类Chen-Qi混沌系统的固定时间自适应同步控制

类Chen-Qi四维混沌系统的渐近稳定控制的同步误差不能在有限时间内收敛到零,有限时间控制的同步误差收敛到零的状况与初值有关.因此,本文应用固定时间控制技术,设计了自适应控制器和参数估计律,试图使得驱动系统与同类型的参数未知的响应系统在固定时间内达到同步,完成了理论证明.应用数值仿真考察同步误差收敛到零的状况.选取不同参数值,不同状态初值,考察状态时程图、同步误差曲线等.结果表明:混沌运动时,固定时间内同步误差收敛到零的效果较好,与状态初值无关,收敛时间符合理论计算值;周期运动时,固定时间内前三个状态的同步误差收敛到零的效果较好,收敛时间符合理论计算值,但第四个状态的同步误差的收敛时间不符合理论计算值,其原因是系统存在的三次非线性项的不平衡、不匹配.

The Essential Role of Zheng Qi in Promoting Health: From the Perspective of Chinese Medicine and Modern Medicine

The concept of Zheng Qi in traditional Chinese medicine (TCM) refers to the vital energy produced by the interaction of Yin and Yang forces in the body. Zheng Qi performs two main functions: Wei Qi (defensive Qi), which shields the body from external pathogens, and Ying Qi (nutritive Qi), which sustains the internal organs and enhances their functionality. In TCM, Chinese tonifying herbs can help restore the balance of Yin/Yang and Qi/Blood function in visceral organs (i.e., optimal physiological functions), thereby fostering the efficient production of Zheng Qi and enhancing health. To ensure the quality of Chinese herbal products, functional assays to measure Yin/Yang, Qi/Blood functions, and Zheng Qi production should be implemented. The efficacy of Yang and Qi herbs can be evaluated by their ability to increase mitochondrial ATP in cultured mouse cardiomyocytes, while Yin and Blood herbs are tested through their immunostimulatory effects on antigen-induced T/B cell proliferation in mouse splenocytes and the production of erythropoietin/nitric oxide in hepatocytes/vascular endothelial cells, respectively. Additionally, Zheng Qi’s effect can be gauged by examining natural killer cell activity and antigen-induced T/B cell proliferation in mice ex vivo. These assays act as biomarkers for assessing the quality and effectiveness of herbal health products within TCM theory.

Integration of 1H-NMR-Based Metabolomics Approach with Traditional Chinese Pulse Diagnosis to Evaluate the Qi-Enhancing Activity of Herbal Tea

Human metabolism is intricately linked to an individual’s health status. Regardless of living habits, it will be reflected in the metabolic characteristics of urine. The utilization of the 1H NMR-based metabolomics method has enabled examine the metabolomic changes in urine under various physiology conditions, providing valuable insights into metabolites. In this particular study, volunteers were divided into two groups based on the strength of their spleen pulses, using the pulse diagnosis method employed in traditional Chinese medicine. Subsequently, their urine samples were analyzed, revealing notable variances in urea, creatinine, citric acid, succinic acid, trimethylamine-N-oxide (TMAO), alanine, hippuric acid, and glycine between the two groups. Interestingly, individuals with weak spleen pulses showed significant improvements after consuming herbal tea. Furthermore, we conducted LC-MS analysis on herbal tea and performed adenosine triphosphate (ATP) activity tests on the C2C12 mouse skeletal muscle cell line. The results indicated that within a reasonable concentration range, exposure to herbal tea led to an increase in the mitochondrial ATP production capacity of C2C12 cells. These findings shed light on the relationship between traditional Chinese medicine pulse diagnosis and urine metabolites, highlighting their potential as non-invasive and straightforward health assessment indicators. They can aid in the preliminary determination of necessary dietary and lifestyle changes to enhance overall bodily health.

Pharmacological Investigation on the Qi-Invigorating Action of Schisandrin B: Effects on Mitochondrial ATP Generation in Multiple Tissues and Innate/Adaptive Immunity in Mice

Schisandrae Fructus, containing schisandrin B (Sch B) as its main active component, is recognized in traditional Chinese medicine (TCM) for its Qi-invigorating properties in the five visceral organs. Our laboratory has shown that the Qi-invigorating action of Chinese tonifying herbs is linked to increased mitochondrial ATP generation and an enhancement in mitochondrial glutathione redox status. To explore whether Sch B can exert Qi-invigorating actions across various tissues, we investigated the effects of Sch B treatment on mitochondrial ATP generation and glutathione redox status in multiple mouse tissues ex vivo. In line with TCM theory, which posits that Zheng Qi generation relies on the Qi function of the visceral organs, we also examined Sch B’s impact on natural killer cell activity and antigen-induced splenocyte proliferation, both serving as indirect measures of Zheng Qi. Our findings revealed that Sch B treatment consistently enhanced mitochondrial ATP generation and improved mitochondrial glutathione redox status in mouse tissues. This boost in mitochondrial function was associated with stimulated innate and adaptive immune responses, marked by increased natural killer cell activity and antigen-induced T/B cell proliferation, potentially through the increased generation of Zheng Qi.

Clinical Observation of the Hot and Humid Compress Therapy of Traditional Chinese Medicine in the Treatment of Qi Stagnation and Blood Stasis Type of Lumbar Disc Herniation

Background: Although a number of studies have reported that the hot and humid compress from traditional Chinese medicine (TCM) is effective in treating lumbar disc herniation (LDH) with qi stagnation and blood stasis, clinical evidence is limited. Objective: The purpose of this study is to provide high-quality evidence to support the effectiveness of the traditional Chinese hot and humid compress in the treatment of LDH with qi stagnation and blood stasis. Methods: From October 2021 to November 2023, 86 patients with LDH of qi stagnation and blood stasis type were recruited in our hospital and divided into a control (n = 43) and an observation group (n = 43) according to the random number table method. The control group was given routine clinical treatment, and the observation group was treated with the hot and humid compress therapy for two weeks. The visual analogue scale (VAS) score, Japanese Orthopaedic Association (JOA) score, TCM syndrome score, serum interleukin-6 (IL-6), serum interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α) were observed and compared between the two groups before and after treatment, and the clinical efficacy of the two groups was evaluated. Results: After treatment, the VAS score, TCM symptom score, and serum IL-6, IL-1β, and TNF-α levels decreased in both groups (P P P P P Conclusions: The hot and humid compress of traditional Chinese medicine can effectively relieve pain, restore lumbar function, improve TCM syndromes, reduce the level of inflammatory factors, and have a curative effect in treating LDH.

扶阳罐治疗尿毒症维持性血液透析患者不安腿综合征的效果及对PSQI评分的影响

目的探析尿毒症维持性血液透析患者不安腿综合征采用扶阳罐治疗的效果。方法选取2021年7月—2023年12月在本院住院并进行规律维持性血液透析的尿毒症患者60例为研究对象,并将患者随机分为试验组(n=30)和对照组(n=30)。其中,对照组采取常规治疗,试验组加用扶阳罐治疗,比较两组治疗效果、临床症状积分、RLS评分、PSQI评分。结果试验组治疗有效率高于对照组,组间差异有统计学意义(P<0.05)。干预前,两组临床症状积分比较差异无统计学意义(P>0.05);干预后,试验组临床症状积分(下肢酸胀、下肢麻木、下肢灼烧感、下肢蚁行感、下肢瘙痒、下肢刺痛)低于对照组,组间差异有统计学意义(P<0.05)。干预后,试验组RLS评分、PSQI评分低于对照组,组间差异有统计学意义(P<0.05)。结论扶阳罐治疗尿毒症维持性血液透析患者不安腿综合征的效果明显,其临床症状显著缓解,患者的睡眠质量提升,临床上可借鉴及推广。

名中医许昕辨治绝经综合征经验

绝经综合征是妇科常见病、多发病,又称围绝经期综合征、更年期综合征,中医称绝经前后诸证,西医常激素治疗。许昕教授认为肾气衰,天癸竭为初始病因,主要病机是肾阴不足,精血亏少,阴阳失调,天癸衰竭而月经闭止,涉及心肝脾胃肺多脏腑,可兼郁夹瘀,变化多端;治疗要标本兼顾,调整阴阳平衡,调和脏腑,调畅气机,帮助患者解除病痛,平稳度过绝经期阶段。

《黄帝内经》理论在肿瘤的临床应用探析

文章从中医肿瘤防治的角度,结合现代医学研究,探讨了《黄帝内经》理论在肿瘤预防、治疗、康复等方面的应用,其中包括调节机体阴阳平衡、调节气血运行、提高免疫力、缓解化疗和放疗的不良反应等方面。在肿瘤预防方面,文章提出了中医强调的“养生保健”理念即从生活方式、饮食习惯等方面着手,调节机体阴阳平衡、提高机体免疫力,达到预防肿瘤的效果。在肿瘤治疗方面,文章从中药、针灸、推拿等多个角度探讨了《黄帝内经》理论在肿瘤治疗中的应用,以达到治疗肿瘤、减轻患者痛苦的目的。在肿瘤康复方面,文章则从运动疗法、营养调理等方面探讨了《黄帝内经》理论在肿瘤康复中的应用,以提高患者生活质量。文章还结合现代医学研究,论证了《黄帝内经》理论在肿瘤防治中的科学性和有效性,进一步证明了中医在肿瘤防治中的独特价值。

原生QI成核中间相炭微球的结构

以含有原生 QI的煤沥青为原料 ,采用热缩聚方法制备出中间相炭微球。用扫描电子显微镜 (SEM)观察了中间相炭微球的形貌和断面结构。经初步判断 ,在实验条件下原生 QI成核煤沥青基中间相炭微球更倾向于“地球仪”型结构。并对以 QI为核形成中间相微球的过程进行了分析。

大型焦炉煤焦油QI含量偏高的原因分析

采用元素分析、红外光谱、XRD及扫描电镜等分析手段对煤焦油QI进行了组成结构的定性分析.结果表明,煤焦油QI主要由焦粉、煤粉、热解碳和高温缩聚产物组成.煤焦油QI经氯化锌溶液浮选分离后,定量地确定了焦粉、煤粉、热解碳和高温缩聚产物在煤焦油中的含量.相关分析数据表明,无烟装煤技术7、.63 m焦炉本身的结构特点和加热制度是造成煤焦油中QI含量偏高的主要原因,其中因高温作用而产生的热解碳及高分子聚合物对QI的贡献占主导地位.

杞精明目汤联合人工泪液对肝肾阴虚型结膜松弛症患者泪液中Th17相关细胞因子的影响

目的:观察中药杞精明目汤联合人工泪液治疗对肝肾阴虚型结膜松弛症(CCH)患者泪液中Th17相关细胞因子的改变。方法:收集56例56眼Ⅱ-Ⅲ级肝肾阴虚型CCH患者,随机分为治疗组(杞精明目汤联合人工泪液)26例26眼和对照组(单纯人工泪液)30例30眼,疗程1 mo,观察治疗前后患者的国际眼表疾病指数(OSDI)、泪膜破裂时间(BUT)、泪河高度(TMH)、球结膜充血指数。采集治疗前后CCH患者的泪液,通过流式免疫荧光发光法对患者泪液中Th17相关细胞因子进行检测和分析。结果:治疗组与对照组CCH患者治疗后OSDI、BUT、球结膜充血指数均较治疗前均明显改善(均P<0.01);治疗后治疗组患者TMH较治疗前显著降低(P<0.01),对照组患者治疗前后TMH无差异(P=0.41)。治疗组CCH患者在治疗后泪液中Th17相关细胞因子IL-17A、IL-22、IFN-γ、IL-17F、IL-1β水平较治疗前明显降低(均P<0.01),且治疗组的变化更为显著(均P<0.05);而对照组治疗前后泪液中Th17相关细胞因子无差异(均P>0.05)。治疗后两组CCH患者泪液中IL-6、TNF-α均较治疗前降低(均P<0.05),但治疗组的变化更为显著(均P<0.01)。结论:杞精明目汤联合人工泪液治疗可有效改善肝肾阴虚型结膜松弛症患者眼表微环境,提高泪膜稳定性,抑制眼表炎症,可能与其降低泪液中Th17相关细胞因子的分泌相关。

黄精补益肾气在老年高血压病辨治中的临床应用

老年高血压病是现代社会危害老年人健康的重要因素,随着中药降压在老年高血压病中的广泛应用,补益肾气法辨治老年高血压病正得到大力发展。黄精作为重要的补益肾气药材,具有补气养阴、健脾、润肺、益肾的功效,但当前缺乏黄精补益肾气在辨治老年高血压病中的系统阐释。文章通过查阅古今文献,对黄精的补益肾气功效进行考证,并通过精气互化、先后天相互资生、金水相生理论对其补益肾气功效系统阐释,完善其在补益肾气法治疗老年高血压病中的应用价值。同时结合化学成分及现代药理学研究,阐述其在治疗高血压病中抑制氧化应激、改善胰岛素抵抗、调节肠道内稳态、调节性激素的作用。旨在为进一步研究及药物开发提供理论指导。

Qi系统的Hopf分叉分析与幅值控制

通过非线性状态反馈,不改变Hopf分叉点,实现对四维Qi系统极限环的幅值控制.推导出Qi系统在第一类非零平衡点上产生Hopf分叉的条件,绘制第一类平衡点的分叉图.采用washout filter非线性控制律,利用中心流形定理对受控系统降维,得到极限环的幅值与控制增益之间的近似解析式.通过数值模拟以及幅值解析解与数值解的比较,验证幅值预测的正确性与控制的有效性.

过滤精度对煤焦油QI的组成和结构的影响

采用精度为2~5μm和20~40μm的滤芯分别对煤焦油进行热过滤,从得到的滤渣中提取出喹啉不溶物(QI)。然后利用元素分析(EA)、激光粒度仪(LPSA)、扫描电子显微镜/X射线能量色散光谱(SEM/EDS)、傅里叶红外光谱(FT-IR)、X射线衍射仪(XRD)、X射线光电子能谱(XPS)等对所得煤焦油QI组分进行对比分析。结果表明:煤焦油QI组分芳构化程度高,有机物多为稠环类物质并带有很多侧链或杂质原子,同时存在少量石英石、方解石以及煤灰等无机物;当煤焦油热过滤时采用的滤芯精度较低时,最终提取出的QI组分缩聚度相对较高,并且稠环结构中所含侧链和杂原子也相对较少。经精度较低的滤芯热过滤后提取的QI组分中金属杂原子含量相对较高,这些金属杂原子主要存在于大颗粒无机物中,部分存在于小颗粒有机物中。当滤芯精度较高时所得QI组分中主要含酚类、醚类和羧酸类有机物,酮类含量相对较少;反之,QI中则主要含酚类、醚类和酮类有机物。因此,煤焦油热过滤所选的滤芯精度不宜过高,尤其不宜选精度在5μm以下的滤芯。

基于“坚者削之,结者散之”治疗消化道息肉理论探析

消化道息肉主要是指胃肠道息肉,目前本病临床上最常用的治疗方法为内镜下治疗,虽见效快,但并发症较多,且治疗后仍有较高的复发率。中医药对于预防本病复发有一定的优势,本课题组通过总结古今相关文献以及结合临床实践研究,认为消化道息肉的核心病机多以脾虚气滞为本,而脾胃气机壅滞进一步产生湿、痰、瘀等病理因素为标,故紧扣病机,根据“坚者削之,结者散之”理论,提出“消散法”辨治消化道息肉,临证时需灵活变通,随症加减,以期为中医药治疗消化道息肉提供新的见解。

煤沥青中原生QI性质分析

利用元素分析、红外光谱、激光粒度仪、原子发射光谱仪等分析手段对攀钢中温煤沥青的原生QI进行了结构组成分析。结果表明,原生QI粒径90%以上小于2μm,为无定型的微晶乱堆结构,其灰分质量分数达到5.8%。元素分析和红外光谱分析表明,QI有机成分主要为高度缩合的炭黑状物质,金属分析表明无机成分主要由耐火材料粉屑和铁件的氧化物构成。这为原生QI的脱除提供了科学依据。

基于Qi算法的Delaunay三角网逐点插入法

Delaunay三角网在很多领域都有着广泛的应用,快速高效地生成Delaunay三角网十分重要。逐点插入法是构建Delaunay三角网中使用最广泛的方法之一。本文深入研究了使用逐点插入法构建不带约束条件Delaunay三角网的过程。在使用该方法生成Delaunay三角网中建立结点拓扑关系这一影响构网效率的关键步骤中引入了Qi算法,简化了该方法生成Delaunay三角网的复杂度。然后在向Delaunay三角网内插入约束边的过程中,再次引入Qi算法,从而提高了构网的效率。为了验证上述模型,我们在Microsoft Visual Studio 2005开发环境下,以C#为开发工具,采用底层开发模式实现了改进的逐点插入法,实验证明引入Qi算法能够提高逐点插入法Delaunay三角网构建及插入约束边的效率。

规范形Qi系统的Hopf分岔分析及控制

文章研究了一个Qi系统的Hopf分岔控制问题.根据计算的极限环曲率系数,判定原系统的Hopf分岔类型,并采用washout滤波器控制该系统的分岔行为.首先讨论了控制器的线性增益对Hopf分岔点位置的影响,然后引入规范形计算方法,求出受控系统的Hopf分岔规范形.分析了规范形中系数对控制参数的选择原则所产生之影响,以及对Hopf分岔类型及极限环幅值的影响.理论和仿真结果表明,控制器的线性增益能使原系统的Hopf分岔点延迟或消失,而非线性增益能则改变极限环的稳定性和极限环幅值的大小.最后把washout滤波器和线性控制器的控制效果作了对比,发现washout滤波器比之线性控制器具有一定的优势.

浸渍剂沥青QI测定的研究

在分析国内外浸渍剂沥青QI测定标准的基础上,对比研究了中国煤沥青QI测试标准对浸渍剂沥青QI测定的适用性,结果发现中国测试标准存在很多问题,分析了造成这些差异的原因,并对制定中国浸渍剂沥青QI测试标准提出了建议。

龙砂开阖六气针法结合24 h眼压曲线探析青风内障证治

龙砂开阖六气针法是在顾植山教授三阴三阳开阖枢理论指导下,结合六经辨证、六脉辨证、脏腑辨证、经络辨证、象态辨证、运气辨证等多种辨证方式进行针刺的一种方法。开阖枢理论是对人体三阴三阳之气升降出入状态的概括,从开阖枢角度,青风内障的病机可概括为开机不利、阖机不利、枢机不利。开机不利,当辨太阳或太阴开机不利;阖机不利,当辨厥阴阖之太过、厥阴阖之不足或阳明阖之太过、阳明阖之不足;枢机不利,当辨少阴枢机不利或少阳枢机不利。此外,导师解晓斌主任医师将24 h眼压曲线与“六经病欲解时”相结合,以眼压峰值的时间节点对应“六经病欲解时”的病变之经来辨时定经。临证以开阖枢理论结合24 h眼压曲线为指导,采用龙砂开阖六气针法,通过辨时定经、辨证定经来明确青风内障所主之经,指导青风内障的临床诊治。