In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relat...In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.展开更多
In this article the high strength micro-expansive concrete that has been applied on big-diameter and long-span steel arch bridge is researched. The applications show that the concrete has some merits, such as good flu...In this article the high strength micro-expansive concrete that has been applied on big-diameter and long-span steel arch bridge is researched. The applications show that the concrete has some merits, such as good fluidity, low bleeding ratio and no segregation, low slump loss, high early strength and high later strength, micro-expansion etc.展开更多
In the tobacco industry,insider employee attack is a thorny problem that is difficult to detect.To solve this issue,this paper proposes an insider threat detection method based on heterogeneous graph embedding.First,t...In the tobacco industry,insider employee attack is a thorny problem that is difficult to detect.To solve this issue,this paper proposes an insider threat detection method based on heterogeneous graph embedding.First,the interrelationships between logs are fully considered,and log entries are converted into heterogeneous graphs based on these relationships.Second,the heterogeneous graph embedding is adopted and each log entry is represented as a low-dimensional feature vector.Then,normal logs and malicious logs are classified into different clusters by clustering algorithm to identify malicious logs.Finally,the effectiveness and superiority of the method is verified through experiments on the CERT dataset.The experimental results show that this method has better performance compared to some baseline methods.展开更多
The 2024 Government Work Report proposes to promote the development and utilization of distributed energy.This marks the inaugural inclusion of“distributed energy”in the Government Work Report.In constructing China...The 2024 Government Work Report proposes to promote the development and utilization of distributed energy.This marks the inaugural inclusion of“distributed energy”in the Government Work Report.In constructing China’s new energy system,distributed energy stands to encounter substantial growth prospects and urgently requires addressing industry challenges and enhancing the market ecosystem for its advancement.展开更多
The achievements of China’s hydropower construction in five decades are shown in the following statistical data. The concise analyses have been made in the aspects of technical economy, geologic exploration, dam cons...The achievements of China’s hydropower construction in five decades are shown in the following statistical data. The concise analyses have been made in the aspects of technical economy, geologic exploration, dam construction technique, underground engineering, flood discharging and energy dissipation etc, which represent the achievements and experiences in hydropower technologies.展开更多
A heat dissipation model of a rectangular porous fin is established based on constructal theory. First, the constructal design of rectangular porous fin is conducted by selecting a complex function minimization, which...A heat dissipation model of a rectangular porous fin is established based on constructal theory. First, the constructal design of rectangular porous fin is conducted by selecting a complex function minimization, which composed of linear weighting sum of maximum temperature difference and pumping power consumption, as optimization objective. Effects of gap height, air inlet velocity, total porous fin volume and porosity on the optimal constructs are investigated, respectively. The findings show that the complex function can attain its double minimum at a value of 0.802 when the fin length and number are optimized, and the corresponding optimal fin length and number are 8.01 mm and 10, respectively. In comparison to original design, the complex function and maximum temperature difference after twice optimization are decreased by 19.80% and 66.31%, respectively.Second, the comprehensive performance of porous fin is improved by simultaneously optimizing the fin length and number. The artificial neural network is applied to predict the fin performances, which is used to conduct multi-objective optimization based on NSGA-II algorithm. Optimal structure of porous fin for multiple requirements is gained by LINMAP and TOPSIS decisionmaking strategies. The findings in this study can serve as theoretical guides for fin thermal designs of electronic devices.展开更多
Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) pa...Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It was shown in a retrospective study that this association was an independent predictive factor for worse progression-free survival (PFS). Objective: To verify the impact of concomitant administration of PPi with Ci on overall survival (OS) and PFS. Material and Methods: This is a retrospective cohort study of patients treated with Ci for HR+HER2-ABC in the period from Feb/2017 to Aug/2020. SPSS software was used for data processing. Univariate analysis was done by the Kaplan-Meier method and log-rank test, and multivariate analysis by COX regression. P-value < 0.05 was considered significant. Results: 80 patients were included. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was palbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone partner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of patients were on PPi, and 70.0% of them were during the entire treatment (23.3% omeprazole, 73.4% pantoprazole, 3.3% others). Patients taking concomitant PPi and Ci had lower OS (OS-3 years 42.6% vs. 63.4%, p = 0.254) and PFS (PFS med 15 m. vs. 21 m., p = 0.733), although with no statistically significant difference. Discussion: In the sample, there was a numerical difference, without the statistical significance in the use of PPi in the survival of patients under Ci. This difference could be more evident with a longer follow-up and a larger sample size. This study intends to alert to the growing importance of checking for drug interactions. Polymedication, advanced age and the presence of several comorbidities are real problems in patients with ABC. Conclusion: Real-world data from this center demonstrate a negative, non-statistically significant impact of PPi treatment on survival outcomes, in patients treated with Ci for HR+HER2-ABC.展开更多
高等桥梁结构理论课程一直是桥梁工程专业研究生的必修课程,也是针对留学生开放的专业课程。从2017—2018学年第一学期开始全英文授课,面向国际学生以及选择英文学习的国内学生。高等桥梁结构理论的英文版教材Advanced Theory of Bridge...高等桥梁结构理论课程一直是桥梁工程专业研究生的必修课程,也是针对留学生开放的专业课程。从2017—2018学年第一学期开始全英文授课,面向国际学生以及选择英文学习的国内学生。高等桥梁结构理论的英文版教材Advanced Theory of Bridge Structures是在中文版基础上内容适当取舍,主干内容不变,并结合教学课时和教学实践编写的全英文教材。该文首先介绍原中文版课程及教材背景,重点对英文版教材的编写思路、目录编排、选材内容特点等进行较为详细的叙述。同时,经过几年的英文版教学实践,该文也介绍英文版教学在课程建设和学生能力提升等方面的进展情况。展开更多
文摘In this paper,the mission and the thermal environment of the Solar Close Observations and Proximity Experiments(SCOPE)spacecraft are analyzed,and an advanced thermal management system(ATMS)is designed for it.The relationship and functions of the integrated database,the intelligent thermal control system and the efficient liquid cooling system in the ATMS are elaborated upon.For the complex thermal field regulation system and extreme space thermal environment,a modular simulation and thermal field planning method are proposed,and the feasibility of the planning algorithm is verified by numerical simulation.A solar array liquid cooling system is developed,and the system simulation results indicate that the temperatures of the solar arrays meet the requirements as the spacecraft flies by perihelion and aphelion.The advanced thermal management study supports the development of the SCOPE program and provides a reference for the thermal management in other deep-space exploration programs.
基金Funded by the State" the Nineth Five-Plan" of Communica-tion Ministry
文摘In this article the high strength micro-expansive concrete that has been applied on big-diameter and long-span steel arch bridge is researched. The applications show that the concrete has some merits, such as good fluidity, low bleeding ratio and no segregation, low slump loss, high early strength and high later strength, micro-expansion etc.
基金Supported by the National Natural Science Foundation of China(No.62203390)the Science and Technology Project of China TobaccoZhejiang Industrial Co.,Ltd(No.ZJZY2022E004)。
文摘In the tobacco industry,insider employee attack is a thorny problem that is difficult to detect.To solve this issue,this paper proposes an insider threat detection method based on heterogeneous graph embedding.First,the interrelationships between logs are fully considered,and log entries are converted into heterogeneous graphs based on these relationships.Second,the heterogeneous graph embedding is adopted and each log entry is represented as a low-dimensional feature vector.Then,normal logs and malicious logs are classified into different clusters by clustering algorithm to identify malicious logs.Finally,the effectiveness and superiority of the method is verified through experiments on the CERT dataset.The experimental results show that this method has better performance compared to some baseline methods.
文摘The 2024 Government Work Report proposes to promote the development and utilization of distributed energy.This marks the inaugural inclusion of“distributed energy”in the Government Work Report.In constructing China’s new energy system,distributed energy stands to encounter substantial growth prospects and urgently requires addressing industry challenges and enhancing the market ecosystem for its advancement.
文摘The achievements of China’s hydropower construction in five decades are shown in the following statistical data. The concise analyses have been made in the aspects of technical economy, geologic exploration, dam construction technique, underground engineering, flood discharging and energy dissipation etc, which represent the achievements and experiences in hydropower technologies.
基金supported by the National Natural Science Foundation of China(Grant No. 52171317)Graduate Innovative Fund of Wuhan Institute of Technology(Grant No. CX2022070)。
文摘A heat dissipation model of a rectangular porous fin is established based on constructal theory. First, the constructal design of rectangular porous fin is conducted by selecting a complex function minimization, which composed of linear weighting sum of maximum temperature difference and pumping power consumption, as optimization objective. Effects of gap height, air inlet velocity, total porous fin volume and porosity on the optimal constructs are investigated, respectively. The findings show that the complex function can attain its double minimum at a value of 0.802 when the fin length and number are optimized, and the corresponding optimal fin length and number are 8.01 mm and 10, respectively. In comparison to original design, the complex function and maximum temperature difference after twice optimization are decreased by 19.80% and 66.31%, respectively.Second, the comprehensive performance of porous fin is improved by simultaneously optimizing the fin length and number. The artificial neural network is applied to predict the fin performances, which is used to conduct multi-objective optimization based on NSGA-II algorithm. Optimal structure of porous fin for multiple requirements is gained by LINMAP and TOPSIS decisionmaking strategies. The findings in this study can serve as theoretical guides for fin thermal designs of electronic devices.
文摘Introduction: Proton pump inhibitors (PPi) are widely prescribed, including in patients undergoing treatment for advanced breast cancer (ABC). Due to the pharmacokinetic characteristics of the CDK4/6 inhibitor (Ci) palbociclib a drug interaction with PPi was hypothesized. It was shown in a retrospective study that this association was an independent predictive factor for worse progression-free survival (PFS). Objective: To verify the impact of concomitant administration of PPi with Ci on overall survival (OS) and PFS. Material and Methods: This is a retrospective cohort study of patients treated with Ci for HR+HER2-ABC in the period from Feb/2017 to Aug/2020. SPSS software was used for data processing. Univariate analysis was done by the Kaplan-Meier method and log-rank test, and multivariate analysis by COX regression. P-value < 0.05 was considered significant. Results: 80 patients were included. The median age at diagnosis of ABC was 56 years (25 - 75). Treatment with Ci was 1st line for ABC in 68.8%. Choice of Ci was palbociclib in 73.8% (n = 59) and ribociclib in 26.3% (n = 21). The hormone partner was a nonsteroidal aromatase inhibitor in 45.0%, and fulvestrant in 55.0% of cases. 37.5% of patients were on PPi, and 70.0% of them were during the entire treatment (23.3% omeprazole, 73.4% pantoprazole, 3.3% others). Patients taking concomitant PPi and Ci had lower OS (OS-3 years 42.6% vs. 63.4%, p = 0.254) and PFS (PFS med 15 m. vs. 21 m., p = 0.733), although with no statistically significant difference. Discussion: In the sample, there was a numerical difference, without the statistical significance in the use of PPi in the survival of patients under Ci. This difference could be more evident with a longer follow-up and a larger sample size. This study intends to alert to the growing importance of checking for drug interactions. Polymedication, advanced age and the presence of several comorbidities are real problems in patients with ABC. Conclusion: Real-world data from this center demonstrate a negative, non-statistically significant impact of PPi treatment on survival outcomes, in patients treated with Ci for HR+HER2-ABC.
基金国家自然科学基金“网格配筋混凝土结构抗剪机理研究”(51178335)2021年同济大学研究生教育研究与改革建设项目“Advanced Theory of Bridge Structures”(2021JC05)。
文摘高等桥梁结构理论课程一直是桥梁工程专业研究生的必修课程,也是针对留学生开放的专业课程。从2017—2018学年第一学期开始全英文授课,面向国际学生以及选择英文学习的国内学生。高等桥梁结构理论的英文版教材Advanced Theory of Bridge Structures是在中文版基础上内容适当取舍,主干内容不变,并结合教学课时和教学实践编写的全英文教材。该文首先介绍原中文版课程及教材背景,重点对英文版教材的编写思路、目录编排、选材内容特点等进行较为详细的叙述。同时,经过几年的英文版教学实践,该文也介绍英文版教学在课程建设和学生能力提升等方面的进展情况。