THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to pos...THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].展开更多
BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induce...BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.展开更多
WE are in an exciting new intelligent era where various Web 3.0 systems emerge and flourish.[1]–[3].In this new epoch,the collaboration of data and knowledge,humans and machines,actual and virtual worlds is undergoin...WE are in an exciting new intelligent era where various Web 3.0 systems emerge and flourish.[1]–[3].In this new epoch,the collaboration of data and knowledge,humans and machines,actual and virtual worlds is undergoing an unprecedented diversification and community-driven transformation,unveiling an open future full of boundless possibilities.However,the value of dispersed data extends far beyond passive storage and application.展开更多
It is universally accepted that the philosophy of the Tao is the essence that animates the Chinese Cosmogony. Therefore, in last decades I have tried to consolidate its scientific background, looking for solid explana...It is universally accepted that the philosophy of the Tao is the essence that animates the Chinese Cosmogony. Therefore, in last decades I have tried to consolidate its scientific background, looking for solid explanations through Exact Sciences (“Between Heaven and Earth” Scientific Basis of the Action of Shao Yin: Lightning’s Physical-Mathematical Analysis”;“Is Traditional Chinese Medicine Definitely an Exact Science?”;“Euclidean Geometry and Traditional Chinese Medicine: Diving into the Real Origin of the Five Elements”;“Solitons: A Cutting-Edge Scientific Proposal Explaining the Mechanisms of Acupuntural Action”) Currently, research on Chinese medicine leads us—with Dr. Erica Arakaki, collaborator and assistant—to verify through a profound bibliographic review the application of Fibonacci’s Golden Ratio in the constitution of T’ai Ji Tu, adding yet more substance to the hypothesis of Acupuncture and demonstrating how said Chinese Ancient Science is not only an empirical knowledge but a wisdom derived from the most ancient exact science: Geometry.展开更多
In the evolution of modern railway thought,it includes not only the discussion of railway planning,sovereignty,debt,and construction,but also the discussion of spiritual guiding ideology such as“Tao,body and utility...In the evolution of modern railway thought,it includes not only the discussion of railway planning,sovereignty,debt,and construction,but also the discussion of spiritual guiding ideology such as“Tao,body and utility”and“material and spirit”.From the perspective of the relationship between road and equipment,the development of modern railway thought in China has experienced three stages.During the Westernization Movement,Li Hongzhang and other people expounded the benefits brought by railway construction from the angle of“utility”,and believed that there was still a unity of“Tao and style”.After the Sino-Japanese Naval Battle,with the emergence of the theory of railway sovereignty and the theory of dividing China,Kang Youwei and others questioned the thought of Westernization school.The unified Tao body was divided into two parts:China and the West.After the May Fourth Movement,railway,as a product of western material civilization,was compared with Eastern spiritual civilization by Liang Shuming,Li Dazhao,and others.The conflict between material and spirit made the Western“Tao style”evolve into the Europe-American way of pursuing“scientific spirit”and the Soviet-Russian way of exploring the ideas of revolution and transformation.The railway has thus become an important carrier of the“scientific spirit”and socialism.展开更多
Based on interpretation of Dao De Jing(a book written by LAO Zi),the connotation of "Tao" had been analyzed and it emphasized that Taoism is the most basic and eternal universal law transcending physical exi...Based on interpretation of Dao De Jing(a book written by LAO Zi),the connotation of "Tao" had been analyzed and it emphasized that Taoism is the most basic and eternal universal law transcending physical existence and the origin of all changes.It pointed out that garden art was integrated art of time and space,Taoism had made profound effect on Chinese landscape art,and its philosophical thought was the important theoretical support for garden artistic creation.On this basis,it laid stress on great influence on artistic creation of Chinese garden produced by Taoist dialectical thoughts and Taoist thoughts such as "Taoism following nature","unity between heaven and human",and "immortal belief";and found ideological source for Chinese landscape art to pursue artistic spirit of natural beauty,uphold designing principle of harmonious coexistence between human and nature,and take supernatural being and fairyland legend as the design version.It also analyzed that Taoist philosophical thought happened to coincide with contrast methods of garden art involving tangibility and intangibility,falsehood and reality,internality and externality,bigness and smallness,highness and lowness,rising and falling,sparseness and denseness,exposedness and unexposedness,and so on.It highlighted artistic charm of "prospect generating beyond images" as the core connotation of Chinese classical garden art;emphasized frequently-used me-thods for garden spatial organization,spatial guidance and indication,layout pattern,arrangement of scenic spots and disposition of landscaping plants which were produced under the influence of Taoism,making Chinese garden be of more implicitness,interestingness and orient glamour.展开更多
Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideol...Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.展开更多
Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred l...Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ～ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year.展开更多
基金supported by the National Natural Science Foundation of China(62302047,62203250)the Science and Technology Development Fund of Macao SAR(0093/2023/RIA2,0050/2020/A1).
文摘THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real environments.In this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].
基金Supported by Liaoning Province“Xingliao Talent Program”Project,No.XLYC2007019.
文摘BACKGROUND Lung cancer(LC)combined with chronic obstructive pulmonary disease(COPD)is a common combination of comorbidities.Anti-inflammation and modulation of oxidative/antioxidative imbalance may prevent COPD-induced LC,and are also crucial to the treatment of LC combined with COPD.Modern studies have shown that Tao Hong Si Wu Tang(THSW)has vasodilatory,anti-inflammatory,anti-fatigue,anti-shock,immunoregulatory,lipid-reducing,micronutrient-supplementing,and anti-allergy effects.AIM To observe the effects of THSW on COPD and LC in mice.METHODS A total of 100 specific pathogen-free C57/BL6 mice were randomly divided into five groups:Blank control group(group A),model control group(group B),THSW group(group C),IL-6 group(group D),and THSW+IL-6 group(group E),with 20 mice in each group.A COPD mouse model was established using fumigation plus lipopolysaccharide intra-airway drip,and an LC model was replicated by in situ inoculation using the Lewis cell method.RESULTS The blank control group exhibited a clear alveolar structure.The model control and IL-6 groups had thickened alveolar walls,with smaller alveolar lumens,interstitial edema,and several inflammatory infiltrating cells.Histopathological changes in the lungs of the THSW and THSW+IL-6 groups were less than those of the model control group.The serum IL-1β,IL-6,and TNF-αlevels and IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R expression levels in lung tissues of mice in the rest of the groups were significantly higher than those of the blank control group(P<0.01).Compared with the model control group,the IL-6 group demonstrated significantly higher levels for the abovementioned proteins in the serum and lung tissues(P<0.01),and the THSW group had significantly higher serum IL-1β,IL-6,and TNF-αlevels and IL-7R expression levels in lung tissues(P<0.01)but significantly decreased IL-6R,JAK,p-JAK,STAT1/3,p-STAT1/3,FOXO,p-FOXO,and IL-7R levels(P<0.01).CONCLUSION THSW reduces the serum IL-1β,IL-6,and TNF-αlevels in the mouse model with anti-inflammatory effects.Its antiinflammatory mechanism lies in inhibiting the overactivation of the JAK/STAT1/3 signaling pathway.
基金partially supported by the National Natural Science Foundation of China (62103411)the Science and Technology Development Fund of Macao SAR (0050/2020/A1)。
文摘WE are in an exciting new intelligent era where various Web 3.0 systems emerge and flourish.[1]–[3].In this new epoch,the collaboration of data and knowledge,humans and machines,actual and virtual worlds is undergoing an unprecedented diversification and community-driven transformation,unveiling an open future full of boundless possibilities.However,the value of dispersed data extends far beyond passive storage and application.
文摘It is universally accepted that the philosophy of the Tao is the essence that animates the Chinese Cosmogony. Therefore, in last decades I have tried to consolidate its scientific background, looking for solid explanations through Exact Sciences (“Between Heaven and Earth” Scientific Basis of the Action of Shao Yin: Lightning’s Physical-Mathematical Analysis”;“Is Traditional Chinese Medicine Definitely an Exact Science?”;“Euclidean Geometry and Traditional Chinese Medicine: Diving into the Real Origin of the Five Elements”;“Solitons: A Cutting-Edge Scientific Proposal Explaining the Mechanisms of Acupuntural Action”) Currently, research on Chinese medicine leads us—with Dr. Erica Arakaki, collaborator and assistant—to verify through a profound bibliographic review the application of Fibonacci’s Golden Ratio in the constitution of T’ai Ji Tu, adding yet more substance to the hypothesis of Acupuncture and demonstrating how said Chinese Ancient Science is not only an empirical knowledge but a wisdom derived from the most ancient exact science: Geometry.
文摘In the evolution of modern railway thought,it includes not only the discussion of railway planning,sovereignty,debt,and construction,but also the discussion of spiritual guiding ideology such as“Tao,body and utility”and“material and spirit”.From the perspective of the relationship between road and equipment,the development of modern railway thought in China has experienced three stages.During the Westernization Movement,Li Hongzhang and other people expounded the benefits brought by railway construction from the angle of“utility”,and believed that there was still a unity of“Tao and style”.After the Sino-Japanese Naval Battle,with the emergence of the theory of railway sovereignty and the theory of dividing China,Kang Youwei and others questioned the thought of Westernization school.The unified Tao body was divided into two parts:China and the West.After the May Fourth Movement,railway,as a product of western material civilization,was compared with Eastern spiritual civilization by Liang Shuming,Li Dazhao,and others.The conflict between material and spirit made the Western“Tao style”evolve into the Europe-American way of pursuing“scientific spirit”and the Soviet-Russian way of exploring the ideas of revolution and transformation.The railway has thus become an important carrier of the“scientific spirit”and socialism.
文摘Based on interpretation of Dao De Jing(a book written by LAO Zi),the connotation of "Tao" had been analyzed and it emphasized that Taoism is the most basic and eternal universal law transcending physical existence and the origin of all changes.It pointed out that garden art was integrated art of time and space,Taoism had made profound effect on Chinese landscape art,and its philosophical thought was the important theoretical support for garden artistic creation.On this basis,it laid stress on great influence on artistic creation of Chinese garden produced by Taoist dialectical thoughts and Taoist thoughts such as "Taoism following nature","unity between heaven and human",and "immortal belief";and found ideological source for Chinese landscape art to pursue artistic spirit of natural beauty,uphold designing principle of harmonious coexistence between human and nature,and take supernatural being and fairyland legend as the design version.It also analyzed that Taoist philosophical thought happened to coincide with contrast methods of garden art involving tangibility and intangibility,falsehood and reality,internality and externality,bigness and smallness,highness and lowness,rising and falling,sparseness and denseness,exposedness and unexposedness,and so on.It highlighted artistic charm of "prospect generating beyond images" as the core connotation of Chinese classical garden art;emphasized frequently-used me-thods for garden spatial organization,spatial guidance and indication,layout pattern,arrangement of scenic spots and disposition of landscaping plants which were produced under the influence of Taoism,making Chinese garden be of more implicitness,interestingness and orient glamour.
基金National Natural Science Foundation of China under Grants(50772112,90922003,50872135)the Director Foundation of Anhui Institute of Optics and Fine Mechanics
基金Supported by Fund for Scientific Research of Nanjing University of Finance and Economics (B2010017)~~
文摘Based on the contents and temperament of pastoral poetries written by TAO Yuan-ming,by centering on respecting the nature,indifference and optimism,and plainness and authenticity,the paper had analyzed aesthetic ideologies contained in his poetries.On this basis,it had discussed the influence of aesthetic ideology of TAO Yuan-ming on the style of classical gardens in South China,which were quiet and natural,elegant and fresh,simple and plain,and far-reaching in artistic conception.By combining with cases,it pointed out that the poetic prose had been directly quoted as the names of gardens or scenic spots of classical gardens in South China,and showed that the aesthetic ideology of TAO Yuan-ming had set up a successful ideal model for cultural landscapes,producing far-reaching influence on the aesthetic state of mind of gardeners or owners of gardens,further instilling humanistic spirit into classical gardens in South China.
文摘Cometary nuclei, the remnant icy bodies of planet formation, located at the outer edge of the solar system, are relatively poorly studied because of their small sizes and thus faintness. Thus far more than a hundred large members (size about 100 km) of this cometary population in the Kuiper belt have been identified. Smaller bodies (10 km) are much too faint to image directly and their number so far can only be extrapolated on theoretical grounds. The Taiwan-America Occultation Survey (TAOS) will conduct a census of the number of Kuiper belt objects down to a few km size by monitoring chance stellar occultations by these cometary nuclei. We will set up an array of small (50cm), wide-field (f/1 9) telescopes, each equipped with a 2K squared CCD camera, along a 7 km baseline in central Taiwan at an elevation above ～ 3000 m. The robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished against a false detection. The Lawrence Livermore National Laboratory, the National Central University, and the Academia Sinica, will each contribute one telescope system. Researchers from an international variety of institutes are also participating in the project. Our experiment provides the only means to study the cometary population in the small-sized end of the distrbution. A great number of scientific byproducts, notably variable stars, will also derive from the huge TAOS database, some 10, 000 giga-bytes worth of photometrical measuremements per year.
