New high throughput DNA technologies resulted in a disproportion between the high number of scored markers for the mapping populations and relatively small sizes of the genotyped populations. Correspondingly, the numb...New high throughput DNA technologies resulted in a disproportion between the high number of scored markers for the mapping populations and relatively small sizes of the genotyped populations. Correspondingly, the number of markers may, by orders of magnitude, exceed the threshold of recombination resolution achievable for a given population size. Hence, only a small part of markers can be genuinely ordered in the map. The question is how to choose the most informative markers for building such a reliable “skeleton” map. We believe that our approach provides a solution to this difficult problem due to: a) powerful tools of discrete optimization for multilocus ordering;b) a verification procedure, which is impossible without fast and high-quality optimization, to control the map quality based on re-sampling techniques;c) an interactive algorithm of marker clustering in complicated situations caused by significant deviation of recombination rates between markers of non-homologous chromosomes from the expected 50% (referred to as quasi-linkage or pseudo-linkage);and d) an algorithm for detection and removing excessive markers to increase the stability of multilocus ordering.展开更多
为打破现存研究普遍以网络拓扑一致性假设为前提的限制,弱化锚节点数量和质量对链接任务的影响,提出一种基于跨网络语义表征的用户链接算法CSRMA(cross-network semantic representation link algorithm based on mask attention mechan...为打破现存研究普遍以网络拓扑一致性假设为前提的限制,弱化锚节点数量和质量对链接任务的影响,提出一种基于跨网络语义表征的用户链接算法CSRMA(cross-network semantic representation link algorithm based on mask attention mechanism)。该算法框架包含3个模块:多视角采样与注意力机制相结合的跨网络表征模块、不同网络共性特征学习的语义空间映射模块、基于k-d树改进Gale-Shapley算法的用户身份精准链接模块。通过4个公开数据集上的实验验证了所提算法的有效性。与多个身份链接算法对比,CSRMA具有更高的精确率。展开更多
Industry progressing caused the pollutants into the surface and groundwater,including organic pollutants such as phenylenediamine(PD)and heavy metals such as Cr(Ⅵ).Herein,a simple"three-in-one"strategy base...Industry progressing caused the pollutants into the surface and groundwater,including organic pollutants such as phenylenediamine(PD)and heavy metals such as Cr(Ⅵ).Herein,a simple"three-in-one"strategy based on MOF-199 was demonstrated.The MOF-199 catalytic system could be used for the rapid detection of Cr(Ⅵ)and o-phenylenediamine(OPD)in linear ranges of 0.5-50.0μmol/L and 7.0-250.0μmol/L,with the limits of detection of 0.1 and 0.5μmol/L,respectively.This method can also efficiently discriminate PD isomers in just 15 min.Meanwhile,Cr(Ⅵ)was reduced to Cr(Ⅲ)and the elimination of OPD was carried out.Given simple synthesis,high sensitivity,easy operation,and low cost,this method presented a potential platform for on-site detection of pollutants in water samples.展开更多
根据杆长限制条件,建立约束方程,进而得出求解球面四杆机构函数综合问题的非线性方程组,并将该方程组的求解转化为鞍点规划问题。以杆长协调、传动角、避免乱支缺陷等为约束条件,提出球面四杆机构近似函数综合的约束优化模型,再应用差...根据杆长限制条件,建立约束方程,进而得出求解球面四杆机构函数综合问题的非线性方程组,并将该方程组的求解转化为鞍点规划问题。以杆长协调、传动角、避免乱支缺陷等为约束条件,提出球面四杆机构近似函数综合的约束优化模型,再应用差分进化(Differential evolution,DE)算法求解该问题。在定义约束违反度和弱、强不可行解的基础上,提出处理约束条件的改进可行性规则,形成求解约束优化问题的可行性规则差分进化(Feasibility-rule-based DE,FRDE)算法。应用4个benchmark约束优化问题测试FRDE算法的优化性能,结果表明,其可靠性和稳健性指标优于对比算法。面向机构优化综合问题,将修复策略融入FRDE算法,发展为带修复策略的FRDE算法(Feasibility-rule-based DE algorithm with repair strategies,FRRDE)。给出5个函数综合实例。结果显示,优化模型和方法可行有效,且FRRDE算法的优化性能好于对比算法。展开更多
文摘New high throughput DNA technologies resulted in a disproportion between the high number of scored markers for the mapping populations and relatively small sizes of the genotyped populations. Correspondingly, the number of markers may, by orders of magnitude, exceed the threshold of recombination resolution achievable for a given population size. Hence, only a small part of markers can be genuinely ordered in the map. The question is how to choose the most informative markers for building such a reliable “skeleton” map. We believe that our approach provides a solution to this difficult problem due to: a) powerful tools of discrete optimization for multilocus ordering;b) a verification procedure, which is impossible without fast and high-quality optimization, to control the map quality based on re-sampling techniques;c) an interactive algorithm of marker clustering in complicated situations caused by significant deviation of recombination rates between markers of non-homologous chromosomes from the expected 50% (referred to as quasi-linkage or pseudo-linkage);and d) an algorithm for detection and removing excessive markers to increase the stability of multilocus ordering.
文摘为打破现存研究普遍以网络拓扑一致性假设为前提的限制,弱化锚节点数量和质量对链接任务的影响,提出一种基于跨网络语义表征的用户链接算法CSRMA(cross-network semantic representation link algorithm based on mask attention mechanism)。该算法框架包含3个模块:多视角采样与注意力机制相结合的跨网络表征模块、不同网络共性特征学习的语义空间映射模块、基于k-d树改进Gale-Shapley算法的用户身份精准链接模块。通过4个公开数据集上的实验验证了所提算法的有效性。与多个身份链接算法对比,CSRMA具有更高的精确率。
基金supported by the National Natural Science Foundation of China(NSFC)Fund(22174058,U21A20282)Sci-tech plan projects of Gansu province(22CX3GA023).
文摘Industry progressing caused the pollutants into the surface and groundwater,including organic pollutants such as phenylenediamine(PD)and heavy metals such as Cr(Ⅵ).Herein,a simple"three-in-one"strategy based on MOF-199 was demonstrated.The MOF-199 catalytic system could be used for the rapid detection of Cr(Ⅵ)and o-phenylenediamine(OPD)in linear ranges of 0.5-50.0μmol/L and 7.0-250.0μmol/L,with the limits of detection of 0.1 and 0.5μmol/L,respectively.This method can also efficiently discriminate PD isomers in just 15 min.Meanwhile,Cr(Ⅵ)was reduced to Cr(Ⅲ)and the elimination of OPD was carried out.Given simple synthesis,high sensitivity,easy operation,and low cost,this method presented a potential platform for on-site detection of pollutants in water samples.
文摘根据杆长限制条件,建立约束方程,进而得出求解球面四杆机构函数综合问题的非线性方程组,并将该方程组的求解转化为鞍点规划问题。以杆长协调、传动角、避免乱支缺陷等为约束条件,提出球面四杆机构近似函数综合的约束优化模型,再应用差分进化(Differential evolution,DE)算法求解该问题。在定义约束违反度和弱、强不可行解的基础上,提出处理约束条件的改进可行性规则,形成求解约束优化问题的可行性规则差分进化(Feasibility-rule-based DE,FRDE)算法。应用4个benchmark约束优化问题测试FRDE算法的优化性能,结果表明,其可靠性和稳健性指标优于对比算法。面向机构优化综合问题,将修复策略融入FRDE算法,发展为带修复策略的FRDE算法(Feasibility-rule-based DE algorithm with repair strategies,FRRDE)。给出5个函数综合实例。结果显示,优化模型和方法可行有效,且FRRDE算法的优化性能好于对比算法。
