Aim To analyse the static temperature field ofthe solid rubber tire(SRT).Methods The mechanical and thermal FE models were developed and analyzed respectively with the FE software ANSYS.Results The maximum temperature...Aim To analyse the static temperature field ofthe solid rubber tire(SRT).Methods The mechanical and thermal FE models were developed and analyzed respectively with the FE software ANSYS.Results The maximum temperature becomes higher with the higher with the higher velocity of tire and scales down slightly with the higher convection coefficients.The mixed models are reasonable.Conclusion The study on static temperature field is important and reasonable.It gives the fundament for life analysis of SRT.展开更多
Research about the auto commuter's pre-trip route choice behavior ignores the combined influence of the real-time information and all respondents' historical information in the existing documents.To overcome this sh...Research about the auto commuter's pre-trip route choice behavior ignores the combined influence of the real-time information and all respondents' historical information in the existing documents.To overcome this shortcoming,an approach to describing the pre-trip route choice behavior with the incorporation of the real-time and historical information is proposed.Two types of real-time information are investigated,which are quantitative information and prescriptive information.By using the bounded rationality theory,the influence of historical information on the real-time information reference process is examined first.Estimation results show that the historical information has a significant influence on the quantitative information reference process,but not on the prescriptive information reference process.Then the route choice behavior is modeled.A comparison is also made among three route choice models,one of which does not incorporate the real-time information reference process,while the others do.Estimation results show that the route choice behavior is better described with the consideration of the reference process of both quantitative and prescriptive information.展开更多
The aim of the present work is to examine whether the price volatility of nonferrous metal futures can be used to predict the aggregate stock market returns in China. During a sample period from January of 2004 to Dec...The aim of the present work is to examine whether the price volatility of nonferrous metal futures can be used to predict the aggregate stock market returns in China. During a sample period from January of 2004 to December of 2011, empirical results show that the price volatility of basic nonferrous metals is a good predictor of value-weighted stock portfolio at various horizons in both in-sample and out-of-sample regressions. The predictive power of metal copper volatility is greater than that of aluminum. The results are robust to alternative measurements of variables and econometric approaches. After controlling several well-known macro pricing variables, the predictive power of copper volatility declines but remains statistically significant. Since the predictability exists only during our sample period, we conjecture that the stock market predictability by metal price volatility is partly driven by commodity financialization.展开更多
[Objective] The matter of chemical fertilizer being overused but organic fertilizer being deficiently used causes environment pollution and soil fertility degradation and holds back agricultural sustainable developmen...[Objective] The matter of chemical fertilizer being overused but organic fertilizer being deficiently used causes environment pollution and soil fertility degradation and holds back agricultural sustainable development in China at present.[Method] A survey of 200 farmers selected from Shandong province was conducted in 2008 to identify the factors influencing farmers willingness to use organic fertilizer.[Result] Logit model results showed that the proportion of non-farm income in total income,awareness of...展开更多
In this paper, supose Γ be a boundary of a Jordan domain D and Γ satisfied Альпер condition, the order that rational type interpolating operators at Fejer's points of f(z)∈C(Γ) converge to f(z) in the se...In this paper, supose Γ be a boundary of a Jordan domain D and Γ satisfied Альпер condition, the order that rational type interpolating operators at Fejer's points of f(z)∈C(Γ) converge to f(z) in the sense of uniformly convergence is obtained.展开更多
To get the quantitive value of abnormal biological tissues, an inverse algorithm about the Young's modulus based on the boundary extraction and the image registration technologies is proposed. With the known displace...To get the quantitive value of abnormal biological tissues, an inverse algorithm about the Young's modulus based on the boundary extraction and the image registration technologies is proposed. With the known displacements of boundary tissues and the force distribution, the Young's modulus is calculated by constructing the unit system and the inverse finite element method (IFEM). Then a tough range of the modulus for the whole tissue is estimated referring the value obtained before. The improved particle swarm optimizer (PSO) method is adopted to calculate the whole Yong's modulus distribution. The presented algorithm overcomes some limitations in other Young's modulus reconstruction methods and relaxes the displacements and force boundary condition requirements. The repetitious numerical simulation shows that errors in boundary displacement are not very sensitive to the estimation of next process; a final feasible solution is obtained by the improved PSO method which is close to the theoretical values obtained during searching in an extensive range.展开更多
The soil organic carbon (SOC) pool is the largest component of terrestrial carbon pools. With the construction of a geographically referenced database taken from the second national general soil survey materials and b...The soil organic carbon (SOC) pool is the largest component of terrestrial carbon pools. With the construction of a geographically referenced database taken from the second national general soil survey materials and based on 1546 typical cropland soil profiles, the paddy field and dryland SOC storage among six regions of China were systematically quantified to characterize the spatial pattern of cropland SOC storage in China and to examine the relationship between mean annual temperature, precipitation, soil texture features and SOC content. In all regions, paddy soils had higher SOC storage than dryland soils, and cropland SOC content was the highest in Southwest China. Climate controlled the spatial distribution of SOC in both paddy and dryland soils, with SOC storage increasing with increasing precipitation and decreasing with increasing temperature.展开更多
In order to improve the seismic performance of Chinese traditional stele relics, a suitable aseismic strengthening method of Chinese traditional stele relics is proposed. Taking the typical stele relic in Xi'an Beili...In order to improve the seismic performance of Chinese traditional stele relics, a suitable aseismic strengthening method of Chinese traditional stele relics is proposed. Taking the typical stele relic in Xi'an Beilin as an example, the on-site investigations were carried out to obtain the actual geometric size and damage state of the stele relic. Then, the structural performance of the stele relic was analyzed by the finite element software ANSYS. Finally, the two different aseismic strengthening methods of the traditional stele relic are proposed and comparatively analyzed. The results show that in addition to the common problems, such as weathering, and cracks, etc, earthquakes seriously threaten the structural safety of stele relics. Under the rarely-occurring earthquake of eight degree, the unstrengthened stele relic will be overturned, and many cracks will occur at the connection area of stele body and stele pedestal. When the stele relic is strengthened by the stainless angle steel strengthening method, the stele relic will not be overturned, but some cracks will occur at the connection area of stele body and stele pedestal. When the stele relic is strengthened by the base isolation strengthening method, the stele relic will not be overturned, and no cracks will occur at the connection area of stele body and stele pedestal. Therefore, the aseismic strengthening effect of the base isolation strengthening method is obviously better than that of the stainless angle steel strengthening method, and this method is a suitable aseismic strengthening method of Chinese traditional stele relics.展开更多
AIM To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn's disease(CD) with tuberculosis infection.METHODS A retrospective study of clinical outcome among children treated with...AIM To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn's disease(CD) with tuberculosis infection.METHODS A retrospective study of clinical outcome among children treated with thalidomide was conducted. All patients had evidence of tuberculosis infection with a failure of anti-tuberculosis treatment for more than one year,and were subsequently diagnosed with CD. All the patients received thalidomide treatment with a starting dose of 1.2-2.5 mg/kg per day. Remission was defined as pediatric CD activity index less than or equal to 10.RESULTS Ten patients with CD were treated with thalidomide at an average age of 7.2 years and followed up for a median of 22.2 mo. Clinical remission rate was 60% after 9-12 mo of thalidomide treatment. One patient with no response had an interleukin-10 receptor alpha gene mutation. Erythrocyte sedimentation rate,C-reactive protein and platelet count showed a dramatic decrease; hemoglobin level and weight improved significantly after thalidomide treatment when compared with the baseline values.CONCLUSION Thalidomide is an effective and safe drug for remission of CD in pediatric patients who have been treated for tuberculosis.展开更多
AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD)...AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April 2011.We also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with DAIBD.An endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was evaluated.To determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were analyzed.RESULTS:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the DAIBD.An endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ulcers.However,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD variance.Patients with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the model.CONCLUSION:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD scores.However,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.展开更多
To compare meiofaunal community in the two mangrove wetlands in Tong'an Bay, Xiamen, China, and probe the response of meiofauna to high organic matter, sampling was carried out in Fenglin and Xiang'an mangrove wetla...To compare meiofaunal community in the two mangrove wetlands in Tong'an Bay, Xiamen, China, and probe the response of meiofauna to high organic matter, sampling was carried out in Fenglin and Xiang'an mangrove wetlands in the bay. The results showed that the Ne/Co ratio (nematode to benthic copepod) and organic matter in Fenglin mangrove wetland were higher than those in Xiang'an mangrove wetland. The meiofaunal abundance in Fenglin mangrove was all lower than that in Xiang'an mangrove wetland in summer, autumn and spring, while the meiofaunal abundance in Fenglin mangrove was higher than that in Xiang'an mangrove wetland in winter. Two-way ANOVA results showed that the meiofaunal abundance and nematode abundance were significantly different between regions, seasons and regionxseason. With all the results in the present study, we confirmed that the positive response of meiofaunal and nematode abundance were only detected for medium organic matter contents according to the Xiang'an wetland's level, and that the distribution of meiofaunal abundance would be influenced by sand content. Higher copepod abundance and lower N/C value usually suggest better environmental quality.展开更多
Landslides are increasing since the 1980s in Xi'an, Shaanxi Province, China. This is due to the increase of the frequency and intensity of precipitation caused by complex geological structures, the presence of ste...Landslides are increasing since the 1980s in Xi'an, Shaanxi Province, China. This is due to the increase of the frequency and intensity of precipitation caused by complex geological structures, the presence of steep landforms, seasonal heavy rainfall, and the intensifcation of human activities. In this study, we propose a landslide prediction model based on the analysis of intraday rainfall(IR) and antecedent effective rainfall(AER). Primarily, the number of days and degressive index of the antecedent effective rainfall which affected landslide occurrences in the areas around Qin Mountains, Li Mountains and Loess Tableland was established. Secondly, the antecedent effective rainfall and intraday rainfall were calculated from weather data which were used to construct critical thresholds for the 10%, 50% and 90% probabilities for future landslide occurrences in Qin Mountain, Li Mountain and Loess Tableland. Finally, the regions corresponding to different warning levels were identified based on the relationship between precipitation and the threshold, that is; "A" region is safe, "B" region is on watch alert, "C" region is on warning alert and "D" region is on severe warning alert. Using this model, a warning program is proposed which can predict rainfall-induced landslides by means of real-time rain gauge data and real-time geo-hazard alert and disaster response programs. Sixteen rain gauges were installed in the Xi'an region by keeping in accordance with the regional geology and landslide risks. Based on the data from gauges, this model accurately achieves the objectives of conducting real-time monitoring as well as providing early warnings of landslides in the Xi'an region.展开更多
Objective To predict the main active ingredients,potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan...Objective To predict the main active ingredients,potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by using databases and literatures.Potential targets were predicted by reverse molecular docking,and then a component-target network was constructed.The target network of Alzheimer's disease(AD)was mapped and analyzed to obtain the“active ingredient-AD target”network.The key targets were screened through network analysis.Finally,the rationality of the prediction was analyzed by comparing with the target reported in the literatures.Results There were180chemical constituents acting on the AD target,and the targets included three key targets(cyclooxygenase-2,muscarinic acetylcholine receptor M1,and muscarinic acetylcholine receptor M2)and an important target(acetylcholine esterase).Alzheimer's disease may be treated by regulating the activity of acetylcholine receptors and the binding toβ-amyloid protein,and its biological process may be concentrated in the acetylcholine receptor signal pathway,negative regulation of synaptic transmission and so on.Conclusion The fact that Yuan Zhi powder can treat AD is consistent with the characteristics of multi-components-multitargets-multiple pathways of traditional Chinese medicine.The important targets obtained from network analysis have a large proportion in literature research,so network analysis have some rationality.展开更多
Information on the palaeoenvironm ent from Late Pleistocene to Holocen e in northwestern Yannan Plateau has been deduced from a study of a 28.81m-long core taken from Napahai Lake.The results from Relative Brightness ...Information on the palaeoenvironm ent from Late Pleistocene to Holocen e in northwestern Yannan Plateau has been deduced from a study of a 28.81m-long core taken from Napahai Lake.The results from Relative Brightness In-dex(RBI )as well as those from the lithological analyses of bulk sediments,total organic carbon and granulometric analy-ses have been used to reconstruct the environmental and climatic evoluti on of the area.The ages were provided by three 14 C datings.The record suggested a climate fluctuation between warm-dry a nd cool-wet from ca.57to 32ka B.P.,which led a shallowing and swamping of the l ake.The water level again increased quickly at ca.32ka B.P.,reached it’ s peak during LGM(Last Glacial Maximum,ca.18-20ka B.P.)and remained relative high until ca.15ka B.P.The high wa-ter level at LGM is attributed to cold-wet conditions.The area experienced an abrupt and unstable climatic ch anges dur-ing the transition period from15to 10ka B.P.with a dominated littoral en vironment.Awarm-dry climate led to the contrac-tion of the lake during the Holocene a nd reed-swamps became dominant.After a minor wet-cool pulse during the L ate Holocene,the modern climate became to be established.展开更多
A geometrical parameters optimization and reducers selection method was proposed for robotic manipulators design. The Lagrangian approach was employed in deriving the dynamic model of a two-DOF manipulator. The flexib...A geometrical parameters optimization and reducers selection method was proposed for robotic manipulators design. The Lagrangian approach was employed in deriving the dynamic model of a two-DOF manipulator. The flexibility of links and joints was taken into account in the mechanical structure dimensions optimization and reducers selection, in which Timoshenko model was used to discretize the hollow links. Two criteria, i.e. maximization of fundamental frequency and minimization of self-mass/load ratio, were utilized to optimize the manipulators. The NSGA-II (fast elitist nondominated sorting genetic algorithms) was employed to solve the multi-objective optimization problem. How the joints flexibility affects the manipulators design was analyzed and shown in the numerical analysis example. The results indicate that simultaneous consideration of the joints and the links flexibility is very necessary for manipulators optimal design. Finally, several optimal combinations were provided. The effectiveness of the optimization method was proved by comparing with ADAMS simulation results. The self-mass/load ratio error of the two methods is within 10%. The maximum error of the natural frequency by the two methods is 23.74%. The method proposed in this work provides a fast and effective pathway for manipulator design and reducers selection.展开更多
The dynamic mechanical properties and miscibility of an organic hybrid made from chlorinated polyethylene (CPE) and 2, 2'-methyIene-bis-( 4-methyl-6-cyclohexylphenol) ( ZKF ) are mainly discussed in this paper. It...The dynamic mechanical properties and miscibility of an organic hybrid made from chlorinated polyethylene (CPE) and 2, 2'-methyIene-bis-( 4-methyl-6-cyclohexylphenol) ( ZKF ) are mainly discussed in this paper. It is found that ZKF acts as an antiplasticizer in CPE matrix and has good miscibility even with large ratio in CPE /ZKF hybrids. The glass transition temperature of various CPE /ZKF hybrids determined by DSC give a good fit to Wood's equation. Bifunctional ZKF is supposed to improve the intermolecular force of CPE, and the improvement is developed when the ZKF content increases. On the other hand, the viscoelastic properties are highly improved with the addition of ZKF. TA and tanδ peak values increase when the ZKF content increase in the CPE /ZKF hybrids, the damping capacity has been improved during the glass transition of CPE /ZKF hybrids. In addition, the glass transition temperature shifts to room temperature from the low temperature with the continuous addition of ZKF to CPE.展开更多
The paper presented a new regular pattern (network structure ) of great earthquakes occurred in China's Mainland during the past 700 years, which may be helpful to improve the understanding of great earthquakes ...The paper presented a new regular pattern (network structure ) of great earthquakes occurred in China's Mainland during the past 700 years, which may be helpful to improve the understanding of great earthquakes and can serve as a base for the study of prediction of future great earthquakes. It can be done because there are quite complete and confident records of historical and recent earthquakes in a wide extent in China.展开更多
From the continuum mechanics perspective, an attempt was made to clarify the role of Terzaghi's effective stress in the theoretical analysis of saturated soil subjected to seepage. The necessity of performing a co...From the continuum mechanics perspective, an attempt was made to clarify the role of Terzaghi's effective stress in the theoretical analysis of saturated soil subjected to seepage. The necessity of performing a coupled hydromechanical analysis to solve the seepage-deformation interaction problem was illustrated by examining the equations of static equilibrium among the effective stress, seepage force, pore-water pressure and total stress. The conceptual definition of stress variable that satisfies the principles of continuum mechanics is applied in the coupled hydromechanical analysis. It is shown that Terzaghi's effective stress is in fact not a stress variable under seepage conditions, and the seepage force acting on the soil skeleton cannot be viewed as a body force. This offers a clue to the underlying cause of a paradox between the real Pascal's hydrostatic state and the hydrostatic state predicted by a class of continuum hydromechanical theories.展开更多
The reforms in oil and gas sector have been accelerated in 2015. The reform of mineral rights has begun and 6 oil and gas exploration zones in Xinjiang Autonomous Region have served as the tender pilots, breaking thro...The reforms in oil and gas sector have been accelerated in 2015. The reform of mineral rights has begun and 6 oil and gas exploration zones in Xinjiang Autonomous Region have served as the tender pilots, breaking through the requirements on the resources varieties, exploration phase and enterprise qual!fication. The right of importing and using of the crude oil has been gradually relaxed and 13 local refineries have obtained the right to use imported crude oil of 55.1888 million tons per year. The natural gas price for non-residential use was unified and a universal price was set ~r the incremental supply and existing supply. Tire Shanghai Petroleum and Gas Exchange (SHPGX) was established and laid foundation for the market mechanism to detervnine the price. The government governance has undergone continuous adjustments such as regulating the tax instead of charging the fees, streamlining administration and delegating power to tire lower levels.The Guidelines on Deepening tire Reform of State-owned Enterprises was released, symbolizing the accomplishment of the overall planning ~ the SOE reform.展开更多
文摘Aim To analyse the static temperature field ofthe solid rubber tire(SRT).Methods The mechanical and thermal FE models were developed and analyzed respectively with the FE software ANSYS.Results The maximum temperature becomes higher with the higher with the higher velocity of tire and scales down slightly with the higher convection coefficients.The mixed models are reasonable.Conclusion The study on static temperature field is important and reasonable.It gives the fundament for life analysis of SRT.
基金The Scientific Research Innovation Project for College Graduates in Jiangsu Province(No.CX10B_071Z)the National High Technology Research and Development Program of China(863 Program)(No.2011AA110304)
文摘Research about the auto commuter's pre-trip route choice behavior ignores the combined influence of the real-time information and all respondents' historical information in the existing documents.To overcome this shortcoming,an approach to describing the pre-trip route choice behavior with the incorporation of the real-time and historical information is proposed.Two types of real-time information are investigated,which are quantitative information and prescriptive information.By using the bounded rationality theory,the influence of historical information on the real-time information reference process is examined first.Estimation results show that the historical information has a significant influence on the quantitative information reference process,but not on the prescriptive information reference process.Then the route choice behavior is modeled.A comparison is also made among three route choice models,one of which does not incorporate the real-time information reference process,while the others do.Estimation results show that the route choice behavior is better described with the consideration of the reference process of both quantitative and prescriptive information.
基金Project(71071166)supported by the National Natural Science Foundation of China
文摘The aim of the present work is to examine whether the price volatility of nonferrous metal futures can be used to predict the aggregate stock market returns in China. During a sample period from January of 2004 to December of 2011, empirical results show that the price volatility of basic nonferrous metals is a good predictor of value-weighted stock portfolio at various horizons in both in-sample and out-of-sample regressions. The predictive power of metal copper volatility is greater than that of aluminum. The results are robust to alternative measurements of variables and econometric approaches. After controlling several well-known macro pricing variables, the predictive power of copper volatility declines but remains statistically significant. Since the predictability exists only during our sample period, we conjecture that the stock market predictability by metal price volatility is partly driven by commodity financialization.
文摘[Objective] The matter of chemical fertilizer being overused but organic fertilizer being deficiently used causes environment pollution and soil fertility degradation and holds back agricultural sustainable development in China at present.[Method] A survey of 200 farmers selected from Shandong province was conducted in 2008 to identify the factors influencing farmers willingness to use organic fertilizer.[Result] Logit model results showed that the proportion of non-farm income in total income,awareness of...
文摘In this paper, supose Γ be a boundary of a Jordan domain D and Γ satisfied Альпер condition, the order that rational type interpolating operators at Fejer's points of f(z)∈C(Γ) converge to f(z) in the sense of uniformly convergence is obtained.
文摘To get the quantitive value of abnormal biological tissues, an inverse algorithm about the Young's modulus based on the boundary extraction and the image registration technologies is proposed. With the known displacements of boundary tissues and the force distribution, the Young's modulus is calculated by constructing the unit system and the inverse finite element method (IFEM). Then a tough range of the modulus for the whole tissue is estimated referring the value obtained before. The improved particle swarm optimizer (PSO) method is adopted to calculate the whole Yong's modulus distribution. The presented algorithm overcomes some limitations in other Young's modulus reconstruction methods and relaxes the displacements and force boundary condition requirements. The repetitious numerical simulation shows that errors in boundary displacement are not very sensitive to the estimation of next process; a final feasible solution is obtained by the improved PSO method which is close to the theoretical values obtained during searching in an extensive range.
基金Project supported by the National Key Basic Research and Development Program of China (No. 2002CB412501), theKnowledge Innovation Key Project of Chinese Academy of Sciences (No. KZCX1-SW-01-19), and the Integrated Interdis-ciplinary Science Plan of Land-Use/Land-Cover and Terrestrial Carbon Process of Institute of Geographical Sciences andNatural Resources Research (No. CXIOG-E01-02-02).
文摘The soil organic carbon (SOC) pool is the largest component of terrestrial carbon pools. With the construction of a geographically referenced database taken from the second national general soil survey materials and based on 1546 typical cropland soil profiles, the paddy field and dryland SOC storage among six regions of China were systematically quantified to characterize the spatial pattern of cropland SOC storage in China and to examine the relationship between mean annual temperature, precipitation, soil texture features and SOC content. In all regions, paddy soils had higher SOC storage than dryland soils, and cropland SOC content was the highest in Southwest China. Climate controlled the spatial distribution of SOC in both paddy and dryland soils, with SOC storage increasing with increasing precipitation and decreasing with increasing temperature.
基金The National Natural Science Foundation of China(No.51578127,51778122)the Foundation for the Author of National Excellent Doctoral Dissertation of China(No.201452)the Fundamental Research Funds for the Central Universities(No.2242016K41065)
文摘In order to improve the seismic performance of Chinese traditional stele relics, a suitable aseismic strengthening method of Chinese traditional stele relics is proposed. Taking the typical stele relic in Xi'an Beilin as an example, the on-site investigations were carried out to obtain the actual geometric size and damage state of the stele relic. Then, the structural performance of the stele relic was analyzed by the finite element software ANSYS. Finally, the two different aseismic strengthening methods of the traditional stele relic are proposed and comparatively analyzed. The results show that in addition to the common problems, such as weathering, and cracks, etc, earthquakes seriously threaten the structural safety of stele relics. Under the rarely-occurring earthquake of eight degree, the unstrengthened stele relic will be overturned, and many cracks will occur at the connection area of stele body and stele pedestal. When the stele relic is strengthened by the stainless angle steel strengthening method, the stele relic will not be overturned, but some cracks will occur at the connection area of stele body and stele pedestal. When the stele relic is strengthened by the base isolation strengthening method, the stele relic will not be overturned, and no cracks will occur at the connection area of stele body and stele pedestal. Therefore, the aseismic strengthening effect of the base isolation strengthening method is obviously better than that of the stainless angle steel strengthening method, and this method is a suitable aseismic strengthening method of Chinese traditional stele relics.
基金Supported by Medical Science and Technology Planning Project of Zhejiang Province,China,No.2015KYB430(to Hong Y)
文摘AIM To evaluate the efficacy of thalidomide for treating troublesome cases of pediatric Crohn's disease(CD) with tuberculosis infection.METHODS A retrospective study of clinical outcome among children treated with thalidomide was conducted. All patients had evidence of tuberculosis infection with a failure of anti-tuberculosis treatment for more than one year,and were subsequently diagnosed with CD. All the patients received thalidomide treatment with a starting dose of 1.2-2.5 mg/kg per day. Remission was defined as pediatric CD activity index less than or equal to 10.RESULTS Ten patients with CD were treated with thalidomide at an average age of 7.2 years and followed up for a median of 22.2 mo. Clinical remission rate was 60% after 9-12 mo of thalidomide treatment. One patient with no response had an interleukin-10 receptor alpha gene mutation. Erythrocyte sedimentation rate,C-reactive protein and platelet count showed a dramatic decrease; hemoglobin level and weight improved significantly after thalidomide treatment when compared with the baseline values.CONCLUSION Thalidomide is an effective and safe drug for remission of CD in pediatric patients who have been treated for tuberculosis.
文摘AIM:To develop a novel endoscopic severity model of intestinal Behcet's disease(BD) and to evaluate its feasibility by comparing it with the actual disease activity index for intestinal Behcet's disease(DAIBD).METHODS:We reviewed the medical records of 167 intestinal BD patients between March 1986 and April 2011.We also investigated the endoscopic parameters including ulcer locations,distribution,number,depth,shape,size and margin to identify independent factors associated with DAIBD.An endoscopic severity model was developed using significant colonoscopic variables identified by multivariate regression analysis and its correlation with the DAIBD was evaluated.To determine factors related to the discrepancy between endoscopic severity and clinical activity,clinical characteristics and laboratory markers of the patients were analyzed.RESULTS:A multivariate regression analysis revealed that the number of intestinal ulcers(≥ 2,P = 0.031) and volcanoshaped ulcers(P = 0.001) were predictive factors for the DAIBD.An endoscopic severity model(Y) was developed based on selected endoscopic variables as follows:Y = 47.44 + 9.04 × non-Ileocecal area + 11.85 ×≥ 2 of intestinal ulcers + 5.03 × shallow ulcers + 12.76 × deep ulcers + 4.47 × geographicshaped ulcers + 26.93 × volcano-shaped ulcers + 8.65 ×≥ 20 mm of intestinal ulcers.However,endoscopic parameters used in the multivariate analysis explained only 18.9% of the DAIBD variance.Patients with severe DAIBD scores but with moderately predicted disease activity by the endoscopic severity model had more symptoms of irritable bowel syndrome(21.4% vs 4.9%,P = 0.026) and a lower rate of corticosteroid use(50.0% vs 75.6%,P = 0.016) than those with severe DAIBD scores and accurately predicted disease by the model.CONCLUSION:Our study showed that the number of intestinal ulcers and volcano-shaped ulcers were predictive factors for severe DAIBD scores.However,the correlation between endoscopic severity and DAIBD(r = 0.434) was weak.
基金supported by the National Natural Science Foundation of China(Grant No.41176089)supported by WEL(abbreviation of Key Laboratory of the Coastal and Wetland Ecosystems,Ministry of Education)Visiting Fellowship Program from Xiamen University
文摘To compare meiofaunal community in the two mangrove wetlands in Tong'an Bay, Xiamen, China, and probe the response of meiofauna to high organic matter, sampling was carried out in Fenglin and Xiang'an mangrove wetlands in the bay. The results showed that the Ne/Co ratio (nematode to benthic copepod) and organic matter in Fenglin mangrove wetland were higher than those in Xiang'an mangrove wetland. The meiofaunal abundance in Fenglin mangrove was all lower than that in Xiang'an mangrove wetland in summer, autumn and spring, while the meiofaunal abundance in Fenglin mangrove was higher than that in Xiang'an mangrove wetland in winter. Two-way ANOVA results showed that the meiofaunal abundance and nematode abundance were significantly different between regions, seasons and regionxseason. With all the results in the present study, we confirmed that the positive response of meiofaunal and nematode abundance were only detected for medium organic matter contents according to the Xiang'an wetland's level, and that the distribution of meiofaunal abundance would be influenced by sand content. Higher copepod abundance and lower N/C value usually suggest better environmental quality.
基金financially supported by the National Natural Science Foundation of China (Grant Nos. 41130753 and 41202244)the National Key Fundamental Research Program of China (973) (Grant No. 2014CB744703)China Postdoctoral Science Foundation (Grant No. 2012M521728)
文摘Landslides are increasing since the 1980s in Xi'an, Shaanxi Province, China. This is due to the increase of the frequency and intensity of precipitation caused by complex geological structures, the presence of steep landforms, seasonal heavy rainfall, and the intensifcation of human activities. In this study, we propose a landslide prediction model based on the analysis of intraday rainfall(IR) and antecedent effective rainfall(AER). Primarily, the number of days and degressive index of the antecedent effective rainfall which affected landslide occurrences in the areas around Qin Mountains, Li Mountains and Loess Tableland was established. Secondly, the antecedent effective rainfall and intraday rainfall were calculated from weather data which were used to construct critical thresholds for the 10%, 50% and 90% probabilities for future landslide occurrences in Qin Mountain, Li Mountain and Loess Tableland. Finally, the regions corresponding to different warning levels were identified based on the relationship between precipitation and the threshold, that is; "A" region is safe, "B" region is on watch alert, "C" region is on warning alert and "D" region is on severe warning alert. Using this model, a warning program is proposed which can predict rainfall-induced landslides by means of real-time rain gauge data and real-time geo-hazard alert and disaster response programs. Sixteen rain gauges were installed in the Xi'an region by keeping in accordance with the regional geology and landslide risks. Based on the data from gauges, this model accurately achieves the objectives of conducting real-time monitoring as well as providing early warnings of landslides in the Xi'an region.
基金funding support from the Major new drug creation project (2017ZX09101002-002-008)National Natural Science Foundation of China (81403171)Autonomous Program of China Academy of Chinese Medical Sciences (QZPT001 and 2014065)
文摘Objective To predict the main active ingredients,potential targets and molecular mechanisms of Yuan Zhi powder in treatment of dementia by using network pharmacology.Methods A database of chemical constituents of Yuan Zhi powder was constructed by using databases and literatures.Potential targets were predicted by reverse molecular docking,and then a component-target network was constructed.The target network of Alzheimer's disease(AD)was mapped and analyzed to obtain the“active ingredient-AD target”network.The key targets were screened through network analysis.Finally,the rationality of the prediction was analyzed by comparing with the target reported in the literatures.Results There were180chemical constituents acting on the AD target,and the targets included three key targets(cyclooxygenase-2,muscarinic acetylcholine receptor M1,and muscarinic acetylcholine receptor M2)and an important target(acetylcholine esterase).Alzheimer's disease may be treated by regulating the activity of acetylcholine receptors and the binding toβ-amyloid protein,and its biological process may be concentrated in the acetylcholine receptor signal pathway,negative regulation of synaptic transmission and so on.Conclusion The fact that Yuan Zhi powder can treat AD is consistent with the characteristics of multi-components-multitargets-multiple pathways of traditional Chinese medicine.The important targets obtained from network analysis have a large proportion in literature research,so network analysis have some rationality.
文摘Information on the palaeoenvironm ent from Late Pleistocene to Holocen e in northwestern Yannan Plateau has been deduced from a study of a 28.81m-long core taken from Napahai Lake.The results from Relative Brightness In-dex(RBI )as well as those from the lithological analyses of bulk sediments,total organic carbon and granulometric analy-ses have been used to reconstruct the environmental and climatic evoluti on of the area.The ages were provided by three 14 C datings.The record suggested a climate fluctuation between warm-dry a nd cool-wet from ca.57to 32ka B.P.,which led a shallowing and swamping of the l ake.The water level again increased quickly at ca.32ka B.P.,reached it’ s peak during LGM(Last Glacial Maximum,ca.18-20ka B.P.)and remained relative high until ca.15ka B.P.The high wa-ter level at LGM is attributed to cold-wet conditions.The area experienced an abrupt and unstable climatic ch anges dur-ing the transition period from15to 10ka B.P.with a dominated littoral en vironment.Awarm-dry climate led to the contrac-tion of the lake during the Holocene a nd reed-swamps became dominant.After a minor wet-cool pulse during the L ate Holocene,the modern climate became to be established.
基金Project(2009AA04Z216) supported by the National High-Tech Research and Development Program (863 Program) of ChinaProject(2009ZX04013-011) supported by the National Science and Technology Major Project of ChinaProject supported by the HIT Oversea Talents Introduction Program,China
文摘A geometrical parameters optimization and reducers selection method was proposed for robotic manipulators design. The Lagrangian approach was employed in deriving the dynamic model of a two-DOF manipulator. The flexibility of links and joints was taken into account in the mechanical structure dimensions optimization and reducers selection, in which Timoshenko model was used to discretize the hollow links. Two criteria, i.e. maximization of fundamental frequency and minimization of self-mass/load ratio, were utilized to optimize the manipulators. The NSGA-II (fast elitist nondominated sorting genetic algorithms) was employed to solve the multi-objective optimization problem. How the joints flexibility affects the manipulators design was analyzed and shown in the numerical analysis example. The results indicate that simultaneous consideration of the joints and the links flexibility is very necessary for manipulators optimal design. Finally, several optimal combinations were provided. The effectiveness of the optimization method was proved by comparing with ADAMS simulation results. The self-mass/load ratio error of the two methods is within 10%. The maximum error of the natural frequency by the two methods is 23.74%. The method proposed in this work provides a fast and effective pathway for manipulator design and reducers selection.
文摘The dynamic mechanical properties and miscibility of an organic hybrid made from chlorinated polyethylene (CPE) and 2, 2'-methyIene-bis-( 4-methyl-6-cyclohexylphenol) ( ZKF ) are mainly discussed in this paper. It is found that ZKF acts as an antiplasticizer in CPE matrix and has good miscibility even with large ratio in CPE /ZKF hybrids. The glass transition temperature of various CPE /ZKF hybrids determined by DSC give a good fit to Wood's equation. Bifunctional ZKF is supposed to improve the intermolecular force of CPE, and the improvement is developed when the ZKF content increases. On the other hand, the viscoelastic properties are highly improved with the addition of ZKF. TA and tanδ peak values increase when the ZKF content increase in the CPE /ZKF hybrids, the damping capacity has been improved during the glass transition of CPE /ZKF hybrids. In addition, the glass transition temperature shifts to room temperature from the low temperature with the continuous addition of ZKF to CPE.
基金The Central Level,Scientific Research Institutes for Basic R & D Special Fund Business (No.2060302)National Natural Science Foundation of China(No.40841016,No.40372131 and No.40702056)Old Experts Science Foundation of China Earthquake Administration(No.201039)
文摘The paper presented a new regular pattern (network structure ) of great earthquakes occurred in China's Mainland during the past 700 years, which may be helpful to improve the understanding of great earthquakes and can serve as a base for the study of prediction of future great earthquakes. It can be done because there are quite complete and confident records of historical and recent earthquakes in a wide extent in China.
基金Project(51278171)supported by the National Natural Science Foundation of ChinaProject(B13024)supported by the"111"Project,China+1 种基金Projects(2014B04914,2011B02814,2010B28114)supported by the Fundamental Research Funds for the Central Universities of ChinaProject(617608)supported by the Research Grants Council of the Hong Kong Special Administrative Region of China
文摘From the continuum mechanics perspective, an attempt was made to clarify the role of Terzaghi's effective stress in the theoretical analysis of saturated soil subjected to seepage. The necessity of performing a coupled hydromechanical analysis to solve the seepage-deformation interaction problem was illustrated by examining the equations of static equilibrium among the effective stress, seepage force, pore-water pressure and total stress. The conceptual definition of stress variable that satisfies the principles of continuum mechanics is applied in the coupled hydromechanical analysis. It is shown that Terzaghi's effective stress is in fact not a stress variable under seepage conditions, and the seepage force acting on the soil skeleton cannot be viewed as a body force. This offers a clue to the underlying cause of a paradox between the real Pascal's hydrostatic state and the hydrostatic state predicted by a class of continuum hydromechanical theories.
文摘The reforms in oil and gas sector have been accelerated in 2015. The reform of mineral rights has begun and 6 oil and gas exploration zones in Xinjiang Autonomous Region have served as the tender pilots, breaking through the requirements on the resources varieties, exploration phase and enterprise qual!fication. The right of importing and using of the crude oil has been gradually relaxed and 13 local refineries have obtained the right to use imported crude oil of 55.1888 million tons per year. The natural gas price for non-residential use was unified and a universal price was set ~r the incremental supply and existing supply. Tire Shanghai Petroleum and Gas Exchange (SHPGX) was established and laid foundation for the market mechanism to detervnine the price. The government governance has undergone continuous adjustments such as regulating the tax instead of charging the fees, streamlining administration and delegating power to tire lower levels.The Guidelines on Deepening tire Reform of State-owned Enterprises was released, symbolizing the accomplishment of the overall planning ~ the SOE reform.