The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning space.In this paper,we pro-pose an adaptive space expansion(ASE)approac...The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning space.In this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible path.The ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary space.Specifically,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is expanded.Thus,the ASE method successively does space exploring and space expan-sion until the final path has been found.Besides,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in it.At last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE strategy.Simulations demon-strate that the computation speed is much faster than that of the state-of-the-art algorithms.The source codes are available at https://github.com/shshlei/ompl.展开更多
Introduction: Acromioclavicular (AC) joint dislocation is a common shoulder injury, comprising 9% - 12% of shoulder girdle injuries. Optimal management remains challenging, with treatment decisions guided by the Rockw...Introduction: Acromioclavicular (AC) joint dislocation is a common shoulder injury, comprising 9% - 12% of shoulder girdle injuries. Optimal management remains challenging, with treatment decisions guided by the Rockwood classification system. Controversies surround grade III injuries, necessitating further classification. Non-operative treatment has shown favorable outcomes, while surgical interventions vary. Anatomical coracoclavicular reconstruction (ACCR) has demonstrated biomechanical advantages over traditional methods. Arthroscopic techniques offer advantages, minimizing deltoid detachment and allowing concurrent pathology identification. This study evaluates the outcomes of arthroscopic-assisted ACCR in chronic AC joint dislocation. Surgical Technique: Arthroscopic-assisted ACCR involves meticulous portal placement, tendon graft harvesting, diagnostic arthroscopy, and coracoid exposure. The clavicle tunnels were made to mimic the conoid and trapezoid ligament positions, using FibreTape#2 loop and Dog Bone Button for correct placement against the coracoid base, and passing the semitendinosus graft through to reconstruct the conoid ligament, reduction done and graft follow through for anatomical reconstruction. Methods: A retrospective cohort study at Hospital Kuala Lumpur analyzed 35 patients undergoing arthroscopic-assisted ACCR for Rockwood grade III - V AC joint dislocations. Inclusion criteria encompassed trauma ≥ 3 weeks prior, no prior shoulder injuries, and ≥12-month follow-up. Functional and radiological assessments utilized ASES scores and coracoclavicular distances, respectively. Statistical analysis employed descriptive statistics and logistic regression. Results: The mean age was 38.9 years (SD 11.26), and 34 of 35 patients were male. Grade IV injuries were predominant (37.1%). Waiting time for surgery averaged 234.9 days. Functional improvement was substantial postoperatively (ASES: 55.5 to 88.9). Radiological outcomes demonstrated reduced coracoclavicular distances and maintained reduction. No significant correlation was observed between injury grade and outcomes. Conclusion: Arthroscopic-assisted ACCR for chronic AC joint dislocation yields significant functional and radiological improvement, irrespective of injury grade. Waiting time for surgery exhibits minor impact on outcomes, emphasizing the procedure’s efficacy. Concomitant injuries do not impede success, highlighting the versatility of this approach in managing shoulder instability. The study contributes valuable insights into the nuanced management of chronic AC joint dislocations and supports the adoption of arthroscopic-assisted ACCR as a viable treatment option.展开更多
Background:Desmoid tumors are rare,locally aggressive,highly recurrent soft-tissue tumors without approved treatments.Methods:We conducted a phase 3,international,double-blind,randomized,placebo-controlled trial of ni...Background:Desmoid tumors are rare,locally aggressive,highly recurrent soft-tissue tumors without approved treatments.Methods:We conducted a phase 3,international,double-blind,randomized,placebo-controlled trial of nirogacestat in adults with progressing desmoid tumors according to the Response Evaluation Criteria in Solid Tumors,version 1.1.Patients were assigned in a 1:1 ratio to receive the oralγ-secretase inhibitor nirogacestat(150 mg)or placebo twice daily.The primary end point was progression-free survival.展开更多
美国Nordost(音乐丝带)以设计及生产各类接驳线材而闻名,其旗下品牌QRT(量子)则主攻电源优化及辅件产品。继刚刚上架的QSINE交流电优化器及QWAVE交流电调谐器之后,QRT在2023年慕尼黑音响展上首度曝光QBASE Mark Ⅲ第三代发烧电源排插,...美国Nordost(音乐丝带)以设计及生产各类接驳线材而闻名,其旗下品牌QRT(量子)则主攻电源优化及辅件产品。继刚刚上架的QSINE交流电优化器及QWAVE交流电调谐器之后,QRT在2023年慕尼黑音响展上首度曝光QBASE Mark Ⅲ第三代发烧电源排插,而且机器已运抵中国香港。相比卖得满堂红的上一代出品,QBASE Mark Ⅲ系列成员的外观造型并没太多变化,贯彻机械调谐技术Mechanically-tuned的非磁性铝合金外壳,运用挤压成型手法生产,严选航天级铝砖挖空生产的左右侧翼表面采用黑色阳极处理。展开更多
根据三轴光纤陀螺的高精度需求,采用大功率高稳定性的高精度双程后向方案掺铒光纤光源。通过对ASE光源的理论分析建立数学模型,并根据所用掺铒光纤及泵浦光源的参数对光源进行谱型分析,确定光路方案。再以掺铒光纤和泵浦激光器的温度特...根据三轴光纤陀螺的高精度需求,采用大功率高稳定性的高精度双程后向方案掺铒光纤光源。通过对ASE光源的理论分析建立数学模型,并根据所用掺铒光纤及泵浦光源的参数对光源进行谱型分析,确定光路方案。再以掺铒光纤和泵浦激光器的温度特性和补偿为研究重点,对掺铒光纤的长度和掺杂浓度以及泵浦功率和铒纤的匹配性进行试验,最终采用铒纤长度19 m,泵浦波长974.6 nm,泵浦功率140 m A,得到光源光功率为20 m W,平均波长变化量小于0.5′10^(-6)/℃,满足光纤陀螺对ASE光源的要求。展开更多
基金supported in part by the National Natural Science Foun-dation of China(51975236)the National Key Research and Development Program of China(2018YFA0703203)the Innovation Project of Optics Valley Laboratory(OVL2021BG007)。
文摘The sampling process is very inefficient for sam-pling-based motion planning algorithms that excess random sam-ples are generated in the planning space.In this paper,we pro-pose an adaptive space expansion(ASE)approach which belongs to the informed sampling category to improve the sampling effi-ciency for quickly finding a feasible path.The ASE method enlarges the search space gradually and restrains the sampling process in a sequence of small hyper-ellipsoid ring subsets to avoid exploring the unnecessary space.Specifically,for a con-structed small hyper-ellipsoid ring subset,if the algorithm cannot find a feasible path in it,then the subset is expanded.Thus,the ASE method successively does space exploring and space expan-sion until the final path has been found.Besides,we present a particular construction method of the hyper-ellipsoid ring that uniform random samples can be directly generated in it.At last,we present a feasible motion planner BiASE and an asymptoti-cally optimal motion planner BiASE*using the bidirectional exploring method and the ASE strategy.Simulations demon-strate that the computation speed is much faster than that of the state-of-the-art algorithms.The source codes are available at https://github.com/shshlei/ompl.
文摘Introduction: Acromioclavicular (AC) joint dislocation is a common shoulder injury, comprising 9% - 12% of shoulder girdle injuries. Optimal management remains challenging, with treatment decisions guided by the Rockwood classification system. Controversies surround grade III injuries, necessitating further classification. Non-operative treatment has shown favorable outcomes, while surgical interventions vary. Anatomical coracoclavicular reconstruction (ACCR) has demonstrated biomechanical advantages over traditional methods. Arthroscopic techniques offer advantages, minimizing deltoid detachment and allowing concurrent pathology identification. This study evaluates the outcomes of arthroscopic-assisted ACCR in chronic AC joint dislocation. Surgical Technique: Arthroscopic-assisted ACCR involves meticulous portal placement, tendon graft harvesting, diagnostic arthroscopy, and coracoid exposure. The clavicle tunnels were made to mimic the conoid and trapezoid ligament positions, using FibreTape#2 loop and Dog Bone Button for correct placement against the coracoid base, and passing the semitendinosus graft through to reconstruct the conoid ligament, reduction done and graft follow through for anatomical reconstruction. Methods: A retrospective cohort study at Hospital Kuala Lumpur analyzed 35 patients undergoing arthroscopic-assisted ACCR for Rockwood grade III - V AC joint dislocations. Inclusion criteria encompassed trauma ≥ 3 weeks prior, no prior shoulder injuries, and ≥12-month follow-up. Functional and radiological assessments utilized ASES scores and coracoclavicular distances, respectively. Statistical analysis employed descriptive statistics and logistic regression. Results: The mean age was 38.9 years (SD 11.26), and 34 of 35 patients were male. Grade IV injuries were predominant (37.1%). Waiting time for surgery averaged 234.9 days. Functional improvement was substantial postoperatively (ASES: 55.5 to 88.9). Radiological outcomes demonstrated reduced coracoclavicular distances and maintained reduction. No significant correlation was observed between injury grade and outcomes. Conclusion: Arthroscopic-assisted ACCR for chronic AC joint dislocation yields significant functional and radiological improvement, irrespective of injury grade. Waiting time for surgery exhibits minor impact on outcomes, emphasizing the procedure’s efficacy. Concomitant injuries do not impede success, highlighting the versatility of this approach in managing shoulder instability. The study contributes valuable insights into the nuanced management of chronic AC joint dislocations and supports the adoption of arthroscopic-assisted ACCR as a viable treatment option.
文摘Background:Desmoid tumors are rare,locally aggressive,highly recurrent soft-tissue tumors without approved treatments.Methods:We conducted a phase 3,international,double-blind,randomized,placebo-controlled trial of nirogacestat in adults with progressing desmoid tumors according to the Response Evaluation Criteria in Solid Tumors,version 1.1.Patients were assigned in a 1:1 ratio to receive the oralγ-secretase inhibitor nirogacestat(150 mg)or placebo twice daily.The primary end point was progression-free survival.
文摘美国Nordost(音乐丝带)以设计及生产各类接驳线材而闻名,其旗下品牌QRT(量子)则主攻电源优化及辅件产品。继刚刚上架的QSINE交流电优化器及QWAVE交流电调谐器之后,QRT在2023年慕尼黑音响展上首度曝光QBASE Mark Ⅲ第三代发烧电源排插,而且机器已运抵中国香港。相比卖得满堂红的上一代出品,QBASE Mark Ⅲ系列成员的外观造型并没太多变化,贯彻机械调谐技术Mechanically-tuned的非磁性铝合金外壳,运用挤压成型手法生产,严选航天级铝砖挖空生产的左右侧翼表面采用黑色阳极处理。
文摘根据三轴光纤陀螺的高精度需求,采用大功率高稳定性的高精度双程后向方案掺铒光纤光源。通过对ASE光源的理论分析建立数学模型,并根据所用掺铒光纤及泵浦光源的参数对光源进行谱型分析,确定光路方案。再以掺铒光纤和泵浦激光器的温度特性和补偿为研究重点,对掺铒光纤的长度和掺杂浓度以及泵浦功率和铒纤的匹配性进行试验,最终采用铒纤长度19 m,泵浦波长974.6 nm,泵浦功率140 m A,得到光源光功率为20 m W,平均波长变化量小于0.5′10^(-6)/℃,满足光纤陀螺对ASE光源的要求。
