目的探讨蚯蚓纤溶酶(earthworm fibrinolytic enzyme,EFE)对裸鼠人肝癌细胞移植瘤生长及CD44v6表达的影响。方法建立肝癌SMMC-7721细胞裸鼠移植瘤模型,随机分为生理盐水组、EFE组、5-Fu组及联合用药组,计算抑瘤率及两药相互作用系数(coe...目的探讨蚯蚓纤溶酶(earthworm fibrinolytic enzyme,EFE)对裸鼠人肝癌细胞移植瘤生长及CD44v6表达的影响。方法建立肝癌SMMC-7721细胞裸鼠移植瘤模型,随机分为生理盐水组、EFE组、5-Fu组及联合用药组,计算抑瘤率及两药相互作用系数(coefficient of drug in interaction,CDI),并行血常规检测评价EFE的副反应。同时采用免疫组化SP染色法、RT-PCR及Western blot方法观察EFE组及生理盐水组瘤组织中CD44v6的表达情况。结果与生理盐水组相比,EFE组和5-Fu组抑瘤率分别为20.53%和23.07%;联合用药组抑瘤率为54.20%,且CDI<1。血常规检测提示EFE对造血系统无明显副反应。免疫组化和Western blot结果显示,EFE组CD44v6蛋白的表达水平较生理盐水组分别下调47.16%、28.37%(P<0.05)。RT-PCR结果表明,EFE组CD44v6 mRNA的表达水平亦较生理盐水组低,下调16.44%(P<0.05)。结论蚯蚓纤溶酶对裸鼠人肝癌移植瘤的生长具有一定的抑制作用,与5-Fu存在一定的协同效应,并可以抑制黏附分子CD44v6的表达。展开更多
The notion of “exceptional family of elements (EFE)” plays a very important role in solving complementarity prob- lems. It has been applied in finite dimensional spaces and Hilbert spaces by many authors. In this pa...The notion of “exceptional family of elements (EFE)” plays a very important role in solving complementarity prob- lems. It has been applied in finite dimensional spaces and Hilbert spaces by many authors. In this paper, by using the generalized projection defined by Alber, we extend this notion from Hilbert spaces to uniformly smooth and uniformly convex Banach spaces, and apply this extension to the study of nonlinear complementarity problems in Banach spaces.展开更多
专门用途西班牙语(Espa觡ol para Fines Específicos,简称EFE)是一个新兴学科,相关研究也不甚丰富。对于这个问题认识的欠缺导致很多西班牙语教师在教学中抱有错误观念,常常轻视西班牙语作为外语的教学中衍生的分支。本文通过回顾...专门用途西班牙语(Espa觡ol para Fines Específicos,简称EFE)是一个新兴学科,相关研究也不甚丰富。对于这个问题认识的欠缺导致很多西班牙语教师在教学中抱有错误观念,常常轻视西班牙语作为外语的教学中衍生的分支。本文通过回顾专门用途西班牙语教学的发展,分析专门用途西班牙语教学的特点,并就可运用的教学方法进行讨论。展开更多
As the share of wind power in power systems continues to increase, the limited predictability of wind power generation brings serious potential risks to power system reliability. Previous research works have generally...As the share of wind power in power systems continues to increase, the limited predictability of wind power generation brings serious potential risks to power system reliability. Previous research works have generally described the uncertainty of wind power forecast errors(WPFEs) based on normal distribution or other standard distribution models, which only characterize the aleatory uncertainty. In fact, epistemic uncertainty in WPFE modeling due to limited data and knowledge should also be addressed. This paper proposes a multi-source information fusion method(MSIFM) to quantify WPFEs when considering both aleatory and epistemic uncertainties. An extended focal element(EFE) selection method based on the adequacy of historical data is developed to consider the characteristics of WPFEs. Two supplementary expert information sources are modeled to improve the accuracy in the case of insufficient historical data. An operation reliability evaluation technique is also developed considering the proposed WPFE model. Finally,a double-layer Monte Carlo simulation method is introduced to generate a time-series output of the wind power. The effectiveness and accuracy of the proposed MSIFM are demonstrated through simulation results.展开更多
文摘目的探讨蚯蚓纤溶酶(earthworm fibrinolytic enzyme,EFE)对裸鼠人肝癌细胞移植瘤生长及CD44v6表达的影响。方法建立肝癌SMMC-7721细胞裸鼠移植瘤模型,随机分为生理盐水组、EFE组、5-Fu组及联合用药组,计算抑瘤率及两药相互作用系数(coefficient of drug in interaction,CDI),并行血常规检测评价EFE的副反应。同时采用免疫组化SP染色法、RT-PCR及Western blot方法观察EFE组及生理盐水组瘤组织中CD44v6的表达情况。结果与生理盐水组相比,EFE组和5-Fu组抑瘤率分别为20.53%和23.07%;联合用药组抑瘤率为54.20%,且CDI<1。血常规检测提示EFE对造血系统无明显副反应。免疫组化和Western blot结果显示,EFE组CD44v6蛋白的表达水平较生理盐水组分别下调47.16%、28.37%(P<0.05)。RT-PCR结果表明,EFE组CD44v6 mRNA的表达水平亦较生理盐水组低,下调16.44%(P<0.05)。结论蚯蚓纤溶酶对裸鼠人肝癌移植瘤的生长具有一定的抑制作用,与5-Fu存在一定的协同效应,并可以抑制黏附分子CD44v6的表达。
文摘The notion of “exceptional family of elements (EFE)” plays a very important role in solving complementarity prob- lems. It has been applied in finite dimensional spaces and Hilbert spaces by many authors. In this paper, by using the generalized projection defined by Alber, we extend this notion from Hilbert spaces to uniformly smooth and uniformly convex Banach spaces, and apply this extension to the study of nonlinear complementarity problems in Banach spaces.
文摘专门用途西班牙语(Espa觡ol para Fines Específicos,简称EFE)是一个新兴学科,相关研究也不甚丰富。对于这个问题认识的欠缺导致很多西班牙语教师在教学中抱有错误观念,常常轻视西班牙语作为外语的教学中衍生的分支。本文通过回顾专门用途西班牙语教学的发展,分析专门用途西班牙语教学的特点,并就可运用的教学方法进行讨论。
基金supported by the Joint Research Fund in Smart Grid (No.U1966601) under cooperative agreement between the National Natural Science Foundation of China (NSFC) and State Grid Corporation of China。
文摘As the share of wind power in power systems continues to increase, the limited predictability of wind power generation brings serious potential risks to power system reliability. Previous research works have generally described the uncertainty of wind power forecast errors(WPFEs) based on normal distribution or other standard distribution models, which only characterize the aleatory uncertainty. In fact, epistemic uncertainty in WPFE modeling due to limited data and knowledge should also be addressed. This paper proposes a multi-source information fusion method(MSIFM) to quantify WPFEs when considering both aleatory and epistemic uncertainties. An extended focal element(EFE) selection method based on the adequacy of historical data is developed to consider the characteristics of WPFEs. Two supplementary expert information sources are modeled to improve the accuracy in the case of insufficient historical data. An operation reliability evaluation technique is also developed considering the proposed WPFE model. Finally,a double-layer Monte Carlo simulation method is introduced to generate a time-series output of the wind power. The effectiveness and accuracy of the proposed MSIFM are demonstrated through simulation results.
