目的观察喘可治注射液(CKZ)对慢性阻塞性肺疾病(COPD)大鼠肺组织IL-12/IL-12R/STAT4信号通路的影响。方法 50只SD大鼠随机分为正常组,模型组,CKZ高、中、低剂量(CKZ-H、CHZ-M、CKZ-L)组。除正常组外,各组复制COPD大鼠模型,并给予相应药...目的观察喘可治注射液(CKZ)对慢性阻塞性肺疾病(COPD)大鼠肺组织IL-12/IL-12R/STAT4信号通路的影响。方法 50只SD大鼠随机分为正常组,模型组,CKZ高、中、低剂量(CKZ-H、CHZ-M、CKZ-L)组。除正常组外,各组复制COPD大鼠模型,并给予相应药物治疗,观察CKZ对COPD大鼠血清和肺泡灌洗液(BALF)中γ-干扰素(IFN-γ)、白细胞介素12(IL-12)、白细胞介素12受体(IL-12R)以及肺组织信号转导子和转录激活子4(STAT4)m RNA表达的影响。结果喘可治注射液各剂量组肺组织病理形态均有不同程度的改善,且降低COPD大鼠血清和BALF中IFN-γ、IL-12、IL-12R(除CKZ-L组BALF中IL-12R外)水平(P<0.05,P<0.01),可抑制大鼠肺组织STAT4 m RNA的表达(P<0.01,P<0.05)。结论喘可治注射液能一定程度改善COPD大鼠肺组织病理损害,其作用机制可能与其抑制IFN-γ、IL-12、IL-12R表达,干扰IL-12/IL-12R/STAT4信号通路对靶基因的激活,下调STAT4 m RNA表达,进而调节Th1/Th2分化失衡有关。展开更多
Novel cyclic esters (1R, 2R, 3R, 5S, 7S, 9R, 12R)-3-(t-butyldimethylsilyl)oxy-7- methoxymethyloxy-2, 10-dimethyl-12-oxatricyclo [7.2.1.05,12] dodecane were prepared when their precursor 1 was treated with SOCl2/pyri...Novel cyclic esters (1R, 2R, 3R, 5S, 7S, 9R, 12R)-3-(t-butyldimethylsilyl)oxy-7- methoxymethyloxy-2, 10-dimethyl-12-oxatricyclo [7.2.1.05,12] dodecane were prepared when their precursor 1 was treated with SOCl2/pyridine. A plausible mechanism was hypothesized.展开更多
针对220 k V线路保护装置或断路器改造中,进行保护双重化配置,以及操作继电器箱中防跃回路与断路器本体防跃回路共存时,引发的隐患问题进行介绍。同时阐述了双重化不合理配置将带来断路器拒动,进而起动母差失灵保护,造成母线所在机组停...针对220 k V线路保护装置或断路器改造中,进行保护双重化配置,以及操作继电器箱中防跃回路与断路器本体防跃回路共存时,引发的隐患问题进行介绍。同时阐述了双重化不合理配置将带来断路器拒动,进而起动母差失灵保护,造成母线所在机组停运、线路跳闸以及防跃回路共存将引起断路器在分断时卡涩进而引起拉弧,严重损坏断路器等一系列重大问题。展开更多
The structure of the low-lying collective excitations in 102Pd is examined within the recently proposed microscopic shell-model version of the Bohr-Mottelson(BM)collective model.A good description of the excitation en...The structure of the low-lying collective excitations in 102Pd is examined within the recently proposed microscopic shell-model version of the Bohr-Mottelson(BM)collective model.A good description of the excitation energies of the lowest ground,γ,andβbands,as well as the staggering function between the collective states of theγband and some other energy-dependent quantities,is obtained.The low-energy intraband and interband quadrupole dynamics is reasonably well described within the present proton-neutron sympletic based shell-model approach without the use of an effective charge and compared with the predictions of nuclear structure models.The obtained results of the present study shed light on the question of the existence of irrotational-flow type quadrupole dynamics,which lies on the ground of the original BM model of quantized vibrations and surface-wave rotations in atomic nuclei.展开更多
In this study,a microscopic shell-model description of the low-lying collective states in the weakly deformed nucleus ^(106)Cd within the recently proposed microscopic version of the Bohr-Mottelson model is provided.A...In this study,a microscopic shell-model description of the low-lying collective states in the weakly deformed nucleus ^(106)Cd within the recently proposed microscopic version of the Bohr-Mottelson model is provided.A good description of the excitation energies of the lowest ground,γ,andβquasibands is obtained without the adjustable kinetic energy term.Furthermore,γdegrees of freedom are shown to play a crucial role in the description of spectroscopy of this nucleus.A modified SU(3)SU(3)preserving high-order interaction is used to produce aγ-unstable type of odd-even staggering,observed experimentally between the states of the quasi-γband.The current approach enables the characterization of observed intraband and interband quadrupole collectivity.The findings of this study propose an alternative interpretation of the fundamental question regarding the nature of low-energy vibrations,as well as the emergence of deformation and collectivity in weakly deformed atomic nuclei.展开更多
The recently proposed microscopic shell-model version of the Bohr-Mottelson(BM) collective model is considered in more detail in the coordinate representation.The latter possesses a clear and transparent physical mean...The recently proposed microscopic shell-model version of the Bohr-Mottelson(BM) collective model is considered in more detail in the coordinate representation.The latter possesses a clear and transparent physical meaning,which reveals several features of the new version of the collective model missed in the previous formulation.The relationship to the original BM model is considered,along with the relationships between the different limiting submodels of the microscopic version of the BM model,which closely resemble the relationships of the original Wilets-Jean and rotor models.The kinematically correct many-particle wave functions of the microscopic version of the BM model,conserving the experimentally observed integrals of motion,are shown to consist of collective irrotational-flow and intrinsic components-in accordance with the original BM unified model.The general BM Hamiltonian is obtained as a contraction limit of the microscopic many-particle nuclear Hamiltonian,or,alternatively,by restricting the latter to the scalar O(m) irreducible collective space.展开更多
The expansion coefficient C-\L\(D) Of Coulomb potential 1/r(12) of atomic system in hyper-spherical harmonics is derived and the explicit expression is given.
文摘目的观察喘可治注射液(CKZ)对慢性阻塞性肺疾病(COPD)大鼠肺组织IL-12/IL-12R/STAT4信号通路的影响。方法 50只SD大鼠随机分为正常组,模型组,CKZ高、中、低剂量(CKZ-H、CHZ-M、CKZ-L)组。除正常组外,各组复制COPD大鼠模型,并给予相应药物治疗,观察CKZ对COPD大鼠血清和肺泡灌洗液(BALF)中γ-干扰素(IFN-γ)、白细胞介素12(IL-12)、白细胞介素12受体(IL-12R)以及肺组织信号转导子和转录激活子4(STAT4)m RNA表达的影响。结果喘可治注射液各剂量组肺组织病理形态均有不同程度的改善,且降低COPD大鼠血清和BALF中IFN-γ、IL-12、IL-12R(除CKZ-L组BALF中IL-12R外)水平(P<0.05,P<0.01),可抑制大鼠肺组织STAT4 m RNA的表达(P<0.01,P<0.05)。结论喘可治注射液能一定程度改善COPD大鼠肺组织病理损害,其作用机制可能与其抑制IFN-γ、IL-12、IL-12R表达,干扰IL-12/IL-12R/STAT4信号通路对靶基因的激活,下调STAT4 m RNA表达,进而调节Th1/Th2分化失衡有关。
文摘Novel cyclic esters (1R, 2R, 3R, 5S, 7S, 9R, 12R)-3-(t-butyldimethylsilyl)oxy-7- methoxymethyloxy-2, 10-dimethyl-12-oxatricyclo [7.2.1.05,12] dodecane were prepared when their precursor 1 was treated with SOCl2/pyridine. A plausible mechanism was hypothesized.
文摘针对220 k V线路保护装置或断路器改造中,进行保护双重化配置,以及操作继电器箱中防跃回路与断路器本体防跃回路共存时,引发的隐患问题进行介绍。同时阐述了双重化不合理配置将带来断路器拒动,进而起动母差失灵保护,造成母线所在机组停运、线路跳闸以及防跃回路共存将引起断路器在分断时卡涩进而引起拉弧,严重损坏断路器等一系列重大问题。
文摘The structure of the low-lying collective excitations in 102Pd is examined within the recently proposed microscopic shell-model version of the Bohr-Mottelson(BM)collective model.A good description of the excitation energies of the lowest ground,γ,andβbands,as well as the staggering function between the collective states of theγband and some other energy-dependent quantities,is obtained.The low-energy intraband and interband quadrupole dynamics is reasonably well described within the present proton-neutron sympletic based shell-model approach without the use of an effective charge and compared with the predictions of nuclear structure models.The obtained results of the present study shed light on the question of the existence of irrotational-flow type quadrupole dynamics,which lies on the ground of the original BM model of quantized vibrations and surface-wave rotations in atomic nuclei.
文摘In this study,a microscopic shell-model description of the low-lying collective states in the weakly deformed nucleus ^(106)Cd within the recently proposed microscopic version of the Bohr-Mottelson model is provided.A good description of the excitation energies of the lowest ground,γ,andβquasibands is obtained without the adjustable kinetic energy term.Furthermore,γdegrees of freedom are shown to play a crucial role in the description of spectroscopy of this nucleus.A modified SU(3)SU(3)preserving high-order interaction is used to produce aγ-unstable type of odd-even staggering,observed experimentally between the states of the quasi-γband.The current approach enables the characterization of observed intraband and interband quadrupole collectivity.The findings of this study propose an alternative interpretation of the fundamental question regarding the nature of low-energy vibrations,as well as the emergence of deformation and collectivity in weakly deformed atomic nuclei.
文摘The recently proposed microscopic shell-model version of the Bohr-Mottelson(BM) collective model is considered in more detail in the coordinate representation.The latter possesses a clear and transparent physical meaning,which reveals several features of the new version of the collective model missed in the previous formulation.The relationship to the original BM model is considered,along with the relationships between the different limiting submodels of the microscopic version of the BM model,which closely resemble the relationships of the original Wilets-Jean and rotor models.The kinematically correct many-particle wave functions of the microscopic version of the BM model,conserving the experimentally observed integrals of motion,are shown to consist of collective irrotational-flow and intrinsic components-in accordance with the original BM unified model.The general BM Hamiltonian is obtained as a contraction limit of the microscopic many-particle nuclear Hamiltonian,or,alternatively,by restricting the latter to the scalar O(m) irreducible collective space.
基金Project supported by the National Natural Science Foundation of China (NO. 29503019) and partially by the U. S. National Science Foundation Grant of PHY-9540854.
文摘The expansion coefficient C-\L\(D) Of Coulomb potential 1/r(12) of atomic system in hyper-spherical harmonics is derived and the explicit expression is given.
