supported by the National Natural Science Foundation of China(No.61173052)the Natural Science Foundation of Hunan Province(No.14JJ4007)
文摘In the quotient space theory of granular computing,the universe structure is assumed to be a topology,therefore,its application is still limited.In this study,based on the quotient space model,the universe structure is assumed as an algebra instead of a topology.As to obtain the algebraic quotient operator,the granulation must be uniquely determined by a congruence relation,and all the congruence relations form a complete semi-order lattice,which is the theoretical basis of granularities ' completeness.When the given equivalence relation is not a congruence relation,it defines the concepts of upper quotient and lower quotient,and discusses some of their properties which demonstrate that falsity preserving principle and truth preserving principle are still valid.Finally,it presents the algorithms and example of upper quotient and lower quotient.The work extends the quotient space theory from structure,and provides theoretical basis for the combination of the quotient space theory and the algebra theory.
基金Key Projects from Science & Technology Depart ment of Hubei Province(2002AA101B06)
文摘A new method based on the traditional method of ray scanning has been introduced to resolve the problem of judging the color in the chromaticity diagram by employing the line segments approximate curve—— using polygonal approximate closed curve. Then a vector coordinate could be used to describe the curve instead of curve equations. So it is easy to judge the topology relation between an area and a point or a locus. And any data processing method has been used to save memory, which makes the improved ray scanning method is quite useful in the measurement of color.
基金Project(2012AA051601)supported by the High-Tech Research and Development Program of China
文摘An observer-based fault diagnosis method and a fault tolerant control for open-switch fault and current sensor fault are proposed for interleaved flyback converters of a micro-inverter system. First, based on the topology of a grid-connected micro-inverter, a mathematical model of the flyback converters is established. Second, a state observer is applied to estimate the currents online and generate corresponding residuals. The fault is diagnosed by comparing the residuals with the thresholds. Finally, a fault-tolerant control that consists of a fault-tolerant topology for the faulty switch and a simple software redundancy control for the faulty current sensor, is proposed to achieve a fault-tolerant operation. The feasibility and effectiveness of the proposed method has been verified by simulation and experimental results.
文摘This paper describes the geometric and statistical properties of areal object under randomness. In order to describe formally such a uncertain topological relation, a new formal model (i.e. 4ID model) is proposed. On the basis of this, the effects of positional uncertainty on topological relations between areal objects are investigated in detail. Some possibility functions for the determination of relations are constructed based on the assumption that randomness of point location complies with a normal distribution, and the concept of uncertain sets of topological relations under randomness is introduced.
基金Supported in part by Chinese National Natural Science Foundation under Grant Nos. 60774016 60875039+2 种基金 60904022 60805039the Science Foundation of Education Office of Shandong Province of China under Grant No. J08LJ01
文摘In this paper, the relations of the network topology and the moving consensus of multi-agent systems are studied. A consensus-prestissimo scale-free network model with the static preferential-consensus attachment is presented on the rewired link of the regular network. The effects of the static preferential-consensus BA network on the algebraic connectivity of the topology graph are compared with the regular network. The robustness gain to delay is analyzed for variable network topology with the same scale. The time to reach the consensus is studied for the dynamic network with and without communication delays. By applying the computer simulations, it is validated that the speed of the convergence of multi-agent systems can be greatly improved in the preferential-consensus BA network model with different configuration.
