Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellu...Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.展开更多
Based on the brief introduction of western contemporary eco-philosophies and Lao Zi’s eco-philosophy,there will be an analysis of the differences according to historical context and critical target and their converge...Based on the brief introduction of western contemporary eco-philosophies and Lao Zi’s eco-philosophy,there will be an analysis of the differences according to historical context and critical target and their convergence.The analysis leads to the conclusion that eco-philosophies,whether contemporary or ancient,are against any form of domination and centrism.展开更多
Xing性is an important topic of ancient Chinese philosophy.The discovery of unearthed documents has deepened our understanding of xing.Xing Zi Ming Chu性自命出is probably the Guodian manuscript that has generated the m...Xing性is an important topic of ancient Chinese philosophy.The discovery of unearthed documents has deepened our understanding of xing.Xing Zi Ming Chu性自命出is probably the Guodian manuscript that has generated the most interest among scholars.This article takes Xing Zi Ming Chu and Xunzi as investigations to explore the significance of xing in the Warring States Period in China.This article believes that the xing in Xing Zi Ming Chu only refers to natural properties,and it is not as specific as Mencius and Xunzi to indicate whether it is good or bad.The article will first review the background of Guodian manuscript,introduce the basic situation of Confucian documents in Guodian manuscripts.This article will also introduce the meaning of xing in Xing Zi Ming Chu and Xunzi,which is of great value for us to understand the meaning of xing in the Warring States Period.展开更多
This review summarizes the process of the discovery,research,and development of a cardioactive component,mesaconine,from the lateral roots of Aconitum carmichaelii(“Fu Zi”).To date,pre-clinical showed that mesaconin...This review summarizes the process of the discovery,research,and development of a cardioactive component,mesaconine,from the lateral roots of Aconitum carmichaelii(“Fu Zi”).To date,pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency,low toxicity,and a new mechanism.展开更多
基金Hubei Chen Xiaoping Science and Technology Development Foundation Special Fund Project (No.CXPJJH12000002-2020010)Education Science Research Project,Beijing University of Chinese Medicine (No.XJY21056)Beijing University of Chinese Medicine New Teachers Start-up Fund Project (No.2022-BUCMXJKY010)。
文摘Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.
文摘Based on the brief introduction of western contemporary eco-philosophies and Lao Zi’s eco-philosophy,there will be an analysis of the differences according to historical context and critical target and their convergence.The analysis leads to the conclusion that eco-philosophies,whether contemporary or ancient,are against any form of domination and centrism.
基金supported by“The Fundamental Research Funds of Shandong University”.
文摘Xing性is an important topic of ancient Chinese philosophy.The discovery of unearthed documents has deepened our understanding of xing.Xing Zi Ming Chu性自命出is probably the Guodian manuscript that has generated the most interest among scholars.This article takes Xing Zi Ming Chu and Xunzi as investigations to explore the significance of xing in the Warring States Period in China.This article believes that the xing in Xing Zi Ming Chu only refers to natural properties,and it is not as specific as Mencius and Xunzi to indicate whether it is good or bad.The article will first review the background of Guodian manuscript,introduce the basic situation of Confucian documents in Guodian manuscripts.This article will also introduce the meaning of xing in Xing Zi Ming Chu and Xunzi,which is of great value for us to understand the meaning of xing in the Warring States Period.
基金Chemical Biology Program,Memorial Sloan Kettering Cancer Center,New York.USA。
文摘This review summarizes the process of the discovery,research,and development of a cardioactive component,mesaconine,from the lateral roots of Aconitum carmichaelii(“Fu Zi”).To date,pre-clinical showed that mesaconine is a novel type of cardiotonic lead drug with relatively high potency,low toxicity,and a new mechanism.
