Real-time prediction of mechanical behaviors of underwater shield tunnel structure using machine learning method based on structural health monitoring data

Predicting the mechanical behaviors of structure and perceiving the anomalies in advance are essential to ensuring the safe operation of infrastructures in the long run.In addition to the incomplete consideration of influencing factors,the prediction time scale of existing studies is rough.Therefore,this study focuses on the development of a real-time prediction model by coupling the spatio-temporal correlation with external load through autoencoder network(ATENet)based on structural health monitoring(SHM)data.An autoencoder mechanism is performed to acquire the high-level representation of raw monitoring data at different spatial positions,and the recurrent neural network is applied to understanding the temporal correlation from the time series.Then,the obtained temporal-spatial information is coupled with dynamic loads through a fully connected layer to predict structural performance in next 12 h.As a case study,the proposed model is formulated on the SHM data collected from a representative underwater shield tunnel.The robustness study is carried out to verify the reliability and the prediction capability of the proposed model.Finally,the ATENet model is compared with some typical models,and the results indicate that it has the best performance.ATENet model is of great value to predict the realtime evolution trend of tunnel structure.

Genome-wide identification,characterization and functional prediction of the SRS gene family in sesame(Sesamum indicum L.)

Sesame(Sesamum indicum L.)is an ancient oilseed crop of the Pedaliaceae family with high oil content and potential health benefits.SHI RELATED SEQUENCE(SRS)proteins are the transcription factors(TFs)specific to plants that contain RING-like zinc finger domain and are associated with the regulation of several physiological and biochemical processes.They also play vital roles in plant growth and development such as root formation,leaf development,floral development,hormone biosynthesis,signal transduction,and biotic and abiotic stress responses.Nevertheless,the SRS gene family was not reported in sesame yet.In this study,identification,molecular characterization,phylogenetic relationship,cis-acting regulatory elements,protein-protein interaction,syntenic relationship,duplication events and expression pattern of SRS genes were analyzed in S.indicum.We identified total six SiSRS genes on seven different linkage groups in the S.indicum genome by comparing with the other species,including the model plant Arabidopsis thaliana.The SiSRS genes showed variation in their structure like2–5 exons and 1–4 introns.Like other species,SiSRS proteins also contained‘RING-like zinc finger'and‘LRP1'domains.Then,the SiSRS genes were clustered into subclasses via phylogenetic analysis with proteins of S.indicum,A.thaliana,and some other plant species.The cis-acting regulatory elements analysis revealed that the promoter region of SiSRS4(SIN_1011561)showed the highest 13 and 16 elements for light-and phytohormone-responses whereas,SiSRS1(SIN_1015187)showed the highest 15 elements for stress-response.The ABREs,or ABA-responsive elements,were found in a maximum of 8 copies in the SiSRS3(SIN 1009100).Moreover,the available RNA-seq based expression of SiSRS genes revealed variation in expression patterns between stress-treated and non-treated samples,especially in drought and salinity conditions in.S.indicum.Two SiSRS genes like SiSRS1(SIN_1015187)and SiSRS5(SIN_1021065),also exhibited variable expression patterns between control vs PEG-treated sesame root samples and three SiSRS genes,including SiSRS1(SIN_1015187),SiSRS2(SIN_1003328)and SiSRS5(SIN_1021065)were responsive to salinity treatments.The present outcomes will encourage more research into the gene expression and functionality analysis of SiSRS genes in S.indicum and other related species.

An Overview of the Achievements of Modern Research on the Flying Shadow Pavilion Pictorial

The current academic research on the Dian Shi Zhai Pictorial founded in 1884 has been perfected,but there is very little research on the Flying Shadow Pavilion Pictorial,which can be said to be derived from Dian Shi Zhai Pictorial terms of both content and form,and which was founded by the Haiist painter Wu Youru in 1890 in order to reward the increasing number of admirers,but it is still in the initial stage.Flying Shadow Pavilion Pictorial consisted of four parts:pictures of ladies in Shanghai costumes,news about current affairs,pictures of animals,and compilations of women,each of which was accompanied by the then popular notebooks,which were popular at the time among the then readers because of the matching of pictures with text and the mixing of narratives and discussions.This paper takes Flying Shadow Pavilion Pictorial as the main object,summarizes the existing literature about Flying Shadow Pavilion Pictorial,points out the deficiencies of the current research on this basis,and points out the development trend of Flying Shadow Pavilion Pictorial in the future research.

Determination of 13 Trace Elements in Anshun Thorn Pear (Rosa roxburghii) and Golden Thorn Pear (Rosa sterilis S.D.Shi) by ICP-MS

[Objectives] This study was conducted to establish an analytical method for the establishment of 13 trace elements in Anshun thorn pear(Rosa roxburghii) and golden thorn pear(Rosa sterilis S. D. Shi). [Methods] Nitric acid was used as the digestion system for microwave digestion. Inductively coupled plasma mass spectrometry(ICP-MS) was used to determine the trace elements in thorn pear and golden thorn pear. [Results] Be, Ti, V, Cr, Mn, Co, Ni, As, Sr, Mo, Cd, Sb and Hg were determined by ICP-MS method in thorn pear and golden thorn pear. The correlation coefficients of the regression equations of the elements were higher than 0.996; the precision RSD was lower than 2.87%; and the recovery ranged from 94.3% to 109.8%. [Conclusions] The method has the advantages of high sensitivity, good accuracy and simultaneous detection of multiple elements, and provides a reference method and theoretical basis for determining trace elements in thorn pear and golden thorn pear and other fruits.

A Network Pharmacology Study on the Effects of Ma Xing Shi Gan Decoction on Influenza

Objective Pharmacological methods were used to screen targets and signaling pathways of Ma Xing Shi Gan Decoction(MXSGD)during influenza treatments,and mechanisms underlying antiinfluenza effects were elucidated.Methods The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and relevant literature were searched under predefined conditions to identify the main compounds and their targets.Interactions between the target proteins were predicted using the STRING database.Gene Ontology(GO)functional enrichment analyses and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analyses were performed on the core targets involved in the influenza protein-protein interaction(PPI)network,using WebGestalt and the reactome database.iGEMDOCK was used for molecular docking of receptors and ligands to produce docking scores,and the results were visualized using Autodock and PyMOL.Results In total,126 major compounds and their respective targets were screened.355 influenza target proteins and 1221 influenza protein interactions were predicted using the STRING database.Influenza-related signaling pathways were strongly enriched in pharmacodynamic targets of MXSGD such as cytokine signaling in immune system and signaling by interleukin.The main biological process was response to the stimulates.Molecular docking results showed that RELALicochalcone A docking elicited by MXSGD,was superior to that of other target proteins and active compounds,suggesting that the docking site is also the main effector site of MXSGD during influenza treatments.Conclusions The results showed that MXSGD exerts antiinfluenza effects by interfering with virus adsorption,inhibiting virus proliferation,influencing immune functions and protecting host cells,which may prevent inflammation-induced tissue damage.

Systematic Pharmacological Strategies to Explore the Regulatory Mechanism of Ma Xing Shi Gan Decoction on COVID-19

Objective To use systematic pharmacological strategies to explore the regulatory mechanisms of Ma Xing Shi Gan Decoction(MXSGD)against the coronavirus disease 2019(COVID-19).Methods Data on the compounds and targets of MXSGD were collected from the Traditional Chinese Medicene Systems Parmacology Database and Analysis Platform(TCMSP)and TCM Databases@Taiwan.Data on ACE2-related targets and the protein-protein interaction(PPI)were collected from the String database.The Cytoscape 3.7.2 was used to construct and analyze the networks.The DAVID platform was used for Gene Ontology(GO)and pathway enrichment analyses.Results Data on 272 MXSGD targets and 21 SARS-CoV-2 potential targets were collected.Four networks were constructed and analyzed based on the data:(1)compound-target network of MXSGD;(2)MXSGD-SARS-CoV-2-PPI network;(3)cluster of MXSGD-SARS-CoV-2-PPI network;(4)Herb-Pathway-Target network.The core targets included AKT1,MAPK3,IL-6,TP53,VEGFA,TNF,CASP3,EGFR,EGF and MAPK1.The antiviral biological processes were inflammatory responses(inflammatory cells,inflammatory cytokines and their signaling pathways),immune responses(T cells,monocytes,B cells and other immune cells),immune factors(IFN-γ,TNF-αand so on),virus defense,humoral immunity and mucosal innate immune response.The antivirus-related signaling pathways included TNF,NOD-like receptor,FoxO,PI3K-AKT and Toll-like receptor signaling pathways.Conclusions MXSGD can control disease progression by regulating multiple compounds and targets;it can reduce inflammation and balance immunity by regulating several proteins that interact with ACE2 and signaling pathways closely related to disease development.

Review: Hu Houxuan, "Xia and the Tu State in the Oracle Inscriptions: A Consideration" Gudai Chengbang Shi Yanjiu (Studies on Ancient City States) Renmin Press, 1989, Pp. 340-353.

This article verified that the Tu state mentioned in the oracle inscriptions was the Xia people after the Xia Dynasty had been conquered by Tang, the first king of the Shang Dynasty m c.a. 16th century B.C. The state of Xia, which originated from Yu, was entitled "Xia Hou"; its king was hence called "Xia Hou Di" (Emperor of Xia Hou), e.g."Xia Hou Di Qi". The Xia people, together with the Yin (Shang) people, and the Zhou people, were the so-called "people of San Dai" (Three Dynasties). As mentioned in "Lunyu, Bayi", they founded the states, with the Xia people being associated with the pine, the Yin people with the cypress, and the Zhou people with the chestnut.

Shi Mingxian──Academician of the Chinese Academy of Engineering

ＳｈｉＭｉｎｇｘｉａｎ──ＡｃａｄｅｍｉｃｉａｎｏｆｔｈｅＣｈｉｎｅｓｅＡｃａｄｅｍｙｏｆＥｎｇｉｎｅｅｒｉｎｇＳｈｉＭｉｎｇｘｉａｎｗａｓｂｏｒｎｉｎＣｈａｎｇｓｈｕ，Ｊｉａｎｇｓｈｕｐｒｏｖｉｎｃｅｉｎ１９３３，ａｎｄｇｒａｄｕａｔｅｄａｓａｐｏ...

海水网箱养殖高体Shi弧菌病致病菌研究

从患病高体Ｓｈｉ病灶上分离到７株可疑致病菌，人工感染试验证明，菌株９５－５－３和９５－５－５为强毒菌株，这２株菌进行人工感染，死亡率均为１００％，症状与自然发病相似。这２株菌的特征一致，根据形态有主生理生化特征，应归入哈维氏弧菌。药敏实验的结果表明，磺胺类药物和先锋必素对致病菌有较强的抑制作用。

一种探测shill出价的数据挖掘模型

随着网上拍卖规模的不断扩大,作为最具隐蔽性的在线欺诈形式,shill出价开始引起人们的广泛关注,但由于传统拍卖理论缺乏对shill出价理论的研究,致使至今仍无有效的方法制约shill出价。本文通过引入生物信息学方法,模拟生物基因的遗传变异特性,在基于shill出价规律序列具有遗传变异的基础上,提出了一种探测shill出价规律序列的数据挖掘模型,模型克服了传统方法因shill可能频繁变更用户ID而失灵的问题。

硼替佐米对急性单核细胞白血病细胞株SHI-1诱导凋亡作用及其对Bcl2l12、Bcl-2和Bax基因表达影响

本研究探讨蛋白酶抑制剂硼替佐米对急性单核细胞白血病细胞株SHI-1增殖和凋亡的影响及Bcl2l12、Bcl-2和Bax基因在其中的作用。用MTT比色法观察硼替佐米对SHI-1细胞的生长抑制作用,用Annexin-V标记、线粒体跨膜电位(Δψm)和DNA凝胶电泳分析细胞凋亡,用RT-PCR方法检测0、6,12和24小时Bcl2l12、Bcl-2和Bax基因表达。结果表明,硼替佐米呈时间和剂量依赖性抑制SHI-1细胞生长,24小时和48小时半数抑制浓度分别为54.13 nmol/L和5.45 nmol/L;硼替佐米能够诱导SHI-1细胞凋亡,在6小时Annexin-V阳性细胞就开始增高并呈时间依赖性,Δψm减低,形态学可见明显细胞核凝聚、固缩和碎裂,DNA凝胶电泳显示DNA片段化;RT-PCR显示,Bcl2l12表达增高,Bcl-2表达减低,但Bax表达无明显改变。结论:硼替佐米抑制SHI-1细胞增殖,并可能通过上调Bcl2l12基因和下调Bcl-2基因,使线粒体膜电位下降而促使SHI-1细胞发生凋亡。

1,25-(OH)_2 D_3对白血病细胞株K562和SHI-1 ppGalNAcTs表达的影响

目的:探讨在维生素D3的作用下,白血病细胞株K562与SHI-1ppGalNAcTs表达的变化。方法:应用RT-PCR法研究在不同浓度维生素D3的作用下,白血病细胞株K562与SHI-1ppGalNAcTs表达的变化。结果1,25-(OH)2D3(10-6-10-8mol/L)可分别上调K562细胞株ppGalNAcT2、T4、T5的表达。但在SHI-I细胞株,随着1,25-(OH)2D3浓度的增加ppGalNAcTI表达增加,T3表达没有变化、T4表达减少。结论:白血病细胞株K562与SHI-1PP-GMNAcTs的表达不同。在不同浓度维生素D3的作用下,白血病细胞株K562与SHI-IppGalNAcTs表达的变化也不同,说明不同ppGalNAcTs对1,25-(OH)2D3的反应不同。

基于语料库的聋生“是……的”句(二)偏误分析

目的基于自建语料库对聋生“是……的”句(二)偏误表现和原因进行分析。方法对北京市67名3~9年级聋生自然产出的“是……的”(二)汉语语料进行搜集、整理、标注与统计分析。结果聋生“是……的”句(二)偏误类型依次为内部偏误(93.51%)、不该用而用(5.19%)、该用未用(1.30%);7~9年级输出率逐级增加,但偏误率较高;手语优势聋生输出率(0.08%)和偏误率(60.20%)均高于口语优势聋生(0.03%/42.86%),手口均差的聋生输出率最低(0.00%)。结论聋生“是……的”句(二)习得水平的影响因素有听力障碍、教学不足、句法和功能表达掌握难度、手语和汉语差异等。建议针对句式特点与难点、不同语言类型学生进行教学。

拟南芥SHI基因在烟草中的表达和矮化、延迟开花的烟草植株的获得

利用聚合酶链式反应(PCR)从拟南芥基因组DNA中克隆了拟南芥SHOTINTERNODS(SHI)基因,并进行了序列测定.以载体pBI121为基本骨架构建了SHI的植物表达载体,并导入根癌农杆菌EHA105.通过农杆菌介导的叶盘法将拟南芥SHI基因转入烟草.PCR和RT-PCR检测证明,拟南芥SHI基因已整合到烟草基因组中并得以表达,获得了矮化、延迟开花的烟草植株.

杜氏Shi链球菌病及其他常见病害防治的研究

本文报道网箱养殖杜氏Ｓｈｉ链球菌及其他常见病害的防治。链球菌病的防治：鱼种阶段在饲料中加入氨苄青霉素７．５ｇ／１０００尾／ｄ，每个疗程５－７ｄ，隔７－１０ｄ进行下一次疗程，使用４个疗程，９０ｄ内不发病；成鱼采用肌肉注射青霉素Ｇ，剂量为；体重４００－５００ｇ注射２０－４０万ＩＵ／尾，体重５００－１０００ｇ注射４０－８０万ＩＵ／尾、体重１０００ｇ以上注射８０万ＩＵ／尾１－３次。

Na_2Cu_5Shi_4·4H_2O配合物的合成、结构及性质研究

合成了Na2 Cu5Shi4 ·4H2 O配合物 ,经元素分析 ,IR ,UV ,NMR ,荧光及分子力学计算等表征了配合物的结构。 2D1 HNMR谱及磁矩等测定表明 ,配合物中水杨酰肟酸π电子分布有大的改变 ,最大吸收峰红移 2 5nm ,芳环d质子表现出烷烃质子性质 ;铜离子之间有强的磁相互作用 ,基态S为 1/2。

Shi鱼养殖技术浅谈

介绍了Ｓｈｉ鱼的生物学特征；并从养殖场地的选择，养殖设备的选择，苗种的培育以及Ｓｈｉ鱼的养成等几个方面介绍了Ｓｈｉ鱼的养殖技术，最后分析了Ｓｈｉ鱼养殖在我国的发展前景。

京津冀地区方言应答语“还是的”研究

基于事件信息类型理论,对京津冀地区口语中使用的应答语“还是的”展开研究。一方面,根据语境以及听说双方掌握信息的差异,阐明“还是的”具有“迂回争辩”“婉曲讽刺”“低位确认”三个方面的话语功能;另一方面,从韵律和话轮构建两个方面说明“还是的”的使用特征,旨在丰富方言中“还是的”的研究。