A computer simulation study on dynamics for the precipitation of δ'(Al_3Li) ordered particles from a disor- dered matrix (α) in binary Al-Li alloys is performed using the microscopic Langevin equation. A unique ...A computer simulation study on dynamics for the precipitation of δ'(Al_3Li) ordered particles from a disor- dered matrix (α) in binary Al-Li alloys is performed using the microscopic Langevin equation. A unique precipitation mechanism is found near the ordering spinodal line. Different from the classical nucleation mechanism in the me- tastable region and the congruent ordering followed by spinodal decomposition in the instable region, a nonstoichi- ometric single ordered phase with composition fluctuations is formed by non-classical nucleation, and this ordered phase decomposes spinodally. It can be concluded that the precipitation dynamics of δ' phase from metastability to instability is gradual, and no sharp transition occurs near the mean-field spinodal line as the mean-field theory pre- dicts.展开更多
To evaluate the changes of 3', 5'-cyclic adenosine monophosphate (cAMP), thrombox-ane A2(TXA2) and prostacyclin (PGI2) in cerebrospinal fluid (CSF) in the asphyxiated newborn and explore their roles in hypoxic...To evaluate the changes of 3', 5'-cyclic adenosine monophosphate (cAMP), thrombox-ane A2(TXA2) and prostacyclin (PGI2) in cerebrospinal fluid (CSF) in the asphyxiated newborn and explore their roles in hypoxic-ischamic brain damage (HIBD). Thirty-six full term newborns were divided into 3 groups, including 12 with moderate-severe hypoxic-ischaemic encephalopathy (HIE), 13 with mild HIE, 11 without HIE (control group). The levels of cAMP, TXB2(TXA2 metabolite) and 6-keto-PGF1α(PGI2 metabolite) in CSF and plasma were measured 36-72 h after birth by RIA, and the concentrations were expressed as nM/L (cAMP), ng/L(TXB2 and 6-keto-PGF1α). The infants were followed-up at 6 and 12 month of age and Mental Development Index (MDI) and Psychomotor Development Index (FDD were measured using Bayley Scales of Infant Development (BSID). The CSF cAMP level in moderate-severe HIE group was 8. 60±2. 40, significantly lower than that of the mild HIE group (14. 83±2. 84) and the control group (24. 43±2. 39)(for both P<0. 01). The levels of TXB2 and 6-keto-PGF1α in CFS in the moderate-severe HIE group (206. 06±29. 74, 168. 47± 23. 02, respectively) were significantly higher than in the mild HIE group (83. 37±28. 57, 131. 42± 16. 57, respectively, P<0. 01) and the control group (41. 77±21. 58, 86. 23±13. 05, respectively, P<0. 01). The level changes of cAMP,TXB2 and 6-keto-PGF1α in plasma in all groups were similar to those in CSF, but no significant difference was found between mild HIE group and the control group (P>0. 05). The follow-up results showed that MDI and PDI of the moderate-severe HIE group were the lowest (84. 79±13. 34, 83. 50±13. 28, respectively), followed by mild HIE group (102.19±7. 02, 99. 94±9. 08, respectively) , with the control group being the highest (116. 63± 12.08, 116. 69±10. 87, respectively). Univariate analysis showed some significant difference (the moderate-severe HIE group vs. the mild HIE group or the control group, P<0. 01; the mild HIE group vs. the control group P<0. 05). The results suggested that the concentration of cAMP, TXA2 and T/K ratio in CSF after neonatal asphyxia might be sensitive markers in evaluating the severity of brain damage in early stage and predicting the future outcome.展开更多
[Objective] The aim was to conduct post-evaluation on environmental planning by means of logical framework approach. [Method] Taking environmental planning during '11th Five-year Plan' in a certain province fo...[Objective] The aim was to conduct post-evaluation on environmental planning by means of logical framework approach. [Method] Taking environmental planning during '11th Five-year Plan' in a certain province for example, by means of logical framework approach (LFA), the post-evaluation on environmental planning was carried out from the aspects of evaluation content, index system, implementation steps, evaluation feedback and input-output analysis of environmental planning. [Result] The post-evaluation on environmental planning by means of LFA achieved expected purpose and various indexes at different stages of environmental planning was assessed, and then corresponding countermeasures were put forward according to the problems which were found by problem tree of environmental planning project. [Conclusion] The study could provide theoretical references for the post-evaluation on environmental planning in future.展开更多
The title compound (C 12 H 10 N 2O 3, M r =230.22) is monoclinic, space group P2 1/c with unit cell of a=7.234 (1), b=8.999 (1), c=16.907(2) ; β=102.47°, V=1099.6(2) 3, Z=4, D c= 1.391g/...The title compound (C 12 H 10 N 2O 3, M r =230.22) is monoclinic, space group P2 1/c with unit cell of a=7.234 (1), b=8.999 (1), c=16.907(2) ; β=102.47°, V=1099.6(2) 3, Z=4, D c= 1.391g/cm 3; λ (Mo Kα )=0.71073 , μ =0.102mm -1 , F (000)=480, final R=0.0322, wR= 0.0770 for 1937 observed reflections [ I>2σ(I) ]. Structure analyses reveal that the two benzene rings are almost perpendicular and the bond angle between the two benzene rings is 118.44°.展开更多
Two title compounds, 4,4?diformyl-diphenoxyethane (compound 1, C16H14O4) and 4,4?4创-triformyl-triphenoxytriethylamine (compound 2, C27H27NO6), were synthesized by condensation of 4-hydroxybenzaldehyde with 1,2-dichlo...Two title compounds, 4,4?diformyl-diphenoxyethane (compound 1, C16H14O4) and 4,4?4创-triformyl-triphenoxytriethylamine (compound 2, C27H27NO6), were synthesized by condensation of 4-hydroxybenzaldehyde with 1,2-dichloroethane and tris(2-chloroethyl)amine, respectively in dimethyl formamide in the presence of anhydrous potassium carbonate. The crystal data are: monoclinic, P21/c, a = 7.571(2), b = 12.608(3), c = 7.357(2) ? b = 105.823(6)? V = 675.7(2) 3, Mr = 270.3, Z = 2, Dc = 1.328 g/cm3, F(000) = 284, m(MoKa) = 0.096 mm-1, R = 0.0537 and wR = 0.2189 for compound 1; and monoclinic, P21/n, a = 11.7162(6), b = 9.0042(6), c = 22.908(2) ? b = 99.505(1)? V = 2383.5(3) ?, Mr = 461.50, Z = 4, Dc = 1.286 g/cm3, F(000)= 976, m(MoKa) = 0.091 mm-1, R = 0.0464 and wR = 0.1462 for compound 2. The molecule of compound 1 (dialdehyde) is located at the crystallographic inversion center nearby the midpoint of C(8)C(8A) single bond. The three chains in the molecule of compound 2 (trialdehyde) are of non-crystallographic pseudo-C3 symmetry, and each of them is quite planar.展开更多
Of the 39 research projects that kicked off in 2005 with the support from the National Basic Research Program (dubbed the 973 Program) across the country, 12 are hosted by CAS scientists (including two under the joint...Of the 39 research projects that kicked off in 2005 with the support from the National Basic Research Program (dubbed the 973 Program) across the country, 12 are hosted by CAS scientists (including two under the joint leadership with other departments). Initiated in March 1997, the 973 Program is the national keystone basic research program organized by the Chinese government. Its strategic objectives are to strengthen the original innovations and to address the important scientific issues concerning the national economic and social development at a higher level and in a wider scope, so as to improve China’s capabilities of independent innovations and to provide scientific sup- port for the future development of the country. The followings are a brief account of some of the projects hosted by CAS in 2005.展开更多
Lymphotoxin(LT) is a glycoprotein secreted by activated T cell. The expression of LT gene is mainly regulated at the level of transcription. By using human LT DNA as a probe, we carried out a RNA dot blotting test and...Lymphotoxin(LT) is a glycoprotein secreted by activated T cell. The expression of LT gene is mainly regulated at the level of transcription. By using human LT DNA as a probe, we carried out a RNA dot blotting test and found that the longer the time of Jurkat human Tlymphoma cells exposed to the PMA and PHA, the more endogenous LT mRNA could be produced. Results of gel retardation assay showed that the nuclear extract from Jurkat cells treated with PMA and PHA formed different DNA-protein complexes. Changes in complex patterns were observed at various time intervals of PMA and PHA induction. A specific protein-binding site was mapped out to be a 22-bp sequence at the 5’upstream regioll of human LT gene by DNase I footprinting analysis. This region was similar to the sequence recognized by the proteins of NFkB family The results of fragment competition and homology analysis indicated that the 22-bp sequence contains a kB-like motif only which is located at the base pairs -100 to -90 (5’-GGGGGCTTCCC-3’). Thus, the NF-kBlike factors were involved in the protein-DNA interaction.Furthermore, there were more than one retarded bands appearing in the gel retardation assay. It suggested that there may be several NF-kB-like factors involved in theregulation of LT gene transcription at the same site.展开更多
Near-infrared spectroscopy(NIRS)technology and Mie theory are utilized for fundamental research on radiofrequency ablation of biological tissue.Firstly,NIRS is utilized to monitor rats undergoing radiofrequency ablati...Near-infrared spectroscopy(NIRS)technology and Mie theory are utilized for fundamental research on radiofrequency ablation of biological tissue.Firstly,NIRS is utilized to monitor rats undergoing radiofrequency ablation surgery in real time so as to explore the relationship between reduced scattering coefficient(μ_(s)')and the degree of thermally induced tissue coagulation.Then,Mie theory is utilized to analyze the morphological structure change of biological tissue so as to explore the basic mechanism of the change of optical parameters caused by thermally induced tissue coagulation.Results show that there is a close relationship between μ_(s)' and the degree of thermally induced tissue coagulation;the degree of thermal coagulation can be obtained by the value of μ_(s)';when biological tissue thermally coagulates,the average equivalent scattering particle decreases,the particle density increases,and the anisotropy factor decreases.展开更多
The National Basic Research Program (dubbed as the " 9 73 Program" is China's on-going national keystone basic research program, which was approved by the Chinese government in June 1997 and is organized...The National Basic Research Program (dubbed as the " 9 73 Program" is China's on-going national keystone basic research program, which was approved by the Chinese government in June 1997 and is organized and implemented by the Ministry of Science and Technology. The strategic objectives of the Program are to strengthen the original innovations and to address the important scientific issues concerning the national economic and social development at a deeper level and in a wider scope, so as to improve China's capabilities of independent innovations and to provide scientific support for the future development of the country. The followings are some of the" 9 73 projects" initiated in 2006 under the coordination of CAS scientists.展开更多
The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the mo...The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the molecule was analyzed by using a series of Systematic pharmacology methods.The results show that the M molecule has a higher drug-like DL value of 0.59 and better molecular property parameters,namely Hdon=4,Hacc=10 and AlogP=0.94;A total of 11 M molecules related targets,namely F2,ESR1,AR,F10,CA2,DPP4,CCNA2,PRSS1,CDK2,GSK3B and PTPN1;A total of 140 diseases are associated with M molecule targets,and these diseases are mainly related to cancer and cardiovascular diseases;A total of 52 pathways involve the pharmacological mechanisms of M molecules,which are mainly related to cancer and other related diseases;GO-enriched analysis showed that these targets are closely related to the regulation of peptidase activity and biological processes such as blood coagulation and hemostasis.This article clearly demonstrated the pharmacological mechanism of M molecule,which provides references for exploring the pharmacological mechanism of new compounds.展开更多
P-phenylene-2,2'-bis(5-aminobenzoxazole) is synthesized by the condensation of 2,4-diaminophenol dihydrochloride and terephthalic acid with high yield of 98% in polyphosphoric acid through adding reductive agent S...P-phenylene-2,2'-bis(5-aminobenzoxazole) is synthesized by the condensation of 2,4-diaminophenol dihydrochloride and terephthalic acid with high yield of 98% in polyphosphoric acid through adding reductive agent SnCl2 to suppress the oxidation of 2,4-diaminophenol dihydrochloride. The structure of the compound is characterized by using melting point, FT-IR,1H NMR, and element analysis.展开更多
The differential pulse voltarametric ( DPV ) method with a glassy carbon electrode was used for the determination of 3,3' 5,5'-tetramethy lbenzidine ( TMB ) , o-tolidine and benzidine in the acidic media. The ...The differential pulse voltarametric ( DPV ) method with a glassy carbon electrode was used for the determination of 3,3' 5,5'-tetramethy lbenzidine ( TMB ) , o-tolidine and benzidine in the acidic media. The pulse amplitude, interval time and scan rate of DPV are optimized to be 50 mV, 0.5 s and 10 mV/s, respectively, The peak current is proportional to the concentration of TMB and its analogues, the linear range is from 10^-8mol/l to 10^-4 mal/l, The electrochemical behaviour of the compounds is discussed, The chemical poisons can be determined directly, or indirectly by the extraction in the waste water of chemical industry and laboratory,展开更多
基金The project was financially supported by the National Science Foundation of China (59871039)
文摘A computer simulation study on dynamics for the precipitation of δ'(Al_3Li) ordered particles from a disor- dered matrix (α) in binary Al-Li alloys is performed using the microscopic Langevin equation. A unique precipitation mechanism is found near the ordering spinodal line. Different from the classical nucleation mechanism in the me- tastable region and the congruent ordering followed by spinodal decomposition in the instable region, a nonstoichi- ometric single ordered phase with composition fluctuations is formed by non-classical nucleation, and this ordered phase decomposes spinodally. It can be concluded that the precipitation dynamics of δ' phase from metastability to instability is gradual, and no sharp transition occurs near the mean-field spinodal line as the mean-field theory pre- dicts.
文摘To evaluate the changes of 3', 5'-cyclic adenosine monophosphate (cAMP), thrombox-ane A2(TXA2) and prostacyclin (PGI2) in cerebrospinal fluid (CSF) in the asphyxiated newborn and explore their roles in hypoxic-ischamic brain damage (HIBD). Thirty-six full term newborns were divided into 3 groups, including 12 with moderate-severe hypoxic-ischaemic encephalopathy (HIE), 13 with mild HIE, 11 without HIE (control group). The levels of cAMP, TXB2(TXA2 metabolite) and 6-keto-PGF1α(PGI2 metabolite) in CSF and plasma were measured 36-72 h after birth by RIA, and the concentrations were expressed as nM/L (cAMP), ng/L(TXB2 and 6-keto-PGF1α). The infants were followed-up at 6 and 12 month of age and Mental Development Index (MDI) and Psychomotor Development Index (FDD were measured using Bayley Scales of Infant Development (BSID). The CSF cAMP level in moderate-severe HIE group was 8. 60±2. 40, significantly lower than that of the mild HIE group (14. 83±2. 84) and the control group (24. 43±2. 39)(for both P<0. 01). The levels of TXB2 and 6-keto-PGF1α in CFS in the moderate-severe HIE group (206. 06±29. 74, 168. 47± 23. 02, respectively) were significantly higher than in the mild HIE group (83. 37±28. 57, 131. 42± 16. 57, respectively, P<0. 01) and the control group (41. 77±21. 58, 86. 23±13. 05, respectively, P<0. 01). The level changes of cAMP,TXB2 and 6-keto-PGF1α in plasma in all groups were similar to those in CSF, but no significant difference was found between mild HIE group and the control group (P>0. 05). The follow-up results showed that MDI and PDI of the moderate-severe HIE group were the lowest (84. 79±13. 34, 83. 50±13. 28, respectively), followed by mild HIE group (102.19±7. 02, 99. 94±9. 08, respectively) , with the control group being the highest (116. 63± 12.08, 116. 69±10. 87, respectively). Univariate analysis showed some significant difference (the moderate-severe HIE group vs. the mild HIE group or the control group, P<0. 01; the mild HIE group vs. the control group P<0. 05). The results suggested that the concentration of cAMP, TXA2 and T/K ratio in CSF after neonatal asphyxia might be sensitive markers in evaluating the severity of brain damage in early stage and predicting the future outcome.
文摘[Objective] The aim was to conduct post-evaluation on environmental planning by means of logical framework approach. [Method] Taking environmental planning during '11th Five-year Plan' in a certain province for example, by means of logical framework approach (LFA), the post-evaluation on environmental planning was carried out from the aspects of evaluation content, index system, implementation steps, evaluation feedback and input-output analysis of environmental planning. [Result] The post-evaluation on environmental planning by means of LFA achieved expected purpose and various indexes at different stages of environmental planning was assessed, and then corresponding countermeasures were put forward according to the problems which were found by problem tree of environmental planning project. [Conclusion] The study could provide theoretical references for the post-evaluation on environmental planning in future.
文摘The title compound (C 12 H 10 N 2O 3, M r =230.22) is monoclinic, space group P2 1/c with unit cell of a=7.234 (1), b=8.999 (1), c=16.907(2) ; β=102.47°, V=1099.6(2) 3, Z=4, D c= 1.391g/cm 3; λ (Mo Kα )=0.71073 , μ =0.102mm -1 , F (000)=480, final R=0.0322, wR= 0.0770 for 1937 observed reflections [ I>2σ(I) ]. Structure analyses reveal that the two benzene rings are almost perpendicular and the bond angle between the two benzene rings is 118.44°.
基金The authors thank the financial support of the Natural Science Foundation of Fujian Province (No. E0110010)
文摘Two title compounds, 4,4?diformyl-diphenoxyethane (compound 1, C16H14O4) and 4,4?4创-triformyl-triphenoxytriethylamine (compound 2, C27H27NO6), were synthesized by condensation of 4-hydroxybenzaldehyde with 1,2-dichloroethane and tris(2-chloroethyl)amine, respectively in dimethyl formamide in the presence of anhydrous potassium carbonate. The crystal data are: monoclinic, P21/c, a = 7.571(2), b = 12.608(3), c = 7.357(2) ? b = 105.823(6)? V = 675.7(2) 3, Mr = 270.3, Z = 2, Dc = 1.328 g/cm3, F(000) = 284, m(MoKa) = 0.096 mm-1, R = 0.0537 and wR = 0.2189 for compound 1; and monoclinic, P21/n, a = 11.7162(6), b = 9.0042(6), c = 22.908(2) ? b = 99.505(1)? V = 2383.5(3) ?, Mr = 461.50, Z = 4, Dc = 1.286 g/cm3, F(000)= 976, m(MoKa) = 0.091 mm-1, R = 0.0464 and wR = 0.1462 for compound 2. The molecule of compound 1 (dialdehyde) is located at the crystallographic inversion center nearby the midpoint of C(8)C(8A) single bond. The three chains in the molecule of compound 2 (trialdehyde) are of non-crystallographic pseudo-C3 symmetry, and each of them is quite planar.
文摘Of the 39 research projects that kicked off in 2005 with the support from the National Basic Research Program (dubbed the 973 Program) across the country, 12 are hosted by CAS scientists (including two under the joint leadership with other departments). Initiated in March 1997, the 973 Program is the national keystone basic research program organized by the Chinese government. Its strategic objectives are to strengthen the original innovations and to address the important scientific issues concerning the national economic and social development at a higher level and in a wider scope, so as to improve China’s capabilities of independent innovations and to provide scientific sup- port for the future development of the country. The followings are a brief account of some of the projects hosted by CAS in 2005.
文摘Lymphotoxin(LT) is a glycoprotein secreted by activated T cell. The expression of LT gene is mainly regulated at the level of transcription. By using human LT DNA as a probe, we carried out a RNA dot blotting test and found that the longer the time of Jurkat human Tlymphoma cells exposed to the PMA and PHA, the more endogenous LT mRNA could be produced. Results of gel retardation assay showed that the nuclear extract from Jurkat cells treated with PMA and PHA formed different DNA-protein complexes. Changes in complex patterns were observed at various time intervals of PMA and PHA induction. A specific protein-binding site was mapped out to be a 22-bp sequence at the 5’upstream regioll of human LT gene by DNase I footprinting analysis. This region was similar to the sequence recognized by the proteins of NFkB family The results of fragment competition and homology analysis indicated that the 22-bp sequence contains a kB-like motif only which is located at the base pairs -100 to -90 (5’-GGGGGCTTCCC-3’). Thus, the NF-kBlike factors were involved in the protein-DNA interaction.Furthermore, there were more than one retarded bands appearing in the gel retardation assay. It suggested that there may be several NF-kB-like factors involved in theregulation of LT gene transcription at the same site.
基金supported by the National Natural Science Foundation(Grant No.30671997)the National High Technology Research and Development Program of China(No.2008AA02Z438).
文摘Near-infrared spectroscopy(NIRS)technology and Mie theory are utilized for fundamental research on radiofrequency ablation of biological tissue.Firstly,NIRS is utilized to monitor rats undergoing radiofrequency ablation surgery in real time so as to explore the relationship between reduced scattering coefficient(μ_(s)')and the degree of thermally induced tissue coagulation.Then,Mie theory is utilized to analyze the morphological structure change of biological tissue so as to explore the basic mechanism of the change of optical parameters caused by thermally induced tissue coagulation.Results show that there is a close relationship between μ_(s)' and the degree of thermally induced tissue coagulation;the degree of thermal coagulation can be obtained by the value of μ_(s)';when biological tissue thermally coagulates,the average equivalent scattering particle decreases,the particle density increases,and the anisotropy factor decreases.
文摘The National Basic Research Program (dubbed as the " 9 73 Program" is China's on-going national keystone basic research program, which was approved by the Chinese government in June 1997 and is organized and implemented by the Ministry of Science and Technology. The strategic objectives of the Program are to strengthen the original innovations and to address the important scientific issues concerning the national economic and social development at a deeper level and in a wider scope, so as to improve China's capabilities of independent innovations and to provide scientific support for the future development of the country. The followings are some of the" 9 73 projects" initiated in 2006 under the coordination of CAS scientists.
基金The study was funded by the Middle-Aged and Young Teachers in Colleges and Universities in Guangxi Basic Ability Promotion Project(No.2017KY0581)and Natural Science Foundation of Guangxi Province(No.2018GXNSFAA138140).
文摘The purpose of this study is to use the newly synthesized molecule Sodium 8-(((carboxymethyl)amino)methyl)-4',7-bishydroxy-isoflavone-3'-sulfonate(M)as a research object,the pharmacological mechanism of the molecule was analyzed by using a series of Systematic pharmacology methods.The results show that the M molecule has a higher drug-like DL value of 0.59 and better molecular property parameters,namely Hdon=4,Hacc=10 and AlogP=0.94;A total of 11 M molecules related targets,namely F2,ESR1,AR,F10,CA2,DPP4,CCNA2,PRSS1,CDK2,GSK3B and PTPN1;A total of 140 diseases are associated with M molecule targets,and these diseases are mainly related to cancer and cardiovascular diseases;A total of 52 pathways involve the pharmacological mechanisms of M molecules,which are mainly related to cancer and other related diseases;GO-enriched analysis showed that these targets are closely related to the regulation of peptidase activity and biological processes such as blood coagulation and hemostasis.This article clearly demonstrated the pharmacological mechanism of M molecule,which provides references for exploring the pharmacological mechanism of new compounds.
文摘P-phenylene-2,2'-bis(5-aminobenzoxazole) is synthesized by the condensation of 2,4-diaminophenol dihydrochloride and terephthalic acid with high yield of 98% in polyphosphoric acid through adding reductive agent SnCl2 to suppress the oxidation of 2,4-diaminophenol dihydrochloride. The structure of the compound is characterized by using melting point, FT-IR,1H NMR, and element analysis.
文摘The differential pulse voltarametric ( DPV ) method with a glassy carbon electrode was used for the determination of 3,3' 5,5'-tetramethy lbenzidine ( TMB ) , o-tolidine and benzidine in the acidic media. The pulse amplitude, interval time and scan rate of DPV are optimized to be 50 mV, 0.5 s and 10 mV/s, respectively, The peak current is proportional to the concentration of TMB and its analogues, the linear range is from 10^-8mol/l to 10^-4 mal/l, The electrochemical behaviour of the compounds is discussed, The chemical poisons can be determined directly, or indirectly by the extraction in the waste water of chemical industry and laboratory,