In this paper, we present an asymmetry conformational potential with a reflecting boundary and an absorbing boundary, in which the diffusive search of the free head of kinesin motor can be biased toward its forward bi...In this paper, we present an asymmetry conformational potential with a reflecting boundary and an absorbing boundary, in which the diffusive search of the free head of kinesin motor can be biased toward its forward binding site. Under a wide range of condition, using first-passage time analysis we perform numerical simulation to the Langevin equation, and obtain the dependence of the dwell time for forward steps on the load force. And we calculate the expression for the dwell time by the Laplace transform method. Both numerical and analytical results show that the dwell times exponentially depend on the load force, which provide a simple physical explanation for experimental data. Our results suggest that ATP binding-conformation change in the neck linker plays an important role in unidirectional steps during kinesin's mechanochemical cycle.展开更多
In this paper, the triple cross and double cross were compared by analysing the characteristics of genetic variation in progeny of triple cross hybrid and double cross hybrid among three parents, based on the successf...In this paper, the triple cross and double cross were compared by analysing the characteristics of genetic variation in progeny of triple cross hybrid and double cross hybrid among three parents, based on the successful breeding practices of Beijing No.10. The results showed that the selection duration of double cross was one year shorter than that of triple cross. The F1 generations of single cross hybrids of double cross showed higher breeding value, and the multiple cross-ing timing of triple cross was more flexible. More wheat varieties have been bred by triple cross, instead of double cross. Moreover, the double cross has a disad-vantage of heavy workload.展开更多
A three-dimensional (3-D) modified cellular automaton (MCA) method was developed for simulating the dendrite morphology of cubic system alloys. Two-dimensional (2-D) equations of growth velocities of the dendrit...A three-dimensional (3-D) modified cellular automaton (MCA) method was developed for simulating the dendrite morphology of cubic system alloys. Two-dimensional (2-D) equations of growth velocities of the dendrite tip, interface curvature and anisotropy of the surface energy were extended to 3-D system in the model. Therefore, the model was able to describe the morphology evolution of 3-D dendrites. Then, the model was applied to simulate the mechanism of spacing adjustment for 3-D columnar dendrite growth, and the competitive growth of columnar dendrites with different preferred growth orientations under constant temperature gradient and pulling velocity. Directional solidification experiments of NH4Cl-H2O transparent alloy were performed. It was found that the simulated results compared well with the experimental results. Therefore, the model was reliable for simulating the 3-D dendrite growth of cubic system alloys.展开更多
By researching the ternary counter and low power circuit design method, a novel design of low power ternary Domino counter on switch-level is proposed. Firstly, the switch-level structure expression of ternary loop op...By researching the ternary counter and low power circuit design method, a novel design of low power ternary Domino counter on switch-level is proposed. Firstly, the switch-level structure expression of ternary loop operation circuit with enable pin is derived according to the switch-signal theory, and the one bit ternary counter is obtained combining the ternary adiabatic Domino literal operation circuit and buffer. Then the switch-level structure expression of enable signal circuit is derived, and the four bits ternary counter is obtained by cascade connection. Finally, the circuit is simulated by Spice tool and the output waveforms transform in proper order indicating that the logic function is correct. The energy consumption of the four bits ternary adiabatic Domino counter is 63% less than the conventional Domino counterpart.展开更多
AIM: To investigate the effect of all-trans-retinoic acid (ATRA) on arsenic trioxide (As2O3)-induced apoptosis of human hepatoma, breast cancer, and lung cancer cells in an attempt to find a better combination th...AIM: To investigate the effect of all-trans-retinoic acid (ATRA) on arsenic trioxide (As2O3)-induced apoptosis of human hepatoma, breast cancer, and lung cancer cells in an attempt to find a better combination therapy for solid tumors. METHODS: Human hepatoma cell lines HepG2, Hep3B, human breast cancer cell line MCF-7, and human lung adenocarcinoma cell line AGZY-83-a were treated with As203 together with ATRA. Cell survival fraction was determined by MTT assay, cell viability and apoptosis were measured by annexin V-fluorescein isothiocyanate (FITC) and PI staining, and intracellular glutathione (GSH) and glutathione-S-transferase (GST) activities were determined using commercial kits. RESULTS: Cytotoxicity of ATRA was low. ATRA (0.1, 1, and 10 μmol/L) could synergistically potentiate As2O3 to exert a dose-dependent inhibition of growth and to induce apoptosis in each of the cell lines. HepG2 and Hep3B with low intracellular GSH or GST activities were remarkably sensitive to As2O3 or As2O3+ATRA, while AGZY-83-a with higher GSH or GST activities was less sensitive to As2O3 or As2O3+ATRA. Treatment with 2 μmol/L As2O3 for 72 h significantly decreased intracellular GSH and GST levels in each of the cell lines, and 1 μmol/L ATRA alone reduced minimal intracellular GSH and GST levels. ATRA potentiated the effect of As2O3 on intracellular GSH levels, but intracellular GST levels were not significantly affected by the combination of As2O3 and ATRA for 72 h as compared to As2O3 alone.CONCLUSION: ATRA can strongly potentiate As2O3- induced growth-inhibition and apoptosis in each of the cell lines, and two drugs can produce a significant synergic effect. The sensitivity to As2O3 or As2O3+ATRA is inversely proportional to intracellular GSH or GST levels in each of the cell lines. The GSH redox system may be the possible mechanism by which ATRA synergistically potentiates As203 to exert a dose-dependent inhibition of growth and to induce apoptosis. 2005 The WJG Press and Elsevier Inc. All rights reserved.展开更多
Thermal parameters of various III-V antimonides,especially the quaternary lattice matched to GaSb or InAs substrates as well as some strained ternaries,have been investigated theoretically.Results show that at most co...Thermal parameters of various III-V antimonides,especially the quaternary lattice matched to GaSb or InAs substrates as well as some strained ternaries,have been investigated theoretically.Results show that at most composition region many ternary and quaternary antimonides exhibit rather lower thermal conductivity compared to related binaries,and the reason has been discussed.The thermal designing rule of the lasers and other power devices using those antimonides also has been discussed.展开更多
Cubic boron nitride(c-BN) films were deposited on W6Mo5Cr4V2 high speed steel(HSS) substrate implanted with boron ion by RF-magnetron sputtering. The films were analyzed by the bending beam method, scratch test, XPS a...Cubic boron nitride(c-BN) films were deposited on W6Mo5Cr4V2 high speed steel(HSS) substrate implanted with boron ion by RF-magnetron sputtering. The films were analyzed by the bending beam method, scratch test, XPS and AFM. The experimental results show that the implantation of boron atom can reduce the internal stress and improve the adhesion strength of the films. The critical load of scratch test rises to 27.45 N, compared to 1.75 N of c-BN film on the unimplanted HSS. The AFM shows that the surface of the c-BN film on the implanted HSS is low in roughness and small in grain size. Then the composition of the boron implanted layer was analyzed by the XPS. And the influence of the boron implanted layer on the internal stress and adhesion strength of c-BN films were investigated.展开更多
the routing protocol for low-power and lossy networks(RPL) has been used in advanced metering infrastructure(AMI)which could provide two-way communication between smart meters and city utilities.To improve the network...the routing protocol for low-power and lossy networks(RPL) has been used in advanced metering infrastructure(AMI)which could provide two-way communication between smart meters and city utilities.To improve the network performance of AMI networks, this paper proposed an improved algorithm of RPL based on triangle module operator(IAR-TMO). IAR-TMO proposes membership functions of the following five typical routing metrics: end-to-end delay, number of hops, expected transmission count(ETX),node remaining energy, and child node count.Moreover, IAR-TMO uses triangle module operator to fuse membership functions of these routing metrics. Then, IAR-TMO selects preferred parents(the next hop) based on the triangle module operator. Theoretical analysis and simulation results show that IAR-TMO has a great improvement when compared with two recent representative algorithms: ETXOF(ETX Objective Function) and OF-FL(Objective Function based on Fuzzy Logic), in terms of network lifetime, average end-to-end delay,etc. Consequently, the network performances of AMI networks can be improved effectively.展开更多
In this paper, the 3-D Wavelet-Fractal coder was used to compress the hyperspectral remote sensing image, which is a combination of 3-D improved set partitioning in hierarchical trees (SPIHT) coding and 3-D fractal ...In this paper, the 3-D Wavelet-Fractal coder was used to compress the hyperspectral remote sensing image, which is a combination of 3-D improved set partitioning in hierarchical trees (SPIHT) coding and 3-D fractal coding. Hyperspectral image date cube was first translated by 3-D wavelet and the 3-D fractal compression ceding was applied to lowest frequency subband. The remaining coefficients of higher frequency sub-bands were encoding by 3-D improved SPIHT. We used the block set instead of the hierarchical trees to enhance SPIHT's flexibility. The classical eight kinds of affme transformations in 2-D fractal image compression were generalized to nineteen for the 3-D fractal image compression. The new compression method had been tested on MATLAB. The experiment results indicate that we can gain high compression ratios and the information loss is acceptable.展开更多
Methods of improving seismic event locations were investigated as part of a research study aimed at reducing ground control safety hazards. Seismic event waveforms collected with a 23-station three-dimensional sensor ...Methods of improving seismic event locations were investigated as part of a research study aimed at reducing ground control safety hazards. Seismic event waveforms collected with a 23-station three-dimensional sensor array during longwall coal mining provide the data set used in the analyses. A spatially variable seismic velocity model is constructed using seismic event sources in a passive tomographic method. The resulting three-dimensional velocity model is used to relocate seismic event positions. An evolutionary optimization algorithm is implemented and used in both the velocity model development and in seeking improved event location solutions. Results obtained using the different velocity models are compared. The combination of the tomographic velocity model development and evolutionary search algorithm provides improvement to the event locations.展开更多
Urban expansion is a phenomenon of urban space increase,and an important measuring index of the process of urbanization.Taking Shanghai as an example,the changes of urban average height and built-up area were studied ...Urban expansion is a phenomenon of urban space increase,and an important measuring index of the process of urbanization.Taking Shanghai as an example,the changes of urban average height and built-up area were studied to represent city's vertical and horizontal increases respectively,and statistical methods were used to analyze the driving forces of urban expansion.The research drew following conclusions:1) The urban expansion process of Shanghai from 1985 to 2006 had a clear periodic feature,and could be divided into three stages:vertical expansion in dominance,coordinated vertical and horizontal expansion,and horizontal expansion in dominance.2) The average height and quantity of buildings in core city were significantly bigger than those in suburbs,but the changing speed of the latter was faster.And 3) urbanization process was the major driving force for the city's horizontal expansion,while industrial structure improvement was the key driving factor for the vertical expansion.Those two driving forces were simultaneously affected by city's political factors.展开更多
In this work,ethylene glycol monomethylether(EE) was chosen as an entrainer for the azeotropic distillation of 1,3,5-trimethylbenzene+1-methyl-2-ethylbenzene system to investigate the influence of the entrainer on vap...In this work,ethylene glycol monomethylether(EE) was chosen as an entrainer for the azeotropic distillation of 1,3,5-trimethylbenzene+1-methyl-2-ethylbenzene system to investigate the influence of the entrainer on vapor liquid equilibrium(VLE) of this system.Three sets of binary VLE data in the system consisting of EE + 1,3,5-trimethylbenzene +1-methyl-2-ethylbenzene were measured using the Dvorak-Boublik still.The binary parameters of NRTL model were correlated by using the likelihood method.The ternary VLE data of the system were measured as well and were predicted by using the binary parameters of NRTL model.The test results indicated that the binary data passed the thermodynamic consistency tests,and the difference between the predicted values of ternary VLE and the experimental data reached the research standard for VLE data.Addition of EE had a great influence on the relative volatility between 1,3,5-trimethylbenzene and 1-methl-2-ethyl-benzene:when the ratio of solvent was 4,and the relative volatility between 1,3,5-trimethylbenzene and 1-methyl-2-ethylbenzene increased from 1.0125(without solvent addition) to 1.283.展开更多
The cpc's 13th Five-Year comprehensive plan put forward a major historic task of building a new socialist countryside. This is the comprehensive implementation of urban and rural development to increase industrial ag...The cpc's 13th Five-Year comprehensive plan put forward a major historic task of building a new socialist countryside. This is the comprehensive implementation of urban and rural development to increase industrial agriculture, move the city to support the countryside, accelerate urbanization and narrow the gap between urban and rural areas. To solve the "three rural issues", the comprehensive construction ofa well-offsociety, has a very important strategic role to ease the contradiction of China's rural and urban ecnomic structure. In the process of building a new socialist countryside, the financial policy, as an important means ofmacroeconomic regulation and control, should play a leading role in solving the effective allocation &funds. Due to various factors affected by the current supply of rural financial market constraints, system defects and environmental constraints, there is a large gap between the level of the existing rural financial services and the requirements of the new rural construction which is to be improved urgently.展开更多
基金Supported by Beijing National Science Foundation under Grant No. 4102031
文摘In this paper, we present an asymmetry conformational potential with a reflecting boundary and an absorbing boundary, in which the diffusive search of the free head of kinesin motor can be biased toward its forward binding site. Under a wide range of condition, using first-passage time analysis we perform numerical simulation to the Langevin equation, and obtain the dependence of the dwell time for forward steps on the load force. And we calculate the expression for the dwell time by the Laplace transform method. Both numerical and analytical results show that the dwell times exponentially depend on the load force, which provide a simple physical explanation for experimental data. Our results suggest that ATP binding-conformation change in the neck linker plays an important role in unidirectional steps during kinesin's mechanochemical cycle.
文摘In this paper, the triple cross and double cross were compared by analysing the characteristics of genetic variation in progeny of triple cross hybrid and double cross hybrid among three parents, based on the successful breeding practices of Beijing No.10. The results showed that the selection duration of double cross was one year shorter than that of triple cross. The F1 generations of single cross hybrids of double cross showed higher breeding value, and the multiple cross-ing timing of triple cross was more flexible. More wheat varieties have been bred by triple cross, instead of double cross. Moreover, the double cross has a disad-vantage of heavy workload.
基金Projects (2005CB724105, 2011CB706801) supported by the National Basic Research Program of ChinaProjects (10477010, 51171089) supported by the National Natural Science Foundation of China+1 种基金Project (2007AA04Z141) supported by the High-Tech Research and Development Program of ChinaProjects (2009ZX04006-041-04, 2011ZX04014-052) supported by the Important National Science & Technology Specific
文摘A three-dimensional (3-D) modified cellular automaton (MCA) method was developed for simulating the dendrite morphology of cubic system alloys. Two-dimensional (2-D) equations of growth velocities of the dendrite tip, interface curvature and anisotropy of the surface energy were extended to 3-D system in the model. Therefore, the model was able to describe the morphology evolution of 3-D dendrites. Then, the model was applied to simulate the mechanism of spacing adjustment for 3-D columnar dendrite growth, and the competitive growth of columnar dendrites with different preferred growth orientations under constant temperature gradient and pulling velocity. Directional solidification experiments of NH4Cl-H2O transparent alloy were performed. It was found that the simulated results compared well with the experimental results. Therefore, the model was reliable for simulating the 3-D dendrite growth of cubic system alloys.
基金Supported by the National Natural Science Foundation of China (No.61234002,61274132)the Key Project of Zhejiang Provincial Natural Science Foundation of China(No.Z1111219)
文摘By researching the ternary counter and low power circuit design method, a novel design of low power ternary Domino counter on switch-level is proposed. Firstly, the switch-level structure expression of ternary loop operation circuit with enable pin is derived according to the switch-signal theory, and the one bit ternary counter is obtained combining the ternary adiabatic Domino literal operation circuit and buffer. Then the switch-level structure expression of enable signal circuit is derived, and the four bits ternary counter is obtained by cascade connection. Finally, the circuit is simulated by Spice tool and the output waveforms transform in proper order indicating that the logic function is correct. The energy consumption of the four bits ternary adiabatic Domino counter is 63% less than the conventional Domino counterpart.
基金Supported by the Key Scientific and Technological Projects of Heilongjiang Province during the 10~(th) Five-Year Plan Period, No. GB05C401-10
文摘AIM: To investigate the effect of all-trans-retinoic acid (ATRA) on arsenic trioxide (As2O3)-induced apoptosis of human hepatoma, breast cancer, and lung cancer cells in an attempt to find a better combination therapy for solid tumors. METHODS: Human hepatoma cell lines HepG2, Hep3B, human breast cancer cell line MCF-7, and human lung adenocarcinoma cell line AGZY-83-a were treated with As203 together with ATRA. Cell survival fraction was determined by MTT assay, cell viability and apoptosis were measured by annexin V-fluorescein isothiocyanate (FITC) and PI staining, and intracellular glutathione (GSH) and glutathione-S-transferase (GST) activities were determined using commercial kits. RESULTS: Cytotoxicity of ATRA was low. ATRA (0.1, 1, and 10 μmol/L) could synergistically potentiate As2O3 to exert a dose-dependent inhibition of growth and to induce apoptosis in each of the cell lines. HepG2 and Hep3B with low intracellular GSH or GST activities were remarkably sensitive to As2O3 or As2O3+ATRA, while AGZY-83-a with higher GSH or GST activities was less sensitive to As2O3 or As2O3+ATRA. Treatment with 2 μmol/L As2O3 for 72 h significantly decreased intracellular GSH and GST levels in each of the cell lines, and 1 μmol/L ATRA alone reduced minimal intracellular GSH and GST levels. ATRA potentiated the effect of As2O3 on intracellular GSH levels, but intracellular GST levels were not significantly affected by the combination of As2O3 and ATRA for 72 h as compared to As2O3 alone.CONCLUSION: ATRA can strongly potentiate As2O3- induced growth-inhibition and apoptosis in each of the cell lines, and two drugs can produce a significant synergic effect. The sensitivity to As2O3 or As2O3+ATRA is inversely proportional to intracellular GSH or GST levels in each of the cell lines. The GSH redox system may be the possible mechanism by which ATRA synergistically potentiates As203 to exert a dose-dependent inhibition of growth and to induce apoptosis. 2005 The WJG Press and Elsevier Inc. All rights reserved.
文摘Thermal parameters of various III-V antimonides,especially the quaternary lattice matched to GaSb or InAs substrates as well as some strained ternaries,have been investigated theoretically.Results show that at most composition region many ternary and quaternary antimonides exhibit rather lower thermal conductivity compared to related binaries,and the reason has been discussed.The thermal designing rule of the lasers and other power devices using those antimonides also has been discussed.
基金National Natural Science Foundation ofChina(No.59971065)
文摘Cubic boron nitride(c-BN) films were deposited on W6Mo5Cr4V2 high speed steel(HSS) substrate implanted with boron ion by RF-magnetron sputtering. The films were analyzed by the bending beam method, scratch test, XPS and AFM. The experimental results show that the implantation of boron atom can reduce the internal stress and improve the adhesion strength of the films. The critical load of scratch test rises to 27.45 N, compared to 1.75 N of c-BN film on the unimplanted HSS. The AFM shows that the surface of the c-BN film on the implanted HSS is low in roughness and small in grain size. Then the composition of the boron implanted layer was analyzed by the XPS. And the influence of the boron implanted layer on the internal stress and adhesion strength of c-BN films were investigated.
基金supported by the Beijing Laboratory of Advanced Information Networks
文摘the routing protocol for low-power and lossy networks(RPL) has been used in advanced metering infrastructure(AMI)which could provide two-way communication between smart meters and city utilities.To improve the network performance of AMI networks, this paper proposed an improved algorithm of RPL based on triangle module operator(IAR-TMO). IAR-TMO proposes membership functions of the following five typical routing metrics: end-to-end delay, number of hops, expected transmission count(ETX),node remaining energy, and child node count.Moreover, IAR-TMO uses triangle module operator to fuse membership functions of these routing metrics. Then, IAR-TMO selects preferred parents(the next hop) based on the triangle module operator. Theoretical analysis and simulation results show that IAR-TMO has a great improvement when compared with two recent representative algorithms: ETXOF(ETX Objective Function) and OF-FL(Objective Function based on Fuzzy Logic), in terms of network lifetime, average end-to-end delay,etc. Consequently, the network performances of AMI networks can be improved effectively.
基金National Natural Science Foundation of China (No.60975084)
文摘In this paper, the 3-D Wavelet-Fractal coder was used to compress the hyperspectral remote sensing image, which is a combination of 3-D improved set partitioning in hierarchical trees (SPIHT) coding and 3-D fractal coding. Hyperspectral image date cube was first translated by 3-D wavelet and the 3-D fractal compression ceding was applied to lowest frequency subband. The remaining coefficients of higher frequency sub-bands were encoding by 3-D improved SPIHT. We used the block set instead of the hierarchical trees to enhance SPIHT's flexibility. The classical eight kinds of affme transformations in 2-D fractal image compression were generalized to nineteen for the 3-D fractal image compression. The new compression method had been tested on MATLAB. The experiment results indicate that we can gain high compression ratios and the information loss is acceptable.
文摘Methods of improving seismic event locations were investigated as part of a research study aimed at reducing ground control safety hazards. Seismic event waveforms collected with a 23-station three-dimensional sensor array during longwall coal mining provide the data set used in the analyses. A spatially variable seismic velocity model is constructed using seismic event sources in a passive tomographic method. The resulting three-dimensional velocity model is used to relocate seismic event positions. An evolutionary optimization algorithm is implemented and used in both the velocity model development and in seeking improved event location solutions. Results obtained using the different velocity models are compared. The combination of the tomographic velocity model development and evolutionary search algorithm provides improvement to the event locations.
基金Under the auspices of the Key Direction in Knowledge Innovation Programs of Chinese Academy of Sciences (No KZCX2-YW-422)National Natural Science Foundation of China (No 40701059)
文摘Urban expansion is a phenomenon of urban space increase,and an important measuring index of the process of urbanization.Taking Shanghai as an example,the changes of urban average height and built-up area were studied to represent city's vertical and horizontal increases respectively,and statistical methods were used to analyze the driving forces of urban expansion.The research drew following conclusions:1) The urban expansion process of Shanghai from 1985 to 2006 had a clear periodic feature,and could be divided into three stages:vertical expansion in dominance,coordinated vertical and horizontal expansion,and horizontal expansion in dominance.2) The average height and quantity of buildings in core city were significantly bigger than those in suburbs,but the changing speed of the latter was faster.And 3) urbanization process was the major driving force for the city's horizontal expansion,while industrial structure improvement was the key driving factor for the vertical expansion.Those two driving forces were simultaneously affected by city's political factors.
基金supported by the SINOPEC Corporation (Contact No. 408069)
文摘In this work,ethylene glycol monomethylether(EE) was chosen as an entrainer for the azeotropic distillation of 1,3,5-trimethylbenzene+1-methyl-2-ethylbenzene system to investigate the influence of the entrainer on vapor liquid equilibrium(VLE) of this system.Three sets of binary VLE data in the system consisting of EE + 1,3,5-trimethylbenzene +1-methyl-2-ethylbenzene were measured using the Dvorak-Boublik still.The binary parameters of NRTL model were correlated by using the likelihood method.The ternary VLE data of the system were measured as well and were predicted by using the binary parameters of NRTL model.The test results indicated that the binary data passed the thermodynamic consistency tests,and the difference between the predicted values of ternary VLE and the experimental data reached the research standard for VLE data.Addition of EE had a great influence on the relative volatility between 1,3,5-trimethylbenzene and 1-methl-2-ethyl-benzene:when the ratio of solvent was 4,and the relative volatility between 1,3,5-trimethylbenzene and 1-methyl-2-ethylbenzene increased from 1.0125(without solvent addition) to 1.283.
文摘The cpc's 13th Five-Year comprehensive plan put forward a major historic task of building a new socialist countryside. This is the comprehensive implementation of urban and rural development to increase industrial agriculture, move the city to support the countryside, accelerate urbanization and narrow the gap between urban and rural areas. To solve the "three rural issues", the comprehensive construction ofa well-offsociety, has a very important strategic role to ease the contradiction of China's rural and urban ecnomic structure. In the process of building a new socialist countryside, the financial policy, as an important means ofmacroeconomic regulation and control, should play a leading role in solving the effective allocation &funds. Due to various factors affected by the current supply of rural financial market constraints, system defects and environmental constraints, there is a large gap between the level of the existing rural financial services and the requirements of the new rural construction which is to be improved urgently.