The principle of ptychography is applied in known plain text attack on the double random phase encoding (DRPE) system. We find that with several pairs of plain texts and cipher texts, the model of attack on DRPE can...The principle of ptychography is applied in known plain text attack on the double random phase encoding (DRPE) system. We find that with several pairs of plain texts and cipher texts, the model of attack on DRPE can be converted to the model of ptyehographical imaging. Owing to the inherent merits of the ptyehographical imaging, the DRPE system can be breached totally in a fast and nearly perfect way, which is unavailable for currently existing attack methods. Further, since the decryption keys can be seen as an object to be imaged from the perspective of imaging, the ptychographical technique may be a kind of new direction to further analysis of the security of other encryption systems based on double random keys.展开更多
Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled a...Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups.Patients in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue tablet.After 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two groups.Results After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental group.Moreover,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.展开更多
In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is de...In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is deeper than anticipated, needle penetration may cause damage to nerves, arteries and veins. Few clinical studies were done to evaluate the depth of needle length insertion reaching the intended gluteal muscle. The aim of this study was to evaluate the suitable depth of injecting RLAI. Twenty-six patients with schizophrenia were treated with RLAI, and randomly divided into two groups: 50 mm needle inserted group (Group-D, deep insertion, n = 13) and 20 mm needle insertion group (Group-S, shallow insertion, n = 13). For Group-S, the needle length was marked with a spacer at exactly 20 mm. Injections were performed by the psychiatrist or nurse, alternating between the two gluteal sites by double-cross method every two weeks. Clinical psychotic symptoms and injection site reactions were recorded throughout the study period. Experienced psychologists who were blinded from the needle-length experimental variable evaluated patients’ psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS) every two weeks. The plasma 9-hydroxyrisperidone (9-OH-RIS) concentrations were measured every two weeks;comparison data were determined on the 8th week and the 14th week. No significant difference was observed in 9-OH-RIS concentrations, psychotic symptoms, injection site skin reactions of subjects in both groups. However, in Group-D, injection site adverse reactions were confirmed in two subjects (15%). In Group-S, injection site reactions were confirmed in six subjects (46%). Although effective 9-OH-RIS concentrations were obtained with the insertion using both depth, it was concluded that the 50 mm insertion length was more suitable for dorsogluteal IM injections in adult patients with schizophrenia as demonstrated by the incidence of local adverse skin reactions.展开更多
We proposed a three-dimensional (3D) image authentication method using binarized phase images in double random phase integral imaging (Ini). Two-dimensional (2D) element images obtained from Ini are encoded using a do...We proposed a three-dimensional (3D) image authentication method using binarized phase images in double random phase integral imaging (Ini). Two-dimensional (2D) element images obtained from Ini are encoded using a double random phase encryption (DRPE) algorithm. Only part of the phase information is used in the proposed method rather than using all of the amplitude and phase information, which can make the final data sparse and beneficial to data compression, storage, and transmission. Experimental results verified the method and successfully proved the developed 3D authentication process using a nonlinear cross correlation method.展开更多
Methods:ARTIC PC was a double-blind,randomised,placebo-controlled trial done at 56 general practices in England.Eligible children were those aged 6 months to 12 years presenting in primary care with acute uncomplicate...Methods:ARTIC PC was a double-blind,randomised,placebo-controlled trial done at 56 general practices in England.Eligible children were those aged 6 months to 12 years presenting in primary care with acute uncomplicated LRTI judged to be infective in origin,where pneumonia was not suspected clinically,with symptoms for less than 21 days.Patients were randomly assigned in a 1:1 ratio to receive amoxicillin 50 mg/kg per day or placebo oral suspension,in three divided doses orally for 7 days.Patients and investigators were masked to treatment assignment.The primary outcome was the duration of symptoms rated moderately bad or worse(measured using a validated diary)for up to 28 days or until symptoms resolved.The primary outcome and safety were assessed in the intention-to-treat population.The trial is registered with the ISRCTN Registry(ISRCTN79914298).展开更多
As an industry accepted storage scheme, hafnium oxide(HfO_x) based resistive random access memory(RRAM)should further improve its thermal stability and data retention for practical applications. We therefore fabri...As an industry accepted storage scheme, hafnium oxide(HfO_x) based resistive random access memory(RRAM)should further improve its thermal stability and data retention for practical applications. We therefore fabricated RRAMs with HfO_x/ZnO double-layer as the storage medium to study their thermal stability as well as data retention. The HfO_x/ZnO double-layer is capable of reversible bipolar switching under ultralow switching current(〈 3 μA) with a Schottky emission dominant conduction for the high resistance state and a Poole–Frenkel emission governed conduction for the low resistance state. Compared with a drastically increased switching current at 120℃ for the single HfO_x layer RRAM, the HfO_x/ZnO double-layer exhibits excellent thermal stability and maintains neglectful fluctuations in switching current at high temperatures(up to 180℃), which might be attributed to the increased Schottky barrier height to suppress current at high temperatures. Additionally, the HfO_x/ZnO double-layer exhibits 10-year data retention @85℃ that is helpful for the practical applications in RRAMs.展开更多
We study the average position and the symmetry of the distribution in the SU(2) open quantum random walk (OQRW). We show that the average position in the central limit theorem (CLT) is non-uniform compared with ...We study the average position and the symmetry of the distribution in the SU(2) open quantum random walk (OQRW). We show that the average position in the central limit theorem (CLT) is non-uniform compared with the average position in the non-CLT. The symmetry of distribution is shown to be even in the CLT.展开更多
In this paper, we extend the works by [1-5] accounting for autocorrelation both in the time specific effect as well as the remainder error term. Several transformations are proposed to circumvent the double autocorrel...In this paper, we extend the works by [1-5] accounting for autocorrelation both in the time specific effect as well as the remainder error term. Several transformations are proposed to circumvent the double autocorrelation problem in some specific cases. Estimation procedures are then derived.展开更多
A double-clamped piezoelectric energy harvester subjected to random excitation is presented,for which corresponding analytical model is established to predict its output characteristics.With the presented theoretical ...A double-clamped piezoelectric energy harvester subjected to random excitation is presented,for which corresponding analytical model is established to predict its output characteristics.With the presented theoretical natural frequency and equivalent stiffness of vibrator,the closed-form expressions of mean power and voltage acquired from the double-clamped piezoelectric energy harvester under random excitation are derived.Finally theoretical analysis is conducted for the output performance of the doubleclamped energy harvester with the change of spectrum density(SD)of acceleration,load resistance,piezoelectric coefficient and natural frequency value,which is found to closely agree with Monte Carlo simulation and experimental results.展开更多
Objective: In a randomized, double-blind, exploratory, active-controlled trial, the efficacy and safety of a patent-pending combination of Ginger and Goldenrod extracts (BDI-630) in alleviating cold symptoms in commun...Objective: In a randomized, double-blind, exploratory, active-controlled trial, the efficacy and safety of a patent-pending combination of Ginger and Goldenrod extracts (BDI-630) in alleviating cold symptoms in community-dwelling adults was compared to a combination of standardized amounts of Echinacea (EC) components. Methods: 44 healthy adults, experiencing new onset of cold symptoms were randomly assigned to receive either BDI-630 (900 mg) or EC (500 mg) twice daily for 10 days. The severity of cold symptoms and the quality of life was assessed by self-reporting of subjects using the Wisconsin Upper Respiratory Symptom Survey (WURSS-21? 2004). Results: The intent-to-treat population (ITT) consisted of 44 subjects (n = 22 for BDI-630;n = 22 for EC). The modified ITT (mITT) population consisted of 40 subjects, excluding four subjects with major protocol deviations related to inclusion/exclusion criteria and/or use of prohibited drugs from the efficacy analysis (n = 3 for BDI-630 and n = 1 for EC). Results indicated a sig-nificant difference between the two groups: the superiority of BDI-630 over EC was particularly noticeable between Day 1 and Day 7, as demonstrated by a 14-fold difference of the mean percentage of change of total score from baseline in the mITT population. Adverse events (AEs) following the intake of BDI-630 were mostly limited to mild gastrointestinal intolerance in less than 10% of the subjects. Conclusions: BDI-630 was shown to be more effective than EC in alleviating cold symptoms in the adult population, particularly during the first 7 days of treatment. BDI-630 was very well tolerated by all subjects.展开更多
Currently, open-source software is gradually being integrated into industrial software, while industry protocolsin industrial software are also gradually transferred to open-source community development. Industrial pr...Currently, open-source software is gradually being integrated into industrial software, while industry protocolsin industrial software are also gradually transferred to open-source community development. Industrial protocolstandardization organizations are confronted with fragmented and numerous code PR (Pull Request) and informalproposals, and differentworkflowswill lead to increased operating costs. The open-source community maintenanceteam needs software that is more intelligent to guide the identification and classification of these issues. To solvethe above problems, this paper proposes a PR review prediction model based on multi-dimensional features. Weextract 43 features of PR and divide them into five dimensions: contributor, reviewer, software project, PR, andsocial network of developers. The model integrates the above five-dimensional features, and a prediction model isbuilt based on a Random Forest Classifier to predict the review results of PR. On the other hand, to improve thequality of rejected PRs, we focus on problems raised in the review process and review comments of similar PRs.Wepropose a PR revision recommendation model based on the PR review knowledge graph. Entity information andrelationships between entities are extracted from text and code information of PRs, historical review comments,and related issues. PR revisions will be recommended to code contributors by graph-based similarity calculation.The experimental results illustrate that the above twomodels are effective and robust in PR review result predictionand PR revision recommendation.展开更多
基金Supported by the National Natural Science Foundation of China under Grant Nos 61575197 and 61307018the K.C.Wong Education Foundation,the President Fund of University of Chinese Academy of Sciencesthe Fusion Funds of Research and Education of Chinese Academy of Sciences
文摘The principle of ptychography is applied in known plain text attack on the double random phase encoding (DRPE) system. We find that with several pairs of plain texts and cipher texts, the model of attack on DRPE can be converted to the model of ptyehographical imaging. Owing to the inherent merits of the ptyehographical imaging, the DRPE system can be breached totally in a fast and nearly perfect way, which is unavailable for currently existing attack methods. Further, since the decryption keys can be seen as an object to be imaged from the perspective of imaging, the ptychographical technique may be a kind of new direction to further analysis of the security of other encryption systems based on double random keys.
基金financially supported by the National Natural Science Foundation of China(No.82170701).
文摘Objective This study aimed to analyze the clinical efficacy of the Jianpi Shengxue tablet for treating renal anemia.Methods A total of 200 patients with renal anemia from December 2020 to December 2022 were enrolled and randomly divided into two groups.Patients in the control group were treated with polysaccharide-iron complex,and those in the experimental group were administered Jianpi Shengxue tablet.After 8 weeks of continuous treatment,the therapeutic outcomes regarding anemia were compared between the two groups.Results After treatment,the red blood cell(RBC)count,hematocrit(HCT),reticulocyte percentage(RET),ferritin(SF),serum iron(SI),transferrin saturation(TSAT),and serum albumin(ALB)all increased(P<0.01),and the clinical symptom score and total iron binding capacity decreased(P<0.01)in the experimental group.Moreover,the improvements in RBC,HCT,RET,SF,SI,TAST,ALB,and clinical symptoms(fatigue,anorexia,dull skin complexion,numbness of hands and feet)in the experimental group were significantly greater than those in the control group(P<0.05).The total effective rate for treating renal anemia was significantly higher in the experimental group than in the control group(P<0.01).Conclusion The Jianpi Shengxue tablet demonstrates efficacy in treating renal anemia,leading to significant improvements in the laboratory examination results and clinical symptoms of patients with renal anemia.
文摘In some cases, if the insertion depth is shallower than expected, intramuscular (IM) injection of risperidone long-acting injectable (RLAI) may not penetrate the muscle fascia. However, if needle insertion depth is deeper than anticipated, needle penetration may cause damage to nerves, arteries and veins. Few clinical studies were done to evaluate the depth of needle length insertion reaching the intended gluteal muscle. The aim of this study was to evaluate the suitable depth of injecting RLAI. Twenty-six patients with schizophrenia were treated with RLAI, and randomly divided into two groups: 50 mm needle inserted group (Group-D, deep insertion, n = 13) and 20 mm needle insertion group (Group-S, shallow insertion, n = 13). For Group-S, the needle length was marked with a spacer at exactly 20 mm. Injections were performed by the psychiatrist or nurse, alternating between the two gluteal sites by double-cross method every two weeks. Clinical psychotic symptoms and injection site reactions were recorded throughout the study period. Experienced psychologists who were blinded from the needle-length experimental variable evaluated patients’ psychotic symptoms using the Positive and Negative Syndrome Scale (PANSS) every two weeks. The plasma 9-hydroxyrisperidone (9-OH-RIS) concentrations were measured every two weeks;comparison data were determined on the 8th week and the 14th week. No significant difference was observed in 9-OH-RIS concentrations, psychotic symptoms, injection site skin reactions of subjects in both groups. However, in Group-D, injection site adverse reactions were confirmed in two subjects (15%). In Group-S, injection site reactions were confirmed in six subjects (46%). Although effective 9-OH-RIS concentrations were obtained with the insertion using both depth, it was concluded that the 50 mm insertion length was more suitable for dorsogluteal IM injections in adult patients with schizophrenia as demonstrated by the incidence of local adverse skin reactions.
基金supported by the National Key Research and Development Program of China(No.2018YFB1005002)the National Natural Science Foundation of China(No.61727808)the National Research Foundation of Singapore(No.NRF-CRP11-2012-01)
文摘We proposed a three-dimensional (3D) image authentication method using binarized phase images in double random phase integral imaging (Ini). Two-dimensional (2D) element images obtained from Ini are encoded using a double random phase encryption (DRPE) algorithm. Only part of the phase information is used in the proposed method rather than using all of the amplitude and phase information, which can make the final data sparse and beneficial to data compression, storage, and transmission. Experimental results verified the method and successfully proved the developed 3D authentication process using a nonlinear cross correlation method.
文摘Methods:ARTIC PC was a double-blind,randomised,placebo-controlled trial done at 56 general practices in England.Eligible children were those aged 6 months to 12 years presenting in primary care with acute uncomplicated LRTI judged to be infective in origin,where pneumonia was not suspected clinically,with symptoms for less than 21 days.Patients were randomly assigned in a 1:1 ratio to receive amoxicillin 50 mg/kg per day or placebo oral suspension,in three divided doses orally for 7 days.Patients and investigators were masked to treatment assignment.The primary outcome was the duration of symptoms rated moderately bad or worse(measured using a validated diary)for up to 28 days or until symptoms resolved.The primary outcome and safety were assessed in the intention-to-treat population.The trial is registered with the ISRCTN Registry(ISRCTN79914298).
基金supported by the National Natural Science Foundation of China(Grant Nos.61006003 and 61674038)the Natural Science Foundation of Fujian Province,China(Grant Nos.2015J01249 and 2010J05134)+1 种基金the Science Foundation of Fujian Education Department of China(Grant No.JAT160073)the Science Foundation of Fujian Provincial Economic and Information Technology Commission of China(Grant No.83016006)
文摘As an industry accepted storage scheme, hafnium oxide(HfO_x) based resistive random access memory(RRAM)should further improve its thermal stability and data retention for practical applications. We therefore fabricated RRAMs with HfO_x/ZnO double-layer as the storage medium to study their thermal stability as well as data retention. The HfO_x/ZnO double-layer is capable of reversible bipolar switching under ultralow switching current(〈 3 μA) with a Schottky emission dominant conduction for the high resistance state and a Poole–Frenkel emission governed conduction for the low resistance state. Compared with a drastically increased switching current at 120℃ for the single HfO_x layer RRAM, the HfO_x/ZnO double-layer exhibits excellent thermal stability and maintains neglectful fluctuations in switching current at high temperatures(up to 180℃), which might be attributed to the increased Schottky barrier height to suppress current at high temperatures. Additionally, the HfO_x/ZnO double-layer exhibits 10-year data retention @85℃ that is helpful for the practical applications in RRAMs.
文摘We study the average position and the symmetry of the distribution in the SU(2) open quantum random walk (OQRW). We show that the average position in the central limit theorem (CLT) is non-uniform compared with the average position in the non-CLT. The symmetry of distribution is shown to be even in the CLT.
文摘In this paper, we extend the works by [1-5] accounting for autocorrelation both in the time specific effect as well as the remainder error term. Several transformations are proposed to circumvent the double autocorrelation problem in some specific cases. Estimation procedures are then derived.
基金Supported by National High Technology R&D Program(SS2013AA041104)
文摘A double-clamped piezoelectric energy harvester subjected to random excitation is presented,for which corresponding analytical model is established to predict its output characteristics.With the presented theoretical natural frequency and equivalent stiffness of vibrator,the closed-form expressions of mean power and voltage acquired from the double-clamped piezoelectric energy harvester under random excitation are derived.Finally theoretical analysis is conducted for the output performance of the doubleclamped energy harvester with the change of spectrum density(SD)of acceleration,load resistance,piezoelectric coefficient and natural frequency value,which is found to closely agree with Monte Carlo simulation and experimental results.
文摘Objective: In a randomized, double-blind, exploratory, active-controlled trial, the efficacy and safety of a patent-pending combination of Ginger and Goldenrod extracts (BDI-630) in alleviating cold symptoms in community-dwelling adults was compared to a combination of standardized amounts of Echinacea (EC) components. Methods: 44 healthy adults, experiencing new onset of cold symptoms were randomly assigned to receive either BDI-630 (900 mg) or EC (500 mg) twice daily for 10 days. The severity of cold symptoms and the quality of life was assessed by self-reporting of subjects using the Wisconsin Upper Respiratory Symptom Survey (WURSS-21? 2004). Results: The intent-to-treat population (ITT) consisted of 44 subjects (n = 22 for BDI-630;n = 22 for EC). The modified ITT (mITT) population consisted of 40 subjects, excluding four subjects with major protocol deviations related to inclusion/exclusion criteria and/or use of prohibited drugs from the efficacy analysis (n = 3 for BDI-630 and n = 1 for EC). Results indicated a sig-nificant difference between the two groups: the superiority of BDI-630 over EC was particularly noticeable between Day 1 and Day 7, as demonstrated by a 14-fold difference of the mean percentage of change of total score from baseline in the mITT population. Adverse events (AEs) following the intake of BDI-630 were mostly limited to mild gastrointestinal intolerance in less than 10% of the subjects. Conclusions: BDI-630 was shown to be more effective than EC in alleviating cold symptoms in the adult population, particularly during the first 7 days of treatment. BDI-630 was very well tolerated by all subjects.
基金support of National Social Science Fund(NSSF)under Grant(No.22BTQ033).
文摘Currently, open-source software is gradually being integrated into industrial software, while industry protocolsin industrial software are also gradually transferred to open-source community development. Industrial protocolstandardization organizations are confronted with fragmented and numerous code PR (Pull Request) and informalproposals, and differentworkflowswill lead to increased operating costs. The open-source community maintenanceteam needs software that is more intelligent to guide the identification and classification of these issues. To solvethe above problems, this paper proposes a PR review prediction model based on multi-dimensional features. Weextract 43 features of PR and divide them into five dimensions: contributor, reviewer, software project, PR, andsocial network of developers. The model integrates the above five-dimensional features, and a prediction model isbuilt based on a Random Forest Classifier to predict the review results of PR. On the other hand, to improve thequality of rejected PRs, we focus on problems raised in the review process and review comments of similar PRs.Wepropose a PR revision recommendation model based on the PR review knowledge graph. Entity information andrelationships between entities are extracted from text and code information of PRs, historical review comments,and related issues. PR revisions will be recommended to code contributors by graph-based similarity calculation.The experimental results illustrate that the above twomodels are effective and robust in PR review result predictionand PR revision recommendation.