地理信息系统(Geographic Information System,简称GIS),是在计算机软硬件系统支持下,融合计算机图形和数据库于一体,用来存储和处理空间信息的高新技术,对现实世界各类空间数据及描述这些空间数据特性的属性进行采集、储存、管理、运...地理信息系统(Geographic Information System,简称GIS),是在计算机软硬件系统支持下,融合计算机图形和数据库于一体,用来存储和处理空间信息的高新技术,对现实世界各类空间数据及描述这些空间数据特性的属性进行采集、储存、管理、运算、分析、显示和描述的技术系统。本文介绍了地理信息系统(GIS)的一些概念,结合实际探讨了地理信息系统的设计与实现一些重要步骤与方法,并展望了GIS技术进一步的发展方向。展开更多
Poly(lactic-co-glycolic)acid(PLGA)particles have become a commonly used drug delivery strategy in the pharmaceutical industry.In this work,we aim to investigate the size-dependent cellular internalization of PLGA part...Poly(lactic-co-glycolic)acid(PLGA)particles have become a commonly used drug delivery strategy in the pharmaceutical industry.In this work,we aim to investigate the size-dependent cellular internalization of PLGA particles and its effects on sustained drug release.We prepared three different-sized particles using PLGA(200,500 and 2000 nm)ranging from submicrometer to micrometer.Dexamethasone(DEX)with excellent anti-inflammatory properties was used as a model drug to prepare DEX-loaded PLGA particles(DPs).We comprehensively investigated the encapsulation efficiency,cellular uptake and in vitro drug release profile.Pharmacodynamic assessment revealed that,in the lipopolysaccharide(LPS)-induced RAW 264.7 cells model,500 nm DPs showed sustained anti-inflammatory efficacy.This work provides important information for designing PLGA-based drug delivery systems for biomedical applications.展开更多
文摘地理信息系统(Geographic Information System,简称GIS),是在计算机软硬件系统支持下,融合计算机图形和数据库于一体,用来存储和处理空间信息的高新技术,对现实世界各类空间数据及描述这些空间数据特性的属性进行采集、储存、管理、运算、分析、显示和描述的技术系统。本文介绍了地理信息系统(GIS)的一些概念,结合实际探讨了地理信息系统的设计与实现一些重要步骤与方法,并展望了GIS技术进一步的发展方向。
基金supported by the National Natural Science Foundation of China (No.22022410,No.82050005,No.12105352)the Youth Innovation Promotion Association of Chinese Academy of Sciences (No.2012205,No.2016236).
文摘Poly(lactic-co-glycolic)acid(PLGA)particles have become a commonly used drug delivery strategy in the pharmaceutical industry.In this work,we aim to investigate the size-dependent cellular internalization of PLGA particles and its effects on sustained drug release.We prepared three different-sized particles using PLGA(200,500 and 2000 nm)ranging from submicrometer to micrometer.Dexamethasone(DEX)with excellent anti-inflammatory properties was used as a model drug to prepare DEX-loaded PLGA particles(DPs).We comprehensively investigated the encapsulation efficiency,cellular uptake and in vitro drug release profile.Pharmacodynamic assessment revealed that,in the lipopolysaccharide(LPS)-induced RAW 264.7 cells model,500 nm DPs showed sustained anti-inflammatory efficacy.This work provides important information for designing PLGA-based drug delivery systems for biomedical applications.
