Elastic moduli,e.g.shear modulus G and bulk modulus K,are important parameters of geotechnical materials,which are not only the indices for the evaluation of the deformation ability of soils but also the important bas...Elastic moduli,e.g.shear modulus G and bulk modulus K,are important parameters of geotechnical materials,which are not only the indices for the evaluation of the deformation ability of soils but also the important basic parameters for the development of the constitutive models of geotechnical materials.In this study,a series of triaxial loading-unloading-reloading shear tests and isotropic loading-unloadingreloading tests are conducted to study several typical mechanical properties of coral calcareous sand(CCS),and the void ratio evolution during loading,unloading and reloading.The test results show that the stress-strain curves during multiple unloading processes are almost parallel,and their slopes are much greater than the deformation modulus at the initial stage of loading.The relationship between the confining pressure and the volumetric strain can be defined approximately by a hyperbolic equation under the condition of monotonic loading of confining pressure.Under the condition of confining pressure unloading,the evolution of void ratio is linear in the e-lnp0 plane,and these lines are a series of almost parallel lines if there are multiple processes of unloading.Based on the experimental results,it is found that the modified Hardin formulae for the elastic modulus estimation have a significant deviation from the tested values for CCS.Based on the experimental results,it is proposed that the elastic modulus of soils should be determined by the intersection line of two spatial surfaces in the G/K-e-p’/pa space(pa:atmosphere pressure).“Ye formulation”is further proposed for the estimation of the elastic modulus of CCS.This new estimation formulation for soil elastic modulus would provide a new method to accurately describe the mechanical behavior of granular soils.展开更多
“Jing Ye Si”is a classical poem with international influence by the Chinese poet Li Bai in the Tang Dynasty,which expresses the poet’s deep nostalgia.This paper compares and analyzes its two English versions transl...“Jing Ye Si”is a classical poem with international influence by the Chinese poet Li Bai in the Tang Dynasty,which expresses the poet’s deep nostalgia.This paper compares and analyzes its two English versions translated by the Chinese translator Xu Yuanchong and the British translator W.J.B.Fletcher based on the“three beauties”principle(beauty in sense,beauty in sound,and beauty in form),and discovers that the English version of Xu basically achieves the unity of the“three beauties”,while the English version of Fletcher realizes the“beauty in sound and form”,but deviates from the“beauty in sense”mainly owing to the inaccurate comprehension of the moon as an image and other factors.This analysis may afford us with certain reference in poetry translation.展开更多
AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous lesions.METHODS: Th...AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous lesions.METHODS: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric carcinoma.RESULTS: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P<0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P<0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk=0.279, P<0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P<0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was signifi cantly higher than that in the group without lymph node metastasis (41.2%), P<0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk=0.246, P<0.01.CONCLUSION: YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.展开更多
Predicting the mechanical behaviors of structure and perceiving the anomalies in advance are essential to ensuring the safe operation of infrastructures in the long run.In addition to the incomplete consideration of i...Predicting the mechanical behaviors of structure and perceiving the anomalies in advance are essential to ensuring the safe operation of infrastructures in the long run.In addition to the incomplete consideration of influencing factors,the prediction time scale of existing studies is rough.Therefore,this study focuses on the development of a real-time prediction model by coupling the spatio-temporal correlation with external load through autoencoder network(ATENet)based on structural health monitoring(SHM)data.An autoencoder mechanism is performed to acquire the high-level representation of raw monitoring data at different spatial positions,and the recurrent neural network is applied to understanding the temporal correlation from the time series.Then,the obtained temporal-spatial information is coupled with dynamic loads through a fully connected layer to predict structural performance in next 12 h.As a case study,the proposed model is formulated on the SHM data collected from a representative underwater shield tunnel.The robustness study is carried out to verify the reliability and the prediction capability of the proposed model.Finally,the ATENet model is compared with some typical models,and the results indicate that it has the best performance.ATENet model is of great value to predict the realtime evolution trend of tunnel structure.展开更多
[Objectives]Through data mining and analysis,the medication characters and ideas of ye Tianshi,a famous physician in Qing Dynasty,in the treatment of tinnitus were explored,so as to provide reference for clinical tinn...[Objectives]Through data mining and analysis,the medication characters and ideas of ye Tianshi,a famous physician in Qing Dynasty,in the treatment of tinnitus were explored,so as to provide reference for clinical tinnitus treatment.[Methods]The medical records of Ye Tianshi's treatment of tinnitus in the Ancient and Modern Consilia Cloud Platform were retrieved and sorted,and the use frequency,properties,metabolic organ and compatibility of related Chinese herbs in the cases were analyzed through system-integrated statistical analysis,cluster analysis,association rules analysis and complex network analysis.[Results]A total of 46 medical cases were finally included,with 15 frequently used Chinese herbs,including poria with hostwood,Radix Rehmanniae Preparata,magnetitum,etc.Most of the drugs are cold and neutral in nature,sweet and bitter in taste,and metabolized in liver and heart.The results of cluster analysis show that the therapeutic drugs for tinnitus are mainly divided into four categories:strengthening spleen,nourishing yin,suppressing symptoms,and clearing heat.The results of association rules analysis show that the commonly used traditional Chinese medicine combination is composed of three herbs,poria with hostwood,Radix Ophiopogonis,and Radix et Rhizoma Glycyrrhizae,which have spleen-strengthening and stomach-tonifying effects.The results of complex network analysis show that the core prescription is based on Siwu Decoction.[Conclusions]In the treatment of tinnitus,Ye Tianshi paid attention to the three internal organs of heart,kidney and gallbladder,and made good use of lung qi-dispersing drugs to clear heat,sweet and cold drugs to tonify stomach and nourish yin,and tonic drugs to suppress symptoms.The core prescription is mainly composed of Radix Rehmanniae,Radix Rehmanniae Preparata,oyster,poria with hostwood,Fructus Forsythiae,Radix Paeoniae Alba,antelope horn,magnetitum and Radix Asparagi.The commonly used single herbs are poria with hostwood,Radix Rehmanniae Preparata and magnetitum.The combination of poria with hostwood,Radix Ophiopogonis and Radix et Rhizoma Glycyrrhizae is more common.展开更多
This paper introduced the history of Su Shi ordering to build the Yellow Tower in the Northern Song Dynasty,and also the cause and effect of rebuilding the Yellow Tower in the 1980s.From its first construction to the ...This paper introduced the history of Su Shi ordering to build the Yellow Tower in the Northern Song Dynasty,and also the cause and effect of rebuilding the Yellow Tower in the 1980s.From its first construction to the process of its several times of collapsing and rebuilding,the Yellow Tower has reflected cultural connotations and spiritual value of different periods,thus the textual research on the history of Yellow Tower is essential for the research on the development of Xu-style landscape architecture.展开更多
基金Professor Jianhong Ye is grateful for the funding support from the National Key Research and Development Program of China(Grant No.2022YFC3102402).
文摘Elastic moduli,e.g.shear modulus G and bulk modulus K,are important parameters of geotechnical materials,which are not only the indices for the evaluation of the deformation ability of soils but also the important basic parameters for the development of the constitutive models of geotechnical materials.In this study,a series of triaxial loading-unloading-reloading shear tests and isotropic loading-unloadingreloading tests are conducted to study several typical mechanical properties of coral calcareous sand(CCS),and the void ratio evolution during loading,unloading and reloading.The test results show that the stress-strain curves during multiple unloading processes are almost parallel,and their slopes are much greater than the deformation modulus at the initial stage of loading.The relationship between the confining pressure and the volumetric strain can be defined approximately by a hyperbolic equation under the condition of monotonic loading of confining pressure.Under the condition of confining pressure unloading,the evolution of void ratio is linear in the e-lnp0 plane,and these lines are a series of almost parallel lines if there are multiple processes of unloading.Based on the experimental results,it is found that the modified Hardin formulae for the elastic modulus estimation have a significant deviation from the tested values for CCS.Based on the experimental results,it is proposed that the elastic modulus of soils should be determined by the intersection line of two spatial surfaces in the G/K-e-p’/pa space(pa:atmosphere pressure).“Ye formulation”is further proposed for the estimation of the elastic modulus of CCS.This new estimation formulation for soil elastic modulus would provide a new method to accurately describe the mechanical behavior of granular soils.
文摘“Jing Ye Si”is a classical poem with international influence by the Chinese poet Li Bai in the Tang Dynasty,which expresses the poet’s deep nostalgia.This paper compares and analyzes its two English versions translated by the Chinese translator Xu Yuanchong and the British translator W.J.B.Fletcher based on the“three beauties”principle(beauty in sense,beauty in sound,and beauty in form),and discovers that the English version of Xu basically achieves the unity of the“three beauties”,while the English version of Fletcher realizes the“beauty in sound and form”,but deviates from the“beauty in sense”mainly owing to the inaccurate comprehension of the moon as an image and other factors.This analysis may afford us with certain reference in poetry translation.
基金Supported by National Natural Science Foundation of China,No.30371607
文摘AIM:To analyze the differences and relevance of Yes-associated protein (YAP) and survivin, and to explore the correlation and signifi cance of their expression in gastric carcinoma and precancerous lesions.METHODS: The PV9000 immunohistochemical method was used to detect the expression of YAP and survivin in 98 cases of normal gastric mucosa, 58 intestinal metaplasia (IM), 32 dysplasia and 98 gastric carcinoma.RESULTS: The positive rates of YAP in dysplasia (37.5%) and gastric carcinoma (48.0%) were significantly higher than that in normal gastric mucosa (13.3%), P<0.01. The positive rates of survivin in IM (53.4%), dysplasia (59.4%) and gastric carcinoma (65.3%) were significantly higher than in normal gastric mucosa (11.2%), P<0.01. Survivin expression gradually increased from 41.7% in well differentiated adenocarcinoma through 58.3% in moderately differentiated adenocarcinoma to 75.6% in poorly differentiated adenocarcinoma, with significant Rank correlation, rk=0.279, P<0.01. The positive rate of survivin in gastric carcinoma of diffused type (74.6%) was significantly higher than that in intestinal type (51.3%), P<0.05. In gastric carcinoma with lymph node metastasis (76.9%), the positive rate of survivin was signifi cantly higher than that in the group without lymph node metastasis (41.2%), P<0.01. In 98 cases of gastric carcinoma, the expression of YAP and of survivin were positively correlated, rk=0.246, P<0.01.CONCLUSION: YAP may play an important role as a carcinogenic factor and may induce survivin expression. Detecting both markers together may help in early diagnosis of gastric carcinoma.
基金This work is supported by the National Natural Science Foundation of China(Grant No.51991392)Key Deployment Projects of Chinese Academy of Sciences(Grant No.ZDRW-ZS-2021-3-3)the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2019QZKK0904).
文摘Predicting the mechanical behaviors of structure and perceiving the anomalies in advance are essential to ensuring the safe operation of infrastructures in the long run.In addition to the incomplete consideration of influencing factors,the prediction time scale of existing studies is rough.Therefore,this study focuses on the development of a real-time prediction model by coupling the spatio-temporal correlation with external load through autoencoder network(ATENet)based on structural health monitoring(SHM)data.An autoencoder mechanism is performed to acquire the high-level representation of raw monitoring data at different spatial positions,and the recurrent neural network is applied to understanding the temporal correlation from the time series.Then,the obtained temporal-spatial information is coupled with dynamic loads through a fully connected layer to predict structural performance in next 12 h.As a case study,the proposed model is formulated on the SHM data collected from a representative underwater shield tunnel.The robustness study is carried out to verify the reliability and the prediction capability of the proposed model.Finally,the ATENet model is compared with some typical models,and the results indicate that it has the best performance.ATENet model is of great value to predict the realtime evolution trend of tunnel structure.
基金Supported by The Second Batch of Training Projects for Excellent Clinical Talents of Traditional Chinese Medicine in Guangdong Province(Yue Zhong Yi Ban Han[2017]No.267).
文摘[Objectives]Through data mining and analysis,the medication characters and ideas of ye Tianshi,a famous physician in Qing Dynasty,in the treatment of tinnitus were explored,so as to provide reference for clinical tinnitus treatment.[Methods]The medical records of Ye Tianshi's treatment of tinnitus in the Ancient and Modern Consilia Cloud Platform were retrieved and sorted,and the use frequency,properties,metabolic organ and compatibility of related Chinese herbs in the cases were analyzed through system-integrated statistical analysis,cluster analysis,association rules analysis and complex network analysis.[Results]A total of 46 medical cases were finally included,with 15 frequently used Chinese herbs,including poria with hostwood,Radix Rehmanniae Preparata,magnetitum,etc.Most of the drugs are cold and neutral in nature,sweet and bitter in taste,and metabolized in liver and heart.The results of cluster analysis show that the therapeutic drugs for tinnitus are mainly divided into four categories:strengthening spleen,nourishing yin,suppressing symptoms,and clearing heat.The results of association rules analysis show that the commonly used traditional Chinese medicine combination is composed of three herbs,poria with hostwood,Radix Ophiopogonis,and Radix et Rhizoma Glycyrrhizae,which have spleen-strengthening and stomach-tonifying effects.The results of complex network analysis show that the core prescription is based on Siwu Decoction.[Conclusions]In the treatment of tinnitus,Ye Tianshi paid attention to the three internal organs of heart,kidney and gallbladder,and made good use of lung qi-dispersing drugs to clear heat,sweet and cold drugs to tonify stomach and nourish yin,and tonic drugs to suppress symptoms.The core prescription is mainly composed of Radix Rehmanniae,Radix Rehmanniae Preparata,oyster,poria with hostwood,Fructus Forsythiae,Radix Paeoniae Alba,antelope horn,magnetitum and Radix Asparagi.The commonly used single herbs are poria with hostwood,Radix Rehmanniae Preparata and magnetitum.The combination of poria with hostwood,Radix Ophiopogonis and Radix et Rhizoma Glycyrrhizae is more common.
文摘This paper introduced the history of Su Shi ordering to build the Yellow Tower in the Northern Song Dynasty,and also the cause and effect of rebuilding the Yellow Tower in the 1980s.From its first construction to the process of its several times of collapsing and rebuilding,the Yellow Tower has reflected cultural connotations and spiritual value of different periods,thus the textual research on the history of Yellow Tower is essential for the research on the development of Xu-style landscape architecture.
