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让孩子的嘴'动'起来——小学英语课堂'说'中'学'的策略研究
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作者 田玲玲 《新东方英语(中英文版)》 2018年第4期186-186,共1页
小学英语课堂中语言交际是语言教学的本质,也是小学英语课堂教学一个很重要的方面.即让学生在学中用,在用中学.学习英语的目的在于借助它加强人与人之间的认知和交流.《英语课程标准》明确指出:在小学英语教学中,教师应该避免单纯的传... 小学英语课堂中语言交际是语言教学的本质,也是小学英语课堂教学一个很重要的方面.即让学生在学中用,在用中学.学习英语的目的在于借助它加强人与人之间的认知和交流.《英语课程标准》明确指出:在小学英语教学中,教师应该避免单纯的传授语言知识的教学.要突出交际能力、综合语言运用能力的培养. 展开更多
关键词 小学生 ''中'' 英语
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浅谈'五商中交'战略背景下的人力资源战略管理 被引量:1
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作者 王珺琇 《中国经贸》 2017年第14期69-71,共3页
从成立到至今的11年时间,中国交建实现了跨越式的发展,成功跻身世界五百强,面临的机会和挑战增加,这就亟需优化企业管理水平和发展水平,增加集团核心竞争力和国际竞争力.'五商中交'战略的提出,是中交集团寻求转型升级的需要,也... 从成立到至今的11年时间,中国交建实现了跨越式的发展,成功跻身世界五百强,面临的机会和挑战增加,这就亟需优化企业管理水平和发展水平,增加集团核心竞争力和国际竞争力.'五商中交'战略的提出,是中交集团寻求转型升级的需要,也是对中交发展历史进行的继承和创新.而中交集团旗下二级单位中交隧道局作为在隧道和地铁工程领域专业突出,技术领先的新兴企业,更应该迎合时代的需求和现阶段体制改革的需要,优化组织架构,合理配置资源;加强定岗定编定员,优化劳动力组合;优化绩效管理制度,降本增效. 展开更多
关键词 '五商' 人力资源 战略管理
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From Chooz to the Ling'ao NPP:The Technology Transfer of Pressurized Water Reactor Technology from France to China
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作者 CHEN Yue LI Yunyi 《Chinese Annals of History of Science and Technology》 2024年第1期97-124,共28页
The transfer of pressurized water reactor(PWR)technology from France to China is an important event in the history of Sino-French scientific and technological relations.China has gradually achieved self-reliance in th... The transfer of pressurized water reactor(PWR)technology from France to China is an important event in the history of Sino-French scientific and technological relations.China has gradually achieved self-reliance in the field of PWR technology through the introduction and subsequent absorption of France's 900 MW reactors.Compared with the process of introducing and absorbing similar technology from the United States by France,China's experience has been more complicated.This circumstance reflects the differences in the nuclear power technology systems between the two countries.France's industrial strength and early acquisition of nuclear power technology laid a solid foundation for mastering PWR technology.On the other hand,although China established a weak foundation through the implementation of the"728 Project,"and tried hard to negotiate with France,the substantive content of the technology transfer was very limited.By way of the policy transition from"unhooking of technology and trade"to"integration of technology and trade,"China ultimately accomplished the absorption and innovation of PWR technology through the Ling'ao NPP. 展开更多
关键词 pressurized water reactor(PWR) technology transfer Sino-French relations Chooz NPP Daya Bay NPP Ling'ao NPP
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Time series analysis of red tide's disaster characteristics in China seas 被引量:2
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作者 徐海龙 谷德贤 +2 位作者 张文亮 高启 乔秀亭 《Marine Science Bulletin》 CAS 2015年第1期1-10,共10页
The annual frequency of red tides from 1977 to 2012 and the monthly frequency of red tides from 2001 to 2012 in China seas were used to establish the time series of red tide annual frequency and monthly frequency, res... The annual frequency of red tides from 1977 to 2012 and the monthly frequency of red tides from 2001 to 2012 in China seas were used to establish the time series of red tide annual frequency and monthly frequency, respectively. The annual frequency fit well with time segments revealed by piecewise linear regression analysis. The seasonal maximum of monthly frequency was in May (-18.22), and the stochastic volatility tended to increase gradually with time series, with peak values occurring from May to July. Holt exponential smoothing and Holt-winter exponential smoothing were used to predict red tide annual and monthly frequencies, which revealed that the annual frequency of red tides would rise slowly by one time from 2013 to 2020, and that red tides would mainly occur from May to July in 2013-2016 with a peak value of about 25 times in May. 展开更多
关键词 China seas red tide FREQUENCY time series
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Numerical simulation of flow regions in red mud separation thickener's feedwell by analysis of residence-time distribution 被引量:4
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作者 周天 李茂 +3 位作者 李秋龙 雷波 周谦 周孑民 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2014年第4期1117-1124,共8页
The residence-time distribution (RTD) and the compartment model were applied to characterizing the flow regions in red mud separation thickener’s feedwells. Combined with the experimental work, validated mathematic... The residence-time distribution (RTD) and the compartment model were applied to characterizing the flow regions in red mud separation thickener’s feedwells. Combined with the experimental work, validated mathematical model as well as three-dimensional computational fluid dynamics (CFD) model was established to analyze the flow regions of feedwells on an industrial scale. The concept of RTD, although a well-known method for the characterization of mixing behavior in conventional mixers and reactors, is still a novel measure for the characterization of mixing in feedwells. Numerical simulation results show that the inlet feed rate and the aspect ratio of feedwells are the most critical parameters which affect the RTD of feedwell. Further simulation experiments were then carried out. Under the optimal operation conditions, the volume fraction of dead zone can reduce by10.8% and an increasement of mixing flow volume fraction by 6.5% is also observed. There is an optimum feed inlet rate depending on the feedwell design. The CFD model in conjunction with the RTD analysis then can be used as an effective tool in the design, evaluation and optimization of thickener feedwell in the red mud separation. 展开更多
关键词 computational fluid dynamics residence-time distribution compartment model feedwell
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Change Trend of Chinese Urban Residents' Food-nitrogen Consumption 被引量:2
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作者 王俊能 许振成 彭晓春 《Agricultural Science & Technology》 CAS 2010年第4期176-179,共4页
Change trend of Chinese urban residents' per capita food-nitrogen annual consumption from 1981 to 2007 was analyzed and predicted by using ARIMA time-series model in order to reveal the change of urban food-nitrogen ... Change trend of Chinese urban residents' per capita food-nitrogen annual consumption from 1981 to 2007 was analyzed and predicted by using ARIMA time-series model in order to reveal the change of urban food-nitrogen consumption during the China's urbanization process.Results showed that after 1980s,the annual consumption of Chinese urban residents' food-nitrogen had a change trend of " increase-decrease-increase" and generally presented as a slight increasing trend;With the acceleration of rapid economic development and urbanization process,Chinese urban residents' food-nitrogen consumption will still keep a rising trend in future,and also has a large rising space. 展开更多
关键词 Food consumption NITROGEN Spearman's rank correlation coefficient ARIMA model Urban residents China
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Prospects of China's Agricultural Development 被引量:9
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作者 魏后凯 韩磊 《China Economist》 2016年第4期46-67,共22页
Remarkable achievements have been made in China's agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives... Remarkable achievements have been made in China's agricultural development since the late 1970s. Nevertheless, deep-rooted problems are arising from inefficient farming practices. From mid- and long-term perspectives, migration of China's agricultural labor will slow and large-scale operation of farmland will accelerate. Although grain supply and demand have maintained a tight balance, new potentials still exist in improving grain production. Under the pressures of resource and environmental constraints, advancing the green and efficient transition of agriculture will become a new trend in China's agricultural development. In this context, the treatment of agricultural pollution, supply-side structural reform and innovation of agricultural subsidy policy are of strategic significance to the transition and upgrade of China's agriculture. 展开更多
关键词 agricultural development mid- and long-term prospects supply-sidestructural reforms transition and upgrade
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Supply-Side Structural Reforms and China's Potential Economic Growth Rate 被引量:10
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作者 李平 娄峰 《China Economist》 2016年第4期4-21,共18页
This paper examines the effect of supply-side structural reforms on China's potential economic growth rate in the coming decade according to the data the authors have gathered. Under the rapid growth scenario with th... This paper examines the effect of supply-side structural reforms on China's potential economic growth rate in the coming decade according to the data the authors have gathered. Under the rapid growth scenario with the implementation of supply-side structural reforms, China's potential economic growth rate will reach an average of 6.5% and 5.8% respectively in the 13th Five-year Plan (2016-2020) and 14th Five-year Plan (2021-2025) periods. These rates are 0.2 and 0.3 percentage points higher, respectively, than that under the baseline scenario with the inertia of historic trends. In implementing supply-side structural reforms, China must transform governmental functions, break monopolies, create a comprehensive competitive market environment, foster the creation of pro-innovation mechanisms, refocus on quality and efficiency, and raise capital utilization and labor productivity. 展开更多
关键词 supply-side structural reforms potential economic growth rate TFP China'seconomy
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Middle Jurassic Sporo-pollen Assemblage from the Yan'an Formation of Dongsheng, Nei Monggol, China 被引量:2
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作者 江德昕 王永栋 《Acta Botanica Sinica》 CSCD 2002年第2期230-238,共9页
The Middle Jurassic palynomorphs from the Yan'an Formation in Dongsheng region of Nei Monggol, consist of 63 species of fossil spores and pollen grains belonging to 34 genera, of which two species were described a... The Middle Jurassic palynomorphs from the Yan'an Formation in Dongsheng region of Nei Monggol, consist of 63 species of fossil spores and pollen grains belonging to 34 genera, of which two species were described as new. Based on statistical analysis of 3 863 specimens identified in 10 samples from Hantaichuan, Nianpanlianggou and Liugou sections, the sporo-pollen assemblage from the Yan'an Formation in Dongsheng region was established, which is generally characterized by the slight dominance of gymnospermous pollen grains (generally attaining proportion of 51%-54%), whereas the pteridophytic spores reach 46%-49% in abundance. In comparison with those of adjacent regions as well as Eurasia and North America, the present sporo-pollen assemblage is regarded to early Middle Jurassic (corresponding to Bajocian Stage) in geological age. According to the climatic conditions reflected by the palynoflora, the paleoclimate in Dongsheng region is suggested to be warm temperate or subtropical warm and humid during the early Middle Jurassic. 展开更多
关键词 Sporo-pollen assemblage Bajocian stage the Yan'an Formation PALEOCLIMATE Nei Monggol
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PROF.ZHANG ANLI'S EXPERIENCE OF TREATING STUBBORN CASES OF FACIAL PALSY 被引量:1
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作者 陈晓军 《World Journal of Acupuncture-Moxibustion》 2007年第4期58-61,共4页
Based on her own experience of many years' clinical practice, Prof. Zhang Anli summarized and created the method in which the shallow insertion at the upper eyelid, acupuncture at the Back-shu points and balanced sel... Based on her own experience of many years' clinical practice, Prof. Zhang Anli summarized and created the method in which the shallow insertion at the upper eyelid, acupuncture at the Back-shu points and balanced selection of points together with the modified Setting Mountain on Fire and application of Fire Needle were applied for the treatment of stubborn cases of facial palsy. The therapeutic effect is good. 展开更多
关键词 Bell's palsy (facial paralysis facial palsy) Acupuncture and moxibustion
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China's Industrial Upgrade and Human Capital Improvement 被引量:1
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作者 张车伟 高文书 《China Economist》 2016年第4期22-45,共24页
Based on statistics, this paper reviews China's economic growth and industrial upgrade since the reform and opening up in 1978 and estimates the contribution of industrial restructuring to economic growth. With the y... Based on statistics, this paper reviews China's economic growth and industrial upgrade since the reform and opening up in 1978 and estimates the contribution of industrial restructuring to economic growth. With the years of schooling as the proxy variable of human capital, this paper describes changes in China's labor competence during the industrial restructuring process. Then, this paper estimates China's future human capital demand and shortage based on economic and demographic forecast. Lastly, this paper proposes recommendations for improving human capital in China with skills development and education. 展开更多
关键词 industrial structure industrial upgrade human capital labor competence China supply-side structural reforms
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补中益气汤含药血清对树突状细胞VDR甲基化及PI3K-AKT-mTOR通路的影响 被引量:2
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作者 文艺 高天舒 《中华中医药学刊》 CAS 北大核心 2024年第1期87-95,共9页
目的补中益气汤对树突状细胞(dendritic cells,DCs)免疫耐受机制的体外研究。方法小鼠树突状细胞株于体外进行培养,分为空白对照组(A组)、中药组(B组)、维生素D组(C组)、中药+维生素D组(D组)、中药+LY组(E组)、维生素D+LY组(F组)、中药+... 目的补中益气汤对树突状细胞(dendritic cells,DCs)免疫耐受机制的体外研究。方法小鼠树突状细胞株于体外进行培养,分为空白对照组(A组)、中药组(B组)、维生素D组(C组)、中药+维生素D组(D组)、中药+LY组(E组)、维生素D+LY组(F组)、中药+VitD+LY组(G组)。以15%含药血清,10μmol·L-1维生素D、1.5μmol·L-1LY294002(PI3K阻滞剂)分别干预7组细胞,于培养箱中分别培养24、48 h后,BSP法检测树突状细胞维生素D受体(vitamin D receptor,VDR)基因DNA甲基化情况;ELISA法检测细胞上清液中VDR、白细胞介素-10(interleukin-10,IL-10)的含量;流式细胞术检测细胞共刺激分子CD40、CD80、CD86、主要组织相容性复合物-Ⅱ(major histocom-patibility complex,MHC-Ⅱ)的表达水平;Western Blot、qPCR检测各组细胞PI3K-AKT-mTOR通路mRNA及蛋白情况。结果(1)中药及维生素D干预后,DCs上VDR的表达增多(P<0.001或P<0.05),VDR基因DNA甲基化情况显著降低(P<0.05)。(2)中药及维生素D能够提高DCs上清液中IL-10含量(P<0.05或P<0.001),阻滞剂作用后,DCs分泌IL-10的功能均降低(P<0.05或P<0.001)。(3)中药及维生素D能够降低DCs表面因子CD40、CD80、CD86及MHCD-Ⅱ的表达(P<0.05或P<0.001),阻滞剂作用后,CD40、CD80、CD86及MHCD-Ⅱ表达均提高(P<0.001)。(4)Western Blot、qPCR结果显示,中药及维生素D能够升高DCs PI3K-AKT-mTOR通路mRNA和蛋白的表达(P<0.05或P<0.001),抑制剂作用后,PI3K-AKT-mTOR通路mRNA和蛋白水平均下降,其中磷酸化蛋白降低显著(P<0.001)。(5)24 h与48 h两个时间点并未见明显差异(P>0.05)。结论补中益气汤通过抑制DCs VDR基因DNA甲基化,激活PI3K-AKT-mTOR通路,使其维持免疫耐受状态。 展开更多
关键词 益气汤 AIT 树突状细胞 VDR PI3K-AKT-mTOR通路
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Studies on forest sustainable development and issues under the condition of WTO's principles in China
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作者 曹培忠 赵静静 周艳波 《Journal of Forestry Research》 SCIE CAS CSCD 2004年第2期161-166,i004,共7页
The World Trade Organization (WTO), an international organization to deal with the world free trade mechanism, allows for the optimal use of the world's resources in accordance with the objective of sustainable de... The World Trade Organization (WTO), an international organization to deal with the world free trade mechanism, allows for the optimal use of the world's resources in accordance with the objective of sustainable development and the protection of environment and trade. China, as a state member of WTO, is challenged by the WTO's agreements and the principles to guideline China sustainable forest development in the future. Forest resources in China will be protected as the basic sections of natural resources. The administrative function of Chinese government will be reformed by the condition of WTO's principles. So, the aim of China forest sustainable development is prior to deal with the relationship between the environment protection and development of economy. Under the condition of the WTO's principles and as a base on the international customary laws, the issues of China forest sustainable development focus on the China forest system reformation that applies for the China nature forest stratagem by the laws and protects the China environment for the sustainable development under the condition of science development, especially in the China forest protection and in dealing with the relationship among the environment and the economy development and others. Establishing the zoological forest industry is basic requirement by both the WTO's agreements and the WTO's principles, especially under the GATT 1947 Art XX, and other principles to protect the China forest sustainable development and to create the international environment for China forest. Keywords WTO's principles - China forest - Sustainable development CLC number S7-05 Document code B Biography: CAO Pei-zhong (1965-), male, Associate Professor of Shandong Agriculture of University. School of Laws and Literature. LLM of University of Canberra, one of ten lawyers with experience of almost ten years, sent by the Government in 2000, arbitrator and engineer. Chief of Shandong Agriculture University Laws Institution, publishing the papers abroad and in China medium At present, dealing with the project and rescarching on.international litigation, especially the WTO and EU law, is major the directionResponsible editor: Chai Ruihal 展开更多
关键词 WTO's principles China forest Sustainable development
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Construction of Strategic Supporting-System for Anti-dumping Measures on China's Agricultural Products
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作者 陈勇生 邓海华 +2 位作者 刘福业 潘方胤 吴文龙 《Agricultural Science & Technology》 CAS 2012年第1期9-12,共4页
With the international trade theories as the basis,this study started with researches on the reality of agricultural products that often experience anti-dumping,carried out a careful study on the construction of busin... With the international trade theories as the basis,this study started with researches on the reality of agricultural products that often experience anti-dumping,carried out a careful study on the construction of business strategic supporting-system to cope with the anti-dumping so as to promote the association governance and industrial warning mechanism and to provide new strategic thinking and theoretical support for the exporters to cope with anti-dumping. 展开更多
关键词 Agricultural products Coping with anti-dumping Strategic supportingsystem
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补中益气汤合增液汤加减治疗功能性便秘气阴两虚证疗效评价 被引量:1
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作者 马晓敏 张虹玺 《辽宁中医药大学学报》 CAS 2024年第2期87-90,共4页
目的探讨补中益气汤合增液汤加减治疗功能性便秘气阴两虚证的临床疗效。方法将该院于2019年1月—2021年12月收治的80例功能性便秘气阴两虚证患者纳入研究,采用随机对照法将所选患者进行分组,分为治疗组及对照组各40例。其中治疗组患者... 目的探讨补中益气汤合增液汤加减治疗功能性便秘气阴两虚证的临床疗效。方法将该院于2019年1月—2021年12月收治的80例功能性便秘气阴两虚证患者纳入研究,采用随机对照法将所选患者进行分组,分为治疗组及对照组各40例。其中治疗组患者应用补中益气汤合增液汤加减治疗,150 mL/次,每日2次。对照组予以枸橼酸莫沙必利分散片5 mg/次口服,每日3次。2组均以4周为1个疗程,比较治疗前后便秘主要症状评分、便秘患者症状自评量表(PAC-SYM)评分变化情况,并比较两组患者的临床疗效。结果药物干预前,两组患者临床症状包括大便性状、排便间隔、排便困难、排便不尽症状评分及腹部症状、直肠症状、大便症状、PAC-SYM量表总分评分对比,差异无统计学意义,均P>0.05;经药物干预后,两组患者大便性状、排便间隔、排便困难、排便不尽症状评分及腹部症状、直肠症状、大便症状、PAC-SYM量表总分评分均明显低于治疗前,且观察组明显低于对照组,均P<0.05。观察组的总有效率明显高于对照组(P<0.05)。结论补中益气汤合增液汤加减治疗功能性便秘气阴两虚证具有较好临床效果,能够显著缓解大便干燥症状,改善患者生存状态,且具有不良反应小、患者认可度高等优势,是值得广泛应用的方案之一。 展开更多
关键词 气阴两虚证 功能性便秘 益气汤 增液汤 临床疗效
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Design and theoretical analysis of test system for propellants' gas pressure in warhead
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作者 边晶晶 武震 《Journal of Measurement Science and Instrumentation》 CAS 2014年第1期10-14,共5页
Aiming at harsh environment of cluster bombs center tube explosion dispersion and difficulties in installation of traditional test systems,a storage test system based on 16-bit ultra-low power microcontroller MSP430 i... Aiming at harsh environment of cluster bombs center tube explosion dispersion and difficulties in installation of traditional test systems,a storage test system based on 16-bit ultra-low power microcontroller MSP430 is designed in order to acquire gas pressure during cluster bombs dispersion.To meet the requirement of low power consumption,the working states of system's modules during data acquisition are elaborated and the equation to calculate the gas pressure change during cylindrical center tube opening the hatch is deduced.The field test is conducted and good test results are obtained. 展开更多
关键词 warhead dispersion center tube explosion dispersion gas pressure storage test and measurement low power consumption
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学术期刊与中国近代法学自主知识体系的形成——以《法律评论》《中华法学杂志》《法学季刊》为例 被引量:1
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作者 刘昕杰 《上海师范大学学报(哲学社会科学版)》 CSSCI 北大核心 2024年第4期110-120,共11页
近代以来,学术期刊是学术研究成果发表的主要载体,伴随着近代中国学术知识体系的形成,学术期刊的出版发行日益成熟。以《法律评论》《中华法学杂志》《法学季刊》为代表的中国近代法学学术期刊,虽然主办单位、出版周期和办刊风格各异,... 近代以来,学术期刊是学术研究成果发表的主要载体,伴随着近代中国学术知识体系的形成,学术期刊的出版发行日益成熟。以《法律评论》《中华法学杂志》《法学季刊》为代表的中国近代法学学术期刊,虽然主办单位、出版周期和办刊风格各异,但在近代中国法学知识体系的形成中都发挥了重要作用。其中关于中华法系的研究、中外法律制度的比较研究,以及英文版期刊的编辑出版,都对当下的法学学术与出版具有借鉴意义。从这三本法学学术期刊发表论文的总体情况来看,重视传统文化、直面实践疑难、保持全球视野,是中国法学学术共同体得以形成的重要原因,也理当成为中国法学学术与出版界继续坚持的学术风格。 展开更多
关键词 学术期刊 法学自主知识体系 法律评论 华法学杂志 法学季刊
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温中和胃汤联合耳穴压豆对脾胃虚寒型慢性胃炎患者治疗疗效及对血清VIP、MTL水平的影响
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作者 韩广明 赵炜 吕迎春 《辽宁中医杂志》 CAS 北大核心 2024年第7期92-96,共5页
目的 温中和胃汤联合耳穴压豆对脾胃虚寒型慢性胃炎(CG)患者的治疗疗效及对血清VIP、MTL水平的影响。方法 选取2021年1月—2022年5月该院接收的脾胃虚寒型CG患者90例,采用随机数字表法分为观察组47例和对照组43例。所有患者均行常规治疗... 目的 温中和胃汤联合耳穴压豆对脾胃虚寒型慢性胃炎(CG)患者的治疗疗效及对血清VIP、MTL水平的影响。方法 选取2021年1月—2022年5月该院接收的脾胃虚寒型CG患者90例,采用随机数字表法分为观察组47例和对照组43例。所有患者均行常规治疗,同时对照组给予耳穴压豆治疗,观察组在对照组基础上联合温中和胃汤治疗。对比两组的治疗疗效、中医证候评分、不良反应发生情况。治疗前后,检测两组患者外周血胃肠功能指标[胃动素(MTL)、血管活性肽(VIP)]以及炎症指标[白细胞介素-1β(IL-1β)以及白细胞介素-6(IL-6)]表达水平。在患者停药3个月后,对其进行为期半年的跟踪随访调查,记录其复发情况。结果 观察组、对照组治疗总有效率分别为93.62%、76.74%,不良反应总共发生率分别为17.02%、9.30%,6个月内复发率分别为0.00%、13.95%。,观察组治疗总有效率较高、6个月复发率较低(P<0.05),两组不良反应发生率无差异(P>0.05)。治疗后中医证候对比,观察组胃隐痛、喜温喜按、劳累/受凉后症状加重和泛吐清水评分低于对照组(P<0.05),两组神疲倦怠、舌淡胖评分无差异(P>0.05)。治疗后,观察组血清MTL高于对照组(P<0.05),VIP、IL-1β低于对照组(P<0.05),两组IL-6浓度无差异(P>0.05)。结论 温中和胃汤联合耳穴压豆可有效提高脾胃虚寒型CG治疗疗效,降低VIP和IL-1β表达,同时提高MTL表达水平,降低短期内复发率。 展开更多
关键词 慢性胃炎 脾胃虚寒型 和胃汤 血管活性肽 复发
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加味补中益气汤治疗哮喘机制的分子对接研究
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作者 王莹 刘艳俊 张春晖 《中华中医药学刊》 CAS 北大核心 2024年第9期175-178,I0040-I0042,共7页
目的运用分子对接技术预测加味补中益气汤治疗哮喘的作用机制。方法依托中药系统药理学数据库平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP),筛选出加味补中益气汤的主要化学成分和... 目的运用分子对接技术预测加味补中益气汤治疗哮喘的作用机制。方法依托中药系统药理学数据库平台(Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,TCMSP),筛选出加味补中益气汤的主要化学成分和相应靶点,利用Cytoscape软件构建“药物-疾病-靶点”的网络关系,将药物主要成分及疾病的交集靶点导入STRING平台构建蛋白相互作用(Protein-protein interaction networks,PPI)网络,并利用AutoDock软件将加味补中益气汤的主要成分与哮喘的关键靶点进行分子对接。结果共筛选出加味补中益气汤有效成分338种,支气管哮喘相关靶点1744个,其中交集靶点120个。PPI网络分析加味补中益气汤主要作用于蛋白激酶Cα(Protein kinase C alpha,PRKCA)、丝裂原活化蛋白激酶14(Mitogen-activated protein kinase 14,MAPK14)、V-Rel网状内皮增生病毒癌基因同源物A(V-Rel reticuloendotheliosis viral oncogene homolog A,RELA)、V-Jun肉瘤病毒17癌基因同源物(V-Jun sarcoma virus 17 oncogene homolog,JUN)和B细胞中κ轻型多肽基因增强子的核因子15(Nuclear factor-k-gene binding15,NFKB15)个核心靶点。分子对接结果表明筛选得到的主要活性成分与靶点有较强的结合。结论加味补中益气汤治疗支气管哮喘或许具有积极作用,其作用机制可能与调节PRKCA、MAPK14、RELA、JUN和NFKB1等信号通路有关。 展开更多
关键词 分子对接技术 加味补益气汤 哮喘 作用机制
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The quantified analysis of China's GM cotton yield capacity by C-D function and stochastic frontier model
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作者 张涛 薛宝娣 《Hunan Agricultural Science & Technology Newsletter》 2004年第1期11-13,共3页
Using a modified C D function and stochastic frontier model, the paper analyzed China's cotton yield capacity and found that the yield and technical efficiency of China's cotton planting system can be increas... Using a modified C D function and stochastic frontier model, the paper analyzed China's cotton yield capacity and found that the yield and technical efficiency of China's cotton planting system can be increased by the use of genetically modified (GM) varieties. 展开更多
关键词 GM cotton yield capacity C D function stochastic frontier model
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