BACKGROUND The increased expression of G3BP1 was positively correlated with the prognosis of liver failure.AIM To investigate the effect of G3BP1 on the prognosis of acute liver failure(ALF)and acute-on-chronic liver ...BACKGROUND The increased expression of G3BP1 was positively correlated with the prognosis of liver failure.AIM To investigate the effect of G3BP1 on the prognosis of acute liver failure(ALF)and acute-on-chronic liver failure(ACLF)after the treatment of artificial liver support system(ALSS).METHODS A total of 244 patients with ALF and ACLF were enrolled in this study.The levels of G3BP1 on admission and at discharge were detected.The validation set of 514 patients was collected to verify the predicted effect of G3BP1 and the viability of prognosis.RESULTS This study was shown that lactate dehydrogenase(LDH),alpha-fetoprotein(AFP)and prothrombin time were closely related to the prognosis of patients.After the ALSS treatment,the patient’amount of decreased G3BP1 index in difference of G3BP1 between the value of discharge and admission(difG3BP1)<0 group had a nearly 10-fold increased risk of progression compared with the amount of increased G3BP1 index.The subgroup analysis showed that the difG3BP1<0 group had a higher risk of progression,regardless of model for end-stage liver disease high-risk or low-risk group.At the same time,compared with the inflam matory marks[tumor necrosis factor-α,interleukin(IL)-1βand IL-18],G3BP1 had higher discrimination and was more stable in the model analysis and validation set.When combined with AFP and LDH,concordance index was respectively 0.84 and 0.8 in training and validation cohorts.CONCLUSION This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with ALSS.The combination of G3BP1,AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients.展开更多
Silica-supported tin chloride and titanium tetrachloride were prepared by the reaction of tin chloride and titanium tetrachloride with activated silica gel in refluxing toluene.These solid acids have been employed as ...Silica-supported tin chloride and titanium tetrachloride were prepared by the reaction of tin chloride and titanium tetrachloride with activated silica gel in refluxing toluene.These solid acids have been employed as the catalysts for the synthesis of bisdihydropyrimidin -2(1H)-ones from aromatic dialdehydes,1,3-dicarbonyl compounds and urea at 90℃under solvent-free conditions.展开更多
An expert decision support system (EDSS) for multi-bins balance and contro1 of orequality in production ore bins of some large-scale open pit iron mine in China has been developed byexpert svitem tool software VP-EXPE...An expert decision support system (EDSS) for multi-bins balance and contro1 of orequality in production ore bins of some large-scale open pit iron mine in China has been developed byexpert svitem tool software VP-EXPERT and integration software LOTUS 1-2-3 in this paper. Itis known by practicing that a medium-scale EDSS constructed on microcomputer is completcly, feaasible by means of VP-EXEPERT to construct knowledge base system (KBS), LOTUS 1-2-3 tomake decision support system (DSS) and link them with BAT.展开更多
Highly active solid superacid catalysts for n-butane isomerization, SZ/A1_2O_3-P, were prepared by supporting SO-(4-2)/ZrO2, (SZ) on y-A1_2O_3 carrier using a precipitation method. The activities of some catalysts wer...Highly active solid superacid catalysts for n-butane isomerization, SZ/A1_2O_3-P, were prepared by supporting SO-(4-2)/ZrO2, (SZ) on y-A1_2O_3 carrier using a precipitation method. The activities of some catalysts were enhanced significantly j The activity of the most active sample. 60%SZ/Al_2O3-P, was even about 2 times more active than that of the SZ catalyst.展开更多
Chromium acetylacetonate and bis(diphenylphosphino)isopropylamine were coordinated in situ and supported on methylaluminoxane-modified silica. The catalyst structure and effects of reaction temperature, reaction press...Chromium acetylacetonate and bis(diphenylphosphino)isopropylamine were coordinated in situ and supported on methylaluminoxane-modified silica. The catalyst structure and effects of reaction temperature, reaction pressure and Al/Cr molar ratio on ethylene tetramerization were investigated in detail. Chromium was uniformly and firmly immobilized on the support and could not be leached off by methylaluminoxane. The supported catalyst, upon being activated with methylaluminoxane, exhibited catalytic activity of 1.70×107 g/(mol Cr·h) for ethylene tetramerization to form 1-octene at a reaction temperatures of 80 ℃, a pressure of 2.0 MPa and an Al/Cr molar ratio of 300. The supported catalyst presented a good tolerance to high temperature.展开更多
Reaction products of 2,4,6-tris(4-phenyl-phenoxy)-1,3,5-triazine derived from 4-phenylphenol cyanate ester and phenyl glycidyl ether were analyzed. In addition to an isocyanurate compound and an oxazolidone compound w...Reaction products of 2,4,6-tris(4-phenyl-phenoxy)-1,3,5-triazine derived from 4-phenylphenol cyanate ester and phenyl glycidyl ether were analyzed. In addition to an isocyanurate compound and an oxazolidone compound which were well known as reaction products of cyanate esters and epoxy resins, compounds with hybrid ring structure of cyanurate/isocyanurate were determined. Gibbs free energies of the compound having hybrid ring structure of cyanurate/isocyanurate with two isocyanurate moiety were found to be lower than that of the compound with cyanurate ring structure through calculations. Calculation data supported the existence of hybrid ring structure of cy-anurate/isocyanurate. It was revealed that isomerization from cyanurate to isocyanurate occurs via hybrid ring structure of cyanurate/isocyanurate in the reaction of aryl cyanurate and epoxy.展开更多
目的:了解国内疾控系统生物安全三级实验室(以下简称“BSL-3实验室”)关键生物安全防护设备的使用现况,为推进国内高等级生物安全实验室关键生物安全防护设备的研发与应用提供参考。方法:利用中国疾控中心流行病学动态数据采集(epidemio...目的:了解国内疾控系统生物安全三级实验室(以下简称“BSL-3实验室”)关键生物安全防护设备的使用现况,为推进国内高等级生物安全实验室关键生物安全防护设备的研发与应用提供参考。方法:利用中国疾控中心流行病学动态数据采集(epidemiological dynamic data collection,EDDC)平台在网上填报、收集信息,运用描述性研究的方法分析生物安全柜、气(汽)体消毒装置、压力蒸汽灭菌器和生物安全型高效空气过滤装置4种设备的品牌、国产/进口占比、使用类型、价格等现况。结果:国内疾控系统BSL-3实验室中生物安全柜、气(汽)体消毒装置和压力蒸汽灭菌器的进口率高于国产率,生物安全型高效空气过滤装置国产化程度较高,各类设备的品牌呈多样化。结论:建议国家和地方管理部门加大对国产产品的扶持力度,鼓励相关企业自主研发实验室关键生物安全防护设备,提升国内实验室设施、设备技术质量,实现由进口为主向自主保障的转变。展开更多
文摘BACKGROUND The increased expression of G3BP1 was positively correlated with the prognosis of liver failure.AIM To investigate the effect of G3BP1 on the prognosis of acute liver failure(ALF)and acute-on-chronic liver failure(ACLF)after the treatment of artificial liver support system(ALSS).METHODS A total of 244 patients with ALF and ACLF were enrolled in this study.The levels of G3BP1 on admission and at discharge were detected.The validation set of 514 patients was collected to verify the predicted effect of G3BP1 and the viability of prognosis.RESULTS This study was shown that lactate dehydrogenase(LDH),alpha-fetoprotein(AFP)and prothrombin time were closely related to the prognosis of patients.After the ALSS treatment,the patient’amount of decreased G3BP1 index in difference of G3BP1 between the value of discharge and admission(difG3BP1)<0 group had a nearly 10-fold increased risk of progression compared with the amount of increased G3BP1 index.The subgroup analysis showed that the difG3BP1<0 group had a higher risk of progression,regardless of model for end-stage liver disease high-risk or low-risk group.At the same time,compared with the inflam matory marks[tumor necrosis factor-α,interleukin(IL)-1βand IL-18],G3BP1 had higher discrimination and was more stable in the model analysis and validation set.When combined with AFP and LDH,concordance index was respectively 0.84 and 0.8 in training and validation cohorts.CONCLUSION This study indicated that G3BP1 could predict the prognosis of ALF or ACLF patients treated with ALSS.The combination of G3BP1,AFP and LDH could accurately evaluate the disease condition and predict the clinical endpoint of patients.
文摘Silica-supported tin chloride and titanium tetrachloride were prepared by the reaction of tin chloride and titanium tetrachloride with activated silica gel in refluxing toluene.These solid acids have been employed as the catalysts for the synthesis of bisdihydropyrimidin -2(1H)-ones from aromatic dialdehydes,1,3-dicarbonyl compounds and urea at 90℃under solvent-free conditions.
文摘An expert decision support system (EDSS) for multi-bins balance and contro1 of orequality in production ore bins of some large-scale open pit iron mine in China has been developed byexpert svitem tool software VP-EXPERT and integration software LOTUS 1-2-3 in this paper. Itis known by practicing that a medium-scale EDSS constructed on microcomputer is completcly, feaasible by means of VP-EXEPERT to construct knowledge base system (KBS), LOTUS 1-2-3 tomake decision support system (DSS) and link them with BAT.
文摘Highly active solid superacid catalysts for n-butane isomerization, SZ/A1_2O_3-P, were prepared by supporting SO-(4-2)/ZrO2, (SZ) on y-A1_2O_3 carrier using a precipitation method. The activities of some catalysts were enhanced significantly j The activity of the most active sample. 60%SZ/Al_2O3-P, was even about 2 times more active than that of the SZ catalyst.
基金supported by the National Natural Science Foundation of China (U1162114)the PetroChina Innovation Foundation (2012D-5006-0501)+2 种基金the Tianjin Municipal Education Commission of China (20110505)the Natural Science Foundation of Tianjin (12JCQNJC06000)the Program for New Century Excellent Talents in University (NCET-07-0142)
文摘Chromium acetylacetonate and bis(diphenylphosphino)isopropylamine were coordinated in situ and supported on methylaluminoxane-modified silica. The catalyst structure and effects of reaction temperature, reaction pressure and Al/Cr molar ratio on ethylene tetramerization were investigated in detail. Chromium was uniformly and firmly immobilized on the support and could not be leached off by methylaluminoxane. The supported catalyst, upon being activated with methylaluminoxane, exhibited catalytic activity of 1.70×107 g/(mol Cr·h) for ethylene tetramerization to form 1-octene at a reaction temperatures of 80 ℃, a pressure of 2.0 MPa and an Al/Cr molar ratio of 300. The supported catalyst presented a good tolerance to high temperature.
文摘Reaction products of 2,4,6-tris(4-phenyl-phenoxy)-1,3,5-triazine derived from 4-phenylphenol cyanate ester and phenyl glycidyl ether were analyzed. In addition to an isocyanurate compound and an oxazolidone compound which were well known as reaction products of cyanate esters and epoxy resins, compounds with hybrid ring structure of cyanurate/isocyanurate were determined. Gibbs free energies of the compound having hybrid ring structure of cyanurate/isocyanurate with two isocyanurate moiety were found to be lower than that of the compound with cyanurate ring structure through calculations. Calculation data supported the existence of hybrid ring structure of cy-anurate/isocyanurate. It was revealed that isomerization from cyanurate to isocyanurate occurs via hybrid ring structure of cyanurate/isocyanurate in the reaction of aryl cyanurate and epoxy.
文摘目的:了解国内疾控系统生物安全三级实验室(以下简称“BSL-3实验室”)关键生物安全防护设备的使用现况,为推进国内高等级生物安全实验室关键生物安全防护设备的研发与应用提供参考。方法:利用中国疾控中心流行病学动态数据采集(epidemiological dynamic data collection,EDDC)平台在网上填报、收集信息,运用描述性研究的方法分析生物安全柜、气(汽)体消毒装置、压力蒸汽灭菌器和生物安全型高效空气过滤装置4种设备的品牌、国产/进口占比、使用类型、价格等现况。结果:国内疾控系统BSL-3实验室中生物安全柜、气(汽)体消毒装置和压力蒸汽灭菌器的进口率高于国产率,生物安全型高效空气过滤装置国产化程度较高,各类设备的品牌呈多样化。结论:建议国家和地方管理部门加大对国产产品的扶持力度,鼓励相关企业自主研发实验室关键生物安全防护设备,提升国内实验室设施、设备技术质量,实现由进口为主向自主保障的转变。
