The changes of development and utilization of karst groundwater in Sangu Spring Basin have made the original groundwater resource evaluation unable to meet the needs of future economic development.Based on analysis of...The changes of development and utilization of karst groundwater in Sangu Spring Basin have made the original groundwater resource evaluation unable to meet the needs of future economic development.Based on analysis of existing data,combined with the characteristics of supplement,runoff and draining of regional karst groundwater,the Visual Modelflow software was used to build a numerical simulation model of Sangu spring Basin.The amount of karst groundwater resource and groundwater environment of the Basin were evaluated under different exploitation schemes,and the changes of karst groundwater environment in the future ten years were also predicted.The fitting error which is less than 0.5 m between the calculated value and measured value of the water level in the fitted borehole accounts for 93%.For the lithologically and structurally complex Sangu Spring Basin,the fitting effect of numerical simulation model was ideal.On the basis of the current mining amount of 111.80 million m3/a,the total redistributed exploited amount in the spring region was 61.79 million m3/a.Under the condition that the quantity of recoverable resources reached 173.59 million m3/a and under different precipitation schemes,all constraint conditions were satisfied,such as regional water level drawdown,maximum allowable water level drawdown in every simulated water source area and the flow rate of Guobi Spring.The results will provide a scientific basis for the rational development and utilization of karst groundwater in Sangu Spring Basin.展开更多
Objective:To study the mechanism of"Sangu Decoction"in the treatment of bone metastatic carcinoma by network pharmacology.Methods:TCMSP,TCMID and TCM Database@Taiwan databases and literature search were used...Objective:To study the mechanism of"Sangu Decoction"in the treatment of bone metastatic carcinoma by network pharmacology.Methods:TCMSP,TCMID and TCM Database@Taiwan databases and literature search were used to screen the main effective components of drugs.Swiss Target and TCMSP databases were used to search the potential therapeutic targets of"Sangu Decoction".DisGeNet and Drugbank databases were used to search the genes of bone metastatic carcinoma.Drug action targets and disease genes were mapped.Cytoscape 3.8.1 software was used to visualize and screen out the core genes.GO and KEGG pathway analysis was performed on potential therapeutic targets.Results:There were 29 main active ingredients in"Sangu Decoction",which contained 413 target proteins.There are 773 disease targets of bone metastatic carcinoma,of which 112 are potential targets of"Sangu Decoction"for the treatment of bone metastatic carcinoma.Through GO and KEGG pathway analysis,it was found that"Sangu Decoction"exerted anti-cancer,inhibiting bone metastasis and immune regulation mechanism through TNF,ErbB,FoxO,PI3K-Akt,Toll-like Receptor,NOD-like Receptor,Rap1 and other signaling pathways in the treatment of bone metastatic carcinoma.The key genes of"Sangu Decoction"in treating bone metastatic carcinoma are VEGFA,AKT1,IL6,TP53,MAPK3,SRC,EGFR and CASP3 and so on.Conclusion:In this study,we constructed a a multi-level interaction"traditional Chinese medicine-compound-target-pathway"network through network pharmacology,and found that the mechanism of"Sangu Decoction"in the treatment of bone metastasis cancer involves multiple targets and pathways,which may be related to anti-cancer,inhibition of bone metastasis,regulation of immunity and so on.展开更多
基金This work was supported by the Fundamental Research Funds for the Chinese Academy of Geosciences(No.JYYWF20180401)the China Geological Survey project(No.DD20160296,DD20201123).
文摘The changes of development and utilization of karst groundwater in Sangu Spring Basin have made the original groundwater resource evaluation unable to meet the needs of future economic development.Based on analysis of existing data,combined with the characteristics of supplement,runoff and draining of regional karst groundwater,the Visual Modelflow software was used to build a numerical simulation model of Sangu spring Basin.The amount of karst groundwater resource and groundwater environment of the Basin were evaluated under different exploitation schemes,and the changes of karst groundwater environment in the future ten years were also predicted.The fitting error which is less than 0.5 m between the calculated value and measured value of the water level in the fitted borehole accounts for 93%.For the lithologically and structurally complex Sangu Spring Basin,the fitting effect of numerical simulation model was ideal.On the basis of the current mining amount of 111.80 million m3/a,the total redistributed exploited amount in the spring region was 61.79 million m3/a.Under the condition that the quantity of recoverable resources reached 173.59 million m3/a and under different precipitation schemes,all constraint conditions were satisfied,such as regional water level drawdown,maximum allowable water level drawdown in every simulated water source area and the flow rate of Guobi Spring.The results will provide a scientific basis for the rational development and utilization of karst groundwater in Sangu Spring Basin.
基金General Program of National Natural Science Foundation of China(No.81973640)。
文摘Objective:To study the mechanism of"Sangu Decoction"in the treatment of bone metastatic carcinoma by network pharmacology.Methods:TCMSP,TCMID and TCM Database@Taiwan databases and literature search were used to screen the main effective components of drugs.Swiss Target and TCMSP databases were used to search the potential therapeutic targets of"Sangu Decoction".DisGeNet and Drugbank databases were used to search the genes of bone metastatic carcinoma.Drug action targets and disease genes were mapped.Cytoscape 3.8.1 software was used to visualize and screen out the core genes.GO and KEGG pathway analysis was performed on potential therapeutic targets.Results:There were 29 main active ingredients in"Sangu Decoction",which contained 413 target proteins.There are 773 disease targets of bone metastatic carcinoma,of which 112 are potential targets of"Sangu Decoction"for the treatment of bone metastatic carcinoma.Through GO and KEGG pathway analysis,it was found that"Sangu Decoction"exerted anti-cancer,inhibiting bone metastasis and immune regulation mechanism through TNF,ErbB,FoxO,PI3K-Akt,Toll-like Receptor,NOD-like Receptor,Rap1 and other signaling pathways in the treatment of bone metastatic carcinoma.The key genes of"Sangu Decoction"in treating bone metastatic carcinoma are VEGFA,AKT1,IL6,TP53,MAPK3,SRC,EGFR and CASP3 and so on.Conclusion:In this study,we constructed a a multi-level interaction"traditional Chinese medicine-compound-target-pathway"network through network pharmacology,and found that the mechanism of"Sangu Decoction"in the treatment of bone metastasis cancer involves multiple targets and pathways,which may be related to anti-cancer,inhibition of bone metastasis,regulation of immunity and so on.
