Depletion calculation is important for studying the transmutation efficiency of minor actinides and longlife fission products in accelerator-driven subcritical reactor system(ADS). Herein the Python language is used t...Depletion calculation is important for studying the transmutation efficiency of minor actinides and longlife fission products in accelerator-driven subcritical reactor system(ADS). Herein the Python language is used to develop a burnup code system called IMPC-Burnup by coupling FLUKA, OpenMC, and ORIGEN2. The program is preliminarily verified by OECD-NEA pin cell and IAEAADS benchmarking by comparison with experimental values and calculated results from other studies. Moreover,the physics design scheme of the CIADS subcritical core is utilized to test the feasibility of IMPC-Burnup program in the burnup calculation of ADS system. Reference results are given by the COUPLE3.0 program. The results of IMPC-Burnup show good agreement with those of COUPLE3.0. In addition, since the upper limit of the neutron transport energy for OpenMC is 20 MeV, neutrons with energies greater than 20 MeV in the CIADS subcritical core cannot be transported; thus, an equivalent flux method has been proposed to consider neutrons above 20 MeV in the OpenMC transport calculation. The results are compared to those that do not include neutrons greater than 20 MeV. The conclusion is that the accuracy of the actinide nuclide mass in the burnup calculation is improved when the equivalent flux method is used. Therefore, the IMPC-Burnup code is suitable for burnup analysis of the ADS system.展开更多
乳腺浸润性微乳头状癌(invasive micropapillary carcinoma of the breast,IMPC)是一种具有高度侵袭性的组织学类型。它与广泛的淋巴结转移及脉管侵犯显著相关,提示其预后较差。病理学诊断是识别乳腺浸润性微乳头状癌的主要方法,其镜下...乳腺浸润性微乳头状癌(invasive micropapillary carcinoma of the breast,IMPC)是一种具有高度侵袭性的组织学类型。它与广泛的淋巴结转移及脉管侵犯显著相关,提示其预后较差。病理学诊断是识别乳腺浸润性微乳头状癌的主要方法,其镜下典型的特征为“主、间质分离”,即排列成桑葚状的肿瘤细胞簇似漂浮在由透明的胶原纤维基质构成的空旷而清晰的空间中。因其发病率不高,目前在治疗方面尚无标准的治疗策略,但鉴于它高度的淋巴结和脉管侵犯倾向以及较高的局部复发率,近年来吸引了越来越多的研究者探索其分子遗传学机制和诊疗方案。展开更多
In this paper, we consider the numerical treatment of an inverse acoustic scattering problem that involves an impenetrable obstacle embedded in a layered medium. We begin by employing a modified version of the well kn...In this paper, we consider the numerical treatment of an inverse acoustic scattering problem that involves an impenetrable obstacle embedded in a layered medium. We begin by employing a modified version of the well known <em>factorization method</em>, in which a computationally effective numerical scheme for the reconstruction of the shape of the scatterer is presented. This is possible, due to a <em>mixed reciprocity principle</em>, which renders the computation of the Green function at the background medium unnecessary. Moreover, to further refine our inversion algorithm, an efficient Tikhonov parameter choice technique, called <em>Improved Maximum Product Criterion</em> (IMPC) is exploited. Our regularization parameter is computed via a fast iterative algorithm which requires no <em>a priori</em> knowledge of the noise level in the far-field data. Finally, the effectiveness of IMPC is illustrated with various numerical examples.展开更多
目的:建立恩格列净片有关物质测定的HPLC法。方法:采用辛烷基硅烷键合硅胶为填充剂的色谱柱(ZORBAX Rx-C8,250 mm×4.6 mm,5μm),以p H 3.5的磷酸水溶液为流动相A,甲醇-乙腈(1∶1)为流动相B,梯度洗脱,流速1.0 m L·min^(-1),检...目的:建立恩格列净片有关物质测定的HPLC法。方法:采用辛烷基硅烷键合硅胶为填充剂的色谱柱(ZORBAX Rx-C8,250 mm×4.6 mm,5μm),以p H 3.5的磷酸水溶液为流动相A,甲醇-乙腈(1∶1)为流动相B,梯度洗脱,流速1.0 m L·min^(-1),检测波长224 nm,柱温为25℃,进样量20μL,对有关物质进行定性、定量分析。结果:在选定的色谱条件下,恩格列净与相邻杂质及各杂质之间的分离度均大于1.5;杂质IMPD(恩格列净还原产物)、杂质IMPC(恩格列净开环产物)、杂质EMGA(恩格列净中间体)、杂质IMPF(恩格列净缩合产物)、杂质IMPG(恩格列净脱葡萄糖醇产物)的定量限分别为28.30、53.07、73.60、65.00和395.57 ng,且在各自的线性范围内线性关系良好(r>0.999,n=5),平均回收率(n=9)分别为100.7%、102.9%、97.4%、102.1%和102.9%。对3批恩格列净片进行有关物质测定,结果总杂质量在0.05%～0.06%范围内。结论:经方法学验证,本法简便、灵敏,专属性好,可用于恩格列净片有关物质的测定。展开更多
基金supported by the ‘‘Strategic Priority Research Program’’ of Chinese Academy of Sciences(No.XDA03030102)
文摘Depletion calculation is important for studying the transmutation efficiency of minor actinides and longlife fission products in accelerator-driven subcritical reactor system(ADS). Herein the Python language is used to develop a burnup code system called IMPC-Burnup by coupling FLUKA, OpenMC, and ORIGEN2. The program is preliminarily verified by OECD-NEA pin cell and IAEAADS benchmarking by comparison with experimental values and calculated results from other studies. Moreover,the physics design scheme of the CIADS subcritical core is utilized to test the feasibility of IMPC-Burnup program in the burnup calculation of ADS system. Reference results are given by the COUPLE3.0 program. The results of IMPC-Burnup show good agreement with those of COUPLE3.0. In addition, since the upper limit of the neutron transport energy for OpenMC is 20 MeV, neutrons with energies greater than 20 MeV in the CIADS subcritical core cannot be transported; thus, an equivalent flux method has been proposed to consider neutrons above 20 MeV in the OpenMC transport calculation. The results are compared to those that do not include neutrons greater than 20 MeV. The conclusion is that the accuracy of the actinide nuclide mass in the burnup calculation is improved when the equivalent flux method is used. Therefore, the IMPC-Burnup code is suitable for burnup analysis of the ADS system.
文摘乳腺浸润性微乳头状癌(invasive micropapillary carcinoma of the breast,IMPC)是一种具有高度侵袭性的组织学类型。它与广泛的淋巴结转移及脉管侵犯显著相关,提示其预后较差。病理学诊断是识别乳腺浸润性微乳头状癌的主要方法,其镜下典型的特征为“主、间质分离”,即排列成桑葚状的肿瘤细胞簇似漂浮在由透明的胶原纤维基质构成的空旷而清晰的空间中。因其发病率不高,目前在治疗方面尚无标准的治疗策略,但鉴于它高度的淋巴结和脉管侵犯倾向以及较高的局部复发率,近年来吸引了越来越多的研究者探索其分子遗传学机制和诊疗方案。
文摘In this paper, we consider the numerical treatment of an inverse acoustic scattering problem that involves an impenetrable obstacle embedded in a layered medium. We begin by employing a modified version of the well known <em>factorization method</em>, in which a computationally effective numerical scheme for the reconstruction of the shape of the scatterer is presented. This is possible, due to a <em>mixed reciprocity principle</em>, which renders the computation of the Green function at the background medium unnecessary. Moreover, to further refine our inversion algorithm, an efficient Tikhonov parameter choice technique, called <em>Improved Maximum Product Criterion</em> (IMPC) is exploited. Our regularization parameter is computed via a fast iterative algorithm which requires no <em>a priori</em> knowledge of the noise level in the far-field data. Finally, the effectiveness of IMPC is illustrated with various numerical examples.
文摘目的:建立恩格列净片有关物质测定的HPLC法。方法:采用辛烷基硅烷键合硅胶为填充剂的色谱柱(ZORBAX Rx-C8,250 mm×4.6 mm,5μm),以p H 3.5的磷酸水溶液为流动相A,甲醇-乙腈(1∶1)为流动相B,梯度洗脱,流速1.0 m L·min^(-1),检测波长224 nm,柱温为25℃,进样量20μL,对有关物质进行定性、定量分析。结果:在选定的色谱条件下,恩格列净与相邻杂质及各杂质之间的分离度均大于1.5;杂质IMPD(恩格列净还原产物)、杂质IMPC(恩格列净开环产物)、杂质EMGA(恩格列净中间体)、杂质IMPF(恩格列净缩合产物)、杂质IMPG(恩格列净脱葡萄糖醇产物)的定量限分别为28.30、53.07、73.60、65.00和395.57 ng,且在各自的线性范围内线性关系良好(r>0.999,n=5),平均回收率(n=9)分别为100.7%、102.9%、97.4%、102.1%和102.9%。对3批恩格列净片进行有关物质测定,结果总杂质量在0.05%～0.06%范围内。结论:经方法学验证,本法简便、灵敏,专属性好,可用于恩格列净片有关物质的测定。
