Four 8, 8'-biflavones were synthesized by the iodination of 2'-hydroxychalcones at 8-position in I-2-H2SO4-DMSO system as the key step followed by coupling under Ullmann reaction conditions.
Three 3, 3'-biflavones were synthesized by using iodination of flavones through I-2-CAN system as the key step followed by the coupling of 3-iodoflavones under the Ullmann reaction conditions.
(+/-)-5,5 '-Dihydroxy-7,7 '-dimethoxy-8,8 '-biflavone ((+/-)-1) was resolved into its optically pure forms via the formation and recrystallization of its (2R)- and (2S)-1-(4-toluenesulfonyl)prolylate, and ...(+/-)-5,5 '-Dihydroxy-7,7 '-dimethoxy-8,8 '-biflavone ((+/-)-1) was resolved into its optically pure forms via the formation and recrystallization of its (2R)- and (2S)-1-(4-toluenesulfonyl)prolylate, and the methylated derivatives of (+)- and (-)-1 were also prepared. The absolute configurations of all these 8,8 '-biflavones have been confirmed by their CD spectra.展开更多
文摘Four 8, 8'-biflavones were synthesized by the iodination of 2'-hydroxychalcones at 8-position in I-2-H2SO4-DMSO system as the key step followed by coupling under Ullmann reaction conditions.
文摘Three 3, 3'-biflavones were synthesized by using iodination of flavones through I-2-CAN system as the key step followed by the coupling of 3-iodoflavones under the Ullmann reaction conditions.
基金Project supported by the National Natural Science Fbundation of China
文摘(+/-)-5,5 '-Dihydroxy-7,7 '-dimethoxy-8,8 '-biflavone ((+/-)-1) was resolved into its optically pure forms via the formation and recrystallization of its (2R)- and (2S)-1-(4-toluenesulfonyl)prolylate, and the methylated derivatives of (+)- and (-)-1 were also prepared. The absolute configurations of all these 8,8 '-biflavones have been confirmed by their CD spectra.
