许斌治疗浆细胞性乳腺炎肿块期经验概要

许斌教授认为浆细胞性乳腺炎肿块期病机关键在于肝经郁热,在治疗过程中以疏肝解郁、散结消痈、清热解毒为原则,辅以调畅情志,运用自拟顺肝消痈汤内服联合水调散外敷的内外兼治的特色疗法,必求于本,明辨主次,并在原方基础上随证加减,做到专人专方从而达到良好的疗效,既减轻患者的痛苦又保持了乳房的美观性,并附以验案1例以佐证。

Molecular Dynamics for Spin Systems

We present a microscopic simulation of particles with time-dependent spins,where different interaction and density are considered.Ferromagnetism has been observed for the attractive spin-spin interaction,while antiferromagnetism and paramagnetism have been observed in different density region for the repulsive spin-spin interaction.The method developed here should be extended to include spin-color interaction into“color molecular dynamics”.

自拟顺气活血汤治疗肺源性心脏病气滞血瘀证的疗效及对血清APN、CPN水平的影响

目的探讨自拟顺气活血汤治疗肺源性心脏病(pulmonary heart disease,PHD)气滞血瘀证的疗效及对血清脂联素(adiponectin,APN)与和肽素(copeptin,CPN)水平的影响。方法纳入2019年1月—2022年1月该院收治的62例PHD气滞血瘀证患者,按照随机数字表法分为治疗组与对照组,每组31例。对照组根据指南进行常规干预措施;治疗组的常规干预措施同对照组,并且采取自拟顺气活血汤内服。两组连续治疗4周。比较两组心功能、肺功能、血气相关指标、临床疗效以及血清APN与和CPN水平。结果治疗4周后,两组患者左室射血分数(left ventricular ejection fraction,LVEF)、每搏输出量(stroke volume,SV)、心输出量(cardiac output,CO)以及第1秒用力呼气容积占预计值百分比(forced expiratory volume in one second/predicted value ratio,FEV1%pred)、第1秒用力呼气容积(forced expiratory volume in one second,FEV1)/用力肺活量(forced vital capacity,FVC)显著上调,并且治疗组上调更加明显(P<0.01);治疗4周后,两组患者动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))显著上调及二氧化碳分压(partial pressure of carbon dioxide,PaCO_(2))明显减低,并且治疗组以上指标改善更加明显(P<0.01);治疗组患者的总有效率(93.55%,29/31)显著高于对照组(67.74%,21/31)(P<0.05)。治疗4周后,两组患者血清APN水平明显增加及CPN水平明显降低,并且治疗组以上指标改善更加明显(P<0.01)。结论于常规治疗措施的基础上加用自拟顺气活血汤治疗PHD气滞血瘀证疗效更佳,有助于患者的心肺功能、血气指标的改善以及调节血清APN与CPN的水平。

Efficient in-situ end-functionalization of polydienes by isothiocyanate via neodymium mediated coordinative chain transfer polymerization system

End-functionalization of polydiene rubbers can not only improve its compatibility with inorganic fillers,but also enhance the overall mechanical properties.Nevertheless,for traditional neodymium(Nd)diene polymerization systems,it is highly challenging to achieve such end-functionalizations,because most of polydienyl chains are capped withη3-allyl-Nd moiety during the end of polymerization,which shows very poor reactivity with nucleophile compounds.We launched a new diene polymerization strategy calling coordinative chain transfer polymerization(CCTP)[1].In such a system,all the polydienyl chains are capped withη1-allyl-Al moieties,which reveal greater reactivity with cyclic esters and epoxide compounds,providing an effective manner to prepare polydiene-polyester amphiphilic block copolymers.Inspired by such findings,we now show herein how such types of chain-ends react with isot-hiocyanate to demonstrate an efficient in-situ manner to access end-functionalized polydienes by using CCTP.

Influence of external nitrogen-containing donors on polymerization behavior of neodymium-based cis-1,4-polybutadiene rubber

Neodymium(Nd)-based catalyst in butadiene(Bd)polymerization has drawn interests due to its availability in affording higher cis-1,4-unit selectivity than transition metal(Ti,Co,Ni,etc.)-based catalysts[1-2].Such outstanding high cis-1,4-unit selecti-vity is hypothetically originated from the presence of 4 f orbitals,that can participate in monomer coordination and thereby govern subsequent enchainment manners.This unique characteristic also renders the active species highly susceptible to Lewis bases,and may impact the overall selectivity as well as polyme-rization behavior after coordination.Nevertheless,it is still a virgin area in such a field,and the influence of Lewis bases on Nd-based diene polymerizations is still a black box.Based on this consideration,how nitrogen-containing donors(D)impacts the overall behaviors of Nd-mediated Bd polymerizations is disclosed.

Effect of welding sequence on residual stress in thin-walled octagonal pipe-plate structure

A three-dimensional finite element approach based on ABAQUS code was developed to investigate the effect of welding sequence on welding residual stress distribution in a thin-walled 6061 aluminum alloy structure. To obtain sound numerical results, the therrno-mechanical behaviour was simulated using a direct-coupled formulation. Nine different simulation sequences were carried out by single-pass TIG welding of an octagonal pipe-plate joint, and the distributions of longitudinal and transverse residual stresses both on the outer and inner surfaces of the pipe were analyzed. The results suggest that the final residual stresses in the weld and its vicinity are not affected by the initial residual stresses of the structure. Selecting a suitable welding sequence can reduce the final residual stress in an octagonal pipe-plate joint.

Effects of Fe_(2)O_(3) content on microstructure and mechanical properties of CaO-Al_(2)O_(3)-SiO_(2) system

The effects of Fe2O3 content on the microstructure and mechanical properties of the CaO-Al2O3-SiO2 system were investigated by differential thermal analysis（DTA）, X-ray diffraction（XRD）, scanning electron microscopy（SEM）, electron spin resonance（ESR）, and Mssbauer spectroscopy. The results show that the addition of Fe2O3 does not affect the main crystalline phase in the prepared glasses, but it reduces the crystallisation peak temperature, increases the crystallisation activation energy, and reduces the crystal granularity. The ESR results indicate that Fe2O3 can promote crystallization, as it leads to the phase separation of the CaO-Al2O3-SiO2 system due to axial distortion. Moreover, Fe2O3 alters the network structure of the CaO-Al2O3-SiO2 system, allowing Fe3＋ to enter octahedral sites that exhibit higher symmetry than tetrahedral sites. All of these factors are favourable to increasing the bending strength. The Mssbauer results reveal that there are two types of coordination for both Fe3＋ and Fe2＋ and the bending strength of the CaO-Al2O3-SiO2 system increases with the amount of six-coordinate Fe3＋. The increasing interaction between Fe3＋ and Fe2＋ can also enhance the bending strength of the CaO-Al2O3-SiO2 system. The microhardness of the CaO-Al2O3-SiO2 system was determined to be HV 896.9 and the bending strength to be 217 MPa under the heat treatment conditions of nucleation temperature of 700 °C and nucleation time of 2 h, crystallization temperature of 910 °C and crystallization time of 3 h.

Vehicle and terrain interaction based on Adams-Matlab co-simulation

A kind of construction truck model is built in Adams based on multi-body dynamic theory. The rigid and elastic wheels of tire-soil contact models are proposed based on the Bekker pressure model and the Jonasi shear soil model, and they are described in the form of S-function to enhance the calculation efficiency and simulation accuracy. Finally, the interaction of truck and soil is simulated by Adams-Maflab co-simulation to study the influence of soft terrain on the ride comfort of vehicles. The co-simulation results reveal that the terrain properties have a great influence on the ride comfort of vehicles as well as driving speed, road roughness and cargo weight. This co-simulation model is convenient for adding the factor of terrain deformation to the analysis of vehicle ride comfort. It can also be used to optimize suspension system parameters especially for off-road vehicles.

Fabrication of superaligned carbon nanotubes reinforced copper matrix laminar composite by electrodeposition

A new kind of laminar metal matrix nanocomposite（MMC） was fabricated by an electrodeposition process with copper and superaligned carbon nanotubes film（SACNT film）.The SACNT film was put on a titanium plate and then a layer of copper was electrodeposited on it.By repeating the above process,the laminar Cu/SACNT composite which contains dozens or hundreds of layers of copper and SACNT films was obtained.The thickness of a single copper layer was controlled by adjusting the process parameter easily and the thinnest layer is less than 2 μm.The microscopic observation shows that the directional alignment structure of SACNT is retained in the composite perfectly.The mechanical and electrical properties testing results show that the tensile and yield strengths of composites are improved obviously compared with those of pure copper,and the high conductivity is retained.This technology is a potential method to make applicable MMC which characterizes high volume fraction and directional alignment of carbon nanotubes.

副词“顺路”的产生和发展

"顺路"在汉语史的发展中,经历了由介宾短语到表情状方式的副词的演变。其演变是由词汇化和语法化两者相互作用的结果。

MINER RULE CONSIDERING FUZZINESS OF STRESS DAMAGE UNDER DIFFERENT LOAD SEQUENCES

Since the traditional Miner rule ignores the influence of the load sequence on the fatigue life, the fuzzy rules are used to analyze the fuzziness of the fatigue damage caused by the stress nearby the fatigue limit under different load sequences. The improved fuzzy Miner rule can reflect the influence of the load sequence on the fatigue life. Results of the example show that the prediction error can be reduced from 61.6% to 21.7%.

Effects of BYHW Decoction and Its Effective Constituents on the Fluidity of the Cell Membrane in a Stroke-Modeled Rat Brain

With in vitro spin labeling electron spin resonance (ESR) spectroscopy, we have studied the effects of Bu Yang Huan Wu (BYHW) decoction and its effective constituents such as astragaloside IV ferulic acid, chuanxiongzine, rutin, chlorogenic acid, 9,10 dimethoxy pterocarpane 7 O β D glucoside, calycosin, formononetin, calycosin 7 O glucoside, paeoniflorin, paeonal and quercein on the cell membrane fluidity of a rat brain which was modeled after the dual cervical arteries were intercepted and released for realizing an ischemia reperfusion injury which was selected as a brain stroke model. Our results indicated that the cell membrane fluidity in the model group decreased approximately 8% compared with the control group, and after brain cells were incubatied with species, the membrane fluidity could be recovered closely to the control level depending on the BYHW decoction and its different constituents. As the membrane fluidity is a very sensitive biological index which reflectsd the cell status, our method will be useful to study the molecular mechanism of tradition Chinese medicine (TCM) and its combination recipe.

A Study of Interaction of Cisplatin and Its Analogues withPhospholipid of Erythrocyte Membrane

The interaction of cisplatin and its analogues with phospholipid molecules of hu-man erythrocyte membranes was studied using IR and ￣31 P NMR methods. Dramatic changes were ob-served at 1300～953 cm￣-1 frequency region on the IR spectra .Based on the IR data analysis, it was speculated that the Pt(II) complexes interacted mainly with the polar head groups of phospholipids through electrostatic interaction and certain coordination patterns. The 1 2 h dynamic experiment showed that a recoverable process occurred in case of cis-DCDP and an unrecoverable one for other pt(II)analogues.A similar conclusion could be obtained from￣31 P NMR experimental results.The di-versity was discussed.

Three 5’-flanking Regions of crtO Encoding β-carotene Oxygenase in Haematococcus pluvialis

Three separate 5＇-flanking regions （1.1 kb, 1.9 kb and 2.2 kb） of crtO were cloned through walking upstream. Results of sequence analysis show that three 5＇-flanking regions of crtO might have some similar putative cis-acting elements such as ABA （abscisic acid）-responsive element （ABRE）, C-repeat/dehydration responsive element （C-repeat/DRE）, light-responsive element （G-box, GAG-motif, I-box and ATC-motif）, wound-responsive element （WUN-motif）, auxin-responsive element （TGA-element）, MeJA-responsive element （TGACG-element） and MYB binding site （MBS）, except for typical TATA box or CCAAT box. These findings might mean diversiform regulatory patterns of crtO being in astaxanthin biosynthesis of Haematococcus pluvialis.

Settlement Spatial Analysis of Buildings in New Countryside in Heshun Ancient Town

In the research, structure and characters of settlement were analyzed in Heshun Ancient Town in Yunnan Province. It is surveyed that growth mechanism of Heshun Ancient Town involves positive and negative effects simultaneously. Positive effect refers to integrity of boundary of Ancient Town and good inheritance of newly- developed public buildings. In contrast, negative effect refers to simplification and shortage of characteristics of newly-developed individual dwelling. With sustainable development, it would be wise for construction of Heshun new countryside to optimize diversified construction symbols.

帛书《周易》“川”卦名当释“顺”字详考

考察先秦至唐有关石刻史料和出土易学文献,可以发现:今本《周易》"坤"卦名本不作"坤",而作"顺"。"顺"卦之名自先秦至唐一直被使用,至唐中期方被"坤"完全取代。"坤"作为卦名为后起字,出现于西汉中期,至东汉末还没有被主流易学所使用,到唐中期方被普遍使用,而取代"顺"卦之名。帛书《周易》经传作为西汉初期抄本,其"川"卦之名当释为"顺"卦,而非"坤"卦。学者关于帛书《周易》"川"卦名当释为"顺"的观点是正确的。

Novel method for exactly evaluating the energy of Catmull-Clark subdivision surfaces

A novel method is produced to evaluate the energy of the Catmull-Clark subdivision surface including extraordinary points in the control mesh. A closed-form analytic formula for thin plate energy of the Catmull-Clark subdivision surface of arbitrary topology is derived through translating the Catmull-Clark subdivision surface into bi-cubic B-spline surface pieces. Using this method, both the membrane energy and the thin plate energy can be evaluated without requiring recursive subdivision. Therefore, it is more efficient and more accurate than the existing methods for calculating the energy of the Catmull-Clark subdivision surface with arbitrary topology. The example of surface fairing demonstrates that this method is efficient and successful for evaluating the energy of subdivision surfaces.

Deletion of 93 bp Far-upstream Fragment of Rice Cytosolic Fructose- 1, 6-Bisphosphatase Promoter Completely Alter Its Expression Pattern

The 1 195 bp 5′ flanking region of rice ( Oryza sativa L.) cytosolic fructose_1, 6_bisphosphatase (cyFBPase) can direct tissue, cell specific expression in transgenic rice. In order to identify sequence elements responsible for the regulation of mesophyll_specific expression, the 5′ flanking regions of -1 195 bp, -1 102 bp, -768 bp, and -644 bp upstream of the translation initiation ATG codon were fused to the reporter gene encoding β_glucuronidase (GUS) and transferred to rice via particle bombardment. Analysis of the 5′ promoter deletions identified that a 93 bp fragment between -1 195 bp and -1 102 bp is essential for directing mesophyll specific expression. High constitutive expression of GUS reporter gene was found in the -768 deletion lines and another two deletion series. These results indicate the great potential utility of the promoter in rice biotechnology.

Construction of Double Cross-over Expression Vector for Chloroplast Multicistron in Brassica napus L.

[Objective] This study aimed to construct Brassica napus chloroplast multi- cistron double cross-over expression vector, to lay the foundation for the genetic engi- neering research of Brassica napus chloroplast. [Method] Two primers were designed based on the known Brassica napus chloroplast DNA sequences AF267640 and Z50868 in GenBank. By using PCR method, two Brassica napus L. chloroplast DNA fragments were obtained, which were named RbcL and ACCD. The two Brassica na- pus chloroplast DNA homologous fragments were then cloned into plasmid pMD18-T to obtain recombinant plasmid pHBM715. Tandem expression cassette harboring spectinomycin-resistant gene aadA, mannanase gene man and green fluorescent pro- tein gene gfp was cloned into the plasmid pHBM715, thereby constructing Brassica napus chloroplast multicistron double cross-over expression vector pHBM716, which was transformed into Escherichia coil for expression and identification. [Result] Plate qualitative analysis was conducted for the functional identification of expression cas- sette in the constructed Brassica napus chloroplast multicistron double cross-over ex- pression vector, results showed that the three genes of the same multicistron were all expressed in E. coil [Conclusion] This study successfully constructed Brassica napus chloroplast multicistron double cross-over expression vector, which laid the foundation for the genetic engineering of Brassica napus chloroplast.

试论邓氏外戚对顺帝初期中枢政局的影响

安帝末年,安帝兴起废太子之议,遭到部分朝臣的反对。这部分朝臣与已逝的和熹邓后以及早已势败的邓氏外戚有着极为密切的联系。他们实际上是邓氏外戚扶植起来的政治势力,与邓氏外戚之间构成了一种特殊的政治利益关系。安帝崩后,废太子(即后来的顺帝)发动宫廷政变,夺回帝位。顺帝借以发动政变的宫省势力与邓后有着密切的联系。安顺之际的一系列政治事变,反映出顺帝与邓后以及邓氏外戚之间有着千丝万缕的联系。这也充分说明,即便邓后崩亡、邓氏外戚势败,邓氏一族仍然保有对当时中枢政治格局很大的影响力。